1.
J Med Chem
; 53(10): 3927-36, 2010 May 27.
Artículo
en Inglés
| MEDLINE
| ID: mdl-20426423
RESUMEN
3-Methoxybenzamide (1) is a weak inhibitor of the essential bacterial cell division protein FtsZ. Alkyl derivatives of 1 are potent antistaphylococcal compounds with suboptimal drug-like properties. Exploration of the structure-activity relationships of analogues of these inhibitors led to the identification of potent antistaphylococcal compounds with improved pharmaceutical properties.