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1.
Drug Alcohol Rev ; 42(5): 1028-1040, 2023 07.
Artículo en Inglés | MEDLINE | ID: mdl-36757806

RESUMEN

INTRODUCTION: Harmful drinking is increasing among mid-life adults. Using social practice theory, this research investigated the knowledge, actions, materials, places and temporalities that comprise home drinking practices among middle-class adults (40-65 years) in Aotearoa New Zealand during 2021-2022 and post the COVID-19 pandemic lockdowns. METHODS: Nine friendship groups (N = 45; 26 females, 19 males from various life stages and ethnicities) discussed their drinking practices. A subset of 10 participants (8 female, 2 male) shared digital content (photos, screenshots) about alcohol and drinking over 2 weeks, which they subsequently discussed in an individual interview. Group and interview transcripts were thematically analysed using the digital content to inform the analysis. RESULTS: Three themes were identified around home drinking practices, namely: (i) alcohol objects as everywhere, embedded throughout spaces and places in the home; (ii) drinking practices as habitual, automatic and conditioned to mundane everyday domestic chores, routines and times; and (iii) drinking practices intentionally used by participants to achieve desired embodied states to manage feelings linked to domestic and everyday routines. DISCUSSION AND CONCLUSIONS: Alcohol was normalised and everywhere within the homes of these midlife adults. Alcohol-related objects and products had their own agency, being entangled with domestic routines and activities, affecting drinking in both automatic and intentional ways. Developing alcohol policy that would change its ubiquitous and ordinary status, and the 'automatic' nature of many drinking practices, is needed. This includes restricting marketing and availability to disrupt the acceptability and normalisation of alcohol in the everyday domestic lives of adults at midlife.


Asunto(s)
Alcoholismo , COVID-19 , Humanos , Masculino , Adulto , Femenino , Consumo de Bebidas Alcohólicas/epidemiología , Pandemias , Control de Enfermedades Transmisibles
2.
Br J Soc Psychol ; 62 Suppl 1: 39-55, 2023 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-36401567

RESUMEN

In Aotearoa New Zealand, the precariat is populated by at least one in six New Zealanders, with Maori (Indigenous peoples) being over-represented within this emerging social class. For Maori, this socio-economic positioning reflects a colonial legacy spanning 150 years of economic and cultural subjugation, and intergenerational experiences of material, cultural and psychological insecurities. Relating our Kaupapa Maori approach (Maori cultural values and principles underlining research initiatives) to the precariat, this article also draws insights from existing scholarship on social class in psychology and Assemblage Theory in the social sciences to extend present conceptualizations of the Maori precariat. In keeping with the praxis orientation central to our approach, we consider three exemplars of how our research into Maori precarity is mobilized in efforts to inform public deliberations and government policies regarding poverty reduction, humanizing the welfare system and promoting decent work. Note: Aotearoa New Zealand has been popularized within the everyday lexicon of New Zealanders as a political statement of Indigenous rights for Maori.


Asunto(s)
Formación de Concepto , Pueblo Maorí , Humanos , Nueva Zelanda , Clase Social
3.
Harm Reduct J ; 19(1): 145, 2022 12 22.
Artículo en Inglés | MEDLINE | ID: mdl-36544156

RESUMEN

BACKGROUND: Needle Exchange Programme (NEP) mobile outreach services in Aotearoa New Zealand distribute injecting equipment to people who inject drugs (PWID) living in remote regions. In disasters, continued access to such services is imperative for the health and wellbeing of PWID. Disasters can compound existing inequities, particularly in regions characterised by poor or limited infrastructure, smaller populations, and challenging socioeconomic conditions. To gain insight into the barriers that prevent access to NEP harm-reduction services and understand the needs of PWID prior to and during disasters, this study foregrounds the voices of PWID based on the West Coast of the South Island, Aotearoa New Zealand. METHODS: This qualitative study applied an interpretive phenomenological analysis approach, where 14 PWID and one key NEP staff member took part in semi-structured interviews. The interviews provided the opportunity for participants to share their experiences and perspectives about accessing sterile drug-injecting equipment during disasters, including the four-week COVID-19 Level 4 lockdown in March 2020. In total five superordinate and 14 subordinate themes were identified from the interveiws. RESULTS: This study focuses on four of the key themes that impacted accessibility to NEP services: infrastructural hazards and equipment costs; social capital and practical support from peers and key contact networks; social stigma in public locations, including NEP-based pharmacies and emergency centres; and potential solutions to NEP equipment accessibility as frequently suggested by participants. CONCLUSIONS: Access to NEP services is essential during natural hazard and human-generated disasters, as such NEP mobile outreach services and disaster resilience efforts should focus on maintaining service continuity for PWID during adverse times. This study champions a needs-based, stigma free approach to inclusive harm-reduction and emergency management practices for groups with specific needs in a disaster context.


Asunto(s)
COVID-19 , Abuso de Sustancias por Vía Intravenosa , Humanos , Abuso de Sustancias por Vía Intravenosa/prevención & control , Accesibilidad a los Servicios de Salud , Nueva Zelanda , Control de Enfermedades Transmisibles , Reducción del Daño
4.
J Community Psychol ; 50(4): 1980-1992, 2022 05.
Artículo en Inglés | MEDLINE | ID: mdl-33999450

RESUMEN

Growing homelessness in Aotearoa New Zealand stems primarily from rising inequalities and poverty. Drawing from scholarship on relational ethics, principled practice and Maori cultural concepts, this paper offers our reflections on nearly two decades of collective work to document and address homelessness. Central to the approach outlined are enduring community partnerships, the cultivation of reciprocal relations, and time spent with homeless people and those trying to work with them. We present exemplars for how we draw on everyday interactions with homeless people and agency staff to enhance local service and broader systemic responses to homelessness.


Asunto(s)
Personas con Mala Vivienda , Humanos , Nativos de Hawái y Otras Islas del Pacífico , Pobreza , Participación Social , Problemas Sociales
5.
Diving Hyperb Med ; 50(1): 34-42, 2020 Mar 31.
Artículo en Inglés | MEDLINE | ID: mdl-32187616

RESUMEN

INTRODUCTION: Divers with suspected decompression illness require high concentration oxygen (O2). There are many different O2 delivery devices, with few data comparing their performance. This study evaluated O2 delivery, using tissue O2 partial pressure (PtcO2), in healthy divers breathing O2 via three different delivery devices. METHODS: Twelve divers had PtcO2 measured at six limb sites. Participants breathed O2 from: a demand valve using an intraoral mask with a nose clip (NC); a medical O2 rebreathing system (MORS) with an oronasal mask and with an intraoral mask; and a non-rebreather mask (NRB) at 15 or 10 L·min⁻¹ O2 flow. In-line inspired O2 FIO2) and nasopharyngeal FIO2 were measured. Participants provided subjective ratings of device comfort, ease of breathing, and overall ease of use. RESULTS: PtcO2 values and nasopharyngeal FIO2 were similar with the demand valve with intraoral mask, MORS with both masks and the NRB at 15 L·min⁻¹. PtcO2 and nasopharyngeal FIO2 values were significantly lower with the NRB at 10 L·min⁻¹. The NRB was rated as the most comfortable to wear, easiest to breathe with, and overall the easiest to use. CONCLUSION: Of the commonly available devices promoted for O2 delivery to injured divers, similar PtcO2 and nasopharyngeal FIO2 values were obtained with the three devices tested: MORS with an oronasal or intraoral mask, demand valve with an intraoral mask and NRB at a flow rate of 15 L·min⁻¹. PtcO2 and nasopharyngeal FIO2 values were significantly lower when the flow rate using the NRB was decreased to 10 L·min⁻¹.


Asunto(s)
Oxígeno/análisis , Adulto , Monitoreo de Gas Sanguíneo Transcutáneo , Enfermedad de Descompresión , Femenino , Humanos , Masculino , Máscaras , Terapia por Inhalación de Oxígeno , Respiración
6.
Glob Chang Biol ; 26(4): 2702-2716, 2020 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-31930639

RESUMEN

The Antarctic is considered to be a pristine environment relative to other regions of the Earth, but it is increasingly vulnerable to invasions by marine, freshwater and terrestrial non-native species. The Antarctic Peninsula region (APR), which encompasses the Antarctic Peninsula, South Shetland Islands and South Orkney Islands, is by far the most invaded part of the Antarctica continent. The risk of introduction of invasive non-native species to the APR is likely to increase with predicted increases in the intensity, diversity and distribution of human activities. Parties that are signatories to the Antarctic Treaty have called for regional assessments of non-native species risk. In response, taxonomic and Antarctic experts undertook a horizon scanning exercise using expert opinion and consensus approaches to identify the species that are likely to present the highest risk to biodiversity and ecosystems within the APR over the next 10 years. One hundred and three species, currently absent in the APR, were identified as relevant for review, with 13 species identified as presenting a high risk of invading the APR. Marine invertebrates dominated the list of highest risk species, with flowering plants and terrestrial invertebrates also represented; however, vertebrate species were thought unlikely to establish in the APR within the 10 year timeframe. We recommend (a) the further development and application of biosecurity measures by all stakeholders active in the APR, including surveillance for species such as those identified during this horizon scanning exercise, and (b) use of this methodology across the other regions of Antarctica. Without the application of appropriate biosecurity measures, rates of introductions and invasions within the APR are likely to increase, resulting in negative consequences for the biodiversity of the whole continent, as introduced species establish and spread further due to climate change and increasing human activity.

7.
J Emerg Manag ; 17(5): 359-369, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-31736042

RESUMEN

OBJECTIVE: To explore how health emergency management (HEM) personnel make sense of professional development, such as education and training, in their everyday roles and responsibilities within an increasingly complex emergency management and disaster field. DESIGN: This in-depth qualitative study comprised of semistructured interviews with 10 Aotearoa New Zealand HEM personnel from a range of healthcare professions, including emergency managers, nurses, clinical support, and paramedics. The thematic, data-driven approach was exploratory. The research identified inductively significant thematic concepts relating to professional development from the health emergency personnel's talk about their roles and responsibilities. RESULTS: The authors identified four themes relating to professional development in the participants' talk: test yourself under pressure; selling what we do; under the pump; and real stuff that actually makes a difference. These themes represent shared sense-making about how the participants negotiated their professional development needs and the needs of others while performing their everyday roles and responsibilities. CONCLUSIONS: Our findings support the production of local and contextually driven knowledge that highlights how HEM personnel discuss professional development as strengths, tensions, challenges, and knowledge gaps. These insights contribute to a broader understanding of what needs to be taken into account when developing competencies, skill sets, and training programs to promote professional development in an increasingly complex emergency management and disaster field.


Asunto(s)
Desastres , Servicios Médicos de Urgencia/organización & administración , Personal de Salud , Competencia Profesional , Creación de Capacidad , Humanos , Nueva Zelanda , Investigación Cualitativa
8.
Diving Hyperb Med ; 48(4): 209-217, 2018 Dec 24.
Artículo en Inglés | MEDLINE | ID: mdl-30517952

RESUMEN

INTRODUCTION: High concentration normobaric oxygen (O2) is a priority in treating divers with suspected decompression illness. The effect of different O2 mask configurations on tissue oxygenation when breathing with a demand valve was evaluated. METHODS: Sixteen divers had tissue oxygen partial pressure (PtcO2) measured at six limb sites. Participants breathed O2 from a demand valve using: an intraoral mask (IOM®) with and without a nose clip (NC), a pocket face mask and an oronasal mask. In-line inspired O2 (FIO2) and nasopharyngeal FIO2 were measured. Participants provided subjective ratings of mask comfort, ease of breathing and holding in position. RESULTS: PtcO2 values and nasopharyngeal FIO2 (median and range) were greatest using the IOM with NC and similar with the IOM without NC. O2 measurements were lowest with the oronasal mask which also was rated as the most difficult to breathe from and to hold in position. The pocket face mask was reported as the most comfortable to wear. The NC was widely described as uncomfortable. The IOM and pocket face mask were rated best for ease of breathing. The IOM was rated as the easiest to hold in position. CONCLUSION: Of the commonly available O2 masks for use with a demand valve, the IOM with NC achieved the highest PtcO2 values. PtcO2 and nasopharyngeal FIO2 values were similar between the IOM with and without NC. Given the reported discomfort of the NC, the IOM without NC may be the best option.


Asunto(s)
Enfermedad de Descompresión/terapia , Consumo de Oxígeno , Terapia por Inhalación de Oxígeno/instrumentación , Oxígeno/metabolismo , Adulto , Enfermedad de Descompresión/metabolismo , Buceo , Femenino , Humanos , Masculino , Máscaras , Oxígeno/administración & dosificación , Respiración
9.
Diving Hyperb Med ; 48(4): 235-240, 2018 Dec 24.
Artículo en Inglés | MEDLINE | ID: mdl-30517957

RESUMEN

INTRODUCTION: Vibration from a helicopter during aeromedical retrieval of divers may increase venous gas emboli (VGE) production, evolution or distribution, potentially worsening the patient's condition. AIM: To review the literature surrounding the helicopter transport of injured divers and establish if vibration contributes to increased VGE. METHOD: A systematic literature search of key databases was conducted to identify articles investigating vibration and bubbles during helicopter retrieval of divers. Level of evidence was graded using the Oxford Centre for Evidence-Based Medicine guidelines. A modified quality assessment tool for studies with diverse designs (QATSDD) was used to assess the overall quality of evidence. RESULTS: Seven studies were included in the review. An in vitro research paper provided some evidence of bubble formation with gas supersaturation and vibration. Only one prospective intervention study was identified which examined the effect of vibration on VGE formation. Bubble duration was used to quantify VGE load with no difference found between the vibration and non-vibration time periods. This study was published in 1980 and technological advances since that time suggest cautious interpretation of the results. The remaining studies were retrospective chart reviews of helicopter retrieval of divers. Mode of transport, altitude exposure, oxygen and intravenous fluids use were examined. CONCLUSION: There is some physical evidence that vibration leads to bubble formation although there is a paucity of research on the specific effects of helicopter vibration and VGE in divers. Technological advances have led to improved assessment of VGE in divers and will aid in further research.


Asunto(s)
Ambulancias Aéreas , Buceo , Embolia Aérea , Vibración/efectos adversos , Enfermedad de Descompresión , Embolia Aérea/etiología , Humanos , Estudios Prospectivos , Estudios Retrospectivos
10.
Diving Hyperb Med ; 48(1): 2-9, 2018 Mar 31.
Artículo en Inglés | MEDLINE | ID: mdl-29557095

RESUMEN

INTRODUCTION: Published normal transcutaneous oxygen partial pressures (PtcO2) for the chest and lower limb have defined tissue hypoxia as a value of < 40 mmHg (< 30 mmHg in some patients, < 50 mmHg in others). AIM: To determine 'normal' PtcO2 for the upper and lower limb in healthy, non-smoking adults using the Radiometer® TCM400 with tc Sensor E5250. METHOD: Thirty-two volunteers had transcutaneous oxygen measurements (TCOM) performed on the chest, upper and lower limbs breathing air, with leg then arm elevated and whilst breathing 100% oxygen. RESULTS: Room-air PtcO2 (mmHg, mean (95% confidence interval)) were: chest: 53.6 (48.7-58.5); upper arm: 60.0 (56.1-64.0); forearm: 52.3 (44.8-55.8); dorsum of hand: 50.2 (46.1-54.3); thenar eminence: 70.8 (67.7-73.8); hypothenar eminence: 77.9 (75.1-80.7); lateral leg: 50.2 (46.2-54.2); lateral malleolus: 50.5 (46.6-54.3); medial malleolus: 48.9 (45.6-52.1); dorsum, between first and second toe: 53.1 (49.2-57.0); dorsum, proximal to fifth toe: 58.5 (55.0 - -62.0); plantar, 1st MTP: 73.7 (70.3-77.1). Nineteen subjects had at least one room-air PtcO2 below 40 mmHg (nine upper limb, 13 lower limb, four chest). Approximately 10% lower limb PtcO2 were < 100 mmHg on normobaric oxygen. Only one subject at one site had an upper limb PtcO2 < 100 mmHg breathing oxygen. CONCLUSION: The broad dispersion in PtcO2 in our healthy cohort reflects the inherent biologic variability in dermal perfusion and oxygen delivery, making it difficult to define narrow, rigid 'normal' values. Thus, we cannot recommend a single PtcO2 value as 'normal' for the upper or lower limb. A thorough patient assessment is essential to establish appropriateness for hyperbaric oxygen therapy, with TCOM used as an aid to guide this decision and not as an absolute.


Asunto(s)
Monitoreo de Gas Sanguíneo Transcutáneo , Oxígeno/sangre , Adolescente , Adulto , Brazo , Femenino , Humanos , Extremidad Inferior , Masculino , Valores de Referencia
11.
Diving Hyperb Med ; 47(2): 82-87, 2017 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-28641320

RESUMEN

INTRODUCTION: Transcutaneous oximetry measurement (TCOM) is a non-invasive method of determining oxygen tension at the skin level using heated electrodes. AIM: To compare TCOM values generated by different machines and to establish lower limb TCOM values in a cohort of healthy individuals younger than 40 years of age. METHOD: Sixteen healthy, non-smoking volunteers aged 18 to 39 years were recruited. TCOM was obtained at six locations on the lower leg and foot using three different Radiometer machines. Measurements were taken with subjects lying supine, breathing air. RESULTS: Except for one sensor site, there were no statistical differences in measurements obtained by the different TCOM machines. There was no statistical difference in measurements comparing left and right legs. Room air TCOM values for the different lower leg sites were (mean (SD) in mmHg): lateral leg 61.5 (9.2); lateral ankle 61.1 (9.7); medial ankle 59.1 (10.8); foot, first and second toe 63.4 (10.6); foot, fifth toe 59.9 (13.2) and plantar foot 74.1 (8.8). The overall mean TCOM value for the lower limb was 61 (10.8; 95% confidence intervals 60.05-62.0) mmHg. CONCLUSION: Lower-leg TCOM measurements using different Radiometer TCOM machines were comparable. Hypoxia has been defined as lower-leg TCOM values of less than 40 mmHg in non-diabetic patients and this is supported by our measurements. The majority (96.9%) of the lower leg TCOM values in healthy young adults are above the hypoxic threshold.


Asunto(s)
Monitoreo de Gas Sanguíneo Transcutáneo/instrumentación , Pierna , Adulto , Factores de Edad , Monitoreo de Gas Sanguíneo Transcutáneo/métodos , Electrodos , Femenino , Voluntarios Sanos , Humanos , Hipoxia , Masculino , Valores de Referencia , Posición Supina , Adulto Joven
12.
Diving Hyperb Med ; 47(1): 33-37, 2017 03.
Artículo en Inglés | MEDLINE | ID: mdl-28357822

RESUMEN

INTRODUCTION: There are limited data on the use of elastomeric infusion pumps during hyperbaric oxygen treatment. AIM: This study evaluated the flow rate of the Baxter elastomeric LV10 Infusor™ pump under normobaric (101.3 kPa) and three hyperbaric conditions of 203 kPa, 243 kPa and 284 kPa. METHODS: Elastomeric pumps were secured to participants in the same manner as for a typical patient, except that a container collected the delivered antibiotic solution. Pumps and tubing were weighed before and after the test period to determine volume delivered and to calculate flow rates at sea level and the three commonly used hyperbaric treatment pressures at two different time periods, 0-2 hours (h) and 19-21 h into the infusion. RESULTS: The mean flow rates in ml·h⁻¹ (SD) were: 9.5 (0.4), 10.3 (0.6), 10.4 (0.6), 10.4 (0.5) at 0-2 h and 10.5 (1.0), 12.2 (0.6), 9.4 (0.5), 10.3 (0.9) at 19-21 h for the normobaric, 203 kPa, 243 kPa and 284 kPa conditions respectively. There was no significant association between flow rate and time period (P = 0.166) but the 203 kPa flow rates were significantly faster than the other flow rates (P = 0.008). In retrospect, the 203 kPa experiments had all been conducted with the same antibiotic solution (ceftazidime 6 g). Repeating that experimental arm using flucloxacillin 8 g produced flow rates of 10.4 (0.8) ml·h⁻¹, with no significant associations between flow rate and time period (P = 0.652) or pressure (P = 0.705). CONCLUSION: In this study, the flow rate of the Baxter LV10 Infusor™ device was not significantly affected by increases in ambient pressure across the pressure range of 101.3 kPa to 284 kPa, and flow rates were generally within a clinically acceptable range of 9-12 ml·h⁻¹. However, there was evidence that the specific antibiotic solution might affect flow rates and this requires further study.


Asunto(s)
Antibacterianos/administración & dosificación , Oxigenoterapia Hiperbárica , Bombas de Infusión , Presión Atmosférica , Ceftazidima/administración & dosificación , Elastómeros , Floxacilina/administración & dosificación , Voluntarios Sanos , Humanos , Polímeros , Temperatura , Factores de Tiempo
13.
Artículo en Inglés | MEDLINE | ID: mdl-27834915

RESUMEN

Opioid Substitution Treatment (OST) is a harm reduction strategy enabling opiate consumers to avoid withdrawal symptoms and maintain health and wellbeing. Some research shows that within a disaster context service disruptions and infrastructure damage affect OST services, including problems with accessibility, dosing, and scripts. Currently little is known about planning for OST in the reduction and response phases of a disaster. This study aimed to identify the views of three professional groups working in Aotearoa/New Zealand about OST provision following a disaster. In-depth, semi-structured interviews were conducted with 17 service workers, health professionals, and emergency managers in OST and disaster planning fields. Thematic analysis of transcripts identified three key themes, namely "health and wellbeing", "developing an emergency management plan", and "stock, dose verification, and scripts" which led to an overarching concept of "service continuity in OST preparedness planning". Participants viewed service continuity as essential for reducing physical and psychological distress for OST clients, their families, and wider communities. Alcohol and drug and OST health professionals understood the specific needs of clients, while emergency managers discussed the need for sufficient preparedness planning to minimise harm. It is concluded that OST preparedness planning must be multidisciplinary, flexible, and inclusive.


Asunto(s)
Actitud del Personal de Salud , Planificación en Desastres , Socorristas/psicología , Personal de Salud/psicología , Tratamiento de Sustitución de Opiáceos/estadística & datos numéricos , Humanos , Nueva Zelanda
15.
Diving Hyperb Med ; 46(1): 58-9, 2016 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-27044471
16.
Diving Hyperb Med ; 45(3): 176-80, 2015 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-26415068

RESUMEN

INTRODUCTION: In Professional Association of Diving Instructors (PADI) Open Water Diver certification courses that cater to tourists, instruction is often condensed and potentially delivered in a language that is not the candidate's native language. OBJECTIVE: To assess the incidence of middle ear barotrauma (MEBt) in open-water diver candidates during a condensed four-day certification course, and to determine if language of instruction affects the incidence of MEBt in these divers. METHOD: The ears of participating diving candidates were assessed prior to commencing any in-water compression. Tympanic membranes (TM) were assessed and graded for MEBt after the confined and open-water training sessions. Tympanometry was performed if the candidate had no movement of their TM during Valsalva. Photographs were taken with a digital otoscope. RESULTS: Sixty-seven candidates participated in the study. Forty-eight had MEBt at some time during their course. MEBt was not associated with instruction in non-native language (adjusted odds ratio = 0.82; 95% confidence intervals 0.21-3.91). There was also no significant association between the severity of MEBt and language of instruction. CONCLUSION: Open-water diver candidates have a high incidence of MEBt. Education in non-native language does not affect the overall incidence of MEBt.


Asunto(s)
Barotrauma/epidemiología , Certificación/normas , Barreras de Comunicación , Buceo/lesiones , Oído Medio/lesiones , Lenguaje , Adulto , Barotrauma/diagnóstico , Buceo/estadística & datos numéricos , Femenino , Humanos , Incidencia , Masculino , Fotograbar , Factores de Riesgo
17.
J Appl Physiol (1985) ; 119(5): 427-34, 2015 Sep 01.
Artículo en Inglés | MEDLINE | ID: mdl-26139218

RESUMEN

Decompression sickness (DCS) is a systemic disorder, assumed due to gas bubbles, but additional factors are likely to play a role. Circulating microparticles (MPs)--vesicular structures with diameters of 0.1-1.0 µm--have been implicated, but data in human divers have been lacking. We hypothesized that the number of blood-borne, Annexin V-positive MPs and neutrophil activation, assessed as surface MPO staining, would differ between self-contained underwater breathing-apparatus divers suffering from DCS vs. asymptomatic divers. Blood was analyzed from 280 divers who had been exposed to maximum depths from 7 to 105 meters; 185 were control/asymptomatic divers, and 90 were diagnosed with DCS. Elevations of MPs and neutrophil activation occurred in all divers but normalized within 24 h in those who were asymptomatic. MPs, bearing the following proteins: CD66b, CD41, CD31, CD142, CD235, and von Willebrand factor, were between 2.4- and 11.7-fold higher in blood from divers with DCS vs. asymptomatic divers, matched for time of sample acquisition, maximum diving depth, and breathing gas. Multiple logistic regression analysis documented significant associations (P < 0.001) between DCS and MPs and for neutrophil MPO staining. Effect estimates were not altered by gender, body mass index, use of nonsteroidal anti-inflammatory agents, or emergency oxygen treatment and were modestly influenced by divers' age, choice of breathing gas during diving, maximum diving depth, and whether repetitive diving had been performed. There were no significant associations between DCS and number of MPs without surface proteins listed above. We conclude that MP production and neutrophil activation exhibit strong associations with DCS.


Asunto(s)
Micropartículas Derivadas de Células/metabolismo , Enfermedad de Descompresión/metabolismo , Buceo/fisiología , Activación Neutrófila/fisiología , Neutrófilos/metabolismo , Adolescente , Adulto , Anciano , Antiinflamatorios no Esteroideos/uso terapéutico , Índice de Masa Corporal , Enfermedad de Descompresión/tratamiento farmacológico , Femenino , Gases/metabolismo , Humanos , Masculino , Persona de Mediana Edad , Activación Neutrófila/efectos de los fármacos , Neutrófilos/efectos de los fármacos , Oxígeno/metabolismo , Adulto Joven
18.
Diving Hyperb Med ; 45(2): 79-83, 2015 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-26165528

RESUMEN

INTRODUCTION: High-concentration normobaric oxygen (O2) administration is the first-aid priority in treating divers with suspected decompression illness. The best O2 delivery device and flow rate are yet to be determined. AIM: To determine whether administering O2 with a non-rebreather mask (NRB) at a flow rate of 10 or 15 L·min ⁻¹ or with a demand valve with oronasal mask significantly affects the tissue partial pressure of O2 (PtcO2) in healthy volunteer scuba divers. METHODS: Fifteen certified scuba divers had PtcO2 measured at six positions on the arm and leg. Measurements were taken with subjects lying supine whilst breathing O2 from a NRB at 10 or 15·L·min⁻¹, a demand valve with an adult Tru-Fit oronasal mask and, as a reference standard, an oxygen 'head hood'. End-tidal carbon dioxide was also measured. RESULTS: While none of the emergency delivery devices performed as well as the head hood, limb tissue oxygenation was greatest when O2 was delivered via the NRB at 15 L·min⁻¹. There were no clinically significant differences in end-tidal carbon dioxide regardless of the delivery device or flow rate. CONCLUSION: Based on transcutaneous oximetry values, of the commonly available emergency O2 delivery devices, the NRB at 15 L·min ⁻¹ is the device and flow rate that deliver the most O2 to body tissues and, therefore, should be considered as a first-line pre-hospital treatment in divers with suspected decompression illness.


Asunto(s)
Consumo de Oxígeno , Terapia por Inhalación de Oxígeno/instrumentación , Adulto , Brazo , Monitoreo de Gas Sanguíneo Transcutáneo/instrumentación , Monitoreo de Gas Sanguíneo Transcutáneo/métodos , Dióxido de Carbono/metabolismo , Buceo , Urgencias Médicas , Femenino , Voluntarios Sanos , Humanos , Pierna , Masculino , Máscaras , Terapia por Inhalación de Oxígeno/métodos , Valores de Referencia , Volumen de Ventilación Pulmonar
19.
Diving Hyperb Med ; 44(3): 146-53, 2014 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-25311321

RESUMEN

INTRODUCTION: Current guidelines for transcutaneous oximetry measurement (TCOM) for the lower limb define tissue hypoxia as a transcutaneous oxygen partial pressure < 40 mmHg. Values obtained with some newer machines and current research bring these reference values into question. AIM: To determine 'normal' TCOM values for the lower limb in healthy, non-smoking adults using the TCM400 oximeter with tc Sensor E5250. METHOD: Thirty-two healthy, non-smoking volunteers had TCOM performed at six positions on the lower leg and foot. Measurements were taken with subjects lying supine breathing air, then with leg elevated and whilst breathing 100 % oxygen. RESULTS: Room-air TCOM values (mean mmHg, 95 % confidence interval (CI) ) were: lateral leg 41.3, CI 37.8 to 44.7; lateral malleolus 38.6, CI 34.1 to 43.1; medial malleolus 43.9, CI 40.2 to 47.6; dorsum, between first and second toe 39.3, CI 35.9 to 42.7; dorsum, proximal to fifth metatarsal-phalangeal joint 46.4, CI 43.4 to 49.3; plantar 52.3, CI 49.6 to 55.1. Using the currently accepted value of less than 40 mmHg for tissue hypoxia, 24 of our 32 'healthy' subjects had at least one air sensor reading that would have been classified as hypoxic. Seventeen subjects had TCOM values less than 100 mmHg when breathing 100 % normobaric oxygen. CONCLUSION: Normal lower limb TCOM readings using the TCOM400 with tc Sensor E5250 may be lower than 40 mmHg, used to define tissue hypoxia, but consistent with the wide range of values found in the literature. Because of the wide variability in TCOM at the different sensor sites we cannot recommend one TCOM value as indicative of tissue hypoxia. A thorough clinical assessment of the patient is essential to establish appropriateness for hyperbaric oxygen treatment, with TCOM used as an aid to help guide this decision, but not as an absolute diagnostic tool.


Asunto(s)
Monitoreo de Gas Sanguíneo Transcutáneo/normas , Pierna , Adulto , Anciano , Anciano de 80 o más Años , Monitoreo de Gas Sanguíneo Transcutáneo/instrumentación , Hipoxia de la Célula , Femenino , Humanos , Masculino , Persona de Mediana Edad , Posicionamiento del Paciente , Valores de Referencia , Estadísticas no Paramétricas , Adulto Joven
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