RESUMEN
The role of Newcastle disease virus and neoadjuvant therapy was assessed in 84 cases of breast cancer T1-4N0-2M0 (2005-2008). Combined use of the virus vaccine and chemotherapy (group A), therapy with the vaccine alone (group B) and chemotherapy regimen identical with that used in group A (group C) were compared. Histological pattern of tumor and stage were identified using expression of receptors of steroid hormones, oncoproteins Her2/neu and p53 as well as proliferation activity (marker Ki-67) before and after therapy. It was shown that the efficiency and safety of Newcastle disease virus (apathogenic strain La-Sotha) met specific immuno- and neoadjuvant therapy standards.
Asunto(s)
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Biomarcadores de Tumor/sangre , Neoplasias de la Mama/terapia , Vacunas contra el Cáncer/uso terapéutico , Terapia Neoadyuvante/métodos , Virus de la Enfermedad de Newcastle , Adulto , Anciano , Neoplasias de la Mama/sangre , Neoplasias de la Mama/tratamiento farmacológico , Neoplasias de la Mama/patología , Neoplasias de la Mama/cirugía , Femenino , Regulación Neoplásica de la Expresión Génica , Humanos , Antígeno Ki-67/sangre , Persona de Mediana Edad , Estadificación de Neoplasias , Receptor ErbB-2/sangre , Receptores de Estrógenos/sangre , Receptores de Progesterona/sangre , Resultado del Tratamiento , Proteína p53 Supresora de Tumor/sangreRESUMEN
Histological and immunohistochemical characteristics of principal types of skin pseudolymphomas, their differential diagnosis with true skin lymphomas are outlined.
Asunto(s)
Seudolinfoma/patología , Neoplasias Cutáneas/patología , Antígenos de Neoplasias/análisis , Diagnóstico Diferencial , Humanos , Inmunohistoquímica , Seudolinfoma/inmunología , Neoplasias Cutáneas/inmunologíaRESUMEN
The data on 25 cases of histologically verified bronchioloalveolar carcinoma and papillary adenocarcinoma are discussed. Reliable differential diagnostic cytological features of both diseases were established using a statistical, program and fine-needle biopsy findings. Statistical analysis data pointed to the sets of cytological features: "serial pattern--clear cell boundaries" and "serial pattern--presence of macrovacuoles" as a major factor of accuracy of bronchiolo-alveolar carcinoma and papillary adenocarcinoma diagnosis. These cytological features may be used for reliable diagnosis of the diseases.
Asunto(s)
Adenocarcinoma Papilar/diagnóstico , Neoplasias de los Bronquios/diagnóstico , Carcinoma/diagnóstico , Alveolos Pulmonares , Diagnóstico Diferencial , HumanosRESUMEN
Pagetoid reticulosis is a rare form of T-cell skin lymphoma. A case of this disease is reported.
Asunto(s)
Enfermedades Linfáticas , Linfoma de Células T , Neoplasias Cutáneas , Humanos , Enfermedades Linfáticas/patología , Enfermedades Linfáticas/radioterapia , Linfoma de Células T/patología , Linfoma de Células T/radioterapia , Masculino , Persona de Mediana Edad , Neoplasias Cutáneas/patología , Neoplasias Cutáneas/radioterapiaRESUMEN
A case of a rare malignant tumour of the sweat glands is reported. Such tumors are often taken for visceral adenocarcinoma metastasis. The tumor was diagnosed by means of immunohistochemistry.
Asunto(s)
Adenocarcinoma Mucinoso/patología , Glándulas Ecrinas/patología , Neoplasias de las Glándulas Sudoríparas/patología , Anciano , Humanos , MasculinoRESUMEN
A case of malignant eccrine cylindroma of the skin studied immunohistochemically is reported.
Asunto(s)
Carcinoma Adenoide Quístico/patología , Neoplasias Cutáneas/patología , Carcinoma Adenoide Quístico/cirugía , Humanos , Masculino , Persona de Mediana Edad , Invasividad Neoplásica , Neoplasias Cutáneas/cirugíaRESUMEN
Cytological differential diagnostic features of bronchiolo-alveolar carcinoma and papillary adenocarcinoma are established basing on the material of needle biopsies by means of Statistica program. It is found that the strongest influence on the cytological diagnosis of these two tumors is associated with the following pairs of cytological features: lane--clear-cut cell borders and lane--the presence of macrovacuoles.
Asunto(s)
Adenocarcinoma Bronquioloalveolar/patología , Adenocarcinoma Papilar/patología , Neoplasias Pulmonares/patología , Biopsia con Aguja , Diagnóstico Diferencial , Femenino , Humanos , MasculinoRESUMEN
One case of a rare vascular tumor which occurs mainly in the childhood is presented. The tumor has a tendency to recurrence and metastases into the regional lymph nodes in spite of a relatively mature structure.
Asunto(s)
Hemangioendotelioma/patología , Neoplasias Cutáneas/patología , Hemangioendotelioma/irrigación sanguínea , Hemangioendotelioma/cirugía , Humanos , Lactante , Masculino , Neoplasias Cutáneas/irrigación sanguínea , Neoplasias Cutáneas/cirugíaRESUMEN
This review concerns the development and progression of one of the forms of peripheral lung cancer--bronchiolo-alveolar carcinoma (BAC). The study is based on the comparison of roentgenological, histological, immunohistochemical examinations and results of surgical treatment of 482 patients with this tumor. Morphological and clinical variants of BAC are defined. It is confirmed that their biological behavior may vary within the forms and differ from common adenocarcinoma. A close correlation exists between clinicoroentgenological picture and histological form of BAC.
Asunto(s)
Adenocarcinoma Bronquioloalveolar , Neoplasias Pulmonares , Adenocarcinoma Bronquioloalveolar/diagnóstico por imagen , Adenocarcinoma Bronquioloalveolar/patología , Adenocarcinoma Bronquioloalveolar/fisiopatología , Adulto , Anciano , Femenino , Humanos , Neoplasias Pulmonares/diagnóstico por imagen , Neoplasias Pulmonares/patología , Neoplasias Pulmonares/fisiopatología , Masculino , Persona de Mediana Edad , RadiografíaRESUMEN
Clinicomorphological analysis was performed in 12 cases of atypical adenomatous hyperplasia of the lung (AAH). This is the proliferative lesion consisting of atypical epithelial cells along the alveolar septa which are found incidentally during pathologic examination of the lung resected because of cancer. We studied morphological and biological characteristics of AAH cells including cytodifferentiation, proliferative activity, tumor-suppressor genes. Our review of the studies of AAH revealed that AAH is alveolar intraepithelial dysplasia and a precursor of lung adenocarcinoma. AAH is an important lesion corresponding to a step in carcinogenesis for peripheral lung adenocarcinomas.
Asunto(s)
Adenocarcinoma/patología , Neoplasias Pulmonares/patología , Adenomatosis Pulmonar/patología , Humanos , Hiperplasia , Lesiones Precancerosas/patologíaRESUMEN
A case of chronic granulomatosis is reported. Its clinical manifestations were affection of the urinary tract with pseudotumors of the urinary bladder and ureteral obstruction. Recommendations for treatment of similar diseases are presented.
Asunto(s)
Enfermedad Granulomatosa Crónica/diagnóstico , Neoplasias de la Vejiga Urinaria/diagnóstico , Enfermedad Crónica , Diagnóstico Diferencial , Errores Diagnósticos , Femenino , Humanos , Obstrucción Ureteral/diagnósticoRESUMEN
Benign epithelial tumor of the skin--eccrine spiradenoma--is characterized in detail clinically and morphologically.
Asunto(s)
Adenoma de las Glándulas Sudoríparas/patología , Neoplasias de las Glándulas Sudoríparas/patología , Adenoma de las Glándulas Sudoríparas/cirugía , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Masculino , Persona de Mediana Edad , Neoplasias de las Glándulas Sudoríparas/cirugíaRESUMEN
4 cases of melanoma of the respiratory tract (trachea and bronchi) are analysed clinico-morphologically. A case of melanoma with a primary multiple location (trachea and the main bronchus), rapid recurrence after surgery and radiation therapy is described in detail. Melanocytic nature of the tumor is proved immunohistochemically.
Asunto(s)
Melanoma , Neoplasias del Sistema Respiratorio , Adulto , Humanos , Masculino , Melanoma/patología , Melanoma/fisiopatología , Melanoma/terapia , Neoplasias del Sistema Respiratorio/patología , Neoplasias del Sistema Respiratorio/fisiopatología , Neoplasias del Sistema Respiratorio/terapiaRESUMEN
Detailed review of literature and analysis of 4 authors's cases of the trachea non-Hodgkin lymphoma and lymphogranulomatosis are presented.
Asunto(s)
Enfermedad de Hodgkin/patología , Linfoma no Hodgkin/patología , Neoplasias de la Tráquea/patología , Adulto , Neoplasias de los Bronquios/patología , Neoplasias de los Bronquios/terapia , Terapia Combinada , Diagnóstico Diferencial , Resultado Fatal , Femenino , Enfermedad de Hodgkin/terapia , Humanos , Neoplasias Laríngeas/patología , Neoplasias Laríngeas/terapia , Linfoma de Células B de la Zona Marginal/patología , Linfoma de Células B de la Zona Marginal/terapia , Linfoma no Hodgkin/terapia , Masculino , Persona de Mediana Edad , Inducción de Remisión , Tráquea/patología , Neoplasias de la Tráquea/terapiaRESUMEN
Results of combined treatment of 113 patients with colon carcinoma receiving a single irradiation (7.5 Gy) before the operation were analysed. The single irradiation was well tolerated by all the patients without complications during the operation and in the postoperative period. It is found at the ultrastructural level that from 70 to 85% of the cells in the tumors removed were irreversibly damaged.
Asunto(s)
Cuidados Preoperatorios/métodos , Neoplasias del Recto/ultraestructura , Terapia Combinada , Relación Dosis-Respuesta en la Radiación , Humanos , Microcirculación/fisiología , Microscopía Electrónica , Tolerancia a Radiación , Neoplasias del Recto/radioterapia , Neoplasias del Recto/cirugíaRESUMEN
A case of skin tumor-cystic epithelioma is reported. Differential-diagnostic features of its distinction from squamous-cell carcinoma are given.
Asunto(s)
Carcinoma de Células Escamosas/diagnóstico , Quiste Epidérmico , Neoplasias Glandulares y Epiteliales , Neoplasias Cutáneas , Carcinoma de Células Escamosas/patología , Diagnóstico Diferencial , Quiste Epidérmico/patología , Quiste Epidérmico/fisiopatología , Femenino , Humanos , Persona de Mediana Edad , Neoplasias Glandulares y Epiteliales/diagnóstico , Neoplasias Glandulares y Epiteliales/patología , Neoplasias Glandulares y Epiteliales/fisiopatología , Neoplasias Cutáneas/diagnóstico , Neoplasias Cutáneas/patología , Neoplasias Cutáneas/fisiopatologíaRESUMEN
Morphology of the thymus in autoimmune and some other conditions with an accidental thymus involution is studied. Metaplasia and dysplasia of epithelial cells which should be regarded as precancer condition were found in 7-10% of cases in the parenchyma in the presence of atrophic changes.
Asunto(s)
Enfermedades Autoinmunes/patología , Lesiones Precancerosas/patología , Timo/patología , Atrofia , Biopsia , Epitelio/patología , Humanos , MetaplasiaRESUMEN
Detailed cytological, histological and electron microscopic characteristics of pulmonary carcinoid tumors are listed on the basis of surgical clinic material. Various variants of the carcinoid tumors structure, their differential diagnosis are presented.