Calcium pantothenate is present in cosmetics and may cause allergic contact dermatitis.

Calcium pantothenate (CAS no. 137-08-6) is the calcium salt of pantothenic acid (vitamin B5). It is used in cosmetics due to its anti-static and hair conditioning properties. A 53-year-old female nurse's aide presented with intermittent facial eruptions (Figure S1). Patch tests were positive to calcium pantothenate, an ingredient of two of her products (a cleansing milk and a facial tonic). To our knowledge, no previous cases of sensitization from calcium pantothenate have been reported except for one case of systemic dermatitis from a nutritional supplement in a dexpanthenol-sensitized patient.

Paraffin-embedded micrographic surgery for the treatment of dermatofibrosarcoma protuberans: Analysis of 33 patients.

BACKGROUND: Dermatofibrosarcoma protuberans is a rare malignant tumor with a high rate of recurrence after surgery. Moh's micrographic surgery allows examination of all surgical margins to ensure complete removal. OBJECTIVE: To evaluate the use of Moh's micrographic surgery using paraffin-embedded sections for the treatment of dermatofibrosarcoma protuberans. METHODS: We performed a retrospective analysis of 33 patients with dermatofibrosarcoma protuberans treated in our department with paraffin-embedded micrographic surgery between January 2002 and June 2015. Our cases included patients with primary untreated disease and also those with persistent disease previously treated surgically elsewhere, with histologically positive margins. RESULTS: Tumors were most commonly located on the trunk. After the first stage of micrographic surgery, including an initial lateral margin, 20 (60.6%) tumors were completely excised, 11 (33.3%) tumors required two stages and one tumor each (3.0%) required 4 and 6 stages respectively. Patients were monitored for recurrence for a mean duration of 6.5 years. There was no recurrence in any of our 33 patients. CONCLUSIONS: Our results indicate that Moh's micrographic surgery with paraffin-embedded sections may be the method of choice to treat dermatofibrosarcoma protuberans with a low recurrence rate, while preserving surrounding normal healthy tissue.

Severe splenic rupture after colorectal endoscopic submucosal dissection.

Splenic rupture (SR) after colonoscopy is a very rare but potentially serious complication. Delayed diagnosis is common, and may increase morbidity and mortality associated. There is no clear relation between SR and difficult diagnostic or therapeutic procedures, but it has been suggested that loop formation and excessive torquing might be risk factors. This is a case of a 65-year-old woman who underwent endoscopic submucosal dissection (ESD) for lateral spreading tumor in the descending colon, and 36 h afterwards presented symptoms and signs of severe hypotension due to SR. Standard splenectomy was completed and the patient recovered uneventfully. Colorectal ESD is usually a long and position-demanding technique, implying torquing and loop formation. To our knowledge this is the first case of SR after colorectal ESD reported in the literature. Endoscopists performing colorectal ESD in the left colon must be aware of this potential complication.

[AIDS and ophthalmology: a contemporary view]. / Sida y oftalmología: una visión actual.

The appearance of the Acquired Immune Deficiency Syndrome (AIDS) meant a revolution in medicine, which has also affected Ophthalmology: the routine presence of ophthalmological pathologies which until then had been exceptional, such as retinitis due to cytomegalovirus (CMV), and the appearance of other new pathologies such as progressive outer retinal necrosis (PORN). The generalised use of high activity antiretroviral therapy (HAART) in the second half of the 1990s represented a turning point, since when the immunological improvement of patients with Human Immunodeficiency Virus (HIV) resulted in a fall in the cases with ophthalmological pathology associated to immunodepression (HIV retinopathy, retinitis due to CMV, PORN...), and the spontaneous improvement of symptoms which until then had had a torpid evolution (Kaposi's ocular sarcoma, Palpebral Molluscum...). On the other hand, the continuous increase in the prevalence of syphilis in these patients means an increase in the number of cases of ocular syphilis unassociated with immunodepression. New ophthalmological alterations also appear that are related to HAART: uveitis due to immune recovery in patients with CMV retinitis in complete remission and the enophthalmos due to the atrophy of orbital fat in the context of lipodystrophy, associated with antiretrovirals. At present preventive ophthalmological checks must be carried out on patients with severe immunodepression until a count of lymphocytes above 100 cells/microl is confirmed. If they also show HIV retinopathy, a monthly check up is advisable until immune recovery, given the greater risk of infection by CMV.