Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Más filtros










Base de datos
Intervalo de año de publicación
1.
Fitoterapia ; 165: 105424, 2023 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-36603699

RESUMEN

Five unusual kaurane diterpenes, designated as bezerraditerpenes A-E (1-5), along with six known ones (6-11), were isolated from the hexane extract of the stems of Erythroxylum bezerrae. Their structures were elucidated based on the interpretation of the NMR spectroscopy, mass spectrometry, and X-ray diffraction analysis. The anti-inflammatory potential of the diterpenes 1-11 was screened through cellular viability and lipopolysaccharide (LPS)-induced nitric oxide (NO) production on murine macrophage-like cells RAW 264.7. Diterpene 6 (cauren-6ß-ol) showed potent cytotoxicity and increased ability to inhibit NO production. Diterpenes 1 (bezerraditerpene A), 2 (bezerraditerpene B), and 8 (ent-kaur-16-ene-3ß,15ß-diol) exhibited the same significant anti-inflammatory activity with NO CI50 inhibition (3.21-3.76 µM) without cytotoxicity, in addition to decreasing the levels of pro-inflammatory cytokines TNF-α and IL-6 in LPS-induced RAW264.7 cells.


Asunto(s)
Diterpenos de Tipo Kaurano , Diterpenos , Animales , Ratones , Antiinflamatorios/farmacología , Diterpenos/farmacología , Diterpenos de Tipo Kaurano/farmacología , Diterpenos de Tipo Kaurano/química , Lipopolisacáridos/farmacología , Estructura Molecular , Óxido Nítrico , Erythroxylaceae/química
2.
Phytochemistry ; 178: 112458, 2020 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-32888670

RESUMEN

Six previously undescribed tropane alkaloids, designated as erythrobezerrines A-F, were isolated from the EtOH extract from the stem bark of Erythroxylum bezerrae Plowman. Their structures were elucidated based on the interpretation of the NMR and MS data and in some instances, confirmed by X-ray diffraction analysis. The cytotoxicity of the isolated compounds was evaluated against the cancer cell lines L929, PC-3, HCT-116, SNB-19 and NCI-H460, but only erythrobezerrine C showed moderate activity with IC50 values of 3.38 and 5.43 µM for HCT-116 and NCI-H460, respectively.


Asunto(s)
Erythroxylaceae , Espectroscopía de Resonancia Magnética , Estructura Molecular , Corteza de la Planta , Tropanos
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA
...