RESUMEN
Although the knowledge of the interferon metabolism is still incomplete, two organs are emerging as elective sites. The kidney and probably the liver may share a major role but only future research will define quantitatively their importance. Many aspects of interferon activity upon cellular processes and its possible function as a 'chalone-type' substance are reviewed.
Asunto(s)
Interferones/metabolismo , Riñón/metabolismo , Hígado/metabolismo , Animales , Semivida , Humanos , Glomérulos Renales/metabolismo , Conejos , Receptores de Droga/metabolismo , Sialoglicoproteínas/metabolismoRESUMEN
The effect of removal of sialic acid on the survival of rabbit serum and urinary interferon (IF) has been investigated in isolate, perfused rabbit liver preparations. In contrast with native IF, which may be already partially desialylated. IF freed of 80 to 90% of its sialic acid was rapidly cleared from the perfusate of normal livers, or livers pre-treated with actinomycin D. The results suggest that the mechanism of IF catabolism by the liver is similar to that reported for several other circulating glycoproteins.
Asunto(s)
Interferones/metabolismo , Hígado/metabolismo , Ácidos Siálicos/metabolismo , Animales , Membrana Celular/metabolismo , Dactinomicina/farmacología , Interferones/sangre , Interferones/orina , Hígado/efectos de los fármacos , Neuraminidasa/metabolismo , Perfusión , ConejosRESUMEN
Rabbit interferon has been extensively desialytated and its metabolic behaviour has been evaluated in the rabbit. The half-life of asialointerferon is significantly shorter than the native interferon and its urinary excretion becomes negligible. Moreover the rapid uptake of asialointerferon by the isolated and perfused rabbit liver, suggests a hitherto unsuspected catobolic pathway for this glycoprotein.
