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2.
Int J Exerc Sci ; 16(2): 1025-1037, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37650034

RESUMEN

Ischemic preconditioning (IPC) has been an excellent strategy for enhancing sports performance recovery, although there is still no consensus on the ideal protocol. Thus, this study aimed to evaluate the effects of IPC with different cuff pressures (low pressure, medium pressure, and high pressure) on the attenuation of neuromuscular fatigue after an isometric test protocol. And to verify whether this improvement was related to muscle oxygen saturation during the test protocol. Thirty males (18-35 years old) with experience in resistance training were allocated to three different groups: low pressure (20 mmHg), medium pressure (100 mmHg), and high pressure (190 mmHg). The individual occlusion pressure of each participant was identified using ultrasound. Each participant performed two test protocols (8 maximal isometric contractions lasting 20-s with a 10-s rest interval) in an extension chair; after the first test protocol, the participant received the IPC intervention with a low, medium, or high cuff pressure or received the noncuff intervention (randomized order). Only the medium-pressure group showed a smaller decrease in mean force change compared to the no-cuff condition (-4.40% vs. -13.10%, p=0.01, respectively), and the low- and high-pressure groups did not exhibit significant pressure differences (IPC vs. noncuff: -8.40% vs. -13.10%, p=0.11 and -9.10% vs. -14.70%, p=0.12, respectively). Muscle oxygen saturation across test protocols showed no significant differences in all IPC conditions (p>0.05). Although, IPC with medium pressure was effective at optimizing the recovery of neuromuscular performance, this improvement is not related to an increase in muscle oxygen saturation during exercise.

3.
Int J Exerc Sci ; 16(4): 217-229, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37113512

RESUMEN

We investigated whether acute ischemic preconditioning (IPC) would affect upper limb maximal strength performance in resistance-trained men. Using a counterbalanced randomized crossover design, fifteen men (29.9 ± 5.9 yrs.; 86.3 ± 9.6 kg; 8.0 ± 5.0 yrs. resistance training experience) performed one-repetition maximum (1-RM) bench press tests on three different occasions: control, 10 min post-IPC or 10 min post-placebo (SHAM). One-way analysis of variance showed that the post-IPC condition increased (P < 0.0001) 1-RM loads compared to both control and post-SHAM (control 113.3 ± 15.9 kg vs. SHAM 113.9 ± 15.8 kg vs. IPC 115.7 ± 15.6 kg), while control and SHAM did not differ (P > 0.05). Individual results showed that 13 participants (~87%) improved their performance post-IPC compared to control, and 11 participants (~73%) performed better post-IPC compared to post-SHAM. Reported session rating of perceived exertion (RPE) was lower (P < 0.0001) post-IPC (8.5 ± 0.6 arb.u) compared to control (9.3 ± 0.5 arb.u) and post-SHAM (9.3 ± 0.5 arb.u). Therefore, we conclude that IPC acutely improves upper limb maximal strength performance and reduces session-RPE in resistance-trained men. These results suggest an acute ergogenic effect of IPC for strength and power sports such as powerlifting.

4.
Transl Sports Med ; 2023: 9507977, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-38654909

RESUMEN

Trained individuals may require variations in training stimuli and advanced resistance training paradigms (ADV) to increase skeletal muscle hypertrophy. However, no meta-analysis has examined how ADV versus traditional (TRAD) approaches may differentially affect hypertrophic outcomes in trained populations. The aim of this review was to determine whether the skeletal muscle hypertrophy responses induced by TRAD differed from ADV in resistance-trained individuals. Furthermore, we sought to examine potential effects of dietary factors, participants' training status, and training loads. We searched for peer-reviewed, randomized controlled trials (published in English) conducted in healthy resistance-trained adults performing a period of TRAD and ADV with pre-to-post measurement(s) of muscle hypertrophy in PubMed, Web of Science, SPORTDiscus, and MEDLINE databases up to October 2022. A formal meta-analysis was conducted in Revman5, and risk of bias was assessed by ROB2. Ten studies met the inclusion criteria. Results indicated no difference between ADV and TRAD for muscle thickness (SMD = 0.05, 95% CI: -0.20 0.29, p = 0.70), lean mass (SMD = -0.01, 95% CI: -0.26 0.23, p = 0.92), muscle cross-sectional area (SMD = -0.07, 95% CI: -0.36 0.22, p = 0.64), or all measurements analyzed together (SMD = -0.00, 95% CI: -0.15 0.14, p = 0.95). No heterogeneity or inconsistencies were observed; however, unclear risk of bias was present in most of the studies. Short-term ADV does not induce superior skeletal muscle hypertrophy responses when compared with TRAD in trained individuals. This review was not previously registered.

5.
Plast Reconstr Surg ; 150(5): 970e-978e, 2022 11 01.
Artículo en Inglés | MEDLINE | ID: mdl-35994334

RESUMEN

BACKGROUND: Breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL) has been diagnosed in more than 1000 patients in more than 30 countries, although only a few cases have been reported in Latin America and the Caribbean to date. As the second-largest global market for breast implants with a predominance of textured-surface implants, Brazil is a major global market for cosmetic augmentations, making it unlikely that cases of BIA-ALCL are actually scarce. METHODS: A local and voluntary registry of patients with BIA-ALCL was initiated in 2018. All patients diagnosed with BIA-ALCL were confirmed by the World Health Organization criteria. Implant characteristics, disease symptoms, treatment, and oncologic outcomes were assessed. RESULTS: Fourteen cases of BIA-ALCL in a Brazilian population were identified in the Paraná state. Disease-specific diagnostic tests were omitted before surgical intervention in 50 percent of patients. With additional cases from a literature review, the treatment and outcomes of 29 cases of BIA-ALCL in Brazil were assessed. CONCLUSIONS: Compared with other populations, these initial observations suggest that awareness of the disease by the local breast surgery community remains low and that a number of cases may remain undiagnosed. Lack of preoperative diagnostic testing compromises disease treatment, oncologic outcomes, and both short- and long-term surveillance.


Asunto(s)
Implantación de Mama , Implantes de Mama , Neoplasias de la Mama , Linfoma Anaplásico de Células Grandes , Humanos , Femenino , Implantes de Mama/efectos adversos , Linfoma Anaplásico de Células Grandes/diagnóstico , Linfoma Anaplásico de Células Grandes/epidemiología , Linfoma Anaplásico de Células Grandes/etiología , Brasil/epidemiología , Implantación de Mama/efectos adversos , Mastectomía , Neoplasias de la Mama/epidemiología , Neoplasias de la Mama/etiología , Neoplasias de la Mama/cirugía
6.
Vet Radiol Ultrasound ; 63(4): E7-E10, 2022 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-35452146

RESUMEN

A 7-year-old male neutered, 6.5 kg, Maltese breed dog was referred with a history of dysuria after undergoing two cystotomies to remove calcium oxalate uroliths. Survey radiographs were inconclusive. Excretory urography allowed visualization of two filling defects in the cranioventral urinary bladder region. Ultrasonography showed urinary bladder sediments, a diffusely thickened wall, and two circumscribed intramural/intraluminal structures with an anechoic interior and a smooth and regular surface. The cystoscopic diagnosis was urinary bladder abscesses and urine cultures were positive for Escherichia coli. Antimicrobial/anti-inflammatory therapy was started with good clinical outcomes and negative culture after 21 days.


Asunto(s)
Enfermedades de los Perros , Vejiga Urinaria , Absceso/diagnóstico por imagen , Absceso/cirugía , Absceso/veterinaria , Animales , Enfermedades de los Perros/diagnóstico por imagen , Enfermedades de los Perros/cirugía , Perros , Masculino , Ultrasonografía/veterinaria , Vejiga Urinaria/diagnóstico por imagen , Urografía/veterinaria
7.
Actas urol. esp ; 46(2): 92-97, mar. 2022. ilus, tab
Artículo en Español | IBECS | ID: ibc-203559

RESUMEN

Introducción La nefrolitotomía percutánea (NLPC) es actualmente el tratamiento de elección para los cálculos renales de gran volumen. El sistema de clasificación de la litiasis de Guy se desarrolló para predecir los resultados del tratamiento. El objetivo de este estudio fue evaluar la relación entre la clasificación de Guy y los resultados en nuestra institución.Materiales y métodos Se evaluaron retrospectivamente las historias clínicas de los pacientes diagnosticados de urolitiasis y tratados mediante NLPC entre enero de 2017 y diciembre de 2018. Los datos analizados incluyeron: edad, sexo, clasificación de Guy según los hallazgos preoperatorios, transfusión, tasa de ausencia de cálculos y requerimiento de procedimientos adicionales. Para la comparación de las proporciones se utilizó la prueba de chi-cuadrado. Se calcularon las odds ratio (OR) con intervalos de confianza (IC) del 95% mediante regresión logística.Resultados Se analizaron 386 pacientes, 53,89% mujeres, con una media de edad de 45,59±15 años. Un total de 112 pacientes (29,04%) fueron clasificados como Guy I, 92 pacientes (23,82%) como Guy II, 94 pacientes (24,34%) como Guy III y 88 pacientes (22,80%) como Guy IV. No hubo diferencias entre los grupos en cuanto a la necesidad de transfusión de sangre. La tasa de ausencia de cálculos fue del 96,43% (n=108) para los pacientes Guy I; 84,78% (n=72) para Guy II; 76,59% (n=72) para Guy III y 50% (n=44) para las categorías Guy IV (p <0,0001). Tomando como referencia el grupo Guy I, las OR para requerir un nuevo tratamiento por cálculos residuales fueron: Guy II 4,85 (IC=0,95 a 24,60, p=0,05) a Guy III 8,25 (IC=1,73 a 39,44, p=0,008) y Guy IV 27 (IC=5,84 a 124,70; p <0,0001).Conclusión Se observó una asociación estadísticamente significativa entre la puntuación de Guy y las tasas de ausencia de cálculos tras la NLPC. La puntuación de Guy fue útil para predecir los resultados de la NLPC en nuestro grupo


Introduction Percutaneous Nephrolithotomy (PCNL) is currently the treatment of choice in large kidney stones. Guýs stone score was developed to predict treatment outcomes. The aim of this study was to evaluate the relationship between Guýs score and outcomes in our institution.Materials and Methods The medical records of patients diagnosed with urolithiasis and treated by PCNL were retrospectively evaluated between January 2017 and December 2018. Analyzed data included: age, sex, Guy's score based on preoperative findings, transfusion, stone-free rate and requirement of auxiliary procedures. Chi-square test was used for the comparison of proportions. Odds ratios (OR) with confidence intervals (CIs) of 95% were calculated by logistic regression.ResultsA total of 386 patients, 53.89% female, mean age of 45.59±15 years were analyzed. Guy's score was as follows: 112 patients (29.04%) were classified as Guy I, 92 patients (23.82%) as Guy II, 94 patients (24.34%) as Guy III, and 88 patients (22.80%) as Guy IV. There were no differences between groups in terms of blood transfusions. Stone-free rate was 96.43% (n=108) for patients Guy I; 84.78% (n=72) for Guy II; 76.59% (n=72) for Guy III and 50% (n=44) for Guy IV categories (p <0.0001). Taking as a reference Guy I group, the OR to require new treatment for residual stones were: Guy II 4.85 (CI=0.95 to 24.60, P=0.05) to Guy III 8.25 (CI=1.73 to 39.44, P=0.008) and Guy IV 27 (CI=5.84 to 124.70; p <0.0001).ConclusionThere was a statistically significant association between Guýs Score and stone-free rates following PCNL. Guy's score was useful to predict results of PCNL in our group (AU)


Asunto(s)
Humanos , Masculino , Femenino , Persona de Mediana Edad , Cálculos Renales/cirugía , Nefrolitotomía Percutánea , Urolitiasis , Resultado del Tratamiento , Estudios Retrospectivos
8.
Actas Urol Esp (Engl Ed) ; 46(2): 92-97, 2022 Mar.
Artículo en Inglés, Español | MEDLINE | ID: mdl-35125338

RESUMEN

INTRODUCTION: Percutaneous Nephrolithotomy (PCNL) is currently the treatment of choice in large kidney stones. Guy's stone score was developed to predict treatment outcomes. The aim of this study was to evaluate the relationship between Guy's score and outcomes in our institution. MATERIALS AND METHODS: The medical records of patients diagnosed with urolithiasis and treated by PCNL were retrospectively evaluated between January 2017 and December 2018. Analyzed data included: age, sex, Guy's score based on preoperative findings, transfusion, stone-free rate and requirement of auxiliary procedures. Chi-square test was used for the comparison of proportions. Odds ratios (OR) with confidence intervals (CIs) of 95% were calculated by logistic regression. RESULTS: A total of 386 patients, 53.89% female, mean age of 45.59 ±â€¯15 years were analyzed. Guy's score was as follows: 112 patients (29.04%) were classified as Guy I, 92 patients (23.82%) as Guy II, 94 patients (24.34%) as Guy III, and 88 patients (22.80%) as Guy IV. There were no differences between groups in terms of blood transfusions. Stone-free rate was 96.43% (n = 108) for patients Guy I; 84.78% (n = 72) for Guy II; 76.59% (n = 72) for Guy III and 50% (n = 44) for Guy IV categories (p < 0.0001). Taking as a reference Guy I group, the OR to require new treatment for residual stones were: Guy II 4.85 (CI = 0.95 to 24.60, P = 0.05) to Guy III 8.25 (CI = 1.73 to 39.44, P = 0.008) and Guy IV 27 (CI = 5.84 to 124.70; p < 0.0001). CONCLUSION: There was a statistically significant association between Guy's Score and stone-free rates following PCNL. Guy's score was useful to predict results of PCNL in our group.


Asunto(s)
Cálculos Renales , Nefrolitotomía Percutánea , Urolitiasis , Adulto , Femenino , Humanos , Cálculos Renales/cirugía , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Resultado del Tratamiento
9.
Vet Med Int ; 2021: 5515559, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-34721833

RESUMEN

Laparoscopic procedures require the creation of pneumoperitoneum. CO2, which must be cold and dry, is the standard gas used in such surgeries. The type of gas used, its temperature, and moisture may change the peritoneal surface and cause systemic and local oxidative stress. Our objective is to evaluate the influence of pneumoperitoneum heating on the occurrence of histological lesions in the peritoneum, inflammation, plasma oxidative stress, and on the mesothelial surface in patients undergoing video-assisted ovariohysterectomy. Twenty canine females were included and distributed evenly into two groups: heated CO2 (HG) and unheated CO2 (UHG). The biomarkers of inflammation and oxidative stress were evaluated before insufflation (T0), at 30 min (T1), and at 60 min (T2) of exposure to CO2. Biopsies of the peritoneal tissue for histological evaluation were performed at T0 and T2. Regarding plasma parameters, acetylcholinesterase (AChE) showed a greater activity in the HG at T1 (p=0.0268) and T2 (p=0.0423); in turn, butyrylcholinesterase (BChE) showed a greater activity at T2 in the HG (p=0.0175) compared with T0. Catalase activity (CAT) was different between HG times; it was higher at T1 (p=0.0253). There was a decrease in the levels of substances reactive to thiobarbituric acid (TBARS) (p=0.0117) and in glutathione (GSH) (p=0.0114) between T0 and T2 in the UHG. Regarding tissue oxidative stress, the CAT in the HG showed a greater activity at T2 than T1 (p=0.0150). By comparing the groups at each time, there was a difference only at T2 (p=0.0288), being greater in the HG. Regarding the activity of superoxide dismutase (SOD) in the HG, there was a difference between T2 in relation to T0 and T1 (p=0.0181); finally, there was an increase only at T1 (p=0.0287) in the UHG when comparing groups at the same time. There were no differences in the histological parameters evaluated. Our study demonstrates that the heating of CO2 generates a greater inflammatory response and forms reactive oxygen species (ROS) at the plasma and peritoneal levels.

13.
Rev. bras. ciênc. mov ; 29(1): [1-8], jan.-mar. 2021. tab
Artículo en Portugués | LILACS | ID: biblio-1348350

RESUMEN

O objetivo do estudo foi realizar um breve comunicado sobre a adoção da densidade com uma nova métrica de quantificação de cargas no treinamento de força. Descrevemos como quantificá-la e destacamos as possíveis implicações da sua manipulação. Uma vez que considera o intervalo de recuperação entre as séries - onde podem ocorrer processos metabólicos importantes, como a ressíntese de fosfocreatina - a densidade pode ser um parâmetro representativo da magnitude do estresse metabólico induzido pelas sessões. Recomendamos que treinadores e pesquisadores da área de ciências do esporte passem a reportar quantificar e reportar a densidade dos treinos. Técnicas de treinamento que manipulam as pausas entre as séries, repetições e exercícios, como os treinos em circuito, o restpause, cluster training, intra-set rest e/ou inter-repetion rest, podem ter novas análises e, consequentemente, resultados interessantes a serem reportados.(AU)


The aim of the study was to provide a short communication about the adoption of density as a new metric to quantify strength training loads. We describe how quantify and highlighted the possible implications of density manipulation. Since considers the rest interval between sets - where important metabolic process such as phosphocreatine resynthesizes may occurs ­ density may represent the magnitude of metabolic stress induced by training session. In this sense, is recommended that sports sciences coach's and researchers report the training density. Training techniques that manipulate the rest intervals between sets, repetitions, and exercises, such as circuit tra ining, rest pause, cluster training, intra-set rest, and/or inter-repetition rest may have new analysis, and consequently interesting results to be reported.(AU)


Asunto(s)
Humanos , Masculino , Femenino , Adulto , Fosfocreatina/metabolismo , Estrés Fisiológico , Entrenamiento de Fuerza/métodos , Crecimiento del Músculo Esquelético
14.
Vet Med Int ; 2021: 8857231, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33575024

RESUMEN

Helicobacter pylori is a spiral-shaped bacterium, which plays a role in the aetiology of gastric diseases in humans. Non-H. pylori Helicobacter (NHPH) species naturally colonise the stomach of animals and also induce gastric lesions in humans, highlighting their zoonotic importance. We evaluated the gastric bacterial colonisation density and gastric lesions and sought to identify the main phylogenetic groups of the Helicobacter spp. obtained from dogs in the central region of Rio Grande do Sul, Brazil, with this study aiming to investigate the occurrence of Helicobacter spp. in saliva and gastric samples from these dogs. This study included 35 dogs and used analysis such as cytology, histopathology, PCR, rapid urease testing, and phylogenetic analysis. Of the dogs, 94.3% were positive for Helicobacter spp., and these bacteria were present in the stomach of 32 dogs and saliva of eight. Respectively, eight, 15, and nine dogs had mild, moderate, and severe colonisation. Lymphocytic-plasmacytic infiltrate was the main gastric lesion. However, the presence of Helicobacter and the density appeared to be unrelated to the gastric lesions. The samples possessed a high nucleotide identity with remarkably similar sequences among some of the species of NHPH such as H. heilmannii s.s., H. salomonis, H. felis, and H. bizzozeronii. The saliva of domestic dogs, even of those who appear clinically healthy, can cause Helicobacter infection in humans and other animals, with, in these dogs, increased density, occurrence rate, and predominance of NHPH of zoonotic importance being found in the stomach with a lower occurrence of Helicobacter spp. in the saliva.

15.
Front Sports Act Living ; 3: 803366, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-35098121

RESUMEN

This conceptual review investigates whether functional training (FT) is a different approach from traditional strength, power, flexibility, and endurance (aerobic or cardiorespiratory) training already adopted in the physical training plan of professional, recreational athletes, healthy, and older adults. The 20 most recent papers published involving FT were searched in the PubMed/Medline database. Definition, concepts, benefits, and the exercises employed in FT programs were analyzed. The main results were: (a) there is no agreement about a universal definition for FT; (b) FT programs aim at developing the same benefits already induced by traditional training programs; (c) exercises employed are also the same. The inability to define FT makes the differentiation from traditional training programs difficult. Physical training programs can be easily described and classified as strength, power, flexibility, endurance, and the specific exercises employed (e.g., traditional resistance training, ballistic exercises, plyometrics and Olympic-style weightlifting, continuous and high-intensity interval training). This apt description and classification may provide consistent and clear communication between students, coaches, athletes, and sports scientists. Based on the current evidence and to avoid confusion and misconceptions, we recommend that the terms FT, high-intensity FT, and functional fitness training no longer describe any physical training program.

16.
Int J Exerc Sci ; 13(1): 723-733, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32509108

RESUMEN

The assessment of neuromuscular fatigue is important for minimizing the risks of nonfunctional overreaching, and monitoring training loads has rapidly grown in recent years. The objective of the study was to compare the acute upper body performance and rating of perceived exertion (RPE) responses to high-volume (HV) and high-intensity (HI) resistance-training loads. Sixteen young resistance-trained men (4 repetition maximum [RM] bench press = 105.8 ± 15.9 kg) were divided into two groups of eight subjects each that performed a HI (3 sets of 4RM with 180 s of rest), and a HV (4 sets of 12RM with 90 s of rest) training sessions. Session RPE was obtained 30 min Post. The medicine-ball throw (MBT) performance was measured at pre, and 10 min post. Training volume load (movements × load), and intensity (volume load ÷ movements) were calculated. Volume load was significantly higher for HV (10890 ± 1241 kg) than HI (2718 ± 413 kg) protocol (p < 0.001). Intensity was significantly higher for HI (100.7 ± 15.3 kg) than HV (75.6 ± 8.6 kg) protocol (p = 0.002). MBT performance was significantly reduced from pre- to post- HV (p < 0.001; Δ = -11%), but not in HI (p = 0.15; Δ = -5%). RPE was significantly higher Post-HI (9.9 ± 0.4) than Post HV (8.9 ± 0.8) (p = 0.01). We conclude that higher volume loads induce greater upper body neuromuscular fatigue in young resistance-trained men. Session RPE may reflect training intensity, but not the performance impairments.

17.
Phys Rev E ; 101(5-1): 052138, 2020 May.
Artículo en Inglés | MEDLINE | ID: mdl-32575275

RESUMEN

We study the Ising model on the square lattice (Z^{2}) and show, via numerical simulation, that allowing interactions between spins separated by distances 1 and m (two ranges), the critical temperature, T_{c}(m), converges monotonically to the critical temperature of the Ising model on Z^{4} as m→∞. Only interactions between spins located in directions parallel to each coordinate axis are considered. We also simulated the model with interactions between spins at distances of 1, m, and u (three ranges), with u a multiple of m; in this case our results indicate that T_{c}(m,u) converges to the critical temperature of the model on Z^{6}. For percolation, analogous results were proven for the critical probability p_{c} [B. N. B. de Lima, R. P. Sanchis, and R. W. C. Silva, Stochast. Process. Appl. 121, 2043 (2011)STOPB70304-414910.1016/j.spa.2011.05.009].

18.
Artículo en Inglés | WPRIM (Pacífico Occidental) | ID: wpr-997638

RESUMEN

@#The COVID-19 pandemic has given rise to medical and non-medical issues. One of the subtler, but equally important issues are the ethical ones. Most prominent among these is the ethical dilemma of health care professionals faced with the decision of whether or not they should continue working and serving the country despite the risks. This paper intends to analyze the said bioethical dilemma by first, examining the ethical conundrum and defining its parameters; second, by assessing a previous attempt to arbitrate this issue and in the process, evaluating two different theories in ethics: egoism and Christian ethics; and third, by proposing a more nuanced normative ethical framework to fully understand the moral picture. In the end, the bioethical dilemma of healthcare professionals cannot be completely analyzed using the lens of egoism and Christian ethics as previously asserted by another scholar. A fuller understanding can be reached by using an Aristotelian normative framework as an anchor for analysis. All healthcare professionals want the good. While a dilemma may ensue because of conflict of values (e.g. for work and for safety), Aristotelian ethics subscribes to the need for hitting the mean between two extremes by honing one's practical wisdom and deliberation. Healthcare professionals exercise this faculty in confronting their dilemma.


Asunto(s)
Bioética , COVID-19 , Filipinas , Personal de Salud
19.
J Neural Transm (Vienna) ; 126(12): 1599-1608, 2019 12.
Artículo en Inglés | MEDLINE | ID: mdl-31673927

RESUMEN

C-reactive protein (CRP) is a biomarker of systemic inflammation that has been linked to accelerated decline in walking speed in older adults. The aim of the present study was to compare the CRP levels of PD patients with vs patients without freezing of gait (FOG). Patients and controls participating in the COPPADIS-2015 study that performed blood extraction for determining molecular serum biomarkers were included. Patients with FOG were identified as those with a score of 1 or greater on item-3 of the Freezing of Gait Questionnaire (FOG-Q). Immunoassay was used for determining ultrasensitive CRP (US-CRP) level (mg/dL). In the PD group (n = 225; 61.8 ± 9.5 years old, 61.8% males), 32% of the patients presented FOG but none in the control group (n = 65; 60.3 ± 6.1 years old, 56.9% males) (p < 0.0001). Differences in US-CRP level were significant in patients with FOG vs patients without FOG and vs controls (0.31 ± 0.52 vs 0.16 ± 0.21 vs 0.21 ± 0.22; p = 0.04). Significant differences were also observed between patients with vs without FOG (p = 0.001) but not between patients and controls (p = 0.163). US-CRP level was related to FOG (OR = 4.369; 95% CI 1.105-17.275; p = 0.036) along with H&Y (OR = 2.974; 95% CI 1.113-7.943; p = 0.030) and non-motor symptoms burden (NMSS total score; OR = 1.017; 95% CI 1.005-1.029; p = 0.006) after adjusting for age, gender, disease duration, equivalent daily levodopa dose, number of non-antiparkinsonian drugs per day, motor fluctuations, cognition, motor phenotype, and chronic use of anti-inflammatory drugs. The present study suggests that serum US-CRP level is related to FOG in PD patients. Inflammation could be linked to FOG development.


Asunto(s)
Biomarcadores/sangre , Proteína C-Reactiva/análisis , Trastornos Neurológicos de la Marcha/sangre , Enfermedad de Parkinson/sangre , Anciano , Femenino , Trastornos Neurológicos de la Marcha/etiología , Humanos , Masculino , Persona de Mediana Edad , Enfermedad de Parkinson/complicaciones
20.
J Hum Kinet ; 70: 115-124, 2019 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-31915481

RESUMEN

The objective of the study was to characterize immunological responses to a Brazilian Jiu-Jitsu high-intensity interval training session. Neuromuscular function, blood, and salivary samples were obtained after a Brazilian Jiu-Jitsu high-intensity interval training session. Saliva and blood samples were collected at Pre- (before the warm-up) and immediately Post-training. Neuromuscular function was evaluated by lower body muscle testing. The horizontal countermovement jump was performed at Pre (after the warm-up) and immediately Post blood and saliva collection, and approximately 5 minutes Post-training. The horizontal countermovement jump performance did not present any significant changes Post-training, while blood leukocytes, urea, IgA and salivary alpha-amylase showed a significant increase. Salivary alpha-amylase activity increased more than six times immediately Post compared to Pre-training. Saliva volume, secretion rate, and uric acid were not significantly different between Pre and Post condition. A Brazilian Jiu-Jitsu high-intensity interval training session elicited an increase in the blood cells responsible for antibody production and muscle damage adaptation after exercise. On the other hand, neuromuscular performance was not significantly affected Post-training, suggesting that immunological and performance responses were not necessarily associated.

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