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Eyebrows and eyelashes serve important anatomical and social functions, and hair loss at these sites can impact patients significantly. Acquired eyebrow and eyelash loss (madarosis) may be due to a variety of underlying local or systemic disease processes; in other cases it may be idiopathic. There is a dearth of literature relating to eyebrow and eyelash loss, and there is limited guidance to help clinicians treat these clinical presentations in comparison with scalp alopecia. Here, we discuss the acquired causes of eyebrow and eyelash alopecia, our clinical approach to diagnosis and review treatment options for clinicians.
Asunto(s)
Pestañas , Humanos , Cejas , Alopecia/diagnóstico , Alopecia/etiología , Alopecia/terapiaRESUMEN
We describe a case of follicular mucinosis presenting with patchy alopecia affecting the eyebrows. On dermoscopy, white gelatinous material (presumed to be mucin) was visible along the hair shafts of the eyebrow lesions. We propose to call this novel dermoscopic finding the 'toothpaste sign'.
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Alopecia Areata , Mucinosis Folicular , Alopecia/patología , Dermoscopía , Cabello/patología , Humanos , Mucinosis Folicular/diagnóstico , Pastas de DientesRESUMEN
Lattices of plasmonic nanorings with particular geometries exhibit singular, tunable resonance features in the infrared. This work examined effects of nanoring inner radius, wall thickness, and lattice constant on the spectral response of single nanorings and in Fano resonant square lattices, combining use of the discrete and coupled dipole approximations. Increasing nanoring inner radius red-shifted and broadened the localized surface plasmon resonance (LSPR), while wall thickness modulated the LSPR wavelength and decreased absorption relative to scattering. The square lattice constant was tuned to observe diffractively-coupled lattice resonances, which increased resonant extinction 4.3-fold over the single-ring LSPR through Fano resonance. Refractive index sensitivities of 760 and 1075 nm RIU(-1) were computed for the plasmon and lattice resonances of an optimized nanoring lattice. Sensitivity of an optimal nanoring lattice to a local change in dielectric, useful for sensing applications, was 4 to 5 times higher than for isolated nanorings or non-coupling arrays. This was attributable to the Fano line-shape in far-field diffractive coupling with near-field LSPR.
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Peptoids are a versatile family of oligomeric synthetic molecules that can be customized for many applications. The submonomer solid-phase synthesis of peptoids allows for quick and inexpensive manufacturing and the selection of side chains is nearly limitless. In addition, peptoids that include chiral, aromatic side chains form stable helical secondary structure that leads to the potential for the formation of supramolecular assemblies. The effects of water solubility, helical content, charge placement, and side chain bulk on microsphere formation were studied for seven peptoid sequences. We found that secondary structure and partial water solubility were essential for microsphere formation. In addition, charge placement and side chain bulk affect both the ability to form microspheres and the diameter of the microspheres.
Asunto(s)
Peptoides/química , Microesferas , Peptoides/síntesis química , Estructura Secundaria de Proteína , Técnicas de Síntesis en Fase Sólida , SolubilidadRESUMEN
Time-resolved, in situ spectroscopy of electroless (EL) gold (Au) films combined with electron microscopy showed that the deposition rate increased up to two-fold on surfaces swept by the bulk flow of adjacent fluid at Reynolds numbers less than 1.0, compared to batch immersion. Deposition rates from 5.0 to 9.0 nm/min and thicknesses of the EL Au film from 20 to 100 nm, respectively, increased predictably with flow rate at conditions when the deposition was limited primarily by Fickian diffusion. Time-frames were identified for metal island nucleation, growth, and subsequent film development during EL Au deposition by real-time UV-visible spectroscopy of photoluminescence (PL) and surface plasmon features of nanoscale metal deposits. Film thicknesses measured by scanning electron microscopy and X-ray photoelectron spectroscopy paired with real-time optical spectroscopy of kinetic aspects of plasmon and PL optical features indicated that Au film deposition on surfaces swept by a steady flow of adjacent fluid can be primarily diffusion limited.
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Optical and thermal activity of plasmon-active nanoparticles in transparent dielectric media is of growing interest in thermal therapies, photovoltaics and optoelectronic components in which localized surface plasmon resonance (LSPR) could play a significant role. This work compares a new method to embed gold nanoparticles (AuNPs) in dense, composite films with an extension of a previously introduced method. Microscopic and spectroscopic properties of the two films are related to thermal behavior induced via laser excitation of LSPR at 532 nm in the optically transparent dielectric. Gold nanoparticles were incorporated into effectively nonporous 680 µm thick polydimethylsiloxane (PDMS) films by (1) direct addition of organic-coated 16 nm nanoparticles; and (2) reduction of hydrogen tetrachloroaurate (TCA) into AuNPs. Power loss at LSPR excitation frequency and steady-state temperature maxima at 100 mW continuous laser irradiation showed corresponding increases with respect to the mass of gold introduced into the PDMS films by either method. Measured rates of temperature increase were higher for organic-coated NP, but higher gold content was achieved by reducing TCA, which resulted in larger overall temperature changes in reduced AuNP films.
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Gold nanoparticle arrays created with electroless gold plating provide a unique means of transforming nanocylinders usually formed in electron beam lithography to spherical nanoparticles. Alone, electroless gold plating is not selective to the substrate and results in the formation of a gold film on all exposed surfaces of an electron beam patterned sample, including the electron resist. Undesired gold plating occurred near patterned features on the substrate surface, which was reduced by increasing post-spin-coat cure time. When the electron resist is removed, some nanocylinders break off with the gold film, leaving partial cylinders or holes in the patterned elements. By presensitizing the substrate surface with tin, gold cylinders may be selectively deposited to the substrate surface without forming a film on the electron resist. Tin presensitized arrays were produced with 47.1 +/- 7.4 nm radius gold nanoparticles with an interparticle distance of 646.0 +/- 12.4 nm. Defects from sheared, missing, and redeposited Au particles associated with the resist removal were minimized, resulting in enhanced size and shape uniformity of pillars and arrays. Hollow particles were eliminated, and relative standard deviation in particle size was reduced by 7.4% on average, while elongation was reduced 12.3% when astigmatism was eliminated.
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Combining a modified two-step chemical etch method with equations to predict etch parameters and photon-plasmon phase-matching resulted in single-mode tapered optical fibers (TOFs) to optimize electromagnetic field enhancement. The phase-matching equation was used to identify the angle of incidence near the TOF cutoff radius at which surface plasmon resonance (SPR) is maximized. The axisymmetric Young-Laplace equation was used to predict the angle of incidence from the fabrication of a TOF via chemical etching. An optimal cone angle of 20.0 degrees , angles of incidence averaging (81.6 +/- 1.9) degrees , and tip diameters of (80.0 +/- 14.1) nm were achieved through a two-step etching process. These TOF characteristics maximize SPR excitation and field enhancement. The refractive index for optimized SPR excitation in the fabricated TOFs at a wavelength of 650 nm was found to be 1.343.