Synthesis and biological evaluation of imidazoline derivatives as potential CNS and CVS agents.

A series of substituted imidazoline derivatives were synthesized and characterized. Compounds were tested in-vivo for their antihypertensive, analgesic, antiaggressive, depressant, antidepressant, and ALD50 activities. The compounds 3a, 3c, 4c, 5a, and 6c showed cardiovascular as well as central nervous system activities and are potential candidate as drug among all fifteen compounds tested. All these compounds have shown better activity for antihypertensive, analgesic, antiaggressive, and depressant-antidepressant, properties than reference compounds clonidine, morphine, diazepam, and imipramine respectively. Most of the compounds have shown ALD50 > 500 mg/kg with maximum in 4a and 5a (>1000 mg/kg).

Oral Health Status and Treatment Needs of Police Personnel in Mathura City.

BACKGROUND: All men are born equal and are endowed by their creator with some basic rights. As the military is to defend the country from external threats, so is the police for maintenance of the internal peace of the community. The irregular shifts in their work schedule lead to neglecting or skipping of their regular diet and indulging into adverse habits. It is the responsibility of the society to safeguard the health of their defenders. MATERIALS AND METHODS: A cross-sectional study was carried out on 475 central reserve police personnels in Mathura city. Consent was obtained from the concerned authorities and the subjects were clinically examined using WHO 2013 "Oral Health Assessment Form." RESULTS: This study revealed that 99.6% subjects were males, 62% subjects were of 21-35 years age group, mean dentition status was found to be 0.66 ± 2.08 and, most of the subjects needed prompt treatment including scaling. CONCLUSION: Police personnels provide a unique opportunity to study a large population from diverse geographic backgrounds. Prevention oriented health education lectures should be delivered and possibly, should also form part of their training curriculum.

Mutans streptococci estimation in saliva before and after consumption of probiotic curd among school children.

BACKGROUND: According to the World Health Organization, probiotics are live microorganisms which when administered in adequate amounts and confer a health benefit to the host. Use of probiotics in children to improve oral health may lead to non-pathogenic bacteria replacing cariogenic bacteria. Dairy foods like cheese, curd, and milk are considered useful vehicles for probiotic bacteria. AIM: To compare the levels of salivary mutans streptococci before and after consumption of probiotic curd. MATERIALS AND METHODS: Thirty school children of Mathura city who were caries free, in the age group of 12-14 years, were selected and divided equally into group I and II which were given 200 ml probiotic curd and normal curd for 7 days, respectively. Assessment of saliva samples was done at baseline, 1 h after consumption, and on the 7(th) day. Mitis Salivarius Bacitracin Agar was used for analysis. The number of colonies was counted and subjected to statistical analysis using unpaired Student's t-test. RESULTS: The study showed mark reduction in salivary mutans streptococci counts in saliva after 1 h and on the 7(th) day in the probiotic group. Results were found to be statistically significant (P ≤ 0.05) when the differences in the reduction of mutans streptococci counts with probiotic curd and normal curd at 1 h and on the 7(th) day were compared. CONCLUSION: Pathogenic microorganisms could be displaced by probiotic bacteria. Thus, use of probiotic products could be exploited for the prevention of enamel demineralization.