RESUMEN
C5-sufficient Swiss-Webster mice (C5+) and C5-deficient DBA/2J mice (C5-) when challenged endotracheally with 2 x 10(7) cfu of Branhamella catarrhalis rapidly clear the lungs of viable bacteria in 48 h. This rapid clearance correlates with a striking influx of polymorphonuclear neutrophils that is of equal magnitude in both C5+ and C5- animals. Supernatant from Todd-Hewitt broth culture of B. catarrhalis exhibits in vivo chemotactic activity in the murine lung and in vitro chemotactic activity in Boyden chambers. The ability of B. catarrhalis to recruit granulocytes, independent of complement, may suggest a role for this organism in promoting protease-mediated lung destruction.
Asunto(s)
Infecciones Bacterianas/inmunología , Complemento C5/inmunología , Pulmón/inmunología , Moraxella catarrhalis/inmunología , Neutrófilos/inmunología , Animales , Líquido del Lavado Bronquioalveolar/inmunología , Líquido del Lavado Bronquioalveolar/microbiología , Quimiotaxis , Complemento C5/deficiencia , Pulmón/microbiología , Masculino , Ratones , Ratones Endogámicos DBARESUMEN
We present a case of a patient with penile squamous carcinoma and unilateral inguinal nodal involvement. Histological sections of the inguinal tumor demonstrated a basaloid (small-cell) squamous carcinoma of the type that arises from modified skin or mucosa. Multiple cutaneous lesions subsequently developed in the ipsilateral lower extremity. Biopsies revealed tumor that had the same histologic appearance as the nodal metastasis but that also showed a smooth and continuous connection with the overlying epidermis. We discuss the significance of this finding and review the pertinent literature.
