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2.
Perit Dial Int ; : 8968608241237400, 2024 Mar 27.
Artículo en Inglés | MEDLINE | ID: mdl-38532707

RESUMEN

Effective treatment of infections is a growing challenge owing to antimicrobial resistance. Peritoneal dialysis (PD) patients experience more frequent hospitalisations than the general population and have greater exposure to antibiotics, making them particularly vulnerable to this threat. Over the last decade, we have noted a surge in cases of complicated peritoneal dialysis-associated peritonitis (PD peritonitis) caused by antimicrobial-resistant organisms, including extended-spectrum beta-lactamase (ESBL), AmpC beta-lactamase-producing Enterobacterales, Pseudomonas aeruginosa and fungi. Practitioners must be alert to these organisms, seek early recognition of these resistance patterns and make timely adjustments in order to avoid delay in treatment that may increase risk of PD catheter removal and technique failure. We present a case of successful treatment of ESBL peritonitis, highlight its challenges, while providing guidance on management of other unusual and complicated PD peritonitis.

4.
J Am Soc Nephrol ; 34(12): 1919-1927, 2023 12 01.
Artículo en Inglés | MEDLINE | ID: mdl-37553867

RESUMEN

ABSTRACT: Peritoneal dialysis (PD) is now commonly prescribed to achieve target clearances for urea or creatinine. The International Society for Peritoneal Dialysis has proposed however that such targets should no longer be imposed. The Society's new guidelines suggest rather that the PD prescription should be adjusted to achieve well-being in individual patients. The relaxation of treatment targets could allow increased use of PD. Measurement of solute levels in patients receiving dialysis individualized to relieve uremic symptoms could also help us identify the solutes responsible for those symptoms and then devise new means to limit their accumulation. This possibility has prompted us to review the extent to which different uremic solutes are removed by PD.


Asunto(s)
Diálisis Peritoneal , Humanos , Diálisis Renal , Urea , Creatinina , Cinética
5.
Perit Dial Int ; 43(1): 5-12, 2023 01.
Artículo en Inglés | MEDLINE | ID: mdl-36113128

RESUMEN

Peritoneal dialysis (PD) patients have higher hospitalisation rates than the general population. The hospitalisations are not always related to dialysis issues, and physicians with little or no experience with PD may be responsible for the care of these hospitalised patients. Furthermore, the hospital may not be familiar with or equipped to manage these patients. This review highlights barriers, knowledge gaps and management strategies to guide the care of hospitalised PD patients.


Asunto(s)
Diálisis Peritoneal , Humanos , Diálisis Renal , Hospitalización
6.
Am J Kidney Dis ; 81(1): 100-109, 2023 01.
Artículo en Inglés | MEDLINE | ID: mdl-36208963

RESUMEN

As the global prevalence of peritoneal dialysis (PD) continues to grow, practitioners must be equipped with prescribing strategies that focus on the needs and preferences of patients. PD is an effective form of kidney replacement therapy that offers numerous benefits to patients, including more flexibility in schedules compared with in-center hemodialysis (HD). Additional benefits of PD include salt and water removal without significant changes in patient hemodynamics. This continuous yet gentle removal of solutes and fluid is associated with better-preserved residual kidney function. Unfortunately, sometimes these advantages are overlooked at the expense of an emphasis on achieving small solute clearance targets. A more patient-centered approach emphasizes the importance of individualized treatment, particularly when considering incremental PD and other prescriptions that align with lifestyle preferences. In shifting the focus from small solute clearance targets to patient needs and clinical goals, PD remains an attractive, patient-centered form of kidney replacement therapy.


Asunto(s)
Fallo Renal Crónico , Diálisis Peritoneal , Humanos , Diálisis Renal , Terapia de Reemplazo Renal , Prescripciones , Agua , Fallo Renal Crónico/terapia
10.
Nephrology (Carlton) ; 27(2): 190-194, 2022 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-34617354

RESUMEN

The severe acute respiratory syndrome coronavirus (SARS-Cov-2) resulting in the coronavirus disease 2019 (COVID-19) is documented to have a negative psychosocial impact on patients. Home dialysis patients may be at risk of additional isolating factors affecting their mental health. The aim of this study is to describe levels of anxiety and quality of life during the COVID-19 pandemic among home dialysis patients. This is a single-centre survey of home dialysis patients in Toronto, Ontario. Surveys were sent to 98 home haemodialysis and 43 peritoneal dialysis patients. Validated instruments (Haemodialysis and Peritoneal Dialysis Treatment Satisfaction Questionnaire, Generalized Anxiety Disorder 7 Item [GAD7] Scale, Patient Health Questionnaire [PHQ-9], Illness Intrusiveness Ratings Scale, Family APGAR Questionnaire and The Self Perceived Burden Scale) assessing well-being were used. Forty of the 141 patients surveyed, participated in September 2020. The mean age was 53.1 ± 12.1 years, with 60% male, and 85% home haemodialysis, 80% of patients rated their satisfaction with dialysis at 8/10 or greater, 82% of respondents reported either "not at all" or "for several days" indicating frequency of anxiety and depressive symptoms, 79% said their illness minimally or moderately impacted their life, 76% of respondents were almost always satisfied with interactions with family members, 91% were never or sometimes worried about caregiver burden. Among our respondents, there was no indication of a negative psychosocial impact from the pandemic, despite the increased social isolation. Our data further supports the use of home dialysis as the optimal form of dialysis.


Asunto(s)
Ansiedad , COVID-19 , Hemodiálisis en el Domicilio , Fallo Renal Crónico , Diálisis Peritoneal , Ansiedad/diagnóstico , Ansiedad/fisiopatología , COVID-19/epidemiología , COVID-19/prevención & control , COVID-19/psicología , Femenino , Hemodiálisis en el Domicilio/métodos , Hemodiálisis en el Domicilio/psicología , Humanos , Fallo Renal Crónico/epidemiología , Fallo Renal Crónico/terapia , Masculino , Salud Mental , Persona de Mediana Edad , Ontario/epidemiología , Diálisis Peritoneal/métodos , Diálisis Peritoneal/psicología , Psicología , Calidad de Vida , SARS-CoV-2 , Aislamiento Social , Encuestas y Cuestionarios
11.
Perit Dial Int ; 42(4): 387-393, 2022 07.
Artículo en Inglés | MEDLINE | ID: mdl-34365846

RESUMEN

BACKGROUND: This retrospective cohort study investigated the characteristics and outcomes of the end-stage kidney disease (ESKD) patients treated with incremental peritoneal dialysis (PD) at a large academic centre. METHODS: ESKD patients initiating PD with a dialysate volume ≤6 L/day were analysed. RESULTS: One hundred and seventy-five patients were included and were followed up for 352.6 patient-years. The baseline residual kidney function (RKF) was 8.3 ± 3.4 mL/min/1.73 m2. The unadjusted 1- to 5-year patient survival rate was 89.6%, 80.4%, 65.4%, 62.7% and 48.8%, respectively, and the corresponding time on PD therapy rate was 95.1%, 89.1%, 89.1%, 82.4% and 77.6%. Greater initial PD dose (hazard ratio = 1.608, 95% confidence interval 1.089-2.375) was associated with death after adjusting for age, Charlson comorbidity index (CCI), haemodialysis prior to PD, assisted PD and baseline RKF, likely as a result of residual confounding. There was no association with PD discontinuation. The average peritonitis rate and hospitalisation rate were 0.122 and 0.645 episodes per patient-year, respectively. The dialysate volume increased from 4.5 (4.3-5.7) L/day to 8.0 (6.0-9.8) L/day at 5 years. Fifty-seven (32.6%) patients graduated to full-dose PD at a median time of 10.3 (6.2, 15.7) months. Male sex, greater body mass index and lower baseline serum albumin were risk factors for increasing PD dose to over 6 L/day within 1 year. CONCLUSIONS: Incremental PD is a safe approach to initiate dialysis, and it offers satisfactory outcomes. Close monitoring, comprehensive evaluation of clinical responses and prompt adjustment of the prescription as needed play a crucial role in this patient-centred treatment.


Asunto(s)
Fallo Renal Crónico , Diálisis Peritoneal , Soluciones para Diálisis , Progresión de la Enfermedad , Humanos , Fallo Renal Crónico/etiología , Fallo Renal Crónico/terapia , Masculino , Diálisis Peritoneal/efectos adversos , Estudios Retrospectivos , Resultado del Tratamiento
12.
Perit Dial Int ; 42(3): 324-327, 2022 05.
Artículo en Inglés | MEDLINE | ID: mdl-34227423

RESUMEN

Home dialysis (peritoneal dialysis (PD) and home haemodialysis (HHD)) are ideal options for kidney replacement therapy (KRT). Occasionally, because of technique failure, patients are required to transition out of home dialysis, and the most common option tends to be to in-centre HD. There are few published studies on home-to-home transition (PD to HHD or HHD to PD) and dynamics during the transition period. We present a retrospective review of 28 patients who transitioned from a home-to-home dialysis modality at our centre over a 24-year period. We observed a total of 911 home dialysis patients with technique failure (826 PD patients and 85 HHD patients) with only 28 patients (3% of the total with technique failure) having successful home-to-home transition. During the transition period, 11 patients (39%) were hospitalized and 13 patients (46%) required variable periods of in-centre HD. After a median follow-up of 48 months following dialysis modality transition, four patients switched to in-centre HD permanently (home dialysis technique survival of 86% censored for death and kidney transplantation) and four patients died resulting in a patient survival of 86% (censored for switch to in-centre HD and transplantation). In our centre, home-to-home transition is a feasible strategy with comparable patient and technique survival. A significant proportion of patients switching from a home-to-home dialysis modality required variable intervals of hospitalization and in-centre HD during transitions. Future efforts should be directed towards assessment and home dialysis education during the entire process of dialysis transition.


Asunto(s)
Fallo Renal Crónico , Diálisis Peritoneal , Cuidado de Transición , Femenino , Hemodiálisis en el Domicilio/métodos , Humanos , Fallo Renal Crónico/diagnóstico , Fallo Renal Crónico/terapia , Masculino , Diálisis Peritoneal/métodos , Diálisis Renal
13.
J Am Soc Nephrol ; 33(10): 1803-1804, 2022 10.
Artículo en Inglés | MEDLINE | ID: mdl-36630519
14.
Cardiol Clin ; 39(3): 447-453, 2021 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-34247757

RESUMEN

The high prevalence of cardiovascular disease is caused by the traditional cardiovascular risk factors common among end-stage renal disease patients, and nontraditional risk factors attributed to underlying kidney disease, including chronic inflammation, anemia, bone mineral disease, and the dialysis procedure itself. Individualization of the treatment of cardiovascular disease in end-stage renal disease that could impact the underlying mechanisms of the cardiovascular diseases is important to improve outcomes. This article reviews and compares hemodialysis and peritoneal dialysis in association with different cardiovascular diseases affecting dialysis patients, including hypertension, coronary artery disease, myocardial stunning, cardiac arrhythmias, heart failure, and the cardiorenal syndrome.


Asunto(s)
Enfermedades Cardiovasculares , Fallo Renal Crónico , Diálisis Peritoneal , Enfermedades Cardiovasculares/epidemiología , Humanos , Fallo Renal Crónico/complicaciones , Fallo Renal Crónico/epidemiología , Fallo Renal Crónico/terapia , Diálisis Renal , Factores de Riesgo
15.
Nephrology (Carlton) ; 26(7): 569-577, 2021 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-33634548

RESUMEN

Home dialysis therapies are flexible kidney replacement strategies with documented clinical benefits. While the incidence of end-stage kidney disease continues to increase globally, the use of home dialysis remains low in most developed countries. Multiple barriers to providing home dialysis have been noted in the published literature. Among known challenges, gaps in clinician knowledge are potentially addressable with a focused education strategy. Recent national surveys in the United States and Australia have highlighted the need for enhanced home dialysis knowledge especially among nephrologists who have recently completed training. Traditional in-person continuing professional educational programmes have had modest success in promoting home dialysis and are limited by scale and the present global COVID-19 pandemic. We hypothesize that the use of a 'Hub and Spoke' model of virtual home dialysis mentorship for nephrologists based on project ECHO would support home dialysis growth. We review the home dialysis literature, known educational gaps and plausible educational interventions to address current limitations in physician education.


Asunto(s)
Hemodiálisis en el Domicilio/educación , Fallo Renal Crónico/terapia , Nefrólogos/educación , Enseñanza , COVID-19/epidemiología , COVID-19/prevención & control , Educación Médica Continua/métodos , Hemodiálisis en el Domicilio/métodos , Humanos , SARS-CoV-2 , Interfaz Usuario-Computador
16.
Can J Kidney Health Dis ; 7: 2054358120979239, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-33343912

RESUMEN

BACKGROUND: Inotropic dependence and diuretic resistance in patients with cardiorenal syndrome (CRS) lead to frequent hospitalizations and are associated with high mortality. Starting peritoneal dialysis (PD) acutely (within 2 weeks of a heart failure hospitalization) offers effective volume removal without hemodynamic compromise in this population. There is little data on this approach in the North American literature. OBJECTIVE: To determine whether volume-overloaded patients with CRS on maximal doses of diuretic therapy had reduced hospitalization for heart failure following PD initiation. DESIGN: Retrospective cohort study. SETTING: Academic hospital network (University Health Network, Toronto, Ontario). PATIENTS: Patients with CRS receiving a bedside catheter and starting PD within 2 weeks of insertion at the University Health Network from January 1, 2013, to December 31, 2018. METHODS AND MEASUREMENTS: Data for heart failure-related hospitalizations and length of stay 6 months before and after PD initiation were collected. Patients who died, switched to hemodialysis, or were transferred to another facility within 6 months of starting PD were excluded from the analysis. RESULTS: We identified 31 patients with CRS who had a bedside PD catheter inserted. The average age of patients was 66.0 ± 13.0 years. There were 7 (22.6%) deaths and 4 (12.9%) transfers to other programs or hemodialysis within 6 months of catheter insertion. After exclusion, we analyzed hospitalization and length of stay data for 20 patients. The hospitalization rate 6 months before PD initiation was 6.9 admissions per 1000 patient-days. This decreased to 2.5 admissions per 1000 patient-days after PD initiation. In addition, there was also a significant reduction in the average length of stay per hospitalization (24.1-3.9 days; P = .001). LIMITATIONS: Our study did not assess the severity of heart failure symptoms using a standardized functional classification system. We did not assess quality of life and illness intrusiveness scores before and after starting dialysis, nor did we capture non-heart-failure-related hospitalizations or external admissions at other hospital sites. We limited eligibility to clinically stable patients with no prior major abdominal surgical history in a single Canadian PD program using bedside ultrasound approach for catheter insertions by experienced nephrologists and included a small number of patients. CONCLUSIONS: Volume-overloaded patients with CRS receiving maximal diuretic therapy have lower hospitalization rates and shorter stays after initiation of PD. The development of a bedside PD catheter insertion program and close collaboration between nephrology and cardiology services may facilitate acute start dialysis in this population.


CONTEXTE: La dépendance inotrope et la résistance aux diurétiques entraînent de fréquentes hospitalisations et sont associées à une mortalité élevée chez les patients atteints du syndrome cardio-rénal (SCR). Dans cette population, l'amorce de la dialyse péritonéale (DP) en temps opportun, soit dans les deux semaines suivant une hospitalisation pour insuffisance cardiaque, permet d'éliminer efficacement la surcharge liquidienne sans compromettre l'hémodynamie. On trouve toutefois peu de données sur cette approche dans la littérature nord-américaine. OBJECTIF: Déterminer si les patients atteints du SCR et présentant une surcharge volémique qui reçoivent une dose maximale de diurétiques sont hospitalisés moins souvent pour insuffisance cardiaque après l'amorce de la DP. TYPE D'ÉTUDE: Une étude de cohorte rétrospective. CADRE: Un réseau de centres hospitaliers universitaires (University Health Network) de Toronto (Ontario). SUJETS: Des patients atteints du SCR, hospitalisés au University Health Network entre le 1er janvier 2013 et le 31 décembre 2018, à qui on avait installé un cathéter de DP au chevet et qui avaient amorcé un traitement de dialyse dans les deux semaines suivant l'insertion. MÉTHODOLOGIE: On a recueilli les données sur les hospitalisations pour insuffisance cardiaque et la durée des séjours dans les six mois avant et après l'initiation de la PD. Les patients décédés, passés à l'hémodialyse ou ayant été transférés vers un autre centre dans les six mois suivant l'amorce de la PD ont été exclus de l'analyse. RÉSULTATS: Nous avons identifié 31 patients atteints du SCR, âgés en moyenne de 66,0 ±13,0 ans, à qui un cathéter de DP avait été installé au chevet. Dans les six mois suivant l'insertion du cathéter, sept patients (22,6 %) sont décédés et quatre (12,9 %) ont été transférés dans un autre centre ou sont passés à l'hémodialyse. À la suite de ces exclusions, l'analyse a porté sur les hospitalisations et les durées de séjour de 20 patients. Le taux d'hospitalisation dans les six mois précédant l'initiation de la DP s'établissait à 6,9 admissions par 1 000 jours-patient; un taux qui est passé à 2,5 admissions par 1 000 jours-patient une fois la DP amorcée. On a également observé une réduction significative de la durée moyenne du séjour, celle-ci étant passée de 24,1 à 3,9 jours (p=0,001). LIMITES: La gravité des symptômes de l'insuffisance cardiaque n'a pas été évaluée à l'aide d'un système de classification fonctionnel normalisé. Les scores de la qualité de vie et du caractère intrusif de la maladie n'ont pas été évalués avant et après l'amorce de la dialyse. Les données des hospitalisations non liées à l'insuffisance cardiaque et des admissions externes dans d'autres sites n'ont pas été colligées. L'admissibilité a été limitée aux patients cliniquement stables et sans antécédent de chirurgie abdominale majeure. Les participants provenaient d'un seul programme canadien de DP où la méthode d'insertion du cathéter utilise une approche par ultrasons pratiquée par un néphrologue expérimenté. Enfin, l'étude porte sur un faible échantillon de sujets. CONCLUSION: Les patients atteints du SCR et présentant une surcharge volémique qui reçoivent une dose maximale de diurétiques ont été moins souvent hospitalisés à la suite de l'amorce de la DP. Le développement d'un programme d'insertion du cathéter de DP au chevet du patient et une collaboration étroite entre les services de cardiologie et de néphrologie pourraient faciliter l'amorce rapide de la dialyse dans cette population.

17.
Kidney Int Rep ; 5(11): 1965-1973, 2020 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-33163717

RESUMEN

INTRODUCTION: As interest for home dialysis is growing, knowledge of comparative clinical outcomes between peritoneal dialysis (PD) and home hemodialysis (HHD) would help to better inform shared decision making with patients and caregivers during modality discussion. This study aimed to assess differences in risk of mortality and technique failure in an incident home dialysis cohort and, specifically, to assess change in this association through eras. METHODS: All adults patients initiating PD or HHD, in Canada (excluding Quebec), within 365 days after kidney replacement therapy (KRT) initiation between 2000 and 2013 were included (administrative censoring 31 December 2014). Mortality and treatment failure (transfer to another modality for >90 days or death) were assessed in a multivariable Cox proportional hazard model, with prespecified stratification based on the year of KRT initiation. RESULTS: The study included 959 HHD and 15,469 PD patients. Compared with incident PD, incident HHD was associated with a lower risk of mortality (adjusted hazard ratio [aHR] = 0.64, 95% confidence interval [CI] = 0.53-0.78), and treatment failure (aHR = 0.52, 95% CI = 0.45-0.60). These lower risks of mortality with HHD were more pronounced for older cohorts (2000-2005: aHR = 0.47, 95% CI = 0.31-0.70; 2006-2010: aHR = 0.70, 95% CI = 0.54-0.89) and not significantly different in the most recent era (2011-2013: aHR = 0.86, 95% CI = 0.51-1.47). CONCLUSION: In Canadian incident KRT patients, HHD was associated with appreciably lower risks of mortality and treatment failure compared to PD, although this association appeared to be attenuated in the most contemporary era.

18.
Can J Kidney Health Dis ; 7: 2054358120964115, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-33101700

RESUMEN

BACKGROUND: Peritonitis remains a major complication in peritoneal dialysis (PD). Abdominal imaging is often performed in the setting of peritonitis to evaluate for concomitant intra-abdominal processes. However, the usefulness of this procedure is unknown. OBJECTIVE: The aim of this study was to assess the prevalence of abdominal imaging performed in the setting of PD peritonitis and to evaluate clinical parameters associated with abnormal imaging results to identify clinical situations in which radiographic examinations are informative. DESIGN: This is a retrospective cohort study. SETTING: The study was conducted at the Toronto General Hospital, Ontario, Canada. PATIENTS: We studied 166 episodes of PD peritonitis in 114 patients between January 1, 2011, and June 30, 2016. MEASUREMENTS: Baseline demographics, characteristics of PD peritonitis, and characteristics of abdominal imaging performed. METHODS: The association between relevant clinical parameters and abnormal abdominal imaging was examined using a univariate and multivariate logistic regression model. RESULTS: Abdominal imaging (computed tomography [CT] scan or ultrasound) was performed in 68 cases (41%). Patients were more likely to undergo imaging if they required hospitalization, were admitted to the intensive care unit (ICU), had polymicrobial or fungal organisms causing peritonitis, had relapsing/recurrent/refractory peritonitis, had an indication for hemodialysis or PD catheter removal, or presented with hypotension, tachycardia, or an elevated serum lactate. Of the imaging performed, abnormalities were found in 32 cases (47%). The most common findings were bowel obstruction, intra-abdominal collection, and biliary abnormalities. In the univariate analysis, ICU admission (43.3% vs 14.3%, P < .01) and need for temporary or permanent hemodialysis (62.5% vs 30.6%, P < .01) were associated with imaging abnormalities. Importantly, the peritonitis organism was not associated with abnormal imaging results. In a multivariate analysis, ICU admission was the only significant clinical parameter associated with imaging abnormalities with an odds ratio (OR) of 4.4 (95% confidence interval [CI]: 1.1-17.4, P = .04). LIMITATIONS: Single-center study, small sample size, and lack of detailed information on the exact indications leading to abdominal imaging. CONCLUSIONS: Abdominal imaging is commonly performed in the setting of PD peritonitis. Abnormalities are not infrequent and are present in almost half of the cases, with need for ICU admission being the most significant clinical parameter associated with abnormal findings. Therefore, abdominal imaging should be performed in carefully selected patients with PD peritonitis, especially if there is evidence of hemodynamic instability. While the finding of fungal or polymicrobial peritonitis was a driver for abdominal imaging, the presence of these organisms did not predict radiologic abnormalities.


CONTEXTE: La péritonite demeure une des principales complications de la dialyse péritonéale (DP), et l'imagerie abdominale est couramment utilisée pour évaluer la présence de processus intra-abdominaux concomitants. OBJECTIFS: Établir la prévalence de l'imagerie abdominale dans les cas de péritonites liées à la DP et déterminer les paramètres cliniques associés à des résultats d'imagerie anormaux afin d'identifier les situations cliniques pour lesquelles les examens radiographiques sont informatifs. TYPE D'ÉTUDE: Étude de cohorte rétrospective. CADRE: L'hôpital général de Toronto (Ontario) au Canada. SUJETS: Nous avons examiné 166 épisodes de péritonites liées à la DP survenues chez 114 patients entre le 1er janvier 2011 et le 30 juin 2016. MESURES: Les données démographiques des patients, les caractéristiques de la péritonite et les caractéristiques de l'imagerie abdominale effectuée. MÉTHODOLOGIE: Le lien entre les paramètres cliniques pertinents et une imagerie abdominale anormale a été établi à l'aide de modèles de régression logistique univariée et multivariée. RÉSULTATS: Une imagerie abdominale (tomodensitométrie ou échographie) a été effectuée dans 68 cas (41 %). Les patients étaient plus susceptibles de subir un examen d'imagerie s'ils devaient être hospitalisés ou admis à l'unité des soins intensifs (USI), si la péritonite était causée par une infection fongique ou polymicrobienne, s'il s'agissait d'une péritonite récurrente/réfractaire ou d'une rechute, s'ils avaient une indication d'hémodialyse ou de retrait du cathéter de DP, ou s'ils présentaient de l'hypotension, de la tachycardie ou un taux élevé de lactate sérique. Une anomalie a été détectée dans 32 (47 %) des tests d'imagerie effectués; une occlusion abdominale, une collection intra-abdominale ou une anomalie biliaire étant les plus fréquemment observées. Dans l'analyse univariée, une admission aux USI (43,3 % vs 14,3 %; P < 0,01) et le besoin d'hémodialyse temporaire ou permanente (62,5 % vs 30,6 %; P < 0,01) ont été associés à des anomalies détectées lors de l'imagerie. La présence de microorganismes causant la péritonite n'a toutefois pas été associée à des résultats d'imagerie anormaux. Dans l'analyse multivariée, seule une admission aux USI a été significativement associée à un résultat d'imagerie anormal, avec un rapport de cotes de 4,4 (IC 95 %: 1,1-17,4; P = 0,04). LIMITES: Étude monocentrique, échantillon de faible taille et manque d'informations détaillées sur les indications pour l'imagerie abdominale. CONCLUSION: L'imagerie abdominale est couramment pratiquée en présence d'une péritonite liée à la dialyse péritonéale. Des anomalies sont observées dans près de la moitié des cas et l'admission aux soins intensifs constitue le paramètre clinique le plus significativement associé à un résultat d'imagerie anormal. Dès lors, l'imagerie abdominale devrait être envisagée pour certains patients soigneusement sélectionnés présentant une péritonite liée à la DP, particulièrement s'il y a instabilité hémodynamique. Enfin, bien qu'un diagnostic de péritonite fongique ou polymicrobienne soit un moteur d'imagerie abdominale, la présence de ces microorganismes ne s'est pas avérée prédictive d'anomalies radiologiques.

19.
Kidney Med ; 2(4): 467-475, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32775987

RESUMEN

Peritonitis is a common complication of peritoneal dialysis that is associated with substantial morbidity and mortality. Peritonitis increases treatment costs and hospitalization events and is the most common reason for transfer to hemodialysis. Although there is much focus on preventing peritoneal dialysis-associated peritonitis, equally as important is appropriate management to minimize the morbidity of a peritonitis episode when it has occurred. Despite the presence of international guidelines on peritonitis treatment, the evidence base to support optimal peritonitis treatment practices is lacking, leaving the practitioner to rely on clinical experience and extrapolate from across other infection treatment practices. This article reviews common mistakes and misconceptions that we have observed in the management of peritonitis that may compromise treatment success. It also provides suggestions on common controversial aspects of peritonitis management based on the best available literature. Although the use of the word mistakes is somewhat controversial and subjective, we acknowledge that evidence is lacking and have based many of our suggestions on clinical judgment, experience, and available data.

20.
Am J Nephrol ; 50(5): 392-400, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-31600760

RESUMEN

BACKGROUND: Home dialysis patients may be at an increased risk of adverse events after transitional states. The home dialysis virtual ward (HDVW) trial was conducted in Canadian dialysis centers and aimed to evaluate potential care gaps and patient satisfaction during the HDVW. METHODS: The HDVW was a multicenter single-arm trial including peritoneal dialysis and home hemodialysis patients after 4 different events (hospital discharge, medical procedure, antibiotics, completion of training). Telephone-led interviews using a standardized assessment tool were performed over a 2-week period to assess a patient's care and adjust treatment as required. Upon completion, patients were surveyed to evaluate their perceived impact on domains of care using a rating scale; 1 not satisfied to 10 completely satisfied. RESULTS: The HDVW trial included 193 patients with a median number of potential care gaps/interventions of 1 (0-2) per patient. Patients admitted to the HDVW after hospital discharge were at a higher risk of potential gaps in care (OR 2.16, 95% CI 1.29-3.62), while longer dialysis vintage was -associated with a lower number of gaps/interventions (OR 0.97 per year, 95% CI 0.95-0.98). A total of 105/193 (54%) patients completed satisfaction surveys. Patients were highly satisfied with the HDVW (median rating scale score 8, IQR 2) and felt it had a positive impact (rating scale score ≥7) on their overall health, understanding of treatment and access to a nephrologist. CONCLUSION: The HDVW was effective at identifying several potential care gaps, and patients were satisfied across several domains of care. This intervention may be valuable in supporting home dialysis patients during care transitions.


Asunto(s)
Cuidados Posteriores/organización & administración , Hemodiálisis en el Domicilio/métodos , Fallo Renal Crónico/terapia , Diálisis Peritoneal/métodos , Brechas de la Práctica Profesional/estadística & datos numéricos , Adulto , Cuidados Posteriores/métodos , Cuidados Posteriores/estadística & datos numéricos , Anciano , Canadá , Femenino , Hemodiálisis en el Domicilio/efectos adversos , Humanos , Masculino , Persona de Mediana Edad , Educación del Paciente como Asunto/métodos , Educación del Paciente como Asunto/organización & administración , Satisfacción del Paciente , Diálisis Peritoneal/efectos adversos , Teléfono , Resultado del Tratamiento
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