Efficient Security and Authentication for Edge-Based Internet of Medical Things.

Internet of Medical Things (IoMT)-driven smart health and emotional care is revolutionizing the healthcare industry by embracing several technologies related to multimodal physiological data collection, communication, intelligent automation, and efficient manufacturing. The authentication and secure exchange of electronic health records (EHRs), comprising of patient data collected using wearable sensors and laboratory investigations, is of paramount importance. In this article, we present a novel high payload and reversible EHR embedding framework to secure the patient information successfully and authenticate the received content. The proposed approach is based on novel left data mapping (LDM), pixel repetition method (PRM), RC4 encryption, and checksum computation. The input image of size [Formula: see text] is upscaled by using PRM that guarantees reversibility with lesser computational complexity. The binary secret data are encrypted using the RC4 encryption algorithm and then the encrypted data are grouped into 3-bit chunks and converted into decimal equivalents. Before embedding, these decimal digits are encoded by LDM. To embed the shifted data, the cover image is divided into [Formula: see text] blocks and then in each block, two digits are embedded into the counter diagonal pixels. For tamper detection and localization, a checksum digit computed from the block is embedded into one of the main diagonal pixels. A fragile logo is embedded into the cover images in addition to EHR to facilitate early tamper detection. The average peak signal to noise ratio (PSNR) of the stego-images obtained is 41.95 dB for a very high embedding capacity of 2.25 bits per pixel. Furthermore, the embedding time is less than 0.2 s. Experimental results reveal that our approach outperforms many state-of-the-art techniques in terms of payload, imperceptibility, computational complexity, and capability to detect and localize tamper. All the attributes affirm that the proposed scheme is a potential candidate for providing better security and authentication solutions for IoMT-based smart health.

Hiding clinical information in medical images: A new high capacity and reversible data hiding technique.

A new high capacity and reversible data hiding scheme for e-healthcare applications has been presented in this paper. Pixel to Block (PTB) conversion technique has been used as an effective and computationally efficient alternative to interpolation for the cover image generation to ensure reversibility of medical images. A fragile watermark and Block Checksum (computed for each 4×4 block) have been embedded in the cover image for facilitating tamper detection and tamper localization, and hence content authentication at receiver. The EPR, watermark data and checksum data has been embedded using Intermediate Significant Bit Substitution (ISBS) to avoid commonly used LSB removal/replacement attack. Non-linear dynamics of chaos have been put to use for encrypting the Electronic Patient Record (EPR)/clinical data and watermark data for improving the security of data embedded. The scheme has been evaluated for perceptual imperceptibility and tamper detection capability by subjecting it to various image processing and geometric attacks. Experimental results reveal that the proposed system besides being completely reversible is capable of providing high quality watermarked images for fairly high payload. Further, it has been observed that the proposed technique is able to detect and localise the tamper. A comparison of the observed results with that of some state-of-art schemes show that our scheme performs better.

Comparison of the efficacy of cardamom (Elettaria cardamomum) with pioglitazone on dexamethasone-induced hepatic steatosis, dyslipidemia, and hyperglycemia in albino rats.

To evaluate the efficacy of cardamom with pioglitazone on dexamethasone-induced hepatic steatosis, dyslipidemia, and hyperglycemia in albino rats. There were four groups of 6 rats each. First group received dexamethasone alone in a dose of 8 mg/kg intraperitoneally for 6 days to induce metabolic changes and considered as dexamethasone control. Second group received cardamom suspension 1 g/kg/10 mL of 2% gum acacia orally 6 days before dexamethasone and 6 days during dexamethasone administration. Third group received pioglitazone 45 mg/kg orally 6 days before dexamethasone and 6 days during dexamethasone administration. Fourth group did not receive any medication and was considered as normal control. Fasting blood sugar, lipid profile, blood sugar 2 h after glucose load, liver weight, liver volume were recorded, and histopathological analysis was done. The effects of cardamom were compared with that of pioglitazone. Dexamethasone caused hepatomegaly, dyslipidemia and hyperglycemia. Both pioglitazone and cardamom significantly reduced hepatomegaly, dyslipidemia, and hyperglycemia (P < 0.01). Reduction of blood sugar levels after glucose load was significant with pioglitazone in comparison to cardamom (P < 0.01). Cardamom has comparable efficacy to pioglitazone in preventing dexamethasone-induced hepatomegaly, dyslipidemia, and fasting hyperglycemia.

5-Flourouracil cardiotoxicity - an elusive cardiopathy: case report.

5-Flourouracil (5-FU) is an S-phase specific, synthetic pyrimidine antimetabolite. It is a frequently administered chemotherapeutic agent for a variety of malignant lesions, either singly or in multidrug regimens. Its adverse side effects involving bone marrow, skin, mucous membranes, GIT and CNS are well known, whereas its cardiotoxicity is relatively uncommon and occurs in 1.2-18%.

Early gastrointestinal complications of stem cell transplant - results of prospective study at IRCH, AIIMS, India.

BACKGROUND: The study was conducted with the purpose of finding clinical profile of early gastrointestinal complications of stem cell transplant at this center. METHODS: 70 consecutive subjects, who were subject to bone marrow transplant from October 2002 to September 2004, were prospectively studied. The gastrointestinal complications were followed in first 100 days of transplant and recorded in a pre-determined format. RESULTS: Study population comprised of 23 allo-transplant (with 3-non-myelablative procedures) and 47 auto-transplant subjects. Gastrointestinal complications included: nausea and vomiting in 19 (82.60%), mucositis- 20 (86.95%), diarrhea- 15 (65.21%), veno-occlusive disease (VOD) - 3 (13.04%) and acute pancreatitis- 1 (4.34%) in allo-transplant group. Nausea and vomiting occurred 36 (76.59%), mucositis- 46 (97.88%) diarrhea- 39 (82.98%), VOD- 5 (10.64%) in auto- transplant subjects. Acute graft versus host disease (AGVHD) involved gut in 3 and liver in 1 case of allo-BMT-group.

A survey of risk factors in carcinoma esophagus in the valley of Kashmir, Northern India.

BACKGROUND/OBJECTIVE: Esophageal cancer has a peculiar geographical distribution and shows marked differences in incidence within a particular geographical region. Presently, as there seems little prospect of early detection of this cancer, an understanding of the etiological factors may suggest opportunities for its primary prevention. In this paper, we have tried to determine the role of diet and other life-style related factors in the etiology of cancer of esophagus. MATERIAL AND METHODS: A total of 100 confirmed squamous cell carcinoma of esophagus patients were enrolled for the study (Group A). 100 healthy subjects were included as controls (Group B). A predesigned questionnaire dealing with the basic patient data, dietary and smoking habits etc. was distributed among the cases in both groups. The data was thoroughly analyzed to define an association with the development of cancer of esophagus. RESULTS: Group A patients included 71 males and 29 females in the age range of 40-70 years. Majority 37% were farmers, 29% house wives. Of the 72% smokers, 66% smoked hookah. 29% had positive family history. More than 90% took salt-tea at breakfast. Meat consumption was low, 44% took it weekly and 42% on monthly basis. 69% took fish yearly. Group B included 75 males and 25 females of which 35.7% were hookah smokers. CONCLUSION: Poor socio-economic status resulting in fewer intakes of fresh fruits, vegetables and fish in addition to heavy hookah smoking are suspected to be the major risk factors for the development of esophageal cancer.

Early infections in the stem cell transplant recipients at AIIMS, New Delhi: a prospective study.

UNLABELLED: The pattern of infections in neutropenic patients including those undergoing stem cell transplant in the west has changed but the same may not be the case in the developing countries as brought out through some earlier observations in some transplant centers in India. The department of medical oncology IRCH, AIIMS has been providing bone marrow transplant facility for over a decade now. It is one of the few bone marrow transplant units in northern India. A prospective study conducted on 70 consecutive bone marrow transplant subjects at this center was carried out with this perspective in view. OBJECTIVES: To determine the frequency and pattern of infections in haemopoietic stem cell transplant (HSCT) recipients at this center in India.

Recurrent malignant Leydig cell tumor of testis: a case report with review of literature.

Malignant Testicular Leydig Cell tumors (leydigomas) are extremely rare to occur and mostly carry a bad prognosis. Here we describe the disease course of a middle aged patient with recurrent / metastatic Leydig cell tumor of testes, who needed repeated oncosurgical intervention and chemotherapy.

Giant cell carcinoma of the lung.

A 50-year-old non-smoking, hypertensive female, presenting with superior vena caval compression, was found to have giant cell carcinoma of the lung. She received intensive combination chemotherapy. However she died in the following 36 hours, as a consequence of refractory hypotension.

A double-blind randomized cross-over comparison of high-dose prochlorperazine with high-dose metoclopramide for cisplatin-induced emesis.

This double-blind randomized cross-over study was conducted to compare the safety and efficacy of high-dose prochlorperazine infusion and dexamethasone (HDPD) with an effective and safe combination of high-dose metoclopramide and dexamethasone (HDMD) in controlling cisplatin-induced emesis. None of the patients entering the study had received any prior chemotherapy. High-dose cisplatin was administered on an inpatient basis. Twenty eligible patients were analyzed based on the assessment made 24 h after the chemotherapy. The parameters compared were severity and duration of nausea and vomiting, severity of retching and side effects. Significantly less vomiting and retching episodes were recorded with HDPD combination. The severity of nausea was also less with this combination. There was no significant difference in the incidence of side effects.