1.
ChemMedChem
; 8(5): 709-18, 2013 May.
Artículo
en Inglés
| MEDLINE
| ID: mdl-23495190
RESUMEN
Greater than the sum of its parts: Artemisinins are currently in phaseâ I-II clinical trials against breast, colorectal and non-small-cell lung cancers. In an attempt to offer increased specificity, a series of hybrid artemisinin-polypyrrole minor groove binder conjugates are described. DNA binding/modelling studies and preliminary biological evaluation give insights into their mechanism of action and the potential of this strategy.