RESUMEN
BACKGROUND: Hepatitis C is a worldwide chronic liver disease. Different factors have been found to be associated with an increased progression to severe liver fibrosis, such as alcohol intake higher than 30 g/day, older age at infection and co-infection. Nevertheless, different research centers have found conflicting data concerning the liver iron overload fibrogenic role. AIM: To assess the association between hepatic iron overload and fibrosis stage grades in hepatitis C Virus carriers, hepatic steatosis and demographic variables. METHODS: In this descriptive study we recruited 290 positive anti-HCV and qualitative HCV-RNA, treatment naive chronic hepatitis C outpatients registered fom 2007 to 2009 at the Federal University of Bahia's Hospital. The variables studied in the liver biopsy results were: 1) fibrosis stage according to META VIR score (F0-F4), 2) iron overload presence or absence according to Perls staining, and 3) presence or absence of steatosis. Fibrosis stages were categorized as mild/moderate (F0-F2) and severe (F3-F4). Exclusion criteria were hepatitis B virus and human immunodeficiency virus co-infection, and primary or secondary hemochromatosis. The statistical analysis was performed using Chi-square and Student's t tests, with the ssoftware: SPSS 17. A P value < 0.05 was considered as significant. RESULTS: Severe fibrosis was statistically associated with older age, iron overload presence (P = 0.003) and steatosis (P = 0.01). CONCLUSIONS: In this study hepatic iron overload and hepatic steatosis were associated with severe hepatic fibrosis (METAVIR F3-F4).
Asunto(s)
Hígado Graso/virología , Hepatitis C Crónica/complicaciones , Sobrecarga de Hierro/complicaciones , Cirrosis Hepática/virología , Alanina Transaminasa , Aspartato Aminotransferasas , Estudios Transversales , Progresión de la Enfermedad , Hígado Graso/metabolismo , Femenino , Genotipo , Hepacivirus/genética , Hepatitis C Crónica/metabolismo , Humanos , Sobrecarga de Hierro/metabolismo , Cirrosis Hepática/metabolismo , Masculino , Persona de Mediana Edad , ARN Viral/genética , Índice de Severidad de la Enfermedad , gamma-GlutamiltransferasaRESUMEN
BACKGROUND: Hepatitis C is a worldwide chronic liver disease. Different factors have been found to be associated with an increased progression to severe liver fibrosis, such as alcohol intake higher than 30 g/day, older age at infection and co-infection. Nevertheless, different research centers have found conflicting data concerning the liver iron overload fibrogenic role. AIM: To assess the association between hepatic iron overload and fibrosis stage grades in hepatitis C Virus carriers, hepatic steatosis and demographic variables. METHODS: In this descriptive study we recruited 290 positive anti-HCV and qualitative HCV-RNA, treatment naive chronic hepatitis C outpatients registered fom 2007 to 2009 at the Federal University of Bahias Hospital. The variables studied in the liver biopsy results were: 1) fibrosis stage according to META VIR score (F0-F4), 2) iron overload presence or absence according to Perls staining, and 3) presence or absence of steatosis. Fibrosis stages were categorized as mild/moderate (F0-F2) and severe (F3-F4). Exclusion criteria were hepatitis B virus and human immunodeficiency virus co-infection, and primary or secondary hemochromatosis. The statistical analysis was performed using Chi-square and Students t tests, with the ssoftware: SPSS 17. A P value < 0.05 was considered as significant. RESULTS: Severe fibrosis was statistically associated with older age, iron overload presence (P = 0.003) and steatosis (P = 0.01). CONCLUSIONS: In this study hepatic iron overload and hepatic steatosis were associated with severe hepatic fibrosis (METAVIR F3-F4).
Asunto(s)
Cirrosis Hepática/virología , Hígado Graso/virología , Hepatitis C Crónica/complicaciones , Sobrecarga de Hierro/complicaciones , Alanina Transaminasa , Aspartato Aminotransferasas , Cirrosis Hepática/metabolismo , Estudios Transversales , Femenino , Hígado Graso/metabolismo , Genotipo , Hepacivirus/genética , Hepatitis C Crónica/metabolismo , Humanos , Masculino , Persona de Mediana Edad , Progresión de la Enfermedad , ARN Viral/genética , Sobrecarga de Hierro/metabolismo , gamma-Glutamiltransferasa , Índice de Severidad de la EnfermedadRESUMEN
BACKGROUND: Hepatitis C is a worldwide chronic liver disease. Different factors have been found to be associated with an increased progression to severe liver fibrosis, such as alcohol intake higher than 30 g/day, older age at infection and co-infection. Nevertheless, different research centers have found conflicting data concerning the liver iron overload fibrogenic role. AIM: To assess the association between hepatic iron overload and fibrosis stage grades in hepatitis C Virus carriers, hepatic steatosis and demographic variables. METHODS: In this descriptive study we recruited 290 positive anti-HCV and qualitative HCV-RNA, treatment naive chronic hepatitis C outpatients registered fom 2007 to 2009 at the Federal University of Bahias Hospital. The variables studied in the liver biopsy results were: 1) fibrosis stage according to META VIR score (F0-F4), 2) iron overload presence or absence according to Perls staining, and 3) presence or absence of steatosis. Fibrosis stages were categorized as mild/moderate (F0-F2) and severe (F3-F4). Exclusion criteria were hepatitis B virus and human immunodeficiency virus co-infection, and primary or secondary hemochromatosis. The statistical analysis was performed using Chi-square and Students t tests, with the ssoftware: SPSS 17. A P value < 0.05 was considered as significant. RESULTS: Severe fibrosis was statistically associated with older age, iron overload presence (P = 0.003) and steatosis (P = 0.01). CONCLUSIONS: In this study hepatic iron overload and hepatic steatosis were associated with severe hepatic fibrosis (METAVIR F3-F4).
Asunto(s)
Hígado Graso/virología , Hepatitis C Crónica/complicaciones , Sobrecarga de Hierro/complicaciones , Cirrosis Hepática/virología , Alanina Transaminasa , Aspartato Aminotransferasas , Estudios Transversales , Progresión de la Enfermedad , Hígado Graso/metabolismo , Femenino , Genotipo , Hepacivirus/genética , Hepatitis C Crónica/metabolismo , Humanos , Sobrecarga de Hierro/metabolismo , Cirrosis Hepática/metabolismo , Masculino , Persona de Mediana Edad , ARN Viral/genética , Índice de Severidad de la Enfermedad , gamma-GlutamiltransferasaRESUMEN
INTRODUCTION: Hepatitis C is the major cause of liver transplantation and hepatocellular carcinoma and shows a global prevalence of 3%. Hepatitis C virus (HCV) is associated with extrahepatic manifestations (e.g., cutaneous affections) and psoriasis has been reported as a comorbidity. However, there are few studies analyzing this association. OBJECTIVES: 1) To evaluate anti-HCV prevalence (confirmed by the detection of HCV-RNA) in patients with psoriasis and its potential clinical implications; 2) to analyze the prevalence of other infections in this population: hepatitis B virus (HBV), human T lymphotropic virus, subtypes I and II (HTLVI/II), and human immunodeficiency virus, subtypes I and II (HIV I/II). METHODS: This is cross sectional study that included patients older than 18 years-old with psoriasis from a Teaching Hospital in Salvador, Bahia. An epidemiological questionnaire was administered and serological tests were performed: surface HBV antigen (HBsAg), antibodies to HBsAg (anti-HBs), anti-HTL VI/II, anti-HIV I/II, and anti-HCV. Anti-HCV positive results were confirmed by HCV-RNA detection and viral genotype was determined. Skin lesions were evaluated using the Psoriasis Area and Severity Index (PASI). Liver biopsies were analyzed according to the METAVIR score. RESULTS: From the 140 patients included in the study, 7.1% were anti-HCV positive confirmed by the detection of HCV RNA. This prevalence was higher than that in the city of Salvador (1.5%). Other serological results were: HBsAg 0%, anti-HBs 25.8%, HTLV I/II (0,9%), and HIV I/II 0%. PASI score was higher in positive anti-HCV patients than in their negative counterparts (19.5 versus 13.4). Histopathological analysis showed 66.7% of patients with METAVIR F3/F4. CONCLUSION: Anti-HCV prevalence was higher in psoriasis patients than in the general population of the city. More severe skin lesions were found in HCV patients.