Bacterial profile and extended spectrum beta lactamase screening of urinary tract infection among asymptomatic and symptomatic pregnant women attending antenatal care in ALERT Hospital, Addis Ababa, Ethiopia.

Introduction: The occurrence of extended spectrum beta lactamase-producing uropathogens, especially in pregnant women can result in life-threatening condition and morbidity for both the mother and the newborn due to very limited drug options for treatment of these pathogens. The aim of this study was to determine the bacterial profile, associated factors, and their antimicrobial susceptibility patterns and to identify extended spectrum beta lactamase-producing bacterial uropathogens. Methods: A hospital-based cross-sectional study was conducted from July to September 2018 on a total of 177 pregnant women with and without symptoms of urinary tract infection at ALERT Hospital, Addis Ababa, Ethiopia. From these study participants, 72 have symptoms, whereas 105 have no symptoms. All urine samples were inoculated onto cysteine lactose electrolyte deficient medium and MacConkey agar. Colonies were counted to check the presence of significant bacteriuria. Pure isolates of bacterial pathogen were characterized and identified at species level by colony morphology, gram stain, and standard biochemical procedures. All Gram-negative isolates were put into Muller-Hinton agar plates for antibiotic susceptibility test by Kirby-Bauer disc diffusion technique. Extended spectrum beta lactamase was detected using double-disk synergy methods on Muller-Hinton agar. The data were double entered into epidemiological Information system and analyzed using Statistical Package for Social Science version 26. Results: The overall proportion of urinary tract infection among pregnant women was 14.7% (n = 26/177). Klebsiella pneumoniae was the predominant bacterial etiologic agent of urinary tract infection 26.9% (n = 7/26). The proportion of extended spectrum beta lactamase among Gram-negative isolates was 50% (n = 6/12). Among extended spectrum beta lactamase-producing isolates (100%), all are resistance to amikacin and gentamicin while intermediate level resistance rate of 66.7% was observed among trimethoprim-sulphamethoxazole. They were susceptible for some limited drugs, and these were Nitrofurantoin (83.3%) and Chloramphenicol (83.3%). Conclusions: Majority of extended spectrum beta lactamase-producing isolates exhibited co-resistance to other commonly prescribed antibiotics. This indicates that the option of treatment for these pathogens rapidly decreased from time to time which results serious life-threatening conditions, especially in mother and newborn unless the appropriate measure is taken.

Burden of lower respiratory infections and associated risk factors across regions in Ethiopia: a subnational analysis of the Global Burden of Diseases 2019 study.

OBJECTIVE: This analysis is to present the burden and trends of morbidity and mortality due to lower respiratory infections (LRIs), their contributing risk factors, and the disparity across administrative regions and cities from 1990 to 2019. DESIGN: This analysis used Global Burden of Disease 2019 framework to estimate morbidity and mortality outcomes of LRI and its contributing risk factors. The Global Burden of Disease study uses all available data sources and Cause of Death Ensemble model to estimate deaths from LRI and a meta-regression disease modelling technique to estimate LRI non-fatal outcomes with 95% uncertainty intervals (UI). STUDY SETTING: The study includes nine region states and two chartered cities of Ethiopia. OUTCOME MEASURES: We calculated incidence, death and years of life lost (YLLs) due to LRIs and contributing risk factors using all accessible data sources. We calculated 95% UIs for the point estimates. RESULTS: In 2019, LRIs incidence, death and YLLs among all age groups were 8313.7 (95% UI 7757.6-8918), 59.4 (95% UI 49.8-71.4) and 2404.5 (95% UI 2059.4-2833.3) per 100 000 people, respectively. From 1990, the corresponding decline rates were 39%, 61% and 76%, respectively. Children under the age of 5 years account for 20% of episodes, 42% of mortalities and 70% of the YLL of the total burden of LRIs in 2019. The mortality rate was significantly higher in predominantly pastoralist regions-Benishangul-Gumuz 101.8 (95% UI 84.0-121.7) and Afar 103.7 (95% UI 86.6-122.6). The Somali region showed the least decline in mortality rates. More than three-fourths of under-5 child deaths due to LRIs were attributed to malnutrition. Household air pollution from solid fuel attributed to nearly half of the risk factors for all age mortalities due to LRIs in the country. CONCLUSION: In Ethiopia, LRIs have reduced significantly across the regions over the years (except in elders), however, are still the third-leading cause of mortality, disproportionately affecting children younger than 5 years old and predominantly pastoralist regions. Interventions need to consider leading risk factors, targeted age groups and pastoralist and cross-border communities.

Smoking Intensity and Associated Factors among Male Smokers in Ethiopia: Further Analysis of 2016 Ethiopian Demographic and Health Survey.

BACKGROUND: Smoking invariably has health, social, economic, and environmental consequences in Ethiopia. Reducing and quitting cigarette smoking improves individual health and increases available household funds for food, education, and better economic productivity. Therefore, this study is aimed at assessing cigarette smoking intensity and associated factors among male smokers in Ethiopia. METHODS: The data were extracted from the 2016 national cross-sectional Ethiopian Demographic and Health Survey. Our study used data from the standardized and adapted men's questionnaire. The study included a total of 391 (weighted) smokers who at least smoked one manufactured cigarette per day. The data were collected using a two-stage cluster design which includes selection of enumeration areas and then selection of households. The number of manufactured cigarettes smokers smoked per day was used to measure smoking intensity. Descriptive statistics were used to summarize the study findings. Bivariable and multivariable truncated negative binomial Poisson regression models were employed to determine smoking intensity. RESULTS: The finding showed that on average men smoked weighted nine cigarettes per day. One in every five of the smokers (21.2%) smoked 10 cigarettes per day. Smokers living in rural areas (IRR = 0.43, 95% CI: 0.244, 0.756), currently married (IRR = 0.64, 95% CI: 0.46, 0.91), formerly married (IRR = 0.54, 95% CI: 0.30, 0.96), richer men (IRR = 0.63, 95% CI: 0.43, 0.90), and richest men (IRR = 0.49, 95% CI: 0.28, 0.87) were associated with lower smoking intensity. Smokers in the Somali (IRR = 2.80, 95% CI: 1.29, 6.11), Harari (IRR = 3.46, 95% CI: 1.14, 10.51), and Dire Dawa (IRR = 3.09, 95% CI: 1.23, 7.80) regions; older age (IRR = 1.77, 95% CI: 1.31, 2.40); affiliated with Protestant religion (IRR = 1.81, 95% CI: 1.12, 2.92); poorer men (IRR = 1.64, 95% CI: 1.19, 2.27); watched television (IRR = 1.18, 95% CI: 1.04, 1.35); drunk alcohol (IRR = 1.37, 95% CI: 1.03, 1.82); and completed primary (IRR = 1.15, 95% CI: 1.01, 0.317) and higher education (IRR = 2.96, 95% CI: 1.88, 4.67) were positively associated with smoking intensity. CONCLUSION: Male smokers in Ethiopia smoked intensively with an average of nine manufactured cigarettes per day. Tobacco control interventions should target the following: Eastern Ethiopia regions, older aged, affiliated with Protestant religion, poorer men, watched television, drunk alcohol, and primary and higher educational level.

Practice of Blood Donation and Associated Factors among Adults of Gondar City, Northwest Ethiopia: Bayesian Analysis Approach.

BACKGROUND: Blood transfusion is an essential part of modern health care. In Ethiopia, it had been planned to collect 202,000 units of blood in 2016-2017, but the actual amount collected was 169,744. The Bayesian approach has an advantage in that estimation of model parameters is conducted based on posterior distribution. This study aimed to assess the practice of blood donation and associated factors among adults of Gondar city, northwest Ethiopia using Bayesian analysis. METHODS: A community-based cross-sectional study was conducted among 554 Gondar adults from February to March 2019. Bayesian binary logistic regression was conducted to assess the relationship between independent and dependent variables using Stata 15 with a 95% CI for statistical significance. RESULTS: A total of 515 were involved with a 97% response rate, among which 342 (66.4%) were females. Eighty (15.53%) had donated blood at least once in their lives. Men were more likely to donate blood (AOR 1.79, 95% CI 1.11-3.12), while those aged 18-24 years were 57% (AOR 0.43, 95% CI 0.15-0.89) less likely to give blood. Individuals with good knowledge (AOR 2.56, 95% CI 1.32-4.53) and favorable attitudes (AOR 1.86, 95% CI 1.01-3.06) were more likely to donate blood. CONCLUSION: The majority of the participants did not donate blood. Male sex, age 18-24 years, good knowledge, and favorable attitudes were statistically significant factors in blood donation. Intervention with females and younger age-groups should shall be better administered. Health education is required to increase knowledge and create a favorable attitudes among the community.