RESUMEN
This corrects the article DOI: 10.1038/ncomms15805.
RESUMEN
Reduced cardiac vagal control reflected in low heart rate variability (HRV) is associated with greater risks for cardiac morbidity and mortality. In two-stage meta-analyses of genome-wide association studies for three HRV traits in up to 53,174 individuals of European ancestry, we detect 17 genome-wide significant SNPs in eight loci. HRV SNPs tag non-synonymous SNPs (in NDUFA11 and KIAA1755), expression quantitative trait loci (eQTLs) (influencing GNG11, RGS6 and NEO1), or are located in genes preferentially expressed in the sinoatrial node (GNG11, RGS6 and HCN4). Genetic risk scores account for 0.9 to 2.6% of the HRV variance. Significant genetic correlation is found for HRV with heart rate (-0.74Asunto(s)
Cardiopatías/genética
, Frecuencia Cardíaca
, Presión Sanguínea
, Estudios de Cohortes
, Predisposición Genética a la Enfermedad
, Estudio de Asociación del Genoma Completo
, Cardiopatías/fisiopatología
, Humanos
, Canales Regulados por Nucleótidos Cíclicos Activados por Hiperpolarización/genética
, Proteínas Musculares/genética
, Polimorfismo de Nucleótido Simple
, Canales de Potasio/genética
, Sitios de Carácter Cuantitativo
, Proteínas RGS/genética
, Factores de Riesgo
, Población Blanca/genética
