MultifacetedProtDB: a database of human proteins with multiple functions.

MultifacetedProtDB is a database of multifunctional human proteins deriving information from other databases, including UniProt, GeneCards, Human Protein Atlas (HPA), Human Phenotype Ontology (HPO) and MONDO. It collects under the label 'multifaceted' multitasking proteins addressed in literature as pleiotropic, multidomain, promiscuous (in relation to enzymes catalysing multiple substrates) and moonlighting (with two or more molecular functions), and difficult to be retrieved with a direct search in existing non-specific databases. The study of multifunctional proteins is an expanding research area aiming to elucidate the complexities of biological processes, particularly in humans, where multifunctional proteins play roles in various processes, including signal transduction, metabolism, gene regulation and cellular communication, and are often involved in disease insurgence and progression. The webserver allows searching by gene, protein and any associated structural and functional information, like available structures from PDB, structural models and interactors, using multiple filters. Protein entries are supplemented with comprehensive annotations including EC number, GO terms (biological pathways, molecular functions, and cellular components), pathways from Reactome, subcellular localization from UniProt, tissue and cell type expression from HPA, and associated diseases following MONDO, Orphanet and OMIM classification. MultiFacetedProtDB is freely available as a web server at: https://multifacetedprotdb.biocomp.unibo.it/.

Gathering Travel Needs and Preferences to Customize Truly Inclusive Experiences. The Case Study of the Interreg E-Chain Project.

Accessibility is a central element of any responsible and sustainable tourism policy: it is both a human rights imperative, and an exceptional business opportunity, as mentioned by UNWTO Secretary-General Taleb Rifai. Accessible tourism for all is not only about providing access to people with disabilities, but also addresses the creation of universally designed environments that can support people that may have temporary disabilities, families with young children, the ever-increasing ageing population, as well as creating a safer environment for employees at work. It must also be considered that accessible tourism benefits everyone: as more individuals enjoy the opportunity to travel, the tourism industry gets more visitors, longer seasons and new incomes. This contribution presents the approach taken within the Italy-Croatia Interreg Project "E-Chain - Enhanced Connectivity and Harmonization of data for the Adriatic Intermodal Network", focused on the provision of useful and personalized information for the traveling user.