[One-year survival improvement in lung cancer in France. Results of the prospective real life studies KBP-2000-CPHG and KBP-2010-CPHG]. / Amélioration de la survie à 1 an dans le cancer du poumon en France. Résultats des études prospectives en vie réelle, KBP-2000-CPHG et KBP-2010-CPHG.

INTRODUCTION: The French college of general hospital respiratory physicians (CPHG) has conducted 10 years apart two prospective observational studies to assess changes in the primary lung cancer epidemiology and outcomes, including 1-year mortality. METHODS: In 2000 and 2010, all volunteer adult patients followed in the respiratory department of general hospitals participating in the study were consecutively included if their lung cancer was histologically or cytologically diagnosed between 01 January and 31 December (sample date). Their vital status at least 1 year after inclusion and date of death (if applicable) were collected. RESULTS: Respectively, 5667 and 7051 patients were included in the study in 2000 and 2010 and vital status of 5441 (96.0%) and 6981 (99%) patients known. One-year mortality rate was 61.8% in 2000 and 56.4% in 2010 (P<0.0001). Mortality rate significantly decreased from 2000 to 2010 in non-small-cell lung cancer (60.7% vs. 55.2%; P<0.0001) but not in small-cell lung cancer (66.9% vs. 64.2%; P=0.22). The year of diagnosis was an independent risk factor of mortality (OR=0.84; 95% CI: 0.77-0.91; P<0.0001). CONCLUSION: Although it remains low (43.6% in 2010), life expectancy at 1 year for patients with lung cancer has improved in 10 years. Five-year results are expected to show whether this improvement is maintained or not over time.

[Interventional bronchoscopy in the management of lung cancer]. / Place de la bronchologie interventionnelle dans la prise en charge des cancers bronchiques.

The techniques of interventional bronchoscopy have acquired an important place in the management of lung cancer. Techniques to relieve obstruction requiring the use of rigid bronchoscopy under general anaesthetic were the first to be introduced. Laser therapy, which was initially used for coagulation can be replaced by electrocautery. The development of endobronchial stents provides a natural complement to techniques aimed at clearing bronchial obstruction by helping to maintain patency in the long term. Other therapeutic techniques can be deployed in association with those already mentioned, including photodynamic therapy and brachytherapy using low doses of radiation applied locally. These have particular potential for the treatment of early disease. Questions remain as to the precise indications for the different techniques and of how to identify which approach is most appropriate for individual patients.