[Effect of thyroxin and thymalin on proliferation and apoptosis of thymocytes in rats after thyroidectomy]. / Vplyv tyroksynu i tymalinu na proliferatsiiu ta apoptoz tymotsytiv u shchuriv pislia tyreoïdektomiï.

It is found that 3 months after removal of thyroid gland in rats, a suppression of thymic endocrine function, loss of weight and cellularity occurs. These changes are mainly caused by a weakening of index of proliferative activity. In animals that postoperatively received substitutive thyroxin hormonotherapy and courses of thymulin these disorders don't occur or they are not expressed significantly.

[Lipid peroxidation and activity of antioxidant enzymes in thyroidectomized rats]. / Perekysne okysnennia lipidiv i aktyvnist' antyoksydantnykh fermentiv u shchuriv pislia tyreoïdektomiï.

The effect of thymalin on peroxidation of lipids in thyroidectomized rats that received thyroxin at a dose 2 mg/ kg was examined. It was found that 3 months after operation a decrease in body weight (over 2 times), weight of spleen and amount of cells in it took place. An increase of TB-activated products in livers and spleens of thyroidectomized rats 3 month later was not essential. Indices of enzyme activity of antioxidant system in liver were within normal ranges while indices of activity of catalase and superoxidedysmuthase in spleen increased by 4,3 and 1,3 times, respectively. Simultaneous administration of thyroxin and thymalin promotes more effective normalization of POL peroxidation, inhibits development of pathologic changes in organism after removal of thyroid gland.

[Effect of thymostimulin on endocrine thymus function in thyroidectomized rats during suppressive hormone therapy]. / Vplyv tymostymulinu na endokrynnu funktsiiu tymusa shchuriv pisla tyreoïdektomiï za umov supresyvnoï hormonoterapiï tyroksynom.

Due to disorders of hormonal balance in the organism, a decrease in thymic endocrine function occurred in rats after thyroidectomy. After removing the thyroid gland, we observed 1,3-2,2-fold decrease in the level of thymic hormone thymulin in the blood serum. When thyroxin was applied at a suppressive dose, endocrine function of the thymus did not restore. Injections of thymostimulin (Tp1) or its combination with thyroxin to thyroidectomized animals restored the level of thymulin up to the level in the intact rats due to effects of either injected preparation or induction of substances possessing thymosine-like activity.

[Endocrine function of the thymus in experimental hypothyroidism]. / Endokrynna funktsiia tymusa pry eksperymental'nomu hipotyreozi.

An Endocrine function of the thymus was studied by analyzing the level of thymulin in rats in 1-6 months after extirpation of the thymus. The level of thymulin in rats after thyroidectomy has been shown to be reduced maximally in 6 months after an operation. An inhibitor of thymulin was detected in the blood serum in a month after extirpation, then it disappeared completely from it. After thyroidectomy the mass of animals decreased, as well as an absolute and relative mass of the thymus and its cellular content. Thyroidectomy was followed with a marked decrease in the thyroid hormones content in the blood serum and a reduce in the adrenal cortex, especially at a distant period following an operation. The data obtained evidence that it is sensible to use the agents of the thymic origin to restore the hormone balance at hypothyroidism, together with the substitute therapy.

[Effect of thymostimulin and thyroxine on lipid peroxidation and antioxidant enzyme activity in experimental hypothyrosis]. / Vplyv tymostymulinu i tyroksynu na peroksydne okyslennia lipidiv ta aktyvnist' antyoksydantnykh fermentiv za eksperymental'noho hipotyreozu u tvaryn.

In the livers and spleens of pseudoectomized, thymectomized, thymthyroidectomized mice and thyroidectomized rats there is clear regularity in the change of lipid peroxidation intensity antioxidant system and enzymes activity depending on the severity and duration of pathologic changes occurred in organism and biological significance of the removed endocrine glands in maintenance of homeostasis. Thymostimulin and thyroxin do not render a direct effect on the intensity of lipid peroxidation, but their injection to the thyroidectomized rats indirectly normalizes content of peroxidant products in tissues of liver and spleen and restores disordered metabolism processes as a result of thyroid gland ectomia.