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STUDY DESIGN: Retrospective comparative study. PURPOSE: To assess differences in computed tomography (CT) imaging parameters between patients with cervical myelopathy and controls. OVERVIEW OF LITERATURE: There is a lack of information regarding the best predictor of symptomatic stenosis based on osseous canal dimensions. We postulate that smaller osseous canal dimensions increase the risk of symptomatic central stenosis. METHODS: CT images and medical records of patients with cervical myelopathy (19 patients, 8 males; average age, 64.4±13.4 years) and controls (18 patients, 14 males; average age, 60.4±11.0 years) were collected. A new measure called the laminar roof pitch angle (=angle between the lamina) was conducted along with linear measures, ratios and surrogates of canal perimeter and area at each level C2-C7 (222 levels). Receiver-operator curves were used to assess the diagnostic value of each. Rater reliability was assessed for the measures. RESULTS: The medial-lateral (ML) diameter (at mid-pedicle level) and calculated canal area (=anterior-posterior.×ML diameters) were the most accurate and highly reliable. ML diameter below 23.5 mm and calculated canal area below 300 mm(2) generated 82% to 84% sensitivity and 67% to 68% sensitivity. No significant correlations were identified between age, height, weight, body mass in dex and gender for each of the CT measures. CONCLUSIONS: CT measures including ML dimensions were most predictive. This study is the first to identify an important role for the ML dimension in cases of slowly progressive compressive myelopathy. A ML reserve may be protective when the canal is progressively compromised in the anterior-posterior dimension.
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DESIGN: Retrospective case study. OBJECTIVE: Percutaneous pedicle screw (PPS) techniques do not allow direct visualization and may lead to erroneous screw placement. A technique utilizing only fluoroscopy is described. Verification of its accuracy and morphometric validation are presented. BACKGROUND: Minimally invasive spine surgical techniques, particularly PPS placement, have been growing in popularity. The purported benefits of minimally invasive spine surgical stated may be even more advantageous in the trauma setting. METHODS: Jamshidi needles were docked in the typical starting position verified with posterior-anterior image. Jamshidi needle (20 mm) was advanced ensuring that the tip remained lateral to the medial pedicle wall. A Kirschner (K-wire) was placed through the needle. Once all the K-wires were placed, a lateral image was taken confirming the correct trajectory and that the wire passed the posterior vertebral body wall. Patients with PPS fixation were retrospectively studied with postoperative computed tomography to verify screw accuracy. Screw grade was assessed as grade I when completely within the pedicle, II <2 mm, III 2-4 mm, and IV >4 mm outside the pedicle. Morphometrically, 40 thoracic and lumbar computed tomography scans of patients (<40 y) without spine fractures were reviewed. The pedicle length was defined as the distance from the dorsal cortical margin to the posterior vertebral body in the pedicle's midaxis. RESULTS: A total of 172 screws were placed. Eighteen percent were found to have cortical breach, but only 2.9% were found to have >grade II breach. The morphometric study demonstrated the pedicle length to range from 14.4 to 22.1 mm. The shortest was in the upper thoracic and the longest at L1-L2. CONCLUSIONS: The morphometric study demonstrates if a K-wire is placed 20 mm into the bone and remains lateral to the medial pedicle wall and the tip just engages the vertebral body, the screw trajectory is safe particularly in the lower thoracic and upper lumbar spine. A smaller distance may be utilized in the upper thoracic. Breach rates are similar to other reports using other techniques; none were clinically significant. The advantage of this technique is the use of only PA fluoroscopy for placing all the wires percutaneously.
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Tornillos Óseos , Vértebras Lumbares/cirugía , Vértebras Torácicas/cirugía , Heridas y Lesiones/cirugía , Accidentes de Tránsito , Adulto , Anciano , Fluoroscopía , Humanos , Ligamentos/cirugía , Vértebras Lumbares/diagnóstico por imagen , Persona de Mediana Edad , Estudios Retrospectivos , Fusión Vertebral/métodos , Vértebras Torácicas/diagnóstico por imagen , Tomografía Computarizada por Rayos X , Resultado del Tratamiento , Adulto JovenRESUMEN
Flexion-extension radiographs are commonly used to assess lumbar fusion. Recommended criteria for solid fusion have varied from 1 to 5 degrees of angular motion between vertebrae. Notwithstanding this wide variation, the validity of these criteria have never been biomechanically tested. As a preliminary and initial step, it was the authors' purpose to quantify measurable angular motion after simulating solid lumbar fusion in human cadaver spines. Seven cadaveric spines (L1 to L4) were tested in a radiolucent jig fixed to a servohydraulic testing apparatus. Flexion and extension moments of 10 Nm were applied. Fusion was simulated using metallic implants spanning the L2-L3 motion segment. These included transverse process plates, a spinous process plate, pedicle screw construct, or an anterior vertebral body plate to simulate an intertransverse, interspinous process, facet, and interbody fusions, respectively. Angular movements were measured on lateral radiographs and statistically compared using a repeated measures analysis of variance. Simulated intertransverse fusion resulted in 13+/-4 degrees of motion; interspinous fusion, 9+/-4 degrees; posterior facet fusion, 5+/-3 degrees; and interbody fusion with plate, 3+/-2 degrees. Compared with the intact, only posterior facet fusion and interbody fusion with plate had statistically significantly less motion (P=0.006 and 0.0001, respectively). The amount of radiographically detectable flexion-extension motion with simulated fusions varies widely and seems to be influenced by fusion type. This study documents a range of measurable motion on flexion-extension radiographs after several types of simulated lumbar fusion. However, as the degrees of motion seemed to be high, future studies should use a fusion simulation other than metallic implants that more closely resembles bony arthrodesis.
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Artrodesis/normas , Vértebras Lumbares/diagnóstico por imagen , Vértebras Lumbares/cirugía , Movimiento/fisiología , Radiografía/métodos , Rango del Movimiento Articular/fisiología , Anciano , Anciano de 80 o más Años , Artrodesis/instrumentación , Artrodesis/métodos , Fenómenos Biomecánicos , Cadáver , Femenino , Humanos , Fijadores Internos/efectos adversos , Fijadores Internos/normas , Vértebras Lumbares/fisiología , Masculino , Modelos Anatómicos , Seudoartrosis/diagnóstico por imagen , Seudoartrosis/fisiopatología , Seudoartrosis/prevención & control , Soporte de Peso/fisiologíaRESUMEN
STUDY DESIGN: Study of posterolateral fusions in a rabbit model. OBJECTIVES: To characterize the contribution of paraspinal musculature to the healing of posterolateral spinal fusions in a rabbit model. SUMMARY OF BACKGROUND DATA: Previous studies have demonstrated that successful spinal arthrodesis requires vascular ingrowth from adjacent decorticated bone. In other areas of the body, such as the tibia, vascular ingrowth from the surrounding musculature has also been shown to be important. The role of the surrounding paraspinal musculature in spinal fusions has yet to be assessed. METHODS: Twenty-five New Zealand white rabbits underwent posterolateral spinal fusion. One side of the animals was treated with autograft alone and served as the control group. On the contralateral side, the autograft was contained within porous or nonporous barrier sheets. Following euthanization, high-resolution radiographs, CT scans, and histologic analyses were performed to assess fusion and characterize vascular ingrowth. RESULTS: Using histologic evaluation, the fusion rate in the porous group was 90%, in the nonporous group 40%, and in the control group 55%. Vascular ingrowth was evident from the muscle through the porous sheet into the fusion mass. CONCLUSIONS: These results support our hypothesis that the paraspinal musculature provides important vascular ingrowth into the fusion site. Use of a porous barrier sheet appears to improve fusion by preventing muscle interposition while allowing vascular ingrowth from surrounding muscle.
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Vértebras Lumbares/irrigación sanguínea , Vértebras Lumbares/cirugía , Músculo Esquelético/irrigación sanguínea , Fusión Vertebral/métodos , Animales , Vértebras Lumbares/diagnóstico por imagen , Músculo Esquelético/diagnóstico por imagen , Conejos , RadiografíaRESUMEN
STUDY DESIGN: A bovine model was used to evaluate the effects of thoracic vertebral screw impingement of the aorta. OBJECTIVES: To evaluate the histologic and biomechanical changes in aortic wall tissue that was severely impinged by abutting instrumentation. SUMMARY OF BACKGROUND DATA: Case reports of vascular injury associated with spinal instrumentation generally describe intraoperative injury; some report delayed presentation of large vessel damage. Risks associated with placing instrumentation adjacent to large vessels are largely unknown. METHODS: Six 1-month-old calves underwent left-sided thoracotomies, exposing the anterior thoracic spine and aorta. With the heads removed, screws were inserted in reverse fashion into T6 through T11, leaving the screw tips 1 cm proud and abutting the aorta. After 3, 6, or 12 months (2 calves each), the spines were resected with the adjacent aorta and underwent radiographic, histologic, and biomechanical testing. RESULTS: Computed tomography revealed varying degrees of vessel impingement. Although there were no frank ruptures, 96% of aortic specimens showed histopathologic changes, including 52% with wall thinning; 43% were no longer impinged, yet 60% of these had increased collagen (scar). Biomechanical testing of screw-impinged aortas demonstrated a lower failure stress (1.2 +/- 0.5 N/mm vs. 1.8 +/- 0.4 N/mm, P = 0.016) but no difference in failure strain (42 +/- 9% vs. 32 +/- 10%, P = 0.06) than controls. CONCLUSIONS: Major impingement of vertebral screws on the aorta caused acute and chronic histopathologic and biomechanical changes in the vessel wall. This model represents a severe form of vessel penetration by a screw that confirms such a "worst case" scenario results in marked compromise of the vessel wall integrity. The sequelae of less severe impingement are unknown.
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Aorta Torácica/lesiones , Tornillos Óseos/efectos adversos , Vértebras Torácicas/cirugía , Animales , Aorta Torácica/patología , Aorta Torácica/fisiopatología , Bovinos , Fijadores Internos/efectos adversos , Complicaciones Intraoperatorias/etiología , Modelos Animales , Fusión Vertebral/efectos adversos , Estrés Mecánico , Vértebras Torácicas/diagnóstico por imagen , Vértebras Torácicas/patología , Tomografía Computarizada por Rayos XRESUMEN
STUDY DESIGN: Growth factor in a collagen sponge carrier was compared to autograft, both packed within an allograft strut following corpectomy in a bovine spinal model. OBJECTIVE: To evaluate incorporation of cortical strut allografts after lumbar corpectomy, comparing augmentation with recombinant human bone morphogenetic protein-2 (rhBMP-2) to local autograft. SUMMARY OF BACKGROUND DATA: Autogenous strut grafts are the gold standard for successful fusion in reconstruction following corpectomy; however, significant donor site morbidity can occur. Recent studies describing consistently successful anterior interbody fusions with BMP augmentation suggest an exciting prospect of unlimited and potent grafting material for these difficult fusions. METHODS: Sixteen calves underwent L3 corpectomy with instrumented strut allograft reconstruction. The rhBMP-2 impregnated collagen sponges filled the empty medullary canal of the allograft in 8 animals. Eight animals had the allograft strut filled with local autogenous bone. After 4 months, the lumbar spines were harvested for radiographic, biomechanical, and histologic evaluation. RESULTS: Computerized tomography revealed allograft fusion in 7 of 8 autograft specimens and 8 of 8 BMP specimens. The BMP treated group had denser bone at the ends of the cortical allograft, but a central void persisted. Autograft filled struts maintained a more uniform distribution of less organized bone throughout the strut canal. Histologic assessment verified remodeling and incorporation of the allografts for both groups. Biomechanical testing confirmed no significant difference in fusion strength between groups. CONCLUSIONS: Large cortical strut allografts (after lumbar corpectomy) supplemented with rhBMP-2 had incorporation and fusion strength comparable to allografts enhanced with cancellous autograft.
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Artroplastia de Reemplazo/métodos , Proteínas Morfogenéticas Óseas/farmacología , Prótesis Articulares , Vértebras Lumbares/cirugía , Oseointegración/efectos de los fármacos , Proteínas Recombinantes/farmacología , Fusión Vertebral/métodos , Factor de Crecimiento Transformador beta/farmacología , Animales , Artroplastia de Reemplazo/instrumentación , Materiales Biocompatibles , Fenómenos Biomecánicos , Proteína Morfogenética Ósea 2 , Trasplante Óseo , Bovinos , Colágeno , Portadores de Fármacos , Humanos , Vértebras Lumbares/efectos de los fármacos , Vértebras Lumbares/patología , Masculino , Modelos Animales , Oseointegración/fisiología , Fusión Vertebral/instrumentación , Tomografía Computarizada por Rayos XRESUMEN
UNLABELLED: Counteracting bone loss is required for future space exploration. We evaluated the ability of treadmill exercise in a LBNP chamber to counteract bone loss in a 30-day bed rest study. Eight pairs of identical twins were randomly assigned to sedentary control or exercise groups. Exercise within LBNP decreased the bone resorption caused by bed rest and may provide a countermeasure for spaceflight. INTRODUCTION: Bone loss is one of the greatest physiological challenges for extended-duration space missions. The ability of exercise to counteract weightlessness-induced bone loss has been studied extensively, but to date, it has proven ineffective. We evaluated the effectiveness of a combination of two countermeasures-treadmill exercise while inside a lower body negative pressure (LBNP) chamber-on bone loss during a 30-day bed rest study. MATERIALS AND METHODS: Eight pairs of identical twins were randomized into sedentary (SED) or exercise/LBNP (EX/LBNP) groups. Blood and urine samples were collected before, several times during, and after the 30-day bed rest period. These samples were analyzed for markers of bone and calcium metabolism. Repeated measures ANOVA was used to determine statistical significance. Because identical twins were used, both time and group were treated as repeated variables. RESULTS: Markers of bone resorption were increased during bed rest in samples from sedentary subjects, including the collagen cross-links and serum and urinary calcium concentrations. For N-telopeptide and deoxypyridinoline, there were significant (p < 0.05) interactions between group (SED versus EX/LBNP) and phase of the study (sample collection point). Pyridinium cross-links were increased above pre-bed rest levels in both groups, but the EX/LBNP group had a smaller increase than the SED group. Markers of bone formation were unchanged by bed rest in both groups. CONCLUSIONS: These data show that this weight-bearing exercise combined with LBNP ameliorates some of the negative effects of simulated weightlessness on bone metabolism. This protocol may pave the way to counteracting bone loss during spaceflight and may provide valuable information about normal and abnormal bone physiology here on Earth.
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Enfermedades Óseas Metabólicas/prevención & control , Prueba de Esfuerzo , Ingravidez/efectos adversos , Fosfatasa Alcalina/sangre , Reposo en Cama , Biomarcadores/sangre , Calcifediol/sangre , Calcitriol/sangre , Calcio/sangre , Humanos , Masculino , Osteocalcina/sangre , Hormona Paratiroidea/sangre , Selección de Paciente , Postura , Vuelo Espacial , Posición Supina , Gemelos MonocigóticosRESUMEN
STUDY DESIGN: In vitro biomechanical assessment of spinal stability after corpectomy reconstruction. OBJECTIVES To gain a more thorough understanding of the biomechanical properties of anterior plate versus dual rod systems used for anterior lumbar corpectomy reconstruction. SUMMARY OF BACKGROUND DATA: Vertebral corpectomy is commonly required in the treatment of several types of spinal pathology (fracture, tumor, infection). Stabilization with strut allograft and anterior instrumentation can be accomplished with one of several anterior implant systems. These include plate systems and rod-based systems with theoretically different structural properties. METHODS: Two instrumentation systems, the ATL Z-plate and the Antares system, were each applied to 10 calf lumbar spines with a cortical strut graft reconstructing an L3 corpectomy defect. All spines were tested biomechanically to determine construct stiffness under physiologic loads in multiple planes and then tested in torsion to failure. RESULTS: There was greater stiffness (P < 0.05) in all directions of bending (flexion, extension, lateral bending) for the Antares dual rod construct compared to the Z-plate constructs. No significant difference was noted in either torsional testing under physiologic loads or torque to failure between the groups. CONCLUSIONS: Although there was significantly greater resistance to bending with the dual rod construct, the ultimate selection of a system will require an individual analysis of implant profile, construct demand, and ease of use. Both systems provided secure initial fixation following lumbar corpectomy; however, the Antares system may increase the likelihood of graft incorporation in cases with greater instability and higher load demands.
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Clavos Ortopédicos , Placas Óseas , Vértebras Lumbares/cirugía , Animales , Fenómenos Biomecánicos , Bovinos , Vértebras Lumbares/anatomía & histologíaRESUMEN
International Classification of Diseases coding of patient charts is used by hospitals to allow for billing of patients. Coding information also is used for assessing physician effectiveness. The purpose of the current study was to examine hospital coding for patients having total hip arthroplasty. One hundred consecutive primary total hip replacements were done at one medical center by two orthopaedic surgeons. Patient charts were coded by hospital coders according to the Health Care Finance Administration guidelines. Subsequently, an orthopaedist-based team did a secondary review of these charts and the two sets of codes were compared. The diagnostic codes were similar between the two groups for 87% (174 of 200 codes) of the cases. Comorbidities generally were undercoded by the hospital coders who reported 2.9 comorbidities per patient, whereas the secondary review reported 3.7 comorbidities per patient. The hospital coders found a complication rate of 1.2 per patient, whereas the secondary review revealed a rate of 0.4 per patient. Based on the results of the current study, the authors conclude that it is important to ensure three issues regarding the standard of coding and quality control: (1) the qualifications of the coders; (2) an interaction between coders and healthcare professionals to check that coding is accurate and reproducible; and (3) communication among various health professionals (including the primary surgeon) and coders to determine what actually are appropriate diagnoses, comorbidities, and complications.
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Artroplastia de Reemplazo de Cadera , Control de Formularios y Registros/métodos , Complicaciones Posoperatorias/diagnóstico , Artroplastia de Reemplazo de Cadera/efectos adversos , Comorbilidad , Humanos , Sistemas de Registros Médicos Computarizados , Complicaciones Posoperatorias/clasificación , Complicaciones Posoperatorias/epidemiologíaRESUMEN
Coding of diagnoses, comorbidities, and complications is important for health care delivery, not only for appropriate hospital and physician reimbursement, but also for a correct assessment of complication rates. The purpose of this study was to determine the agreement of coding of diagnoses, comorbidities, and complications for total knee arthroplasty between 2 groups of coders. Between January 1, 1997, and November 18, 1997, 100 consecutive primary total knee arthroplasties were done by 2 orthopaedic surgeons. Diagnoses, comorbidities, and complications were coded by professional hospital coders according to the Healthcare Finance Administration guidelines, then recoded by a second team with orthopaedic experience. Although the hospital coders matched diagnoses with the orthopaedic team 96.5% of the time, they determined a complication rate of 1.4 per patient and a comorbidity rate of 2.9 per patient, whereas the orthopaedic team coded for 0.7 complications per patient and 3.7 comorbidities. Based on these results, there should be interaction and communication between hospital coders and health care professionals to check that coding is accurate and reproducible.