Outcomes of hip fracture in centenarians: a systematic review and meta-analysis.

PURPOSE: Outcomes of hip fractures in centenarians remain underreported owing to the small number of patients reaching 100 years of age. This review aimed to determine outcomes of hip fracture in centenarians and to identify the most common comorbidities among centenarians with hip fracture to better characterise this population. METHODS: Published and unpublished literature databases, conference proceedings and the reference lists of included studies were searched to the 25th of January 2023. A random-effects meta-analysis was performed. Included studies were appraised using tools respective of study design. RESULTS: Twenty-three studies (6970 centenarians) were included (retrospective period: 1990-2020). The evidence was largely moderate to low in quality. One-year mortality following a hip fracture was 53.8% (95% CI 47.2 to 60.3%). Pooled complication rate following a hip fracture in centenarians was 50.5% (95% CI 25.3 to 75.6%). Dementia (26.2%, 95% CI 15.7 to 38.2%), hypertension (15.6%, 95% CI 3.4 to 33.1%), and diabetes (5.5%, 95% CI 1.9 to 10.7%) were the most common comorbidities among centenarians with hip fracture. CONCLUSION: Hip fractures in centenarians typically involve complex patient presentations with diverse comorbidities. However, the current evidence-base is moderate to low in quality. Effective cross-discipline communication and intervention is suggested to promote treatment outcomes.

Predisposing factors for Hoffa's fat pad syndrome: a systematic review.

BACKGROUND: Hoffa's fat pad syndrome has been defined as impingement of Hoffa's fat pad, leading to oedema and fibrosis. The primary aim of this systematic review was to identify morphological differences in Hoffa's fat pad between patients with and without Hoffa's fat pad syndrome, evaluating them as risk factors predisposing to its development. The secondary aim was to summarize and evaluate current evidence pertaining to the management of Hoffa's fat pad syndrome. MATERIALS AND METHODS: The protocol for this review was prospectively registered (PROSPERO registration: CRD42022357036). Electronic databases, currently registered studies, conference proceedings and the reference lists of included studies were searched. All studies evaluating differences in Hoffa's fat pad anatomy under imaging between patients with and without Hoffa's fat pad syndrome were included, as well as those exploring epidemiological factors predisposing to its development (ethnicity, employment status, sex, age and BMI), and studies reporting on the effect of treatment on Hoffa's fat pad morphology. RESULTS: A total of 3871 records were screened. Twenty one articles satisfied the inclusion criteria, evaluating 3603 knees of 3518 patients. Patella alta, increased tibial tubercle-tibial groove distance, and increased trochlear angle were found to predispose the development of Hoffa's fat pad syndrome. Trochlear inclination, sulcus angle, patient age and BMI were not associated with this condition. The link between Hoffa's fat pad syndrome and ethnicity, employment, patellar alignment, Hoffa's fat pad composition, physical activity and other pathological processes cannot be established due to lack of evidence. No studies reporting on treatment for Hoffa's fat pad syndrome were identified. Though weight loss and gene therapy may provide symptomatic relief, further research is required to corroborate these claims. CONCLUSION: Current evidence suggests that high patellar height, TT-TG distance, and trochlear angle predispose the development of Hoffa's fat pad syndrome. In addition, trochlear inclination, sulcus angle, patient age and BMI do not seem to be associated with this condition. Further research should explore the link between Hoffa's fat pad syndrome and sport as well as other conditions pertaining to the knee. In addition, further study evaluating treatment approaches for Hoffa's fat pad syndrome is required.

Variations in the origin of the infrapyloric artery: A systematic review and meta-analysis.

BACKGROUND: The infrapyloric artery (IPA) supplies the pylorus and the large curvature of the antrum. Its common origin points include the gastroduodenal artery (GDA) and right gastroepiploic artery (RGEA). The prevalence of variations in IPA origins can be of interest to gastric cancer surgeons who wish to increase their understanding of this vessel. The primary aim of this study was to perform a systematic review and meta-analysis on the origin of the IPA. The secondary aims were to assess imaging identification accuracy, to identify IPA morphological features, and to explore the relationship of IPA origin and clinicopathological characteristics. METHODS: Electronic databases, currently registered studies, conference proceedings and the reference lists of included studies were searched through March 2023. There were no constraints based on language, publication status, or patient demographics. Database search, data extraction and risk of bias assessment were performed independently by two reviewers. The point of origin of the IPA was the primary outcome. Secondary outcomes were imaging identification accuracy, relationship between IPA origin and clinicopathological characteristics, and IPA morphological features. A random-effects meta-analysis of the prevalence of different IPA origins was conducted. Secondary outcomes were narratively synthesized given the heterogeneity of studies reporting on these. RESULTS: A total of 7279 records were screened in the initial search. Seven studies were included in the meta-analysis, assessing 998 patients. The IPA arose most frequently from the anterior superior pancreaticoduodenal artery (ASPDA), with a pooled prevalence of 40.4% (95% CI 17.1-55.8%), followed by the RGEA with a pooled prevalence of 27.6% (95% CI 8.7-43.7%), and the GDA with a pooled prevalence of 23.7% (95% CI 6.4-39.7%). Cases of multiple IPAs had a pooled prevalence of 4.9% (95% CI 0-14.3%). The IPA was absent in 2.6% (95% CI 0-10.3%) of cases and arose from the posterior superior pancreaticoduodenal artery (PSPDA) in the remaining 0.8% (95% CI 0 - 6.1%). Distance between the pylorus and the proximal branch of the IPA and distance from the pylorus to the first gastric branch of the RGEA when the IPA originated from the ASPDA and RGEA were longer than when the IPA originated from the GDA. The IPA is a small vessel (<1 mm), and its origin is not related to clinicopathological characteristics including patient sex, age, and tumor stage and location. CONCLUSIONS: Surgeons must be aware of the most common origin points of the IPA. Recommendations for future study include the stratification of IPA origin according to demographic characteristics, and further investigation into IPA morphological parameters such as tortuosity, course and relation to adjacent lymph nodes, aiding the creation of a standardized classification system pertaining to the anatomy of this vessel.