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ACS Appl Bio Mater ; 7(5): 3033-3040, 2024 05 20.
Artículo en Inglés | MEDLINE | ID: mdl-38587908

RESUMEN

Regenerative medicine based on cell therapy has emerged as a promising approach for the treatment of various medical conditions. However, the success of cell therapy heavily relies on the development of suitable injectable hydrogels that can encapsulate cells and provide a conducive environment for their survival, proliferation, and tissue regeneration. Herein, we address the medical need for cyto- and biocompatible injectable hydrogels by reporting on the synthesis of a hydrogel-forming thermosensitive copolymer. The copolymer was synthesized by grafting poly(N-isopropylacrylamide-co-carboxymethyl acrylate) (PNIPAM-COOH) onto chitosan through amide coupling. This chemical modification resulted in the formation of hydrogels that exhibit a sol-gel transition with an onset at approximately 27 °C, making them ideal for use in injectable applications. The hydrogels supported the survival and proliferation of cells for several days, which is critical for cell encapsulation. Furthermore, the study evaluates the addition of collagen/chitosan hybrid microspheres to support the adhesion of mesenchymal stem cells within the hydrogels. Altogether, these results demonstrate the potential of the PNIPAM-chitosan thermogel for cell encapsulation and its possible applications in regenerative medicine.


Asunto(s)
Resinas Acrílicas , Materiales Biocompatibles , Quitosano , Hidrogeles , Ensayo de Materiales , Células Madre Mesenquimatosas , Microesferas , Quitosano/química , Resinas Acrílicas/química , Resinas Acrílicas/síntesis química , Hidrogeles/química , Hidrogeles/síntesis química , Hidrogeles/farmacología , Células Madre Mesenquimatosas/citología , Materiales Biocompatibles/química , Materiales Biocompatibles/farmacología , Materiales Biocompatibles/síntesis química , Tamaño de la Partícula , Supervivencia Celular/efectos de los fármacos , Proliferación Celular/efectos de los fármacos , Humanos
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