Neuropsychology of chronic back pain managed with long-term opioid use.

Chronic pain is commonly treated with long-term opioids, but the neuropsychological outcomes associated with stable long-duration opioid use remain unclear. Here, we contrasted the psychological profiles, brain activity, and brain structure of 70 chronic back pain patients on opioids (CBP+O, average opioid exposure 6.2 years) with 70 patients managing their pain without opioids. CBP+O exhibited moderately worse psychological profiles and small differences in brain morphology. However, CBP+O had starkly different spontaneous brain activity, dominated by increased mesocorticolimbic and decreased dorsolateral-prefrontal activity, even after controlling for pain intensity and duration. These differences strongly reflected cortical opioid and serotonin receptor densities and mapped to two antagonistic resting-state circuits. The circuits' dynamics were explained by mesocorticolimbic activity and reflected negative affect. We reassessed a sub-group of CBP+O after they briefly abstained from taking opioids. Network dynamics, but not spontaneous activity, reflected exacerbated signs of withdrawal. Our results have implications for the management and tapering of opioids in chronic pain.

Mechanical hyperalgesia and neuropathic pain qualities impart risk for chronic postoperative pain after total knee replacement.

Total knee replacement (TKR) is the gold-standard treatment for end-stage chronic osteoarthritis pain, yet many patients report chronic postoperative pain after TKR. The search for preoperative predictors for chronic postoperative pain following TKR has been studied with inconsistent findings. This study investigates the predictive value of quantitative sensory testing (QST) and PainDETECT for postoperative pain 3, 6, and 12 months post-TKR. We assessed baseline and postoperative (3- and 6-months) QST measures in 77 patients with knee OA (KOA) and 41 healthy controls, along with neuropathic pain scores in patients (PainDETECT). QST parameters included pressure pain pressure threshold (PPT), pain tolerance threshold (PTT), conditioned pain modulation (CPM), and temporal summation (TS) using cuff algometry, alongside mechanical hyperalgesia, and mechanical temporal summation to repeated pinprick stimulation. Compared to healthy controls, KOA patients at baseline demonstrated hyperalgesia to pinprick stimulation at the medial OA-affected knee and cuff pressure on the ipsilateral calf. Lower cuff algometry PTT and mechanical pinprick hyperalgesia were associated with baseline KOA pain intensity. Moreover, baseline pinprick pain hyperalgesia explained 25% of variance in pain intensity 12 months post-TKR and preoperative neuropathic pain scores also captured 30% and 20% of the variance in postoperative pain at 6- and 12-months, respectively. A decrease in mechanical pinprick hyperalgesia from before surgery to 3 months after TKR was associated with lower postoperative pain at the 12 months post-TKR follow-up, and vice-versa. Our findings suggest that preoperative pinprick hyperalgesia and PainDETECT neuropathic-like pain symptoms show predictive value for the development of chronic post-TKR pain.

Vertical Slot Fishways: Incremental Knowledge to Define the Best Solution.

River artificial fragmentation is arguably the most imperilling threat for freshwater-dependent fish species. Fish need to be able to freely move along river networks as not only spawning grounds but also refuge and feeding areas may be spatially and temporally separated. This incapacity of free displacement may result in genetic depletion of some populations, density reduction and even community changes, which may in turn affect how meta-community balances are regulated, potentially resulting in functional resilience reduction and ecosystem processes' malfunction. Fishways are the most common and widely used method to improve connectivity for fish species. These structures allow fish to negotiate full barriers, thus reducing their connectivity impairment. Among all technical fishway types, vertical slot fishways (VSF) are considered to be the best solution, as they remain operational even with fluctuating water discharges and allow fish to negotiate each cross-wall at their desired depth. In the present study, we collected both published and original data on fish experiments within VSF, to address two questions, (1) What variables affect fish passage during experimental fishway studies? and (2) What is the best VSF configuration? We used Bayesian Generalized Mixed Models accounting for random effects of non-controlled factors, limiting inherent data dependencies, that may influence the model outcome. Results highlight that fish size, regardless of the species, is a good predictor of fishway negotiation success. Generally, multiple slot fishways with one orifice proved to be the best solution. Future work should be focused on small-sized fish to further improve the design of holistic fishways.

O Estado Regulador no direito à saúde: aspectos constitucionais da regulação / The Regulatory State in the right to health: constitutional aspects of regulation / El Estado Regulador en el derecho a la salud: aspectos constitucionales de la regulación

Objetivo: analisar os elementos gerais da regulação e o papel do Estado Regulador brasileiro com foco na salvaguarda dos direitos fundamentais, em especial do direito à saúde. Metodologia: a pesquisa apoiou-se no método dedutivo de René Descartes, utilizando, como premissas, os princípios gerais do direito, o ordenamento jurídico em torno do direito da saúde e do papel do Estado Regulador e a jurisprudência do Supremo Tribunal Federal relativa à vigilância sanitária. Resultados: a efetiva proteção da saúde, que envolve a garantia de que os cidadãos terão acesso a produtos e serviços de saúde seguros e eficazes, demanda uma estrutura regulatória sólida e devidamente reconhecida pelas instituições democráticas do país. O agente regulador deve interferir nas atividades econômicas que destoam do que se considera contrário ao interesse público e, sobretudo, no que concerne ao direito fundamental à saúde. Conclusão: a atuação independente e bem fundamentada das agências reguladoras é essencial para garantir a segurança e o bem-estar dos cidadãos em matéria de saúde.

Objective: to analyze general elements of regulation and the role of the Brazilian Regulatory State, focusing on the safeguarding of fundamental rights, especially the right to health. Methodology: the research was based on the deductive method of René Descartes using, as premises, the general principles of law, the legal system around health law and the role of the Regulatory State and the jurisprudence of the Supreme Court on health surveillance. Results: effective health protection, which involves ensuring that citizens will have access to safe and effective health products and services, demands a solid regulatory framework duly recognized by the country's democratic institutions. The regulatory agent must interfere in economic activities that deviate fromwhat is considered contrary to the public interest and, above all, with regard to the fundamental right to health. Conclusion: the independent and well-founded action of regulatory agencies is essential to ensure the safety and well-being of citizens in health matters.

Objetivo: analizar los elementos generales de la regulación y el papel del Estado Regulador brasileño, con foco en la salvaguarda de los derechos fundamentales, en especial del derecho a la salud. Metodología: la investigación se apoyó en el método deductivo de René Descartes, utilizando, como premisas, los principios generales del derecho, el ordenamiento jurídico en torno al derecho de la salud y al papel del Estado Regulador y la jurisprudencia del Supremo Tribunal Federal relativa a la vigilancia sanitaria. Resultados: la efectiva protección de la salud, que implica la garantía de que los ciudadanos tendrán acceso a productos y servicios de salud seguros y eficaces, demanda una estructura regulatoria sólida y debidamente reconocida por las instituciones democráticas del país. El agente regulador debe interferir en las actividades económicas que se aparten de lo que se considera contrario al interés público y, sobre todo, al derecho fundamental a la salud. Conclusión: la actuación independiente y bien fundamentada de las agencias reguladoras es esencial para garantizar la seguridad y el bienestar de los ciudadanos en materia de salud.

Subcortical brain anatomy as a potential biomarker of persistent pain after total knee replacement in osteoarthritis.

ABSTRACT: The neural mechanisms for the persistence of pain after a technically successful arthroplasty in osteoarthritis (OA) remain minimally studied, and direct evidence of the brain as a predisposing factor for pain chronicity in this setting has not been investigated. We undertook this study as a first effort to identify presurgical brain and clinical markers of postarthroplasty pain in knee OA. Patients with knee OA (n = 81) awaiting total arthroplasty underwent clinical and psychological assessment and brain magnetic resonance imagining. Postoperative pain scores were measured at 6 months after surgery. Brain subcortical anatomic properties (volume and shape) and clinical indices were studied as determinants of postoperative pain. We show that presurgical subcortical volumes (bilateral amygdala, thalamus, and left hippocampus), together with shape deformations of the right anterior hippocampus and right amygdala, associate with pain persistence 6 months after surgery in OA. Longer pain duration, higher levels of presurgical anxiety, and the neuropathic character of pain were also prognostic of postsurgical pain outcome. Brain and clinical indices accounted for unique influences on postoperative pain. Our study demonstrates the presence of presurgical subcortical brain factors that relate to postsurgical persistence of OA pain. These preliminary results challenge the current dominant view that mechanisms of OA pain predominantly underlie local joint mechanisms, implying novel clinical management and treatment strategies.

Terapia Centrada na Pessoa e Processo de Reorganização da Autoimagem e Autoestima: Pesquisa-Ação / Person-Centered Therapy and the Reorganizing Self-Image and Self-Esteem Process: Action Research / Terapia No Dirigida y el Proceso de Reorganización de la Autoimagen y la Autoestima: Investigación-Acción

Este artigo objetivou compreender o processo terapêutico proporcionado por uma prática interventiva de curta-duração centrada em pessoas com problemas de autoimagem corporal e autoestima. Seguindo um delineamento metodológico qualitativo, a pesquisa e as intervenções terapêuticas aconteceram sob a influência do desenho de pesquisa-ação. Trabalhou-se com as seguintes etapas: planejamento do processo terapêutico à luz das condições necessárias e suficientes para mudança de personalidade e as fases do processo terapêutico; desenvolvimento da prática de ajuda; monitoramento da ação a partir da supervisão, revisão dos atendimentos e entrevistas semiestruturadas com os participantes; análise fenomenológica empírica dos impactos afetivos da terapia a partir da perspectiva dos clientes atendidos; entendimento disso a partir do referencial rogeriano. Foram elaborados e discutidos os seguintes eixos temáticos relacionados ao processo terapêutico: fatores que levaram à busca por ajuda psicológica e constituíram a atmosfera terapêutica; significação negativa da experiência corporal; significação real da experiência de autoestima em relação ao corpo; mudanças de atitudes em relação à percepção de si e ao autocuidado. Concluiu-se que a terapia centrada na pessoa produziu impactos afetivos significativos que ajudaram esses clientes a lidar com suas experiências de imagem corporal e autoestima.

This article aimed to understand the therapeutic process provided by a short-term interventional practice centered on people with body self-esteem and self-image problems. Following a qualitative methodological design, the research and therapeutic interventions took place under the influence of the action research design. The following stages were used: planning the therapeutic process in light of the necessary and sufficient conditions for personality change and the therapeutic process phases; development of aid practice; action monitoring based on supervision, service review and semi-structured interviews with the participants; empirical phenomenological analysis of the affective impacts of therapy from the perspective of the clients assisted; understanding of this from the Rogerian framework. The following thematic axes related to the therapeutic process were elaborated and discussed: factors that led to the search for psychological help and constituted the therapeutic atmosphere; negative meaning of bodily experience; real meaning of the self-esteem experience in relation to the body; changes in attitudes towards self-perception and self-care. It was concluded that person-centered therapy produces significant affective impacts that helped these clients to deal with their body image and self-esteem experiences.

Este articulo tuvo como objetivo comprender el proceso terapéutico proporcionado por una práctica intervencionista de corta duración centrada en personas con problemas de autoimagen corporal y autoestima. Siguiendo un diseño metodológico cualitativo, la investigación y las intervenciones terapéuticas se desarrollaron bajo la investigación-acción. Se trabajó con los siguientes pasos: planificación del proceso terapéutico a la luz de las condiciones necesarias y suficientes para el cambio de personalidad y las fases del proceso terapéutico; desarrollo de prácticas de ayuda; seguimiento de la acción basado en la supervisión, revisión del servicio y entrevistas semiestructuradas con los participantes; análisis fenomenológico empírico de los impactos afectivos de la terapia desde la perspectiva de los clientes atendidos; comprensión de esto desde el referencial rogeriano. Fueron elaborados los siguientes ejes: factores que llevaron a búsqueda de ayuda psicológica y constituyen una atmósfera terapéutica; significado negativo de la experiencia corporal; significación real de la experiencia de la autoestima en relación con el cuerpo; cambios en las actitudes en relación con la autopercepción y autocuidado. Se concluyó que la terapia centrada en la persona produjo impactos afectivos significativos que ayudaron a estos clientes a lidiar con sus experiencias de imagen corporal y autoestima.

Predicting placebo analgesia in patients with chronic pain using natural language processing: a preliminary validation study.

ABSTRACT: Patients with chronic pain show large placebo effects in clinical trials, and inert pills can lead to clinically meaningful analgesia that can last from days to weeks. Whether the placebo response can be predicted reliably, and how to best predict it, is still unknown. We have shown previously that placebo responders can be identified through the language content of patients because they speak about their life, and their pain, after a placebo treatment. In this study, we examine whether these language properties are present before placebo treatment and are thus predictive of placebo response and whether a placebo prediction model can also dissociate between placebo and drug responders. We report the fine-tuning of a language model built based on a longitudinal treatment study where patients with chronic back pain received a placebo (study 1) and its validation on an independent study where patients received a placebo or drug (study 2). A model built on language features from an exit interview from study 1 was able to predict, a priori, the placebo response of patients in study 2 (area under the curve = 0.71). Furthermore, the model predicted as placebo responders exhibited an average of 30% pain relief from an inert pill, compared with 3% for those predicted as nonresponders. The model was not able to predict who responded to naproxen nor spontaneous recovery in a no-treatment arm, suggesting specificity of the prediction to placebo. Taken together, our initial findings suggest that placebo response is predictable using ecological and quick measures such as language use.

Structural brain connectivity predicts early acute pain after mild traumatic brain injury.

ABSTRACT: Mild traumatic brain injury (mTBI), is a leading cause of disability worldwide, with acute pain manifesting as one of its most debilitating symptoms. Understanding acute postinjury pain is important because it is a strong predictor of long-term outcomes. In this study, we imaged the brains of 157 patients with mTBI, following a motorized vehicle collision. We extracted white matter structural connectivity networks and used a machine learning approach to predict acute pain. Stronger white matter tracts within the sensorimotor, thalamiccortical, and default-mode systems predicted 20% of the variance in pain severity within 72 hours of the injury. This result generalized in 2 independent groups: 39 mTBI patients and 13 mTBI patients without whiplash symptoms. White matter measures collected at 6 months after the collision still predicted mTBI pain at that timepoint (n = 36). These white matter connections were associated with 2 nociceptive psychophysical outcomes tested at a remote body site-namely, conditioned pain modulation and magnitude of suprathreshold pain-and with pain sensitivity questionnaire scores. Our findings demonstrate a stable white matter network, the properties of which determine an important amount of pain experienced after acute injury, pinpointing a circuitry engaged in the transformation and amplification of nociceptive inputs to pain perception.

Brain Connectivity Predicts Chronic Pain in Acute Mild Traumatic Brain Injury.

OBJECTIVES: Previous studies have established the role of the cortico-mesolimbic and descending pain modulation systems in chronic pain prediction. Mild traumatic brain injury (mTBI) is an acute pain model where chronic pain is prevalent and complicated for prediction. In this study, we set out to study whether functional connectivity (FC) of the nucleus accumbens (NAc) and the periaqueductal gray matter (PAG) is predictive of pain chronification in early-acute mTBI. METHODS: To estimate FC, resting-state functional magnetic resonance imaging (fMRI) of 105 participants with mTBI following a motor vehicle collision was acquired within 72 hours post-accident. Participants were classified according to pain ratings provided at 12-months post-collision into chronic pain (head/neck pain ≥30/100, n = 44) and recovery (n = 61) groups, and their FC maps were compared. RESULTS: The chronic pain group exhibited reduced negative FC between NAc and a region within the primary motor cortex corresponding with the expected representation of the area of injury. A complementary pattern was also demonstrated between PAG and the primary somatosensory cortex. PAG and NAc also shared increased FC to the rostral anterior cingulate cortex (rACC) within the recovery group. Brain connectivity further shows high classification accuracy (area under the curve [AUC] = .86) for future chronic pain, when combined with an acute pain intensity report. INTERPRETATION: FC features obtained shortly after mTBI predict its transition to long-term chronic pain, and may reflect an underlying interaction of injury-related primary sensorimotor cortical areas with the mesolimbic and pain modulation systems. Our findings indicate a potential predictive biomarker and highlight targets for future early preventive interventions. ANN NEUROL 2022;92:819-833.

Proposição de um modelo de pesquisa-ação para aprimorar práticas humanistas centradas na pessoa: apontamentos metodológicos / Proposition of an action-research model to improve person-centered humanistic practices: methodological appointments

Este artigo objetiva propor um modelo de pesquisa-ação para aprimorar práticas individuais, educacionais e grupais norteadas pelo referencial da Psicologia Humanista de Carl Rogers. Inicialmente, apresenta as pesquisas desenvolvidas por ele durante a construção do seu método interventivo, segundo um delineamento quase-experimental. Posteriormente, demonstra como Rogers contatou a ideia de pesquisa-ação elaborada por Kurt Lewin e indicou o paradigma fenomenológico e sua metodologia empírica como recursos qualitativos para desenvolver a Psicologia Humanista. Depois, apresenta em que consiste a pesquisa-ação. Em seguida, demonstra como tratar um objeto de estudo e intervenção no referencial rogeriano, organizando-o em um ciclo de pesquisa e ação mediante as etapas de: registro de ideias, teorias e conceitos; planejamento da ação; intervenção; monitoramento da ação com base na Versão de Sentido concebida por Mauro Amatuzzi; e avaliação da ação conforme o método fenomenológico empírico de Amedeo Giorgi. Esse modelo segue critérios metodológicos os quais possibilitam avanços na abordagem rogeriana, na medida em que investiga as implicações das práticas humanistas com certos tipos de experiências e as desenvolve quando necessário.

This article aims to propose an action-research model to improve individual, educational and group practices guided by the framework of Carl Rogers' Humanistic Psychology. Initially, it presents the research developed by Rogers during the construction of his interventionist method, according to a quasi-experimental design. Subsequently, we demonstrate how Rogers contacted the idea of action research developed by Kurt Lewin and indicated the phenomenological paradigm and its empirical methodology as qualitative resources to develop Humanistic Psychology. After that, we present what the action-research consists of. Finally, we demonstrate how to treat a study object and intervention in a Rogerian referential, organizing it in a cycle of research and action through the stages of the recording of ideas, theories, and concepts; action planning; intervention; action monitoring based on the Sense Version designed by Mauro Amatuzzi; and action evaluation according to the Amedeo Giogi's empirical phenomenological method. We conclude that this model follows methodological criteria, which enable advances in the Rogerian approach insofar as it investigates humanistic practices' implications with certain types of experiences and develops them when necessary.

Activity, boldness and schooling in freshwater fish are affected by river salinization.

Rivers are experiencing increasing anthropogenic pressures and salinity has shown to affect freshwater fish behaviour, potentially disrupting ecological processes. In this study, the aim was to determine the sub-lethal effects of salinization on freshwater fish behaviour, using a widespread native cyprinid species, the Iberian barbel (Luciobarbus bocagei) as the model species. Behavioural trials in a mesocosms setting were performed to assess the effects of three levels of a salinity gradient - control (no salt added to the water, 0.8 mS/cm), low (9 mS/cm), and high concentration (18 mS/cm) - on fish routine activity, shoal cohesion and boldness. Upon increasing the salinity levels in the flume-channels, fish showed a significant reduction on their i) swimming activity (76% of searching behaviour in the control vs. 57% in high salinity), and ii) shoal cohesion (0.95 shoal cohesion ratio in the control vs. 0.76 in high salinity), while iii) an increase of bolder individuals, measured by a higher number of attempts to escape the altered environment (106 total jumps in the control vs. 262 in high salinity), was simultaneously observed. Behavioural changes in fish can reflect shifts in ecological condition. Thus, the behavioural responses of fish caused by salinization stress should be further researched, in addition to the interaction with other environmental stressors, in order to understand the true scope of the consequences of salinization for fish species.

Os censos do INEP como critério para entender a formação em Psicologia: gênese, panorama e indicadores atuais / INEP censuses as a criterion to understand Psychology professional education: genesis, overview,and current indicators

Objetivamos refletir como os censos do INEP podem possibilitar um critério para analisar a formação do psicólogo no Brasil. Estabelecemos uma estratégia metodológica baseada na pesquisa bibliográfica e análise documental. Contextualizamos o surgimento do INEP e a sua lógica de estabelecer o censo do ensino superior pelas figuras de Lourenço Filho e Anísio Teixeira, suas estadas na Universidade de Columbia e apropriações de ideias psicológicas, educacionais e administrativas. Adentramos tais censos, entre 1940-2010, para entender o expansionismo educacional e a formação do psicólogo. No censo de 2020,observamos: predominância de cursos privados sobre os públicos; expansão formativa em cursos interioranos; expressão da mercantilização da Psicologia; discrepância entre os cursos de Bacharelado e Licenciatura; equivalência e diminuição da oferta de cursos de Licenciatura no ensino público e privado. Concluímos que a análise empreendida ajuda a entender o campo da formação do psicólogo em suas nuances históricas, políticas, estatísticas, sociais e educacionais.

We aim to reflect on how the INEP’s censuses mayprovide a criterion to analyze the professional education of psychologists in Brazil.We established a methodological strategy based on bibliographic-research and document analysis. We contextualized the INEP’s emergence and its logic of establishing higher education census through the figures of Lourenço Filho and Anísio Teixeira, their stays at Columbia University and appropriations of psychological, educational and administrative ideas. Weexamedsuch censuses, between1940-2010, to understand the educational expansionism and professional education of psychologists.In the 2020 census, we observe: predominance of private courses over public ones; educationalexpansion in inland courses; expression of a commodified Psychology; discrepancy between the Bachelor’s and the Teaching License Degree in the education of psychologists; equivalence and reduced offers of Psychology Degreecourses in public and private education. We conclude that the analysis undertakenhelps to understand the psychologist professional educationfield in its historical, political, statistical, social and educational nuances.

Os censos do INEP como critério para entender a formação em Psicologia: gênese, panorama e indicadores atuais / INEP censuses as a criterion to understand Psychology professional education: genesis, overview,and current indicators

Objetivamos refletir como os censos do INEP podem possibilitar um critério para analisar a formação do psicólogo no Brasil. Estabelecemos uma estratégia metodológica baseada na pesquisa bibliográfica e análise documental. Contextualizamos o surgimento do INEP e a sua lógica de estabelecer o censo do ensino superior pelas figuras de Lourenço Filho e Anísio Teixeira, suas estadas na Universidade de Columbia e apropriações de ideias psicológicas, educacionais e administrativas. Adentramos tais censos, entre 1940-2010, para entender o expansionismo educacional e a formação do psicólogo. No censo de 2020,observamos: predominância de cursos privados sobre os públicos; expansão formativa em cursos interioranos; expressão da mercantilização da Psicologia; discrepância entre os cursos de Bacharelado e Licenciatura; equivalência e diminuição da oferta de cursos de Licenciatura no ensino público e privado. Concluímos que a análise empreendida ajuda a entender o campo da formação do psicólogo em suas nuances históricas, políticas, estatísticas, sociais e educacionais.

We aim to reflect on how the INEP's censuses mayprovide a criterion to analyze the professional education of psychologists in Brazil.We established a methodological strategy based on bibliographic-research and document analysis. We contextualized the INEP's emergence and its logic of establishing higher education census through the figures of Lourenço Filho and Anísio Teixeira, their stays at Columbia University and appropriations of psychological, educational and administrative ideas. Weexamedsuch censuses, between1940-2010, to understand the educational expansionism and professional education of psychologists.In the 2020 census, we observe: predominance of private courses over public ones; educationalexpansion in inland courses; expression of a commodified Psychology; discrepancy between the Bachelor's and the Teaching License Degree in the education of psychologists; equivalence and reduced offers of Psychology Degreecourses in public and private education. We conclude that the analysis undertakenhelps to understand the psychologist professional educationfield in its historical, political, statistical, social and educational nuances.

Riverscape approaches in practice: perspectives and applications.

Landscape perspectives in riverine ecology have been undertaken increasingly in the last 30 years, leading aquatic ecologists to develop a diverse set of approaches for conceptualizing, mapping and understanding 'riverscapes'. Spatiotemporally explicit perspectives of rivers and their biota nested within the socio-ecological landscape now provide guiding principles and approaches in inland fisheries and watershed management. During the last two decades, scientific literature on riverscapes has increased rapidly, indicating that the term and associated approaches are serving an important purpose in freshwater science and management. We trace the origins and theoretical foundations of riverscape perspectives and approaches and examine trends in the published literature to assess the state of the science and demonstrate how they are being applied to address recent challenges in the management of riverine ecosystems. We focus on approaches for studying and visualizing rivers and streams with remote sensing, modelling and sampling designs that enable pattern detection as seen from above (e.g. river channel, floodplain, and riparian areas) but also into the water itself (e.g. aquatic organisms and the aqueous environment). Key concepts from landscape ecology that are central to riverscape approaches are heterogeneity, scale (resolution, extent and scope) and connectivity (structural and functional), which underpin spatial and temporal aspects of study design, data collection and analysis. Mapping of physical and biological characteristics of rivers and floodplains with high-resolution, spatially intensive techniques improves understanding of the causes and ecological consequences of spatial patterns at multiple scales. This information is crucial for managing river ecosystems, especially for the successful implementation of conservation, restoration and monitoring programs. Recent advances in remote sensing, field-sampling approaches and geospatial technology are making it increasingly feasible to collect high-resolution data over larger scales in space and time. We highlight challenges and opportunities and discuss future avenues of research with emerging tools that can potentially help to overcome obstacles to collecting, analysing and displaying these data. This synthesis is intended to help researchers and resource managers understand and apply these concepts and approaches to address real-world problems in freshwater management.

iPODfish - A new method to infer the historical occurrence of diadromous fish species along river networks.

Available information on diadromous fish species historical occurrences is generally biased and incomplete across species distribution range and spatial scales. This work aims to establish a new methodological framework (iPODfish - Inferring Past Occurrences of Diadromous Fish) to obtain a more complete representation of the historical occurrences of diadromous fish species over their full distribution range. The iPODfish is based on assumptions, rules and thresholds derived from the interplay between freshwater network features, diadromous fish species ecology and known historical occurrence. These are used to establish historical pseudo-occurrences at the segment scale, i.e., locations where the species was most likely to be present or absent. The methodology is expressed by a tree-like representation of a stepwise, information supported, decision process. It has five steps (separating main river segments from tributary segments; accounting for segments specificities; imposing the relative distance threshold; imposing the Strahler value threshold, and; establishing the sub-basin Strahler threshold), divides into two moments of application (main river followed by the tributaries) and establishes presences, pseudo-presences and pseudo-absences. The iPODfish can deal with multiple information sources, cope with data bias and provide a reliable consistent historical occurrence output at the segment scale for the known historical geographical range of the species. Despite its inference nature, iPODfish is still a conservative procedure leading to ecologically coherent outputs that may be applied to any diadromous fish species (with a relevant amount of historical data available) in any river network throughout the globe because the concepts and definitions used are general ecological features of diadromous and freshwater networks. The method outputs are applicable in biogeographical and/or macroecological studies using historical data and may prove useful to the management and conservation of diadromous fish species.

Carl Rogers e a Recepção da Fenomenologia na Psicologia Estadunidense / Carl Rogers and the Phenomenology' Reception in American Psychology

Resumo Objetivou-se revisitar a relação de Rogers com o movimento de recepção da Fenomenologia na Psicologia estadunidense, empregando a noção historiográfica de recepção para investigar o que foi contatado por ele, em seus aspectos históricos internalistas e externalistas. Baseados nas menções de Rogers à Fenomenologia, identificaram-se sete momentos característicos de tal relação, entre 1940-1970. Como resultado, foi constatado que a Fenomenologia que Rogers menciona não é a oriunda da Filosofia europeia, mas advém de um paradigma de ciência alternativo ao positivismo hegemônico no behaviorismo. No contexto clínico, Rogers percebeu implicações desse movimento para o desenvolvimento de pesquisas e intervenções sobre o self. No campo filosófico, ele esboçou uma teoria do conhecimento baseada na experiência tácita e pré-conceitual. Na pesquisa, ele foi simpático ao desenvolvimento de investigações fenomenológicas empíricas, mas não chegou a desenvolver uma. Conclui-se que a Filosofia fenomenológica não influenciou diretamente Rogers, mas o movimento fenomenológico na Psicologia estadunidense sim.

Abstract We aim to revisit Rogers' relationship with the reception movement of Phenomenology in American Psychology. We use the historiographical notion of reception to investigate what was contacted in its internal-external historical aspects. Based on the Rogers mentions to the Phenomenology, we identify seven moments of such relationship, among 1940-1970. The Phenomenology that Rogers mentions does not derives from the European Philosophy, but it rather comes from a paradigm alternative to the hegemonic positivism in the behaviorism. In the clinic, Rogers perceived the implications of this movement for the development of research and interventions on the self. In the philosophy, he outlined a knowledge theory, based on tacit and pre-conceptual experiences. In the research, he was sympathetic to the development of empirical phenomenological investigations but did not develop any. We conclude that the phenomenological Philosophy did not influence Rogers directly, but the phenomenological movement in American Psychology did.

Knowledge Gaps in the Definition of Threats for the Red List Assessment of European Freshwater-Dependent Fish Species.

Freshwater ecosystems are disproportionally important for biodiversity conservation, as they support more than 9% of known animal species while representing less than 1% of the Earth's surface. However, the vast majority of the threats (99%, or 826 out of 837) identified by the International Union for Conservation of Nature Red List of Threatened Species known to affect the 434 known freshwater-dependent fish and lampreys of Europe are not supported by validated published scientific knowledge. This general lack of information about freshwater-dependent fish and lamprey species may have deleterious effects on species conservation, and additional funding is required to fill baseline knowledge gaps.

Major threats to European freshwater fish species.

In Europe, freshwater fish are the richest group amongst European vertebrates and the second most threatened animal group, surpassed only by freshwater molluscs. The identification of threats is a major benefit for conservation efforts, as it allows actions to be bespoke to specific threats imperilling fish communities in sensitive areas. In this work, we analyse all threats identified under the International Union for Conservation of Nature (IUCN) Red List of Threatened Species for all European native freshwater dependent fish and lamprey species and relate them with the species distribution, conservation status and migratory phenology. Results show that the current level of imperilment of European freshwater fish fauna is high, especially in the Iberian Peninsula fish communities where low richness is combined with a proportion of threatened species surpassing 50% in several catchments The most relevant threats affecting European freshwater fish are: "Dams & Water Management/Use", "Droughts", "Invasive Non-Native/Alien Species/Diseases", "Agricultural & Forestry Effluents" and "Fishing & Harvesting Aquatic Resources". The present work contributes to the ultimate goal of species conservation by highlighting the main threats affecting freshwater fish species in Europe and by demonstrating how specific regions need particular attention. Increasing longitudinal connectivity stands out as a measure with the potential to increase species' resilience to the several threats affecting them, and it should be coupled with additional efforts to reduce water pollution, control alien species and effectively manage fishing.

A global-scale screening of non-native aquatic organisms to identify potentially invasive species under current and future climate conditions.

The threat posed by invasive non-native species worldwide requires a global approach to identify which introduced species are likely to pose an elevated risk of impact to native species and ecosystems. To inform policy, stakeholders and management decisions on global threats to aquatic ecosystems, 195 assessors representing 120 risk assessment areas across all six inhabited continents screened 819 non-native species from 15 groups of aquatic organisms (freshwater, brackish, marine plants and animals) using the Aquatic Species Invasiveness Screening Kit. This multi-lingual decision-support tool for the risk screening of aquatic organisms provides assessors with risk scores for a species under current and future climate change conditions that, following a statistically based calibration, permits the accurate classification of species into high-, medium- and low-risk categories under current and predicted climate conditions. The 1730 screenings undertaken encompassed wide geographical areas (regions, political entities, parts thereof, water bodies, river basins, lake drainage basins, and marine regions), which permitted thresholds to be identified for almost all aquatic organismal groups screened as well as for tropical, temperate and continental climate classes, and for tropical and temperate marine ecoregions. In total, 33 species were identified as posing a 'very high risk' of being or becoming invasive, and the scores of several of these species under current climate increased under future climate conditions, primarily due to their wide thermal tolerances. The risk thresholds determined for taxonomic groups and climate zones provide a basis against which area-specific or climate-based calibrated thresholds may be interpreted. In turn, the risk rankings help decision-makers identify which species require an immediate 'rapid' management action (e.g. eradication, control) to avoid or mitigate adverse impacts, which require a full risk assessment, and which are to be restricted or banned with regard to importation and/or sale as ornamental or aquarium/fishery enhancement.

Brain mechanisms of chronic pain: critical role of translational approach.

Chronic pain is a leading cause of disability worldwide and its prevalence is likely to increase over the next decades. Treatment for chronic pain remains insufficient and therapeutical advances have not made comparable progress with that for many chronic disorders, thus amplifying the concern on the future burden of the disease. At the same time, and even after decades of intense research, the underlying pathophysiology of chronic pain remains minimally understood. We believe advancing our current understanding of chronic pain requires mechanistically explicit, hypothesis-driven, and clinically focused models. In this review we highlight some of the main findings over the last decades that have contributed to the present knowledge of brain mechanisms of chronic pain, and how such advances were possible due to a reverse translational research approach. We argue that this approach is essential in the chronic pain field, in order to generate new scientific hypotheses, probe physiological mechanisms, develop therapeutic strategies and translate findings back into promising human clinical trials.