RESUMEN
This review will focus on a systems medicine approach to neonatal abstinence syndrome (NAS). Systems medicine utilizes information gained from the application of "omics" technology and bioinformatics (1). The omic approaches we will emphasize include genomics, epigenomics, proteomics, and metabolomics. The goals of systems medicine are to provide clinically relevant and objective insights into disease diagnosis, prognosis, and stratification as well as pharmacological strategies and evidence-based individualized clinical guidance. Despite the increasing incidence of NAS and its societal and economic costs, there has been only a very modest emphasis on utilizing a systems medicine approach, and this has been primarily in the areas of genomics and epigenomics. As detailed below, proteomics and metabolomics hold great promise in advancing our knowledge of NAS and its treatment. Metabolomics, in particular, can provide a quantitative assessment of the exposome, which is a comprehensive picture of both internal and external environmental factors affecting health.
Asunto(s)
Genómica/métodos , Metabolómica/métodos , Síndrome de Abstinencia Neonatal/genética , Síndrome de Abstinencia Neonatal/metabolismo , Proteómica/métodos , Análisis de Sistemas , Biología Computacional/métodos , Epigenómica/métodos , Perfilación de la Expresión Génica/métodos , Humanos , Recién Nacido , Síndrome de Abstinencia Neonatal/diagnósticoRESUMEN
Vitreous hemorrhages are uncommon in the neonatal period. This article describes a neonatal who had bilateral vitreous hemorrhages after intrauterine bowel infarction.
Asunto(s)
Procedimientos Quirúrgicos del Sistema Digestivo/métodos , Coagulación Intravascular Diseminada , Enfermedades Fetales , Infarto , Vólvulo Intestinal , Intestinos/irrigación sanguínea , Hemorragia Vítrea , Anastomosis Quirúrgica/métodos , Coagulación Intravascular Diseminada/sangre , Coagulación Intravascular Diseminada/diagnóstico , Coagulación Intravascular Diseminada/terapia , Nutrición Enteral/métodos , Femenino , Enfermedades Fetales/diagnóstico , Enfermedades Fetales/fisiopatología , Enfermedades Fetales/cirugía , Humanos , Recién Nacido , Recién Nacido Pequeño para la Edad Gestacional , Infarto/diagnóstico , Infarto/fisiopatología , Infarto/cirugía , Vólvulo Intestinal/diagnóstico , Vólvulo Intestinal/fisiopatología , Vólvulo Intestinal/cirugía , Manejo de Atención al Paciente/métodos , Resultado del Tratamiento , Hemorragia Vítrea/diagnóstico , Hemorragia Vítrea/etiología , Hemorragia Vítrea/fisiopatologíaAsunto(s)
Infarto de la Arteria Cerebral Media , Convulsiones , Femenino , Humanos , Recién Nacido , Infarto de la Arteria Cerebral Media/complicaciones , Infarto de la Arteria Cerebral Media/diagnóstico , Infarto de la Arteria Cerebral Media/fisiopatología , Imagen por Resonancia Magnética , Convulsiones/etiología , Convulsiones/fisiopatologíaRESUMEN
Little is known about the effect of inhalation of methanol and other solvents on the pregnancy and the growth of the fetus. We report a preterm male infant who developed cerebral infarcts in utero, leading to large areas of bilateral frontal cortical leukomalacia following chronic maternal inhalation of carburetor-cleaning fluid during pregnancy. The infant presented with acute fetal distress with significant metabolic acidosis at birth. Initial hypotonia was followed by generalized hypertonicity. This infant did not exhibit typical facial features of fetal alcohol syndrome.
Asunto(s)
Infarto Cerebral/inducido químicamente , Enfermedades Fetales/inducido químicamente , Enfermedades del Prematuro/inducido químicamente , Leucomalacia Periventricular/inducido químicamente , Efectos Tardíos de la Exposición Prenatal , Solventes/efectos adversos , Trastornos Relacionados con Sustancias/complicaciones , Acetona/efectos adversos , Acidosis/inducido químicamente , Combinación de Medicamentos , Femenino , Humanos , Recién Nacido , Recien Nacido Prematuro , Leucomalacia Periventricular/diagnóstico por imagen , Masculino , Metanol/efectos adversos , Embarazo , Tolueno/efectos adversos , UltrasonografíaRESUMEN
We are reporting an unusual case of cat-scratch disease in a young adolescent girl presenting with recurrent ascites. The illness started with nonspecific symptoms followed by ascites and an axillary lymph node enlargement. She had recurrent ascites for 18 months associated with constrictive pericarditis. Following pericardiectomy, she had a resolution of ascites and was back to her normal life. This is a first documented report of a constrictive pericarditis following cat scratch diseases in English literature.