RESUMEN
Persistent organic pollutants are synthetic chemicals highly resistant to degradation with strong tendency to bioaccumulation. Assessment of human exposure to these compounds is crucial for public health protection, especially during vulnerable periods. The aim of the present cohort study was to evaluate the level of contamination to PCBs, o,p'- and p,p'-DDE, o,p' and p,p'-DDD, o,p' and p,p'-DDT and HCB in pregnant women. Hair, amniotic fluid and serum samples were collected and analyzed by HS-SPME-GCMS. The most detected analytes in amniotic fluids were p,p'-DDE, p,p'-DDD, o,p'-DDE and PCB101, in serum p,p'-DDE, HCB and PCB101 and in hair p,p'-DDE, HCB and PCB101. The levels of HCB and PCB101 in amniotic fluids were positively correlated with those in hair. Higher levels of DDDs and DDTs in hair samples and PCB28 in amniotic fluids were observed in smoker pregnant women. Gestation age was inversely proportional with the detected levels of PCB101 in all tested samples.
Asunto(s)
Líquido Amniótico/metabolismo , Contaminantes Ambientales/análisis , Cabello/química , Hidrocarburos Clorados/análisis , Exposición Materna/estadística & datos numéricos , Adulto , DDT , Diclorodifenil Dicloroetileno , Contaminantes Ambientales/metabolismo , Femenino , Grecia , Humanos , Hidrocarburos Clorados/metabolismo , Plaguicidas , Bifenilos Policlorados , EmbarazoRESUMEN
OBJECTIVE: To describe the first trimester diagnosis of agenesis of the corpus callosum (ACC). METHODS: The midbrain and falx cerebri were examined in stored images of the midsagittal view of the fetal brain at 11(+0)-13(+6) weeks' gestation from 15 fetuses with ACC and 500 normal controls. The midbrain diameter and falx diameter were measured and their ratio was calculated. The values in fetuses with ACC and normal controls were compared. RESULTS: In the control group, the midbrain and falx diameters increased significantly with crown-rump length (CRL) from respective mean values of 5.1 and 6.9 mm at CRL of 45-6.9 mm and 12.1 mm at CRL of 84 mm. In the ACC group the midbrain diameter was above the 95th percentile of the control group in 8 (53.3%) cases, the falx diameter was below the 5th percentile in 6 (40.0%) cases and the midbrain diameter-to-falx diameter ratio was above the 95th percentile in 13 (86.7%) cases. CONCLUSIONS: In the midsagittal view of the fetal brain at 11-13 weeks, the majority of fetuses with ACC have measurable abnormalities in the midbrain and falx area of the brain.
