1.
Chemistry
; 18(29): 8882-5, 2012 Jul 16.
Artículo
en Inglés
| MEDLINE
| ID: mdl-22730204
RESUMEN
Water makes it possible: The Cu(2)O-catalyzed reaction between easily available o-bromobenzylbromides and benzamidines by using Cs(2)CO(3) as the base and N,N'-dimethylethylenediamine (DMEDA) as the additive in water as the solvent gives access to substituted quinazolines in a single step with yields ranging from 57 to 85 % (see scheme).