1.
Bioorg Med Chem Lett
; 9(5): 765-70, 1999 Mar 08.
Artículo
en Inglés
| MEDLINE
| ID: mdl-10201844
RESUMEN
A novel series of derivatives of oxo-7H-benzo[e]perimidine-4-carboxylic acid (I) potently displaced radioligand binding of 125I-CRF to both CRF1 and CRF2 receptors. The members of this series antagonized CRF-stimulated cAMP formation and CRF-stimulated corticotropin release from rat pituitary in vivo. These are the first nonpeptide antagonists to show activity at both CRF1 and CRF2 receptors.