RESUMEN
The use of guinea pigs as a laboratory model was proven to be appropriate in investigating the protective properties of a heterological immunoglobulin against Bolivian hemorrhagic fever at the preclinical stage of the study. A highly pathogenic Machupo virus strain that caused guinea pigs' death with respect with an agent's dose was cultivated. Injection of 1.0 ml of the immunoglobulin provided a 100% protective effect for the guinea pigs infected with the highly pathogenic Machupo virus strain in a dose of 10 LD50.
Asunto(s)
Infecciones por Arenaviridae/terapia , Arenavirus del Nuevo Mundo , Inmunoglobulinas/administración & dosificación , Inmunoglobulinas/inmunología , Animales , Modelos Animales de Enfermedad , Relación Dosis-Respuesta Inmunológica , Evaluación Preclínica de Medicamentos , Cobayas , Inyecciones IntramuscularesRESUMEN
The evaluation of the biological and epidemiological properties of Ebola, Marburg, Lassa, and Machupo viruses suggests that they are of social importance for health care authorities. The studies have created prerequisites to the development of reliable biosafety means against these pathogens. Particular emphasis is laid on the methods for infection diagnosis and on the studies to design specific protective agents--immunoglobulins and inactivated vaccines.