RESUMEN
Allergy to insulin became a rare complication due to the introduction of recombinant human insulin preparations. Nevertheless, allergic reactions to components of such preparations can occur. We report a case of a 61-year-old man with an atopic background and affected by diabetes mellitus type 2 since 27 years, who experienced generalized allergy to insulin at the moment of switching oral anti-diabetics to insulin. Prick tests revealed an allergy specifically to zinc, and the patient was treated with zinc-free glulisine insulin. After 8 months of such treatment, patient's glucose is stable and he never experienced allergic reactions to insulin injections. Even insulin allergy due specifically to zinc is rare, such complication must be assessed especially in a patient suffering from multiple allergies.
Asunto(s)
Diabetes Mellitus Tipo 2/tratamiento farmacológico , Hipersensibilidad a las Drogas/etiología , Insulina Isófana/efectos adversos , Insulina/análogos & derivados , Zinc/efectos adversos , Diabetes Mellitus Tipo 2/inmunología , Hipersensibilidad a las Drogas/inmunología , Humanos , Hipoglucemiantes/química , Hipoglucemiantes/uso terapéutico , Insulina/química , Insulina/uso terapéutico , Insulina Isófana/uso terapéutico , Masculino , Persona de Mediana Edad , Zinc/inmunologíaRESUMEN
BACKGROUND: the association of diabetes type 1 and celiac disease seems to pose many problems diagnostic, therapeutic and psychological. Aim of our work is to study in eight patients with type 1 diabetes associated with celiac disease their daily experience and the constraints that this pathological association imposes. METHODS: This cross-sectional study involved eight patients with type 1 diabetes and celiac disease known for at least 1 year. All patients were given a thorough interrogation specifying the regular monitoring of the two diseases and the quality of the observance of the diabetic dietary and gluten-free diet, as well as an assessment of impact of diabetes. RESULTS: the caloric intake in relation to the recommendations is very insufficient. Taking snack is not respected. There is also the consumption of certain foods containing gluten masked and regular consumption of sucrose by our patients despite a long-term evolution of diabetes (19 +/- 6 years) and celiac disease (11 +/- 7.8 years). Half of patients have degenerative complications of diabetes. CONCLUSION: In light of these results, a frequent evaluation of nutrition education in these patients and a psychological care seems necessary.