Impact of MR Acquisition Parameters on DTI Scalar Indexes: A Tractography Based Approach.

Acquisition parameters play a crucial role in Diffusion Tensor Imaging (DTI), as they have a major impact on the values of scalar measures such as Fractional Anisotropy (FA) or Mean Diffusivity (MD) that are usually the focus of clinical studies based on white matter analysis. This paper presents an analysis on the impact of the variation of several acquisition parameters on these scalar measures with a novel double focus. First, a tractography-based approach is employed, motivated by the significant number of clinical studies that are carried out using this technique. Second, the consequences of simultaneous changes in multiple parameters are analyzed: number of gradient directions, b-value and voxel resolution. Results indicate that the FA is most affected by changes in the number of gradients and voxel resolution, while MD is specially influenced by variations in the b-value. Even if the choice of a tractography algorithm has an effect on the numerical values of the final scalar measures, the evolution of these measures when acquisition parameters are modified is parallel.

Attention deficit/hyperactivity disorder and medication with stimulants in young children: a DTI study.

The relationship between attention deficit/hyperactivity disorder (ADHD) and white matter connectivity has not been well established yet, specially for children under 10 years of age. In addition, the effects of treatment on brain structure have not been sufficiently explored from a Diffusion Tensor Imaging (DTI) perspective. In this study, the influence of treatment with methylphenidate in the white matter of children with ADHD was investigated using two different and complementary DTI analysis methods: Tract-Based Spatial Statistics (TBSS) and a robust tractography selection method. No significant differences were found in Fractional Anisotropy (FA) between medicated, drug-naïve patients and healthy controls, but a reduced Mean Diffusivity (MD) was found in ADHD patients under treatment with respect to both healthy controls and drug-naïve ADHD patients. Also, correlations were found between MD increases and performance indicators of ADHD. These findings may help elucidate the nature of white matter alterations in ADHD, their relationship with symptoms and the effects of treatment with psychostimulants.