Increased carotid intima-media thickness in children-adolescents, and young adults with a parental history of premature myocardial infarction.

AIMS: The present study was designed to test whether early carotid structural changes are demonstrable (by high resolution B-mode ultrasound) in children, adolescents and young adults with a history of premature parental myocardial infarction. METHODS AND RESULTS: One hundred and fourteen healthy young (5 to 30 years) subjects with a parental history of premature myocardial infarction and 114 age- and sex-matched control subjects were enrolled in the study. They were divided into two age groups: children and adolescents (age 5 to 18 years) (54 individuals with a parental history of premature myocardial infarction and their control subjects; mean age 12.8+/-3.8 years) and young adults (age 19 to 30 years) (60 individuals with a parental history and their controls; mean age 23.8+/-3.3 years). All subjects underwent high resolution B-mode ultrasonographic evaluation of common carotid artery intima-media thickness. Lipid profile, resting blood pressure, body mass index and smoking status were also evaluated. In both age groups, compared to controls, subjects with a parental history of premature myocardial infarction had increased intima-media thickness of common carotid arteries (mean of combined sites: age 5-18 years: 0.45+/-0.076 mm vs 0.40+/-0.066 mm in controls, P=0.008; age 19-30 years: 0.48+/-0.077 mm vs 0.45+/-0.078 mm in controls,P =0.007) Offspring of coronary patients showed an unfavourable lipid profile, however, the association between a parental history of premature myocardial infarction and carotid intima-media thickness was independent of lipids, apolipoproteins and other traditional risk factors. CONCLUSIONS: Vascular structural changes associated with a parental history of premature myocardial infarction are already detectable in childhood and adolescence and occur independently of several traditional cardiovascular risk factors.

[Lipoprotein (a) and serum lipid levels young subjects with parents suffering from myocardial infarct]. / Livelli della lipoproteina (a) e dei lipidi sierici in giovani con familiarita per infarto del miocardio.

BACKGROUND: Elevated concentrations of lipoprotein (a) have been shown to increase the risk of coronary artery disease, especially in females, and have been found to be elevated in white US children with parental myocardial infarction. METHODS: To confirm the generality of this finding and to determine the influence of gender, we studied 143 children with parental myocardial infarction (cases), 71 males and 72 females, mean age 17 +/- 5 years, body mass index 22.1 +/- 3.8 and 102 controls, 50 males and 52 females, mean age 18 +/- 5 years, body mass index 23 +/- 4.3. RESULTS: The serum cholesterol and lipoprotein (a) levels were significantly higher, whereas the HDL level was significantly lower in cases than in controls; lipoprotein (a) levels > 30 md/dl were significantly more prevalent in cases than in controls. Among the males, serum HDL cholesterol was significantly lower in cases than in controls, whereas no significant differences were found in serum total cholesterol and in lipoprotein (a). Among the females, cases had lower HDL cholesterol level and higher serum total cholesterol and lipoprotein (a) levels in comparison to controls. CONCLUSION: Children with parental myocardial infarction, in particular the females, have a more unfavourable serum lipid profile than controls.