RESUMEN
The major function of platelets is to contribute to hemostasis. If an impairment in their production and/or function occurs, abnormal bleeding can develop. An 18-year-old male presented to our hospital after four episodes of hematemesis. His medical history was relevant for Glanzmann thrombasthenia diagnosed during early childhood. On initial examination, he appeared pale and with normal blood pressure. His complete blood count included a hemoglobin concentration of 11.0 g/dL, additional laboratory tests were within the normal ranges. The initial approach consisted of a high dose of proton pump inhibitors. Hours later, esophagogastroduodenoscopy revealed diffuse oozing bleeding from gastric mucosa with no other visible lesions such as peptic ulcers or varices.
Asunto(s)
Úlcera Péptica , Trombastenia , Masculino , Humanos , Preescolar , Adolescente , Trombastenia/complicaciones , Trombastenia/diagnóstico , Hemorragia Gastrointestinal/etiología , Hemorragia Gastrointestinal/diagnóstico , Hematemesis/etiología , Enfermedad AgudaRESUMEN
A 61-year-old man with a history of progressive dysphagia in the last three years and current COVID-19 diagnosis, presented to our emergency department with sudden dyspnea and loss of consciousness. Initial examination revealed a respiratory rate of 30 bpm with an oxygen saturation of 94% with room air. A venous blood gas exam showed acute hypercapnic respiratory failure; therefore, he was intubated and admitted to the medical intensive care unit.
Asunto(s)
COVID-19 , Acalasia del Esófago , Insuficiencia Respiratoria , Masculino , Humanos , Persona de Mediana Edad , COVID-19/complicaciones , Prueba de COVID-19 , Insuficiencia Respiratoria/etiología , Insuficiencia Respiratoria/diagnóstico , HospitalizaciónRESUMEN
Acute cholangitis is a life-threatening infection, and several features are associated with a worse prognosis if prompt treatment is not started. Eighty-six subjects with acute cholangitis were included in a retrospective analysis. Patients had a median age of 53 years (range: 34.5 to 70 years) and 55 (64.0 %) were female. Of the entire cohort, 16 patients had a history of diabetes mellitus. Regarding acute cholangitis severity, 17 (19.8 %) cases were classified as severe, 41 (47.7 %) as moderate, and 28 (32.6 %) as mild.
Asunto(s)
Infecciones Bacterianas , Colangitis , Diabetes Mellitus Tipo 2 , Infecciones Intraabdominales , Enfermedad Aguda , Adulto , Anciano , Bacterias , Infecciones Bacterianas/complicaciones , Colangitis/etiología , Diabetes Mellitus Tipo 2/complicaciones , Femenino , Humanos , Infecciones Intraabdominales/complicaciones , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Factores de Riesgo , Índice de Severidad de la EnfermedadRESUMEN
Myasthenia gravis (MG) is an autoimmune disease that affects the postsynaptic membrane at the neuromuscular junction. In MG, antibodies bind to acetylcholine receptors inducing muscle weakness. The weakness typically increases with exercise and repetitive muscle use. Improvement of muscular weakness after rest and/or administration of anticholinesterase drugs (edrophonium) are characteristic of MG. We report a patient with unexplained dysphagia, dysphonia, and dysarthria, whose diagnosis was suggested by high-resolution esophageal motility and edrophonium infusion. We highlight the importance of dysphagia as presenting or dominant symptom in MG and review the esophageal motility findings in this rare, but treatable disorder.
RESUMEN
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