Informal E-waste dismantling activities accelerated the releasing of liquid crystal monomers (LCMs) in Pakistan: Occurrence, distribution, and exposure assessment.

Liquid crystal monomers (LCMs) are emerging contaminants characterized by their persistence, bioaccumulation potential, and toxicity. They have been observed in several environmental matrices associated with electronic waste (e-waste) dismantling activities, particularly in China. However, there is currently no information on the pollution caused by LCMs in other developing countries, such as Pakistan. In this study, we collected soil samples (n = 59) from e-waste dismantling areas with different functions in Pakistan for quantification analysis of 52 target LCMs. Thirty out of 52 LCMs were detected in the soil samples, with the concentrations ranging from 2.14 to 191 ng/g (median: 16.3 ng/g), suggesting widespread contamination by these emerging contaminants. Fluorinated LCMs (median: 10.4 ng/g, range: 1.27-116 ng/g) were frequently detected and their levels were significantly (P < 0.05) higher than those of non-fluorinated LCMs (median: 6.11 ng/g, range: not detected (ND)-76.7 ng/g). The concentrations and profiles of the observed LCMs in the soil samples from the four functional areas varied. The informal dismantling of e-waste poses a potential exposure risk to adults and infants, with median estimated daily intake (EDI, ng/kg bw/day) values of 0.0420 and 0.1013, respectively. Calculation of the hazard quotient (HQ) suggested that some LCMs (e.g., ETFMBC (1.374) and EDFPB (1.257)) may pose potential health risks to occupational workers and their families. Considering the widespread contamination and risks associated with LCMs, we strongly recommend enhancing e-waste management and regulation in Pakistan.

Aromatic amine antioxidants (AAs) and p-phenylenediamines-quinones (PPD-Qs) in e-waste recycling industry park: Occupational exposure and liver X receptors (LXRs) disruption potential.

Recently, evidence of aromatic amine antioxidants (AAs) existence in the dust of the electronic waste (e-waste) dismantling area has been exposed. However, there are limited studies investigating occupational exposure and toxicity associated with AAs and their transformation products (p-phenylenediamines-quinones, i.e., PPD-Qs). In this study, 115 dust and 42 hand wipe samples collected from an e-waste recycling industrial park in central China were analyzed for 19 AAs and 6 PPD-Qs. Notably, the median concentration of ∑6PPD-Qs (1,110 ng/g and 1,970 ng/m2) was significantly higher (p < 0.05, Mann-Whitney U test) than that of ∑6PPDs (147 ng/g and 34.0 ng/m2) in dust and hand wipes. Among the detected analytes, 4-phenylaminodiphenylamine quinone (DPPD-Q) (median: 781 ng/g) and 1,4-Bis(2-naphthylamino) benzene quinone (DNPD-Q) (median: 156 ng/g), were particularly prominent, which were first detected in the e-waste dismantling area. Occupational exposure assessments and nuclear receptor interference ability, conducted through estimated daily intake (EDI) and molecular docking analysis, respectively, indicated significant occupational exposure to PPD-Qs and suggested prioritized Liver X receptors (LXRs) disruption potential of PPDs and PPD-Qs. The study provides the first evidence of considerable levels of AAs and PPD-Qs in the e-waste-related hand wipe samples and underscores the importance of assessing occupational exposure and associated toxicity effects.

Spatial distribution and ecological risk assessment of short and medium chain chlorinated paraffins in water and sediments of river Ravi, Pakistan.

Short (SCCPs) and medium (MCCPs) chain chlorinated paraffins being the emerging organic pollutants have raised serious concerns due to their widespread use and related human health risks. However, their occurrence in aquatic bodies like rivers and associated damage to ecological integrity is yet unknown in some regions of the world. The current study is the first ever assessment of SCCPs and MCCPs in sediment and water of river Ravi, Pakistan. Spatial occurrence and associated ecological risks were investigated from sediments (n = 16) and composite water samples (n = 8) collected at eight locations along the stretch of river Ravi. The concentrations of SCCPs and MCCPs varied from below limit of detection (

Waste management of solar cells in South Asia: an environmental concern of the emerging market.

The share of solar energy in the energy mix has become a major concern, and the global effort is to increase its contribution. Photovoltaic technology is an environment-friendly way of electricity production compared to fossil fuels. Currently, third generation of solar cells with a maximum average conversion efficiency of 20% has been achieved. Asia is an emerging market for photovoltaic technology, and it has recorded the highest installation capacity for 2018 (280 MW), 2030 (1860 MW), and 2050 (4837 MW). Meanwhile, Asia is estimated to be the highest producer of PV waste by 2040, with 5,580,000 metric tons of waste volume. Solid waste management is already a big environmental issue in South Asian countries, and untested landfilling of solar cells can further increase the burden. This review emphasizes the end-of-life scenario of solar cells in developing South Asian countries. Solar cell waste is hazardous e-waste that can lead to environmental and health impacts if not managed properly. It consists of metals with market value, which can be waste or gold, depending on its management. The study finds that recycling is the economically and environmentally effective waste management option for solar cells in South Asia. This paper reviews the deficiencies in the existing solar cell waste management framework in South Asian countries. Moreover, practical implications are presented for designing an effective waste management plan for solar cells in South Asian countries. Strong legislation, sufficient recycling infrastructure, and high stakeholders' interests are required to resolve this environmental concern.

Nontarget Identification of Novel Per- and Polyfluoroalkyl Substances (PFAS) in Soils from an Oil Refinery in Southwestern China: A Combined Approach with TOP Assay.

Oil refinery activity can be an emission source of perfluoroalkyl and polyfluoroalkyl substances (PFAS) to the environment, while the contamination profiles in soils remain unknown. This study investigated 44 target PFAS in soil samples collected from an oil refinery in Southeastern China, identified novel PFAS, and characterized their behaviors by assessing their changes before and after employing advanced oxidation using a combination of nontarget analysis and a total oxidizable precursor (TOP) assay. Thirty-four target PFAS were detected in soil samples. Trifluoroacetic acid (TFA) and hexafluoropropylene oxide dimer acid (HFPO-DA) were the dominant PFAS. Twenty-three novel PFAS of 14 classes were identified, including 8 precursors, 11 products, and 4 stable PFAS characterized by the TOP assay. Particularly, three per-/polyfluorinated alcohols were identified for the first time, and hexafluoroisopropanol (HFIP) quantified up to 657 ng/g dw is a novel precursor for TFA. Bistriflimide (NTf2) potentially associated with an oil refinery was also reported for the first time in the soil samples. This study highlighted the advantage of embedding the TOP assay in nontarget analysis to reveal not only the presence of unknown PFAS but also their roles in environmental processes. Overall, this approach provides an efficient way to uncover contamination profiles of PFAS especially in source-impacted areas.

Distribution, bioaccumulation, and health risk assessment of organochlorines across the riverine ecosystem of Punjab Province, Pakistan.

This study was designed to assess the distribution of organochlorines (OCs) in fish species, their spatio-temporal variations, bioaccumulation potential, and associated human health risks via dietary intake. The levels of twenty-three organochlorine pesticides (OCPs) and thirty-five polychlorinated biphenyls (PCBs) were analyzed in six fish species collected from the riverine ecosystem of Punjab Province, Pakistan. The results indicated that the mean levels of Σ23OCPs were 74.1 ng/g ww and 184 ng/g ww, and for Σ35PCBs the levels were 38.8 ng/g ww and 74.8 ng/g ww in herbivorous and carnivorous fish species, respectively. The most abundant contaminants in all fish species were DDTs (65%) and HCHs (14%) among OCPs and heavier PCB congeners (62%) among PCBs. As for dioxin-like PCBs, the WHO toxic equivalency values (ng TEQ/g ww) were in the range of 0.21 (Cyprinus Carpio) to 2.38 (Rita Rita), exceeding the maximum allowable limit of 0.004 ng TEQ/g, ww by the European Commission. Spatio-temporal analysis indicated relatively higher OC levels in winter season with elevated concentrations in fish samples from industrial zone. The bioconcentration factor (L/kg) values ranged from 723 to 2773 for PCBs and 315 to 923 for OCPs in all fish species, with higher levels were reported in carnivorous species. The human health risk assessment at both 50th and 95th percentiles revealed the absence of any significant non-carcinogenic risk as calculated HR was less than 1. However, the critical carcinogenic risk was found to be associated for most of the contaminants, signifying the dietary exposure to OCPs and PCBs might pose the public health concern.

Percutaneous Penetration of Liquid Crystal Monomers (LCMs) by In Vitro Three-Dimensional Human Skin Equivalents: Possible Mechanisms and Implications for Human Dermal Exposure Risks.

Liquid crystal monomers (LCMs) are indispensable materials in liquid crystal displays, which have been recognized as emerging persistent, bioaccumulative, and toxic organic pollutants. Occupational and nonoccupational exposure risk assessment suggested that dermal exposure is the primary exposure route for LCMs. However, the bioavailability and possible mechanisms of dermal exposure to LCMs via skin absorption and penetration remain unclear. Herein, we used EpiKutis 3D-Human Skin Equivalents (3D-HSE) to quantitatively assess the percutaneous penetration of nine LCMs, which were detected in e-waste dismantling workers' hand wipes with high detection frequencies. LCMs with higher log Kow and greater molecular weight (MW) were more difficult to penetrate through the skin. Molecular docking results showed that ABCG2 (an efflux transporter) may be responsible for percutaneous penetration of LCMs. These results suggest that passive diffusion and active efflux transport may be involved in the penetration of LCMs across the skin barrier. Furthermore, the occupational dermal exposure risks evaluated based on the dermal absorption factor suggested the underestimation of the continuous LCMs' health risks via dermal previously.

Electronic-waste-associated pollution of per- and polyfluoroalkyl substances: Environmental occurrence and human exposure.

Occupational exposure to per- and polyfluoroalkyl substances (PFASs) is of serious concern because their adverse health effects. Nevertheless, knowledge regarding contamination in e-waste dismantling regions is rather scarce. We therefore analysed seven neutral PFASs (n-PFASs) and forty ionized PFASs (i-PFASs) in dust and hand wipes collected from an e-waste dismantling plant and homes. Both dust (1370 ng/g) and workers' hand wipe (1100 ng/m2) in e-waste dismantling workshops contained significantly higher median levels of ∑PFASs than those from homes (684 ng/g and 444 ng/m2) (p < 0.01). ∑PFAS concentrations in dust and on workers' hand wipes from workshops were significantly higher than those from storage area. 8:2 fluorotelomer alcohol was the dominant n-PFAS in workshop dust (70.7%) and on worker's hand wipes (46.6%). Perfluoroalkyl carboxylic acids (C2 -C3) were the significant components (based on concentration) of i-PFASs in dust (57.9%) and on hand wipes (89.6%). A significant positive correlation (p < 0.001) of ∑PFAS concentrations between workshop dust and workers' hand wipes was observed, indicating that they come from common sources. Compared to dust ingestion, hand-to-mouth contact was highlighted as a vital exposure route, accounting for 68.8% for workers and 72.2% for residential population, respectively, of the sum of two exposure doses.

Organochlorines in the riverine ecosystem of Punjab province, Pakistan: contamination status, seasonal variation, source apportionment, and ecological risk assessment.

The aim of the present study was to determine the occurrence, spatio-temporal variations, source apportioning, and ecological risk assessment of selected PCBs and OCPs in surface water and sediments collected riverine environment of Punjab province, Pakistan. The concentration of ΣOCPs (water: 64-455 ng/L; sediments: 117-616 ng/g) and ΣPCBs (water: 2-132 ng/L; sediments: 3.27-200 ng/g) was found comparatively higher than the levels reported from other parts of the world. The higher concentrations of DDTs and HCHs were detected in both studied matrices, whereas among PCBs, CB-28, 49 and CB-37, 82 were dominant in water and sediments, respectively. The isomeric ratios including α-HCH/γ-HCH, (DDE + DDD) / DDTs, and α /ß-endosulfan reflected the recent use of lindane, technical DDT, and endosulfan in the study area. The WHO-TEQ values of DL-PCBs ranged from 3.6 × 10-6 to 0.115 ng/L and 8.7 × 10-6 to 0.157 ng/g in surface water and sediments in both seasons, respectively. The spatial variation analysis revealed that the sites in the industrial and agricultural zones were highly contaminated. The OCPs and PCBs fluxes to downstream areas were estimated to be 12.4 tons/year and 1.9 tons/year, respectively. The significant ecological risks were estimated to be posed by OCPs and PCBs, as their levels in 67% and 62% of surface water and sediment samples were exceeding the threshold limits, highlighting effects to ecological integrities.

Association of human cohorts exposed to blood and urinary biomarkers of PAHs with adult asthma in a South Asian metropolitan city.

Semi-volatile organic compounds (SVOCs) are a major global problem that causes the greatest impact on urban settings and have been linked to bronchial asthma in both children and adults in Pakistan. The association between exposure of polycyclic aromatic hydrocarbons (PAHs) and asthma in the adult population is less clear. The current study aimed to assess the clinico-chemical parameters and blood levels of naphthalene phenanthrene, pyrene, and 1,2-benzanthracene and urinary levels of 1-OH pyrene and 1-OH phenanthrene as well as asthma-related biomarkers immunoglobulin E (IgE), resistin, and superoxide dismutase (SOD) of oxidative stress and other hematologic parameters in adults and their relationship with bronchial asthma. The GC/MS analysis showed higher mean concentrations of blood PAHs in asthma respondents (4.48 ± 1.34, 3.46 ± 1.04, 0.10 ± 0.03, and 0.29 ± 0.09) (ng/mL) as compared to controls (3.07 ± 0.92, 1.71 ± 0.51, 0.06 ± 0.02, and 0.11 ± 0.03) (ng/mL), with p = .006, p = .001, p = .050, and p = .001. Similarly, urinary levels of 1-OHpyr and 1-OHphe were significantly increased in adults with bronchial asthma (0.54 ± 0.16; 0.13 ± 0.04) (µmol/mol-Cr) than in controls (0.30 ± 0.09; 0.05 ± 0.02) (µmol/mol-Cr), with p = .002 and p = .0001, respectively, with a significant positive correlation to asthma severity. The asthma-related biomarkers IgE, resistin, and SOD were significantly higher (p 0.0001, 0.0001, and 0.0001) in people with asthma than in control persons. The findings showed that higher blood and urine PAHs levels were linked to higher asthma risk in adults and significant interaction with participants who smoked, had allergies, had a family history of asthma, and were exposed to dust. The current study's findings will be useful to local regulatory agencies in Lahore in terms of managing exposure and advocating efforts to minimize PAH pollution and manage health.

Role of ambient air pollution in asthma spread among various population groups of Lahore City: a case study.

Air pollution levels rise as a result of industrial and vehicular emissions, epidemiological issues such as asthma become more prevalent in Lahore, Punjab, Pakistan and cause adverse public health effects. Many studies explored the association between air pollutants and frequency of asthma hospital visits, although their effects are unclear. This study examined the link between air pollution, asthma, and socioeconomic and demographic factors. A questionnaire survey was administered among four age groups (15-25, 25-45, 45-60, and over 60 years old) in public and private hospitals of Lahore city. Daily average concentrations of five air pollutants including carbon monoxide (CO), nitrogen dioxide (NO2), sulfur dioxide (SO2), ozone (O3), and particulate matter (PM2.5 and PM10) were recorded at ten fixed air monitoring sites in Lahore city. There were favorable connections between outpatient department (OPD) asthma visits (64%) and levels of outdoor air quality during winter season throughout the study period. The correlation between 1, 29, and 370 asthma patients and average daily air pollution levels found that the condition was more prevalent in females (53%) than males (47%). There was a significant correlation between PM10 exposure and asthma OPD visits in the city (p 0.001), as well as the elevated PM10 levels were substantially linked with OPD asthma visits over the winter season in the city. The hazard index (HI) for all adult population was estimated 0.001132. The study's findings indicate that exposure to ambient air pollution is a significant predictor of asthma hospital visits, particularly among the elderly. Strategies can be developed by policymakers in response to the worrying situation of allergic disease asthma in industrial cities due to air pollution.

Source identification and risk assessment of polycyclic aromatic hydrocarbons (PAHs) in air and dust samples of Lahore City.

During two consecutive summer and winter seasons in Lahore, the health risk of air and dust-borne polycyclic aromatic hydrocarbons (PAHs) was evaluated. Gas chromatography/mass spectrometry (GS/MS) was used to determine air and dust samples from various functional areas across the city. The mean ∑16PAHs were higher in air 1035.8 ± 310.7 (pg m-3) and dust 963.4 ± 289.0 (ng g-1 d.w.) during winter seasons as compared to summer seasons in air 1010.9 ± 303.3 (pg m-3) and dust matrices 945.2 ± 283.6 (ng g-1 d.w.), respectively. PAHs ring profile recognized 3 and 4 rings PAHs as most dominant in air and dust samples. Estimated results of incremental lifetime cancer risk (ILCR) highlighted high carcinogenic risk among the residents of Lahore via ingestion and dermal contact on exposure to atmospheric PAHs. The total ILCR values in air among children (summer: 9.61E - 02, winter: 2.09E - 02) and adults (summer: 1.45E - 01, winter: 3.14E - 02) and in dust, children (summer: 9.16E - 03, winter: 8.80E - 03) and adults (summer: 1.38E - 02, winter: 1.33E - 02) during the study period. The isomeric ratios in the study area revealed mixed PAH sources, including vehicular emission, petroleum, diesel and biomass combustion. As a result, it is advised that atmospheric PAHs should be monitored throughout the year and the ecologically friendly fuels be used to prevent PAHs pollution and health concerns in the city. The findings of this study are beneficial to the local regulating bodies in terms of controlling the exposure and promoting steps to reduce PAHs pollution and manage health in Lahore.

Assessment of organochlorine pesticides and health risk in tobacco farming associated with River Barandu of Pakistan.

Diffuse pesticide pollution through tobacco fields is a serious threat to both natural integrities and living beings because tobacco is known as a pesticide-intensive crop. Upsurge in the knowledge of detrimental impacts caused by organochlorine pesticides (OCPs) has made them a burning issue particularly in developing countries. Pakistan is a country famous for its agro-based economy and simultaneously is the second most significant pesticide consumer in South Asian countries. The studied area is tobacco hub of the country. Thus, the present work is aimed to investigate the contamination profile that highlights the ecological and health risk posed by OCPs in River Barandu, located in the proximity of tobacco farming region. ΣOCP levels in sediments ranged between 32.918 and 98.810 ng/g and in water between 0.340 and 0.935 µg/L. Hexachlorocyclohexanes (HCHs) and heptachlor were the most prevailing pesticides in both matrices of the river. Isomeric composition of DDTs and HCHs highlighted that the ß-HCH and p,p'-DDT were dominant isomers in water, while α-HCH and p,p'-DDT in sediment compartment. Enantiomeric compositions of HCH and DDT indicate both recent and historic uses of these compounds in the area. Indirect contamination through nearby tobacco clusters has been depicted through spatial analysis. Ecological risk assessment based upon the risk quotient (RQ) method revealed that α-endosulfan, dieldrin, heptachlor, and ∑HCHs represent a very high level of ecological risks. The OCPs' lifetime carcinogenic and non-carcinogenic health risks associated with dermal exposure to river's water were considered nominal for surrounding populations. However, detailed ecological and health risk studies are recommended considering the bio-accumulating nature of these contaminants in the food chain.

Polychlorinated biphenyls in indoor dust from urban dwellings of Lahore, Pakistan: Congener profile, toxicity equivalency, and human health implications.

This study is the pioneer assessment of the PCBs in indoor dust particles (from air conditioners) of an urbanized megacity from South Asian. The ∑35 PCB concentration ranged from 0.27 to 152.9 ng/g (mean: 24.84 ± 22.10 ng/g). The tri- and tetra-PCBs were dominant homologues, contributing 57.36% of the total PCB concentrations. The mean levels of Σ8 -dioxin-like (DL), Σ6 -indicator PCBs and WHO2005 -TEQ for DL-PCBs were 2.22 ± 2.55 ng/g, 9.49 ± 8.04 ng/g and 4.77 ± 4.89 pg/g, respectively. The multiple linear regression indicated a significant correlation of dusting frequency (p = 1.06 × 10-04) and age of the house (p = 1.02 × 10-06) with PCB concentrations in indoor environment. The spatial variation of PCB profile revealed relatively higher concentrations from sites near to illegal waste burning spots, electrical locomotive workshops, and grid stations. Human health risk assessment of PCBs for adults and toddlers through all three exposure routes (ie, inhalation, ingestion, and dermal contact) demonstrated that toddlers were vulnerable to high cancer risk (4.32 × 10-04 ), while adults were susceptible from low to moderate levels of risk (3.16 × 10-05 ). Therefore, comprehensive investigations for PCBs in the indoor settings, focusing particularly on the sensitive populations with relationship to the electronic devices, transformers, and illegal waste burning sites, are recommended.

Organochlorine pesticides (OCPs) in air-conditioner filter dust of indoor urban setting: Implication for health risk in a developing country.

This preliminary investigation highlights the occurrence of organochlorine pesticides (OCPs) in the indoor environment of a megacity, Lahore, Pakistan using the dust ensnared by air-conditioner filters. The Σ16 OCPs concentration ranged from 7.53 to 1272.87 ng/g with the highest percent contribution by ΣDDT (dichlorodiphenyltrichloroethane; 87.21%) and aldrin (6.58%). The spatial variation of OCPs profile revealed relatively higher concentration from homes near to agricultural and abandoned DDT manufacturing sites. Calculated isomer ratios revealed historic sources of hexachlorocyclohexanes (HCHs) and the fresh input of technical DDT and chlordane by the dwellers. The air conditioner dust was helpful to better understand the health risk in the indoor environment. So far a high lifetime cancer risk (10-3 ) was predicted for toddlers via accidental ingestion, inhalation, and dermal exposure. Similarly, the non-carcinogenic risk-based hazard quotient was found to be high for toddlers (6.94) and within the permissible limit (<1) for adults.

Assessment of polychlorinated biphenyls (PCBs) in the Himalayan Riverine Network of Azad Jammu and Kashmir.

The emission of polychlorinated biphenyls (PCBs) in South Asian countries is one of the great environmental concerns and has resulted in the contamination of surrounding high altitude regions such as Azad Jammu and Kashmir (AJK), Pakistan. This first investigation of Polychlorinated Biphenyl (PCBs) concentrations in the ambient air, water and surface soil was conducted along the extensive stream network in the AJK valley of the Himalayan Region. In 2014, surface soil samples were taken and passive air and water samplers were deployed along the four main rivers, namely Jhelum, Neelum, Poonch and Kunhar, and analysed for PCBs (33 congeners) using GC-MS/MS. The ∑33PCBs concentrations ranged from 31.17 to 175.2 (mean ±â€¯SD: 81 ±â€¯46.4 pg/L), ND to 1908 (1054 ±â€¯588.5 pg/g), and 29.8 to 94.4 (52.9 ±â€¯22.7 pg/m3) in surface water, soil and air matrices, respectively. The levels of dioxin-like PCBs (∑8DL-PCBs) contributed considerably towards the total PCBs concentrations: 60.63% (water), 43.87% (air) and 13.76% (soil). The log transformed air-water fugacity (log fa/fw) ratios ranged from -9.37 to 2.58; with 86.3% of the sampling sites showing net volatilization of selected PCB congeners. Similarly, the fugacity fractions for air-soil exchange exhibited narrow variation (0.8 to < 1) indicating net volatilization of PCBs. The ecological risk assessment showed low potential ecological risks (Eri  = 1.58-7.63) associated with PCB contamination. The present findings provide baseline data that suggest cold trapping of POPs in the remote mountainous areas of Pakistan and can support environmental management of POPs at the regional level. This pioneer investigation campaign to assess the PCBs concentrations in Himalayan Riverine Network of Azad Jammu and Kashmir, Pakistan helps to develop baseline data of PCBs from the strategically important riverine environment that would help in future regional as well as global ecological studies. However, the effects of temperature variations on the sampling rates of chemicals across a wide spectrum of volatility along the elevation gradient were not taken under consideration for PCBs atmospheric concentrations.

Organochlorine pesticides in the surrounding soils of POPs destruction facility: source fingerprinting, human health, and ecological risks assessment.

The elimination of persistent organic pollutants (POPs) obsolete pesticides stockpiles, particularly the organochlorine pesticides (OCPs), is one of the critical environmental issues faced by many developing countries. This pioneering study aimed to investigate the occurrence, source fingerprinting, human health, and ecological risks of OCPs in the surroundings of the lone POPs pesticide destruction facility in Pakistan. The ΣOCPs residual levels in soil ranged from 35.98 to 566.77 ng/g dry weight (dw), with a mean concentration of 174.42 + 111.62 ng/g (dw). The OCPs contamination levels in the soil followed the pattern as ΣHCHs > Σendrins > Σendosulfans > dieldrin > Σheptachlors > ΣDDTs > Σchlordanes > methoxychlor. The ΣHCHs residual concentrations were comparatively higher than the previous national and global soil studies. The recent accumulation of HCHs, DDTs, and heptachlor was observed in the study area as identified by ß-HCH/∑HCHs, (DDE + DDD)/ΣDDTs, heptachlor/Σheptachlor, and heptachlor exo-epoxide/heptachlor ratios. The OCPs' lifetime carcinogenic risk through ingestion, dermal, and inhalation exposure routes ranged from 1.65E-08 to 2.91E-07, whereas the noncarcinogenic hazard quotient (HQ) ranged from 9.12E-05 to 1.61E-03. The risk vulnerability among age groups was in the order: adult > toddler > child > teen > infant. The calculated risk levels were within an acceptable limit of one in a million (1 × 10-6) for carcinogenic risk and HQ < 1 for noncarcinogenic risk. The current OCPs residual levels, especially dieldrin and endrin, exhibited low to medium ecological risks when compared to various worldwide limits. The upsurge of the OCPs' environmental contamination levels over the years and consideration of the food chain transfer might amplify the human health and ecological risks intensities.

Screening of human health risk to infants associated with the polychlorinated biphenyl (PCB) levels in human milk from Punjab Province, Pakistan.

This study assessed the polychlorinated biphenyl (PCB) levels in human milk and its associated health risk to infants from rural and urban settings of five districts of Punjab Province, Pakistan. The ∑34PCB concentrations ranged from 30.9 to 68.3 ng g-1 on lipid weight (l.w.) basis. The ∑8DL-PCB concentrations were ranged from 0.29 to 1.35 ng g-1 l.w., (mean 6.2 ± 8.7 ng g-1 l.w.), with toxicity equivalent to polychlorinated dibenzodioxins (PCDDs) ranging from 8.58 × 10-6 to 0.05 ng TEQ g-1 l.w. The spatial trend of PCB levels in human milk revealed higher bioaccumulative levels for urban mothers as compared with rural counterparts. The estimated daily intake (EDI) values of DL-PCBs to infants through trans-mammary transfer were considerably higher than tolerable daily intake limits established by WHO (i.e., 1-4 pg TEQ kg-1 bw) and other globally recognized organizations. Similarly, the hazard quotient values for TEQ ∑8DL-PCBs (range 1.21 to 79.87) were far above the benchmark value of 1 at all the sampling sites, indicating the high levels of adverse health risks to infants in the region through breast milk consumption. The ∑34PCB levels were found to be negatively correlated with mother' age (r = -0.31; p = 0.02), parity (r = - 0.85; p = 0.001), and infant' birth weight (r = - 0.73; p = 0.01). The present study suggests undertaking comprehensive public health risk assessment studies and firm regulatory measures to safeguard human health risks.

Removal of pharmaceuticals and personal care products using constructed wetlands: effective plant-bacteria synergism may enhance degradation efficiency.

Post-industrial era has witnessed significant advancements at unprecedented rates in the field of medicine and cosmetics, which has led to affluent use of pharmaceuticals and personal care products (PPCPs). However, this has exacerbated the influx of various pollutants in the environment affecting living organisms through multiple routes. Thousands of PPCPs of various classes-prescription and non-prescription drugs-are discharged directly into the environment. In this review, we have surveyed literature investigating plant-based remediation practices to remove PPCPs from the environment. Our specific aim is to highlight the importance of plant-bacteria interplay for sustainable remediation of PPCPs. The green technologies not only are successfully curbing organic pollutants but also have displayed certain limitations. For example, the presence of biologically active compounds within plant rhizosphere may affect plant growth and hence compromise the phytoremediation potential of constructed wetlands. To overcome these hindrances, combined use of plants and beneficial bacteria has been employed. The microbes (both rhizo- and endophytes) in this type of system not only degrade PPCPs directly but also accelerate plant growth by producing growth-promoting enzymes and hence remediation potential of constructed wetlands.