RESUMEN
282 (564 eyes) premature infants born at mean 27 +/- 2,5 weeks of gestation with birth weight 914+/- 247g were enrolled in the study. Comparative study showed preventive treatment with histochrome in infants with risk of retinopathy of prematurity (RP) to decrease the incidence of RP compared to infants treated with emoxipine and no antioxidant therapy. Incidence of RP in infants preventively treated with combination antioxidant agents (dicynon and emoxipine) was significantly lower compared to the group without preventive antioxidant treatment. Use of histochrome in treatment of RP via periocular injections and forced instillations promoted more favorable outcome of the disease.
Asunto(s)
Antioxidantes/administración & dosificación , Recien Nacido Prematuro , Retinopatía de la Prematuridad/prevención & control , Relación Dosis-Respuesta a Droga , Estudios de Seguimiento , Edad Gestacional , Humanos , Incidencia , Recién Nacido , Instilación de Medicamentos , Soluciones Oftálmicas/administración & dosificación , Retinopatía de la Prematuridad/epidemiología , Estudios Retrospectivos , Federación de Rusia/epidemiología , Resultado del TratamientoRESUMEN
The objective of the study was to evaluate the efficacy of the Russian drug Histochrome in the treatment of 554 children at different ages who had intraocular hemorrhages of various degrees and sites in relation to the route and time of its administration. Histochrome therapy was shown to reduce the time of resorption of hyphemas and hemophthalmos by two times and retinal hemorrhages to 2 weeks. There was a positive effect in increasing visual acuity by 0.2 or more in 70.3% of cases.
Asunto(s)
Antioxidantes/uso terapéutico , Hemorragia del Ojo/tratamiento farmacológico , Naftoquinonas/uso terapéutico , Adolescente , Niño , Preescolar , Hemorragia del Ojo/etiología , Femenino , Humanos , Masculino , Heridas y Lesiones/complicacionesRESUMEN
Analysis of intraocular fluid and the vitreous body in 7 rabbits (14 eyes) by high performance liquid chromatography reveals histochrom metabolic products and, possibly, histrochrom itself during intravenous and subconjunctival injections and retrobulbar administration of histochrom through the irrigation system on models of experimental rabbit hyphema and hemophthalmia, which suggests that histochrom is able to penetrate across the blood-ocular barrier.