1.
Angew Chem Int Ed Engl
; 62(20): e202301091, 2023 May 08.
Artículo
en Inglés
| MEDLINE
| ID: mdl-36929860
RESUMEN
A cobalt-catalyzed deuteration of amidoacrylates using deuterated methanol afforded α,ß-dideuterio-α-amino esters in excellent enantiomeric ratios (mostly >95 : 5) and almost complete deuteration (99 %). The new protocol was used to prepare dideuterio-α-amino acid fragments in some drugs. Furthermore, the stereoselective deuteration was applied in a concise synthesis of dideuterio l-DOPA.