Examination of the Relationship Between the Theory of Mind, Neurocognitive Functions and Thought-Language Features in the Schizophrenia and Bipolar Affective Disorder I Groups. / Sizofreni ve Bipolar Afektif Bozukluk I Gruplarinda, Zihin Kuraminin Nörobilissel Islevler ve Düsünce-Dil Özellikleri ile Iliskisinin Incelenmesi.

OBJECTIVE: In this study, it was aimed to examine the relationship of ToM with face-emotion recognition, executive functions and thought disorders in the schizophrenia (SC) and bipolar affective disorder I (BAD I) groups. METHOD: 40 SC, 40 BAD I and 40 healthy control groups were included, matched for age, gender, and educational status. Dokuz Eylül Theory of Mind Scale (DEToMS)) and Reading Mind in Eyes (RMET) test, Benton face recognition test (BFRT), Ekman emotion recognition battery, Wisconsin Card Sorting Test (WCST), Stroop test, Thought and Language Index (TLI) were used. Positive and Negative Symptoms Rating Scale (PANNS) in the SZ group, Young Mania Rating Scale (YMRS) in the BAD I group were used. RESULTS: The number of perseverative responses in WSCT was higher in the SC group than the BAD I group. Recognition of the fearful expression scores, DEToMS total and subscale scores except irony were higher and scores of TLI were lower in healthy controls more than patients group. Recognition of the fearful expression scores, DEToMS total and subscale scores except irony were higher and scores of TLI were lower in BAD I group more than SC group. There was no difference between SC and BAD I groups between BFRT, emotion recognition except fearful expression and RMET scores. The best predictors of DEToMS were executive functions and TLI total score in the SC group and was emotion recognition in the BAD I group. The best predictors of the RMET score were executive functions and emotion recognition for both groups. CONCLUSION: Our findings suggest that social cognition remains a biomarker in patients with SZ and BAD I.

Temperament and Character Profiles of Ankylosing Spondylitis Patients Compared With Major Depression Patients and Healthy Controls.

BACKGROUND/OBJECTIVE: Depressive disorder is common in patients with ankylosing spondylitis (AS), who exhibit specific brain imaging abnormalities resembling those in major depression (MD). We compared temperament and character profiles between patients with AS and MD. METHODS: The study involved 36 patients with AS, 40 with MD, and 36 healthy controls (HCs). The participants were age-, sex-, and education-matched. Depression, anxiety, temperament, and character were evaluated using the Temperament and Character Inventory and physician-rated Hamilton Depression and Anxiety Scales. Disease severity was assessed using the Bath Ankylosing Spondylitis Disease Activity, Radiology, Metrology, and Functionality Indexes; erythrocyte sedimentation rate; and C-reactive protein. RESULTS: Depression and anxiety scores were highest in MD, lowest in HCs, and intermediate in AS (p < 0.001). Harm avoidance was significantly higher in MD and AS than HCs (p = 0.01). Reward dependency was lower (p = 0.011) and self-transcendence higher in AS only (p = 0.034). Bath Ankylosing Spondylitis Radiology Index was negatively correlated with depression (p = 0.020). Bath Ankylosing Spondylitis Radiology Index and Bath Ankylosing Spondylitis Metrology Index were negatively correlated with harm avoidance (p < 0.05). Disease duration was negatively correlated with self-transcendence (p = 0.027). Harm avoidance was correlated with depression score (p = 0.029). Patients under tumor necrosis factor α inhibitor treatment had lower cooperativeness score (p = 0.022). CONCLUSIONS: Patients with AS had a specific Temperament and Character Inventory pattern. Harm avoidance was common in both AS and MD. In AS, harm avoidance and depression decreased in patients with progression, probably because progressive fusion of the spinal segments causes decrease in pain. Harm avoidance (fear of pain) seemed to be an acting factor for occurrence of depressive symptoms in AS.

The relationship of cognitive impairment with neurological and psychiatric variables in multiple sclerosis patients.

OBJECTIVE: Cognitive impairment (CI) in multiple sclerosis (MS) can develop any time. CI is associated with the degree of neuronal loss, but disease duration, fatigue, comorbid affective disorder, and drug dose may also affect cognition. Our aim was to assess which cognitive domain was disturbed primarily in mild MS patients and to see whether CI was related with clinical and psychiatric features. METHOD: Neurological and psychiatric evaluation of 31 MS patients and 31 age, sex, and education-matched healthy controls were made with Structured Clinical Interview for Axis I Disorders (SCID-I). Depression, anxiety, functionality, fatigue, and disability scoring were determined with Hamilton Depression-Anxiety scales, Global Assessment of Functionality, Fatigue Severity and Expanded Disability Status Scales. Cognitive functions were assessed using Mini Mental, Serial Digit Learning, Verbal and Nonverbal Cancellation, Stroop and Rey Auditory Verbal Learning tests. RESULTS: Retrieval from long-term memory and psychomotor speed were significantly worse in MS group. CI was correlated with disease duration, number of attacks, and physical disability but not with depression and anxiety severity. Disease duration predicted disturbances in recall and psychomotor speed, whereas fatigue and disability predicted depression. CONCLUSION: Psychomotor speed and memory were primarily impaired in MS patients, and CI was closely associated with clinical aspects of MS rather than with depression and anxiety.