RESUMEN
67 patients were included in two different protocols with cisplatin and 5-fluorouracil as induction chemotherapy. Group A (30 patients), received cisplatin in bolus and 5-FU in continuous infusion for 120 hours, and Group B (37 patients), were treated with cisplatin and 5-FU both in continuous infusion for 96 hours. All patients received surgery and/or radiotherapy after chemotherapy. Overall response in Group A was 73% with 27% Complete Clinic Response (CCR), and in Group B 81% with 40.5% (CCR). Overall survival at 24 months was 58% and 63%, respectively.
Asunto(s)
Carcinoma de Células Escamosas/tratamiento farmacológico , Cisplatino/administración & dosificación , Fluorouracilo/administración & dosificación , Neoplasias de Cabeza y Cuello/tratamiento farmacológico , Protocolos de Quimioterapia Combinada Antineoplásica , Esquema de Medicación , Humanos , Infusiones ParenteralesRESUMEN
We have studied 37 patients with advanced head and neck cancer. A combination of Cis-Platinum and 5-Fluorouracil, both administered four days continuously as infusion, was assessed. There were 15 complete responses (40.5%), 15 partial responses (40.5%) and the number of objective responses was 30 (81.5%). Survival is 79.1% at 22 months and none of the patients in complete responses has relapsed during this period.
Asunto(s)
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Neoplasias de Cabeza y Cuello/tratamiento farmacológico , Adulto , Anciano , Protocolos de Quimioterapia Combinada Antineoplásica/efectos adversos , Cisplatino/administración & dosificación , Cisplatino/efectos adversos , Terapia Combinada , Fluorouracilo/administración & dosificación , Fluorouracilo/efectos adversos , Estudios de Seguimiento , Neoplasias de Cabeza y Cuello/patología , Humanos , Persona de Mediana Edad , Estadificación de Neoplasias , Estudios Prospectivos , Inducción de RemisiónRESUMEN
A combination of cisplatin and 5-fluorouracil, both administered 4 days continuously as infusion, was assessed in advanced head and neck cancer. Of the 37 patients studied, there were 15 complete and 17 partial responses (40.5% and 45.9%, respectively). Survival is 79.1% at 22 months. None of the patients in complete response has relapsed. In general toxic effects were moderate. Given as initial treatment, the regimen is effective and of considerable use in this type of patient.