Antioxidant status in the serum of persons with intellectual disability and hypothyroidism: a pilot study.

Hypothyroidism (HPO) in humans is widely believed to impair health. The biochemical factors mediating decline in health, however, are poorly elucidated. Pathological consequences of HPO point to a high potential for antioxidant imbalance. The objectives of this study were to investigate the major antioxidants in persons with intellectual disability (ID) and HPO in order to find the effect of chronic disease on the level of antioxidative parameters. This is a prospective, nonrandomized study. A total of 11 people with HPO and 11 age-matched healthy participants were examined. The following antioxidative defense were examined: superoxide dismutase (SOD), catalase, glutathione peroxidase (GSH-Px), and glutathione reductase (GR) as well as two biochemical parameters creatinine and albumin. Compared to healthy control subjects without complications, persons with ID and HOP had significantly lower SOD (p<0.05), catalase (p<0.05), GSH-Px (p<0.05), except the GR level (p=NS). A significant correlation was found between age and gender and AO values in experimental group SOD (r=-0.882), catalase (r=-0.724) and GSH-Px (r=-0.782). Our preliminary results confirm the hypothesis that there is a reduction of the antioxidative defense in persons with HPO and in particularly among males.

Biochemical assessments of total antioxidant status in active and nonactive female adults with intellectual disability.

Long-term physical activity is known to increase the antioxidant defense (AOD) system, whereas sedentary lifestyle is associated with oxidative stress (OS). The underlying molecular mechanisms are incompletely understood. The aim of this prospective, nonrandomized study was to evaluate and compare the relationship between long-term physical activity and inactivity and plasma antioxidant status in female adults with intellectual disability (ID) that were diagnosed after birth. A total of 21 adults with ID were examined. The following AOD was examined: superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), vitamin E, and vitamin A. Inactive persons with ID had significantly lower SOD (p<0.05), CAT (p<0.05), and GPX (p<0.05). All plasma vitamin levels were significantly higher in physically active subjects (vitamin A: 1.42 +/- 0.05 mmol/l, vitamin E: 31.32 +/- 2.62 mmol/l) than in sedentary control subjects (vitamin A: 1.02 +/- 0.03 mmol/l, vitamin E: 18.88 +/- 2.23 mmol/l) p<0.01. These results suggest that regular physical activity is associated with preserved AODs in adults with ID. As opposed to a physically active lifestyle, an inactive results in low levels of antioxidants.

Does passive leg activity influence oxygen saturation and activity in sedentary elderly adults?

This study aimed to investigate whether any physiological changes might have a clinically significant effect on function in sedentary, institutionalized, older adults treated by a passive training program. A total of 18 subjects (mean age 60.7 +/- 3.4) with intellectual disability (ID) participated. We measured SpO2 (arterial oxygen saturation) before, during, and after passive training, and used Barthel Index to measure daily living activities. The general trend indicated that inactive people with ID evidenced a continual increase in SpO2% levels and some functional gains during passive treatment, with superiority to manual passive treatment compared to mechanical active passive training. For current clinical practice, most sedentary patients who experience clinically significant deconditioning and desaturation can benefit from passive treatment.