RESUMEN
Metaplastic carcinoma of the breast is a rare heterogeneous malignancy, accounting for <1% of all invasive breast carcinomas, in which adenocarcinoma is found to coexist with an admixture of spindle, squamous, chondroid or bone-forming neoplastic cells. Metaplastic breast carcinoma composed of both epithelial and melanocytic elements is rare, and only seven cases have been reported so far. Reported herein is the case of a 38-year-old woman with a nodular mass in her left breast suspicious of malignancy, discovered during routine ultrasound examination. After histological and immunohistochemical examination of the resected tumor mass, initial diagnosis was collision tumor: ductal invasive carcinoma and metastatic melanoma. The patient underwent quadrantectomy, chemotherapy and radiotherapy. At 6 years follow up the patient was alive and healthy, without local recurrence or metastases. After revising slides and the literature, in addition to patient follow up, it was concluded that this case represents metaplastic carcinoma with melanocytic differentiation.
Asunto(s)
Adenocarcinoma/patología , Neoplasias de la Mama/patología , Melanocitos/patología , Adenocarcinoma/química , Adulto , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Biomarcadores de Tumor/análisis , Neoplasias de la Mama/química , Terapia Combinada , Diagnóstico Diferencial , Supervivencia sin Enfermedad , Femenino , Humanos , Mastectomía Segmentaria , Melanocitos/química , Metaplasia , Neoplasias Glandulares y Epiteliales/patologíaRESUMEN
PURPOSE: To assess the angles between craniofacial planes and the gravity horizontal plane (GHP). MATERIALS AND METHODS: The plumb line was hung from the ceiling, the Fox plane (FoxP) was placed in the mouth, and 56 Angle Class I subjects were photographed in a natural head position. FoxP represents the extraoral view of the occlusal plane. RESULTS: In frontal view, bipupilar plane (BP) and occlusal plane (FoxP) were almost parallel to GHP. In lateral view, FoxP was almost parallel to GHP, but Frankfort horizontal plane (FHP) and Camper's plane (CP) were not. FoxP and CP were not parallel. CONCLUSION: CP is not a reliable landmark for occlusal plane reconstruction. FHP does not represent GHP.
Asunto(s)
Cefalometría/métodos , Oclusión Dental , Cara/anatomía & histología , Huesos Faciales/anatomía & histología , Cabeza/anatomía & histología , Femenino , Gravitación , Humanos , Procesamiento de Imagen Asistido por Computador , Masculino , Órbita/anatomía & histología , Fotograbar , Postura , Pupila , Silla Turca/anatomía & histologíaRESUMEN
We report a case of cutaneous angiosarcoma in a 77-year-old female patient with systemic sclerosis. The tumor developed around a large telangiectasia in the left temporal region. Later on, extensive asymptomatic redness and edema with several nodules over the whole left side of the face developed. Since the conservative therapy failed to produce any improvement, a diagnostic skin biopsy was performed. The pathohistological diagnosis was moderately differentiated angiosarcoma. The patient was treated with a combination of chemotherapy and electron beam irradiation. Despite a notable cutaneous improvement, the control check-up revealed the presence of metastases of the lung and liver. This is the first report of cutaneous angiosarcoma occurring in sclerodermatous skin. The possible pathogenesis of this rare tumorogenic transformation of soft tissues is discussed.
