[Myelokaryocytes and leukocytes of circulating blood in elimination of erythrocyte transporting immune complexes and xenogenic antigens].

Interacting with erythrocytes which transport immune complexes and xenogenic antigens myelocariocytes and leukocytes of circulating blood produce from them erythroclasic clusters in bone marrow and autorosettes in circulating blood. Formation of these cellular associations is completed with exocytic lysis of included in them erythrocytes by myelocariocytes and leukocytes. It is supposed that the lysis of erythrocytes within erythroclasic clusters and autorosettes is the final stage of erythrocytic clearance of immune complexes and xenogenic antigens.

[Bone marrow as an organ of erythrocyte destruction in hematological disorders].

Bone marrow of patients with hematological diseases contains a great number of erythroclasic clusters characterized by exocytic lysis of the constituent erythrocytes by cluster-forming myelocaryocytes including erythrocaryocytes. The content of erythroclasic clusters with exocytic lysis of erythrocytes varied from 21% of total erythroclasic clusters in bone marrow of patients with aplastic anemia to 81% in bone marrow of patients with an active phase of acute lymphoblastic leukemia showing high intensity of hemolysis in the bone marrow. Most intensive lysis of erythrocytes in erythroclasic clusters took place in the bone marrow of patients in an active stage of acute lymphoblastic leukemia and patients with chronic myeloid leukemia. At the time of the investigation tens of thousands of erythrocytes were undergoing destruction in erythroclasic clusters in one mcl of bone marrow of such patients. These findings confirm the idea of the bone marrow as an organ of erythrocyte destruction.

[Concerning the condition of the bone marrow in patients with multiple myeloma]. / O sostoianii kostnogo mozga pri mnozhestvennoi mielome.

The bone marrow of 48 patients with multiple myeloma was studied prior to therapy. A relationships was established between cluster formation rate, on the one hand, and the numbers of myelocaryocytes, erythrocytes and circulating immune complexes, on the other. In patients with stage III disease, the diminished cellularity of the marrow was due to decreased levels of granulocytes and normocytes. Moreover, those patients revealed fewer erythroclastic marrow clusters. Similar changes in the granulocytic component of hemopoiesis were present in those who died within earlier stages (20 months) after the beginning of therapy. It is suggested that diminished granulocyte pool alongside reduced cluster formation rate may play a role in infectious complication development.

[Endogenous auto-rosette formation in the peripheral blood in experimental acute post-hemorrhagic and hemolytic anemias]. / Endogennoe autorozetkoobrazovanie v perifericheskoi krovi pri éksperimental'nykh ostrykh postgemorrhagicheskoi i gemoliticheskoi anemiiakh.

There was an increase in counts of auto-rosettes formed by monocytes or segmented neutrophils in the peripheral blood of rabbits with posthemorrhagic and phenylhydrazine hemolytic anemias. The intensification of autogenous rosette formation in circulating blood during the anemias under study coincides with enhanced erythrodieresis in time. This makes the authors conclude that autogenic rosette formation is one of the possible mechanisms responsible for erythrodieresis in experimental anemias.

[Erythroclastic bone marrow clusters and prognostication of the character of the course of acute lymphoblastic leukemia]. / Eritroklazicheskie kostnomozgovye klastery i prognozirovanie kharaktera techeniia ostrogo limfoblastnogo leikoza.

A new variety of bone marrow clusters was revealed, that is formed of mature red cells by bone-marrow macrophages and other myelokaryocytes containing hydrolytic enzymes. Exocytotic lysis of the red cells, contained in these clusters, by cluster-forming cells is frequently observed. This fact permitted calling this variety 'erythroclastic clusters'. The number of clusters, in which exocytotic red cell lysis occurs, was found to grow fourfold in the active phase of acute lymphoblastic leukemia; this fact may be used for the early diagnosis of the disease or for prediction of its recurrence.

[Relationship between parameters of central hemodynamics and the degree of obesity in men with elevated arterial pressure]. / Zavisimost' parametrov tsentral'noi gemodinamiki ot stepeni ozhireniia u muzhchin pri povyshenii arterial'nogo davleniia.

The authors studied the correlation between the values of the fatty and lean components of the body mass (BM) and the central hemodynamic (CHD) parameters in 169 males of the work-capable age with normal arterial pressure (AP), borderline arterial hypertension, and arterial hypertension. It was established that increase of the fatty and decrease of the lean components of the BM in males with normal AP have a negative effect on CHD and significantly correlate with diminution of the cardiac output values and increase of peripheral vascular resistance. Increase of AP in males weakens the relationship of the CHD parameters on the changes of fat deposition in the BM composition and is characterized by essential reduction or loss of the significance of correlation between the anthropometric and hemodynamic parameters.

[Mechanism of self-maintenance of experimental atherogenic hyperlipoproteinemia]. / O mekhanizme samopodderzhaniia éksperimental'noi aterogennoi giperlipoproteinemii.

Disorders of lipid catabolism in the liver and increased formation and intensified secretion into the blood of lipoproteins synthesized in the liver evidently play a significant role in the maintenance of experimental atherogenic hyperlipoproteinemia induced in rabbits by prolonged administration of atherogenic lipoproteins.

[Intravascular autorosette-formation in hemolytic anemia]. / Vnutrisosudistoe autorozetkoobrazovanie pri gemoliticheskikh anemiiakh.

It has been established that monocyte and neutrophil autorosette-formation resultant in exocytic lysis of erythrocytes--constituents of autorosettes--takes a low-intensive course in the blood of children with chronic non-hematologic diseases. This process is significantly activated in hereditary microspherocytic and elliptocytic anemias. It has been suggested that autorosette-formation culminating in exocytic lysis of erythrocytes is a mechanism of eliminating pathological, damaged and old erythrocytes from the blood, both under physiological conditions and in varying diseases.

[Change in myocardial phospholipid composition in cardiac hyperfunction as one of the possible prerequisites of sudden death]. / Izmenenie fosfolipidnogo sostava miokarda pri giperfuktsii serdtsa kak odna iz vozmozhnykh metabolicheskikh predposyok vnezapnoi smerti.

It is shown that additional load on a compensatory hypertrophied heart disturbs its adaptation mechanisms. Lipid peroxidation is activated, the amount of some types of unsaturated phospholipids reduces, and lysophospholipids, detergents damaging the cell membranes and causing an arrhythmogenic effect accumulate.

[Cellular interactions and changes in the peripheral blood leukocyte composition in hypokinetic rats]. / Kletochnye vzaimodeistviia i izmeneniia sostava leikotsitov v perifericheskoi krovi krys pri kipokinezii.

Along with leukocytosis and an increased number of moderate-size lymphocytes, the peripheral blood of hypokinetic albino rats was found to contain a large number of large mononuclear cells forming rosette-like structures with the erythrocytes. The pathophysiological significance of cell interrelations encountered in the peripheral blood of rats in hypokinesia is discussed.

[The lipid and phospholipid composition of the myocardium in hyperfunction caused by aortic coarctation]. / Lipidnyi i fosfolipidnyi sostav miokarda pri ego giperfunktsii, vyzvannoi koarktatsiei aorty.

It is shown that in the first 10-12 days of heart hyperfunction caused by subdiaphragmatic constriction of the aorta adaptational changes in lipid metabolism develop in the myocardium in addition to its hypertrophy. These changes are capable of leading to reduced viscosity of the myocardial membranes and activation of enzymatic processes providing for the intensified work of the heart.

[The metabolic changes in myocardial subcellular fractions in the pathogenesis of ischemic heart disease]. / Metabolicheskie izmeneniia subkletochnykh fraktsii miokarda v patogeneze ishemicheskoi bolezni serdtsa.

In the myocardial mitochondria (MCh) of persons who had died from ischemic heart disease (IHD) the content of phosphatidylcholine (PCh) and cardiolipin reduces while the amount of the products of their hydrolysis--free fatty acids (FFA) and lysophospholipids--increases. This is evidence of the breakdown of the membrane MCh phospholipids (PL). The content of PL, protein, FChS, FFA, and lysophosphatidylethanolamine in the sarcoplasmic reticulum increases. The increase in the amount of PL, protein, and free cholesterol (FChS) may be explained by an increase of their synthesis due to myocardial hypertrophy which was encountered in all of the cases studied. The accumulation of FFA and lysophosphatidylethanolamine is probably not linked with PL hydrolysis (their amount in this subcellular fraction increases) but is a consequence of other changes in myocardial lipid metabolism. Thus, in IHD hydrolysis of PL prevails in the myocardial MCh and their synthesis in the sarcoplasma reticulum. These changes in the metabolism of the subcellular fractions may lead to damage of the membranes of the cardiomyocyte MCh, which may be the cause of disorders of electrolyte metabolism and contractile properties of the myocardium in IHD.

[The effectiveness of physical training in treating patients with neurocirculatory dystonia]. / Effektivnost' fizicheskikh trenirovki pri lechenii bol'nykh neirotsirkuliatornoi distoniei.

Physical training (8 to 10 km walking at a rate of 5.5 km/h daily for 4 to 6 months) prescribed to patients suffering from neurocirculatory dystonia promoted amelioration of the patients' mental status, diminution of the hypochondriac and anxious-depressive manifestations of the disease, increased exercise tolerance, and led to the decline in the blood plasma of cholesterol, triglycerides, free fatty acids and of very low and low density lipoproteins.

[Features of blood lipid composition during emotional stress in rabbits with dyslipoproteinemia]. / Osobennosti lipidnogo sostava krovi pri émotsional'nom napriazhenii u krolikov s dislioproteinemiei.

Only the concentration of essential fatty acids increases in blood serum under the effect of emotional stress in intact rabbits. In experimental dyslipoproteinemia, emotional stress, besides increasing the amount of essential fatty acids also causes marked changes of lipid metabolism of an atherogenic character. The mechanisms of lipidemia activation and maintenance are discussed.