RESUMEN
A case of fulminant hepatic failure two days following an uneventful operation during isoflurane anesthesia is presented. Investigations included elevated bilirubin and serum transaminases in the absence of any other cause of hepatic dysfunction. The patient died on the fourth postoperative day. Subsequent postmortem examination showed centrilobular coagulative necrosis consistent with drug toxicity, with isoflurane as the most likely toxic agent.
Asunto(s)
Anestésicos por Inhalación/efectos adversos , Enfermedad Hepática Inducida por Sustancias y Drogas/etiología , Isoflurano/efectos adversos , Fallo Hepático Agudo/inducido químicamente , Anciano , Anestésicos por Inhalación/administración & dosificación , Enfermedad Hepática Inducida por Sustancias y Drogas/fisiopatología , Resultado Fatal , Femenino , Humanos , Isoflurano/administración & dosificación , Fallo Hepático Agudo/fisiopatología , NecrosisRESUMEN
BACKGROUND: Microscopic examination of all surgical specimens is controversial. CASE PRESENTATION: We report two cases where examination has revealed unexpected results that have changed patient management and treatment. CONCLUSIONS: Histopathological examination of all tissue should be considered. The benefits and disadvantages of routine examination of tissue are discussed.
