RESUMEN
Standard troponin has long been pivotal in diagnosing coronary syndrome, especially Non-ST-Segment Elevation Myocardial Infarction (NSTEMI). The recent introduction of high-sensitivity troponin (hs-cTnI) has elevated it to the gold standard. Yet, its nuanced role in predicting angiographic lesions and clinical outcomes, notably in specific populations like obesity, remains underexplored. Aim: To evaluate the association between hs-cTnI magnitude in NSTEMI patients and angiographic findings, progression to acute heart failure, and its performance in obesity. Methods: Retrospective study of 208 NSTEMI patients at a large university center (2020-2023). Hs-cTnI values were assessed for angiographic severity, acute heart failure, and characteristics in the obese population. Data collected and diagnostic performance were evaluated using manufacturer-specified cutoffs. Results: 97.12% of patients had a single culprit vessel. Hs-cTnI elevation correlated with angiographic stenosis severity. Performance for detecting severe coronary disease was low, with no improvement using a higher cutoff. No association was found between hs-cTnI and the culprit vessel location. Hs-cTnI did not predict acute heart failure progression. In the obese population, hs-cTnI levels were higher, but acute heart failure occurred less frequently than in non-obese counterparts. Conclusions: In NSTEMI, hs-cTnI elevation is associated with significant stenosis, but not with location or acute heart failure. Obesity correlates with higher hs-cTnI levels but a reduced risk of acute heart failure during NSTEMI.
RESUMEN
Obesity is a disorder that is defined as a complex, multifactorial disease in which an increase of food intake compensates unpleasant emotional states. A qualitative, exploratory study with a sample size of 8 participants age 18 to 25 years old, in Santiago Chile was conducted through structured interviews. The interviews were analyzed using open, axial and selective coding. The analysis found that there is a level of affective activation in obese adolescents when overeating. The emotional response to overeating is driven by unpleasant emotions such as anxiety, anguish, loneliness and sadness; in addition to relevant events that are experienced as triggers. The participants explained that they manifest a negative association in regards to their body image thus feeling societal pressure towards their weight and appearance. It is important to offer new alternatives as well as continuing to better understand the emotional aspects of the disease in regards to understanding, treatment and prevention because of its complex nature. For future investigations, it is suggested to increase the sample size to better confirm the findings
