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[This corrects the article DOI: 10.1155/2013/408582.].
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BACKGROUND: Evidence for the effect of dietary energy on BMI z-scores in young children is limited. We aim to investigate cross-sectional and longitudinal effects of daily energy intake (EI) on BMI z-scores of European boys and girls considering growth-related height dependencies of EI using residual EI. METHODS: To investigate cross-sectional and longitudinal effects of daily energy intake (EI) on BMI z-scores of European boys and girls considering growth-related height dependencies of EI using residual EI. METHODS: Subjects were children aged 2- < 10 y old (N = 2753, 48.2% girls) participating in the IDEFICS (Identification and prevention of Dietary- and lifestyle-induced health EFfects In Children and infantS) baseline and follow-up examination. Usual EI (kcal/day) was calculated based on the National Cancer Institute-method excluding subjects with implausible reported EI. Effect of age, height and sex-adjusted residuals of EI on BMI z-score was investigated stratified by baseline age -group (2- < 4 y, 4- < 6 y, 6- < 8 y and 8- < 10 y) cross-sectionally using linear regression models adjusted for relevant confounders (crude model: age, sex, country; fully adjusted model: plus parental ISCED level, parental BMI, screen time; subgroup analysis: plus objectively measured physical activity). Longitudinal associations were estimated between changes in (Δ) residual EI per year and ΔBMI z-score per year with adjustments analogously to the cross-sectional models but with additional adjustment for residual EI at baseline. RESULTS: Cross-sectionally, positive associations were observed between residual EI and BMI z-score for the full study sample, for boys and in older (≥6 years) but not in younger children in the crude and fully adjusted model. Longitudinally, small positive associations were observed between Δresidual EI per y on ΔBMI z-score per y for the full study sample and in 4- < 6 y olds in the crude and fully adjusted model. CONCLUSION: In conclusion, EI above the average intakes for a certain sex, age and height are weakly associated with BMI z-scores in European children. Residual EI may be considered as a useful exposure measure in children as it accounts for growth-related changes in usual EI during childhood.
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Índice de Masa Corporal , Ingestión de Energía/fisiología , Encuestas Epidemiológicas/estadística & datos numéricos , Niño , Preescolar , Estudios de Cohortes , Estudios Transversales , Dieta/estadística & datos numéricos , Europa (Continente) , Ejercicio Físico , Femenino , Humanos , Estudios Longitudinales , Masculino , Estudios Prospectivos , Encuestas y CuestionariosRESUMEN
Exploring changes in children's diet over time and the relationship between these changes and socio-economic status (SES) may help to understand the impact of social inequalities on dietary patterns. The aim of the present study was to describe dietary patterns by applying a cluster analysis to 9301 children participating in the baseline (2-9 years old) and follow-up (4-11 years old) surveys of the Identification and Prevention of Dietary- and Lifestyle-induced Health Effects in Children and Infants Study, and to describe the cluster memberships of these children over time and their association with SES. We applied the K-means clustering algorithm based on the similarities between the relative frequencies of consumption of forty-two food items. The following three consistent clusters were obtained at baseline and follow-up: processed (higher frequency of consumption of snacks and fast food); sweet (higher frequency of consumption of sweet foods and sweetened drinks); healthy (higher frequency of consumption of fruits, vegetables and wholemeal products). Children with higher-educated mothers and fathers and the highest household income were more likely to be allocated to the healthy cluster at baseline and follow-up and less likely to be allocated to the sweet cluster. Migrants were more likely to be allocated to the processed cluster at baseline and follow-up. Applying the cluster analysis to derive dietary patterns at the two time points allowed us to identify groups of children from a lower socio-economic background presenting persistently unhealthier dietary profiles. This finding reflects the need for healthy eating interventions specifically targeting children from lower socio-economic backgrounds.
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Dieta , Estilo de Vida , Clase Social , Niño , Fenómenos Fisiológicos Nutricionales Infantiles , Preescolar , Dieta/efectos adversos , Dieta/estadística & datos numéricos , Carbohidratos de la Dieta/administración & dosificación , Escolaridad , Europa (Continente) , Comida Rápida , Femenino , Frutas , Estado de Salud , Humanos , Masculino , Padres , Prevención Primaria , Estudios Prospectivos , Bocadillos , VerdurasRESUMEN
BACKGROUND/OBJECTIVES: High blood pressure (HBP) is one of the most important risk factors for cardiovascular diseases and it has a high prevalence in pediatric populations. However, the determinants of the incidence of Pre-HBP and HBP in children are not well known. i) To describe the incidence of HBP in European children; and ii) to evaluate the effect of physical activity (PA) and sedentary behavior (SB) on the Pre-HBP and HBP. METHODS: The IDEFICS cohort study. A total of 16,228 children 2-9years at baseline were recruited by complex sampling population-based survey in eight European countries. At baseline (T0), 5221 children were selected for accelerometer measurements; 5061 children were re-examined 2years later (T1). We estimated the incidence of Pre-HBP and HBP and evaluate the effect of PA and SB on the Pre-HBP and HBP, by computing relative risks and the corresponding 95% confidence intervals (RR, 95% CI). RESULTS: Incidences of Pre-HBP and HBP per year were: 121/1000 children and 110/1000 children, respectively. We found that children maintaining SB>2h/d during the two year follow-up showed a RR of having HBP of 1.28 (1.03-1.60). Children in T1 not performing the recommended amount of PA (<60min/d) have a RR of HBP of 1.53 (1.12 to 2.09). We found no association between pre-HBP and the behaviors. CONCLUSION: The incidence of pre-HBP and HBP is high in European children. Maintaining sedentary behaviors during childhood increases the risk of developing HBP after two years of follow-up.
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Presión Sanguínea/fisiología , Hipertensión/epidemiología , Actividad Motora/fisiología , Obesidad/complicaciones , Conducta Sedentaria , Niño , Preescolar , Europa (Continente)/epidemiología , Femenino , Humanos , Hipertensión/etiología , Incidencia , Masculino , Obesidad/epidemiología , Obesidad/fisiopatología , Prevalencia , Estudios Retrospectivos , Factores de RiesgoRESUMEN
OBJECTIVE: The aim of the present study was to investigate if context-specific measures of parental-reported physical activity and sedentary behaviour are associated with objectively measured physical activity and sedentary time in children. DESIGN: Cross-sectional study. SETTING: Seven European countries taking part in the IDEFICS (Identification and Prevention of Dietary- and Lifestyle-induced Health Effects in Children and Infants) study. SUBJECTS: Data were analysed from 2-9-year-old children (n 5982) who provided both parental-reported and accelerometer-derived physical activity/sedentary behaviour measures. Parents reported their children's daily screen-time, weekly sports participation and daily outdoor playtime by means of the Outdoor Playtime Checklist (OPC) and Outdoor Playtime Recall Questions (OPRQ). RESULTS: Sports participation, OPC- and OPRQ-derived outdoor play were positively associated with accelerometer-derived physical activity. Television viewing and computer use were positively associated with accelerometer-derived sedentary time. All parental-reported measures that were significantly associated with accelerometer outcomes explained only a minor part of the variance in accelerometer-derived physical activity or sedentary time. CONCLUSIONS: Parental-reported measures of physical activity and sedentary behaviour are not useful as a proxy for 2-9-year-old children's physical activity and sedentary time. Findings do not preclude the use of context-specific measures but imply that conclusions should be limited to the context-specific behaviours that are actually measured. Depending on the aim of the study, future research should carefully consider the choice of measurements, including the use of subjective or objective measures of the behaviour of interest or a combination of both.
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Conducta Infantil , Actividad Motora , Conducta Sedentaria , Acelerometría , Lista de Verificación , Niño , Preescolar , Estudios de Cohortes , Estudios Transversales , Europa (Continente) , Femenino , Humanos , Masculino , Padres , Proyectos Piloto , Juego e Implementos de Juego , Reproducibilidad de los Resultados , Autoinforme , DeportesRESUMEN
OBJECTIVE: To analyse the association between family structure and adiposity in children. DESIGN: Cross-sectional and longitudinal analysis of the IDEFICS (Identification and prevention of dietary- and lifestyle-induced health effects in children and infants) study cohort. SETTING: Primary schools and kindergartens. SUBJECTS: Children (n 12 350; aged 7·9 (SD 1·8) years) for the cross-sectional analysis and children (n 5236; at baseline: normal weight, aged 5·9 (SD 1·8) years) for the longitudinal study underwent anthropometry. Family structure was analysed as (i) number and type of cohabiting adults and (ii) number of siblings. RESULTS: In the cross-sectional analysis, after controlling for covariates, children living with grandparents had significantly higher BMI Z-score than those living with both parents (0·63; 95% CI 0·33, 0·92 v. 0·19; 95% CI 0·17, 0·22; P < 0·01); in addition, the higher the number of siblings, the lower the BMI Z-score (only child = 0·31; 95% CI 0·24, 0·38; 1 sibling = 0·19; 95% CI 0·16, 0·23; 2 siblings = 0·15; 95% CI 0·09, 0·20; >2 siblings = 0·07, 95% CI 0·04, 0·19; P < 0·001). Over the 2-year follow-up, differences in weight gain were observed across family-structure categories. Further, the risk of incidence of overweight/obesity was significantly lower the higher the number of siblings living in the household (v. only child: 1 sibling = 0·74, 95% CI 0·57, 0·96; 2 siblings = 0·63, 95% CI 0·45, 0·88; >2 siblings = 0·40, 95% CI 0·21, 0·77), independently of confounders. CONCLUSIONS: The study suggests that an independent association between family structure and childhood obesity exists.
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Adiposidad , Fenómenos Fisiológicos Nutricionales Infantiles , Dieta/efectos adversos , Composición Familiar , Sobrepeso/etiología , Obesidad Infantil/etiología , Adiposidad/etnología , Índice de Masa Corporal , Niño , Fenómenos Fisiológicos Nutricionales Infantiles/etnología , Preescolar , Estudios de Cohortes , Estudios Transversales , Dieta/etnología , Europa (Continente)/epidemiología , Composición Familiar/etnología , Femenino , Humanos , Incidencia , Estudios Longitudinales , Masculino , Encuestas Nutricionales , Sobrepeso/epidemiología , Sobrepeso/etnología , Obesidad Infantil/epidemiología , Obesidad Infantil/etnología , Prevalencia , Riesgo , Instituciones Académicas , Escuelas de PárvulosRESUMEN
To understand the rising prevalence of childhood obesity in affluent societies, it is necessary to take into account the growing obesity infrastructure, which over past decades has developed into an obesogenic environment. This study examines the effects of one of the constituent factors of consumer societies and a potential contributory factor to childhood obesity: commercial food communication targeted to children. Specifically, it investigates the impact of TV advertising on children's food knowledge and food preferences and correlates these findings with their weight status. Evaluations of traditional information- and education-based interventions suggest that they may not sustainably change food patterns. Based on prior consumer research, we propose five hypotheses, which we then test using a subsample from the IDEFICS study, a large-scale pan-European intervention study on childhood obesity. The results indicate that advertising has divergent effects on children's food knowledge and preferences and that food knowledge is unrelated to food preferences. This finding has important implications for both future research and public policy.
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Publicidad , Conducta Infantil , Preferencias Alimentarias , Conductas Relacionadas con la Salud , Conocimientos, Actitudes y Práctica en Salud , Medios de Comunicación de Masas , Peso Corporal , Distribución de Chi-Cuadrado , Niño , Ambiente , Europa (Continente)/epidemiología , Conducta Alimentaria , Femenino , Humanos , Análisis de los Mínimos Cuadrados , Estilo de Vida , Masculino , Obesidad Infantil/epidemiología , Obesidad Infantil/psicología , Percepción , Factores de RiesgoRESUMEN
OBJECTIVE: To assess the relationship between parental education level and the consumption frequency of obesity-related foods in European children. DESIGN: The analysis was based on data from the cross-sectional baseline survey of a prospective cohort study. The effects of parental education on food consumption were explored using analysis of covariance and logistic regression. SETTING: Primary schools and pre-schools of selected regions in Italy, Estonia, Cyprus, Belgium, Sweden, Hungary, Germany and Spain. SUBJECTS: Participants (n 14,426) of the IDEFICS baseline cohort study aged 2 to 9 years. RESULTS: Parental education level affected the intake of obesity-related foods in children. Children in the low and medium parental education level groups had lower odds of more frequently eating low-sugar and low-fat foods (vegetables, fruits, pasta/noodles/rice and wholemeal bread) and higher odds of more frequently eating high-sugar and high-fat foods (fried potatoes, fruits with sugar and nuts, snacks/desserts and sugared beverages; P < 0.001). The largest odds ratio differences were found in the low category (reference category: high) for vegetables (OR = 0.56; 95 % CI 0.47, 0.65), fruits (OR = 0.56; 95% CI 0.48, 0.65), fruits with sugar and nuts (OR = 2.23; 95% CI 1.92, 2.59) and sugared beverages (OR = 2.01; 95% CI 1.77, 2.37). CONCLUSIONS: Low parental education level was associated with intakes of sugar-rich and fatty foods among children, while high parental education level was associated with intakes of low-sugar and low-fat foods. These findings should be taken into account in public health interventions, with more targeted policies aiming at an improvement of children's diet.
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Dieta/normas , Escolaridad , Conducta Alimentaria , Conductas Relacionadas con la Salud , Obesidad/etiología , Padres , Análisis de Varianza , Niño , Preescolar , Estudios Transversales , Europa (Continente) , Femenino , Humanos , Modelos Logísticos , Masculino , Oportunidad Relativa , Estudios Prospectivos , Factores de RiesgoRESUMEN
The aim of this study was to investigate the relationship between markers of body fat and bone status assessed as calcaneal bone stiffness in a large sample of European healthy pre- and primary school children. Participants were 7,447 children from the IDEFICS study (spread over eight different European countries), age 6.1 ± 1.8 years (range 2.1-9.9), 50.5 % boys. Anthropometric measurements (weight, height, bioelectrical impedance, waist and hip circumference, and tricipital and subscapular skinfold thickness) as well as quantitative ultrasonographic measurements to determine calcaneal stiffness index (SI) were performed. Partial correlation analysis, linear regression analysis, and ANCOVA were stratified by sex and age group: preschool boys (n = 1,699) and girls (n = 1,599) and primary school boys (n = 2,062) and girls (n = 2,087). In the overall study population, the average calcaneal SI was equal to 80.2 ± 14.0, ranging 42.4-153. The results showed that preschool children with higher body fat had lower calcaneal SI (significant correlation coefficients between -0.05 and -0.20), while primary school children with higher body fat had higher calcaneal SI (significant correlation coefficients between 0.05 and 0.13). After adjusting for fat-free mass, both preschool and primary school children showed an inverse relationship between body fat and calcaneal stiffness. To conclude, body fat is negatively associated with calcaneal bone stiffness in children after adjustment for fat-free mass. Fat-free mass may confound the association in primary school children but not in preschool children. Muscle mass may therefore be an important determinant of bone stiffness.
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Tejido Adiposo , Calcáneo/metabolismo , Antropometría , Biomarcadores/metabolismo , Composición Corporal/fisiología , Índice de Masa Corporal , Peso Corporal , Calcáneo/anatomía & histología , Niño , Preescolar , Estudios de Cohortes , Recolección de Datos , Impedancia Eléctrica , Femenino , Humanos , Masculino , Instituciones AcadémicasRESUMEN
Early television exposure has been associated with various health outcomes including childhood obesity. This paper describes associations between patterns of television viewing, on one hand, and diet, taste preference and weight status, on the other, in European preschoolers and schoolchildren. The IDEFICS baseline survey was conducted at examination centers in Italy, Estonia, Cyprus, Belgium, Sweden, Germany, Hungary, and Spain. 15,144 children aged 2-9 completed the basic protocol, including anthropometry and parental questionnaires on their diets and television habits. A subsample of 1,696 schoolchildren underwent further sensory testing for fat and sweet taste preferences. Three dichotomous indicators described: children's habitual television exposure time; television viewing during meals; and having televisions in their bedrooms. Based on these variables we investigated television habits in relation to overweight (IOTF) and usual consumption of foods high in fat and sugar. A possible role of taste preference in the latter association was tested in the sensory subgroup. All television indicators were significantly associated with increased risk of overweight, with odds ratios ranging from 1.21 to 1.30, in fully adjusted models. Children's propensities to consume high-fat and high-sugar foods were positively and, in most analyses, monotonically associated with high-risk television behaviors. The associations between television and diet propensities were not explained by preference for added fat or sugar in test foods. To summarize, in addition to being more overweight, children with high-risk television behaviors may, independent of objectively measured taste preferences for fat and sugar, passively overconsume higher-fat and particularly higher-sugar diets.
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Grasas de la Dieta/administración & dosificación , Sacarosa en la Dieta/administración & dosificación , Preferencias Alimentarias , Sobrepeso/epidemiología , Gusto , Televisión/estadística & datos numéricos , Población Blanca/estadística & datos numéricos , Índice de Masa Corporal , Niño , Preescolar , Estudios Transversales , Dieta/estadística & datos numéricos , Europa (Continente)/epidemiología , Conducta Alimentaria , Femenino , Preferencias Alimentarias/psicología , Humanos , Masculino , Sobrepeso/etiología , Padres , Factores Socioeconómicos , Encuestas y Cuestionarios , Percepción del GustoRESUMEN
UNLABELLED: Sleep duration has been identified as risk factor for obesity already in children. Besides investigating the role of fat mass (FM), this study addressed the question whether endocrine mechanisms act as intermediates in the association between sleep duration and overweight/obesity. Within the framework of the IDEFICS study, the present research was conducted in 609 German resident children aged 2-9 years with information on fasting insulin, C-reactive protein and cortisol levels next to anthropometric measurements and parental questionnaires. Emphasising methodological aspects, an age-specific measure of sleep duration was derived to account for alteration in sleep duration during childhood/period of growth. Multivariate linear regression and quantile regression models confirmed an inverse relationship between sleep duration and measures of overweight/obesity. The estimate for the association of sleep duration and body mass index (BMI) was approximately halved after adjustment for FM, but remained significant. The strength of this association was also markedly attenuated when adjusting for insulin mainly for the upper BMI quantiles (Q80, ß = -0.36 vs. ß = -0.26; Q95, ß = -0.87 vs. ß = -0.47). Adjustment for cortisol and CrP did not yield this attenuation. CONCLUSION: The inverse relationship between sleep duration and BMI is mainly explained by the association between sleep duration and FM. Insulin may explain part of this association, in particular at the upper tail of the BMI distribution.
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Adiposidad , Índice de Masa Corporal , Obesidad/etiología , Sueño/fisiología , Biomarcadores/metabolismo , Proteína C-Reactiva/metabolismo , Niño , Preescolar , Estudios Transversales , Femenino , Encuestas Epidemiológicas , Humanos , Hidrocortisona/metabolismo , Insulina/metabolismo , Modelos Lineales , Masculino , Análisis Multivariante , Obesidad/metabolismo , Obesidad/fisiopatología , Sobrepeso/etiología , Encuestas y Cuestionarios , Factores de TiempoRESUMEN
BACKGROUND: The prevalence of childhood obesity has increased during the past decades and is now considered an urgent public health problem. Although stabilizing trends in obesity prevalence have been identified in parts of Europe, preventive efforts in children are still needed. Using the socio-ecological approach as the underlying theoretical perspective, the IDEFICS project aimed to develop, implement and evaluate a community-based intervention for the prevention of childhood obesity in eight European countries. The aim of the present manuscript was to describe the content and developmental process of the IDEFICS intervention. METHODS: The intervention mapping protocol (IMP) was used to develop the community-based intervention for the prevention of childhood obesity in 3 to 10 years old children. It is a theory- and evidence-based tool for the structured planning and development of health promotion programs that requires the completion of six different steps. These steps were elaborated by two coordinating centers and discussed with the other participating centers until agreement was reached. Focus group research was performed in all participating centers to provide an informed basis for intervention development. RESULTS: The application of the IMP resulted in an overall intervention framework with ten intervention modules targeting environmental and personal factors through the family, the school and the community. The summary results of the focus group research were used to inform the development of the overall intervention. The cultural adaptation of the overall intervention was realised by using country specific focus group results. The need for cultural adaptation was considered during the entire process to improve program adoption and implementation. A plan was developed to evaluate program effectiveness and quality of implementation. CONCLUSIONS: The IDEFICS project developed a community-based intervention for the prevention of childhood obesity by using to the intervention mapping heuristic. The IDEFICS intervention consists of a general and standardized intervention framework that allows for cultural adaptation to make the intervention feasible and to enhance deliverability in all participating countries. The present manuscript demonstrates that the development of an intervention is a long process that needs to be done systematically. Time, human resources and finances need to be planned beforehand to make interventions evidence-based and culturally relevant.
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Promoción de la Salud/métodos , Obesidad/epidemiología , Obesidad/prevención & control , Niño , Preescolar , Dieta , Europa (Continente)/epidemiología , Medicina Basada en la Evidencia , Frutas , Planificación en Salud , Humanos , Actividad Motora , Evaluación de Necesidades , Prevalencia , Evaluación de Programas y Proyectos de Salud , Salud Pública , Factores de Riesgo , Instituciones Académicas , Factores Socioeconómicos , Televisión , VerdurasRESUMEN
STUDY OBJECTIVES: To investigate differences and a possible effect modification by geographical region in the association between sleep duration and overweight. DESIGN: Cross-sectional. SETTING: Primary schools and preschools in 8 European countries. PARTICIPANTS: 7867 children aged 2 to 9 years. INTERVENTIONS: Not applicable. MEASUREMENTS: Nocturnal sleep duration was assessed as part of a parental 24-h recall. Height and weight were measured by standardized procedures across centers. Data on personal, social, environmental and behavioral factors were collected using a standardized parental questionnaire. RESULTS: Sleep duration differed (P < 0.001) between European regions and normal vs. overweight children. A dose-dependent inverse association between sleep duration and overweight could be seen, with crude odds ratios ranging from 1.73 (99% CI 1.33; 2.25) for sleeping between 10 and 11 h to 3.81 (99% CI 2.85; 5.09) for sleeping less than 9 h (reference category > 11 h). This persisted after adjustment, but remained significant only for sleeping less than 9 h per night (north: OR = 1.70; 99% CI 1.13; 2.58 vs. south: OR = 2.84; 99% CI 1.57; 5.12) if stratified by region. No effect modification by region could be found, but adjustment for region accounted for changes in the effect estimate for sleeping less than 9 h (OR = 2.22; 99% CI 1.64; 3.02). The association was stronger in school children than in preschool children. CONCLUSION: Geographic region and related aspects-even if they do not seem to modify the association between sleep and overweight-should in any case be taken in consideration as a confounding factor on this association.
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Sobrepeso/epidemiología , Trastornos del Sueño-Vigilia/epidemiología , Sueño/fisiología , Niño , Preescolar , Factores de Confusión Epidemiológicos , Estudios Transversales , Europa (Continente)/epidemiología , Femenino , Geografía , Humanos , Lactante , Masculino , Oportunidad RelativaRESUMEN
STUDY OBJECTIVES: To compare nocturnal sleep duration in children from 8 European countries and identify its determinants. DESIGN: Cross-sectional. SETTING: Primary schools and preschools participating in the IDEFICS study. PARTICIPANTS: 8,542 children aged 2 to 9 years from 8 European countries with complete information on nocturnal sleep duration. INTERVENTIONS: Not applicable. MEASUREMENTS: Nocturnal sleep duration was assessed by means of a computer based parental 24-h recall. Data on personal, social, environmental, and behavioral factors were collected by means of standardized parental questionnaire. Physical activity was surveyed with accelerometers. RESULTS: Nocturnal sleep duration in the participating countries ranged from 9.5 h (SD 0.8) in Estonia to 11.2 h (SD 0.7) in Belgium and differed significantly between countries (P < 0.001) in univariate as well as in multivariate analyses, with children from northern countries sleeping the longest. Sleep duration decreased by about 6 min with each year of age over all countries. No effect of season, daylight duration, overweight, parental education level, or lifestyle factors could be seen. CONCLUSION: Sleep duration differs significantly between countries. Our findings allow for the conclusion that regional affiliation, including culture and environmental characteristics, seems to overlay individual determinants of sleep duration.
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Sueño , Factores de Edad , Análisis de Varianza , Índice de Masa Corporal , Distribución de Chi-Cuadrado , Niño , Preescolar , Estudios Transversales , Europa (Continente) , Femenino , Humanos , Masculino , Encuestas y Cuestionarios , Factores de TiempoRESUMEN
OBJECTIVES: The objective of this study was to assess the relation between the level of habitual potassium intake and the incidence of cardiovascular disease (CVD). BACKGROUND: Prospective cohort studies have evaluated the relationship between habitual potassium intake and incidence of vascular disease, but their results have not been not entirely consistent. METHODS: We performed a systematic search for prospective studies published, without language restrictions (1966 to December 2009). Criteria for inclusion were prospective adult population study, assessment of baseline potassium intake, assessment of vascular events as outcome, and follow-up of at least 4 years. For each study, relative risks (RRs) and 95% confidence intervals (CIs) were extracted and pooled using a random-effect model, weighted for the inverse of the variance. Heterogeneity, publication bias, subgroup, and meta-regression analyses were performed. RESULTS: Eleven studies were identified, providing 15 cohort samples that included 247,510 male and female participants (follow-up 5 to 19 years), 7,066 strokes, 3,058 coronary heart disease (CHD) events, and 2,497 total CVD events. Potassium intake was assessed by 24-h dietary recall (n = 2), food frequency questionnaire (n = 6), or 24-h urinary excretion (n = 3). In the pooled analysis, a 1.64-g (42 mmol) per day higher potassium intake was associated with a 21% lower risk of stroke (RR: 0.79; 95% CI: 0.68 to 0.90; p = 0.0007), with a trend toward lower risk of CHD and total CVD that attained statistical significance after the exclusion of a single cohort, based on sensitivity analysis (RR: 0.93; 95% CI: 0.87 to 0.99; p = 0.03 and RR: 0.74; 95% CI: 0.60 to 0.91; p = 0.0037). CONCLUSIONS: Higher dietary potassium intake is associated with lower rates of stroke and might also reduce the risk of CHD and total CVD. These results support recommendations for higher consumption of potassium-rich foods to prevent vascular diseases.
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Enfermedades Cardiovasculares/prevención & control , Potasio en la Dieta/administración & dosificación , Accidente Cerebrovascular/prevención & control , Presión Sanguínea/fisiología , Femenino , Humanos , Masculino , Potasio en la Dieta/orina , Estudios Prospectivos , Sodio en la Dieta/administración & dosificaciónAsunto(s)
Enfermedades Cardiovasculares/prevención & control , Hipertensión/prevención & control , Sodio en la Dieta/uso terapéutico , Presión Sanguínea/fisiología , Enfermedades Cardiovasculares/fisiopatología , Dieta Hiposódica , Humanos , Hipertensión/fisiopatología , Tolerancia a la Sal/fisiología , Sodio en la Dieta/farmacologíaRESUMEN
BACKGROUND: The blood pressure (BP) increase with age is well documented in adults and children. However, in the pediatric age group, body size is the most important determinant of age-related BP increases. The aim of the present analysis was to investigate the relationships between age, gender, and body size and BP in children. METHODS: To this purpose, data were analyzed from 4,514 prepubertal children, aged 6-11 years (71% of the eligible sample; boys = 2,283, girls = 2,231) from the ARCA Project, a screening of childhood obesity carried out in southern Italy. Girls who reported the occurrence of menarche were excluded from the analysis. The sample constituted roughly 20% of all the children attending the primary schools in the area. Weight, height, waist circumference, and BP were measured according to standardized procedures. RESULTS: As expected, both systolic and diastolic BP significantly increased (P < 0.001) with age in boys and girls. However, after adjustment for waist circumference (as index of adiposity) and height (as index of body size), BP significantly increased with age only in girls (systolic BP: F = 4.380, P = 0.002; diastolic BP: F = 3.093, P = 0.01) but not in boys (systolic BP: F = 0.711, P = 0.55; diastolic BP: F = 2.180, P = 0.07). The association, however, was no longer apparent after the exclusion of children aged >10 years. CONCLUSIONS: In prepubertal girls in the age range 6-11 years, but not in boys, age is significantly associated with BP independently of body size and adiposity.
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Presión Sanguínea/fisiología , Estatura , Peso Corporal , Circunferencia de la Cintura , Factores de Edad , Niño , Femenino , Humanos , Masculino , Factores SexualesRESUMEN
OBJECTIVE: Gender and ethnicity modulate the phenotypic expression of cardiovascular risk factors. In particular, men are at higher risk of developing cardiovascular diseases compared to women, whereas black populations of African origin display reduced mortality from coronary heart disease (CHD) as compared to both whites and South Asians. Because the male-specific region (MSY) of the human Y chromosome is an obvious candidate for gender-related differences in the development of cardiovascular diseases, we aimed to identify genetic variants of MSY influencing cardiovascular risk profile in different ethnic groups. METHODS AND RESULTS: We genotyped 4 polymorphisms of MSY (HindIII+/-, rs768983 of TBL1Y, rs3212292 of USP9Y, and rs9341273 of UTY genes) in 579 men of different ethnic groups (blacks, South Asians, and whites) from UK and in 301 whites in Italy. We found that the TBL1Y(A) USP9Y(A) haplotype, present only in blacks in whom it represents the most frequent allelic combinations (AA: n=125; all other combinations: n=45), was associated with lower levels of triglycerides (P=0.025) and higher levels of HDL-cholesterol (P=0.005) as compared to the other haplotypes. CONCLUSIONS: The TBL1Y(A) USP9Y(A) haplotype of the Y chromosome, present only in black people of African origin, attributes a favorable lipoprotein pattern, likely to contribute to their reduced susceptibility to coronary heart disease.
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Población Negra/genética , HDL-Colesterol/genética , Cromosomas Humanos Y/genética , Enfermedad Coronaria/genética , Polimorfismo de Nucleótido Simple/genética , Triglicéridos/genética , Pueblo Asiatico , HDL-Colesterol/sangre , Estudios Transversales , Haplotipos/genética , Humanos , Masculino , Antígenos de Histocompatibilidad Menor , Transducina/genética , Triglicéridos/sangre , Ubiquitina Tiolesterasa/genética , Población BlancaRESUMEN
OBJECTIVE: To investigate whether maternal perception of child body shape is different for boys and girls and whether this subjective parameter is associated with objective indices of cardiovascular health. DESIGN: Cross-sectional survey (the ARCA Project). SETTING: Southern Italy. SUBJECTS: Body mass index, waist circumference and blood pressure were measured according to standardised procedures in 3551 children (Boys = 1778; Girls = 1773) aged 6-11 years. Maternal perception of child body shape was investigated by inviting mothers to choose, within two sets of seven, 9-year-old child silhouettes (one set for boys and one set for girls), the body shape they perceived as that of a healthy child. RESULTS: Although the majority of mothers indicated the median silhouette as 'healthy', mothers of girls chose a fatter silhouette as 'healthy' more often than the mothers of boys (P = 0.001). By regression analysis, mothers' perception of a child's body shape was a significant determinant (P < 0.01) of blood pressure in both genders, and of anthropometric indices in girls only, independently of parental overweight, education, birth weight and physical activity. CONCLUSIONS: Our study suggests that maternal perception of a healthy body shape in children is associated with her child's blood pressure and degree of adiposity; with regard to the latter, differences between genders are apparent.
Asunto(s)
Presión Sanguínea , Imagen Corporal , Índice de Masa Corporal , Tamaño Corporal , Conocimientos, Actitudes y Práctica en Salud , Madres/psicología , Percepción , Adiposidad , Peso al Nacer , Niño , Estudios Transversales , Ejercicio Físico , Femenino , Indicadores de Salud , Humanos , Italia , Masculino , Actividad Motora , Factores SexualesRESUMEN
The reliability of measurement of body temperature using a new infrared skin thermometer was evaluated in 107 newborns. The use of the device was associated with low operator-related variability and acceptable limits of agreement with the temperature measured with a rectal mercury thermometer. Use of the infrared skin thermometer is a comfortable and reliable way of measurement of body temperature in newborns.