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Experience sampling (ES) - also referred to as ecological momentary assessment (EMA) - is a data collection method that involves asking study participants to report on their thoughts, feelings, behaviors, activities, and environments in (or near) real time. ES/EMA is typically administered using an intensive longitudinal design (repeated assessments within and across days). Although use of ES/EMA is widespread in psychology and health sciences, uptake of the method among sociologists has been limited. We argue that ES/EMA offers key advantages for the investigation of sociologically relevant phenomena, particularly in light of recent disciplinary emphasis on investigating the everyday mechanisms through which social structures and micro (individual and relational) processes are mutually constitutive. We describe extant and potential research applications illustrating advantages of ES/EMA regarding enhanced validity, disentangling short-term dynamics, and the potential for linkage with spatially and temporally referenced data sources. We also consider methodological challenges facing sociological research using ES/EMA.
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A longstanding urban sociological literature emphasizes the geographic isolation of city dwellers in residence and everyday routines, expecting exposures to neighborhood racial and socio-economic structure driven principally by city-wide segregation and the role of proximity and homophily in mobility. The compelled mobility approach emphasizes the uneven distribution of organizational and institutional resources across urban space, expecting residents of poor Black-segregated neighborhoods to exhibit non-trivial levels of everyday exposure to White, non-poor areas for resource seeking. We use two sets of location data in the hypersegregated Chicago metro to examine these two approaches: Global Positioning System (GPS) location tracking on a sample of older adults from the Chicago Health and Activity Space in Real-Time (CHART) study and travel diaries on a sample of younger adults by the Chicago Metropolitan Agency for Planning (CMAP). We introduce a novel and flexible individual-level method for assessing activity space exposures that accounts for the spatially proximate environment around home. Analyses reveal that activity space contexts mimic the racial/ethnic and socio-economic landscape of respondents' broad residential environment. However, after residential-based adjustment, Black younger (CMAP) adults from poor Black neighborhoods are disproportionately exposed to Whiter, less Black but less non-poor neighborhoods. Older (CHART) adult activity spaces align more closely with their residential areas; however, activity spaces of poor-Black-neighborhood-residing CHART Blacks are systematically poorer and, less consistently, more Black and less White after local area adjustment. Implications for understanding contextual exposures on well-being and the potential for age or cohort differences in isolation are discussed.
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BACKGROUND: Child maltreatment may alter the way that adolescents engage in and interact within the places they visit in their daily routines, namely youth activity spaces. Thus, it is important to understand how maltreatment experiences are linked to adolescents' exposure to environmental and contextual risks within their activity spaces. OBJECTIVE: The aim of the study was to explore the associations between child maltreatment and patterns of risk exposures within youth activity spaces among adolescents. PARTICIPANTS AND SETTING: Study participants were 1364 adolescents between the ages of 11 and 17, living in a Midwest state in the United States. METHODS: We linked data from the Adolescent Health and Development in Context (AHDC) study and the Statewide Automated Child Welfare Information System (SACWIS). A three-step latent class analysis (LCA) was employed. RESULTS: Three contextual risk exposure classes were identified: 1) The aggression/violence class (7.7 %); 2) The smoking and drinking class (12.3 %); and 3) The non-risk class (80.0 %). Adolescents with more maltreatment reports were more likely to be in the aggression/violence class compared to the non-risk class. CONCLUSIONS: Capitalizing on the novel linkage between administrative child welfare records and ecological momentary assessment (EMA)-based youth spatial/environmental exposure data, we found a positive link between the number of maltreatment reports made to child protective services and membership in the aggression/violence class. Intervention efforts should be directed toward youths with a history of child maltreatment, ensuring that they have access to safe, structured, and non-violent environments during their daily routines.
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Maltrato a los Niños , Análisis de Clases Latentes , Humanos , Adolescente , Maltrato a los Niños/estadística & datos numéricos , Maltrato a los Niños/psicología , Femenino , Masculino , Niño , Medio Oeste de Estados Unidos/epidemiología , Fumar/epidemiología , Fumar/psicología , Consumo de Bebidas Alcohólicas/psicología , Consumo de Bebidas Alcohólicas/epidemiología , Agresión/psicología , Conducta del Adolescente/psicología , Factores de RiesgoRESUMEN
Collective efficacy-the capacity of communities to exert social control toward the realization of their shared goals-is a foundational concept in the urban sociology and neighborhood effects literature. Traditionally, empirical studies of collective efficacy use large sample surveys to estimate collective efficacy of different neighborhoods within an urban setting. Such studies have demonstrated an association between collective efficacy and local variation in community violence, educational achievement, and health. Unlike traditional collective efficacy measurement strategies, the Adolescent Health and Development in Context (AHDC) Study implemented a new approach, obtaining spatially-referenced, place-based ratings of collective efficacy from a representative sample of individuals residing in Columbus, OH. In this paper we introduce a novel nonstationary spatial model for interpolation of the AHDC collective efficacy ratings across the study area, which leverages administrative data on land use. Our constructive model specification strategy involves dimension expansion of a latent spatial process and the use of a filter defined by the land-use partition of the study region to connect the latent multivariate spatial process to the observed ordinal ratings of collective efficacy. Careful consideration is given to the issues of parameter identifiability, computational efficiency of an MCMC algorithm for model fitting, and fine-scale spatial prediction of collective efficacy.
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PURPOSE: The everyday experience of safety promotes health and successful development during adolescence. To date, few studies have examined racial variation in the spatial determinants of in-the-moment perceived safety. METHODS: Drawing on data from the Columbus, Ohio-based Adolescent Health and Development in Context study (N = 1,405), we consider the influence of intraindividual variability in Global Positioning System-based exposure to both high-proportion White urban neighborhoods and neighborhood violence for the everyday location-based safety perceptions of Black and White youth (ages 11-17) as captured by ecological momentary assessment. RESULTS: Exposure to higher area-level violence reduces youths' safety perceptions. Momentary exposure to residentially White-dominated neighborhoods also reduces perceived safety, but only for Black youth who spend more time, on average, in White areas. In contrast, we observe some limited evidence that White youth perceive greater safety when in White neighborhoods if they spend more time in white neighborhoods on average. DISCUSSION: These findings point to the need for greater attention to in situ experiences in understanding the origins of racial disparities in health and wellbeing. For Black youth, a restricted focus on the consequences of residing in Black segregated neighborhoods may obscure potentially health consequential exposures beyond these areas.
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Negro o Afroamericano , Características de la Residencia , Seguridad , Población Urbana , Blanco , Adolescente , Niño , Femenino , Humanos , Masculino , Negro o Afroamericano/psicología , Sistemas de Información Geográfica , Ohio , Percepción , Violencia/etnologíaRESUMEN
Depression and anxiety symptoms are on the rise among adolescents. With increasing evidence that cellular aging may be associated with depressive and anxiety symptoms, there is an urgent need to identify the social environment context that may moderate this link. This study addresses this research gap by investigating the moderating role of the social environment on the relation between telomere length and emotional health among adolescents. Participants were 411 non-Hispanic (88.56%) Black (100%) adolescents (M = 14.23 years, SD = 1.85, female = 54%) in a major metropolitan city. Youth and parents reported on an array of social risk and protective factors, and youth provided DNA samples for telomere length measurement. Results demonstrated that the association of telomere length and anxiety symptoms was stronger among youth with higher perceived stress or lower school belongingness, and the association of telomere length with depressive symptoms was stronger under conditions of higher parent inter-partner psychological aggression. The results enhance our understanding of the complex associations between biological aging, the social environment, and mental health in adolescence.
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Depresión , Emociones , Humanos , Adolescente , Femenino , Depresión/psicología , Ansiedad/psicología , Medio Social , TelómeroRESUMEN
BACKGROUND: Although there is a well-established link between child maltreatment and adolescent substance use, it remains unclear if and how longitudinal patterns of maltreatment experiences are associated with substance use in adolescence. OBJECTIVE: The purpose of the study was to examine how distinct patterns of longitudinal maltreatment experiences are associated with adolescent substance use. PARTICIPANTS AND SETTING: The participants were 899 adolescents from the Longitudinal Studies of Child Abuse and Neglect (LONGSCAN). METHODS: We conducted repeated measures latent class analysis (RMLCA) to identify patterns of physical abuse, sexual abuse, and neglect from birth to age 17 and their relations to tobacco, alcohol, and marijuana use at age 18. RESULTS: RMLCA identified three physical abuse classes (Stable low physical abuse; School age peak physical abuse; Physical abuse primarily in infancy/toddlerhood), two sexual abuse classes (Stable no/low sexual abuse; School age peak sexual abuse), and three neglect classes (High neglect in childhood; Neglect primarily in infancy/toddlerhood; Neglect primarily at school age). Adolescents in the school age peak physical abuse class showed greater alcohol, cigarette, and marijuana use, compared to other physical abuse classes. Similarly, adolescents in the school age peak sexual abuse class showed greater substance use than those in the stable no/low sexual abuse class. Lastly, adolescents in the neglect primarily in infancy/toddlerhood class showed significantly less substance use than those in the other two neglect classes. CONCLUSIONS: Findings highlight the importance of early intervention and ongoing maltreatment prevention.
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Maltrato a los Niños , Trastornos Relacionados con Sustancias , Humanos , Niño , Adolescente , Trastornos Relacionados con Sustancias/epidemiología , Abuso Físico , Estudios Longitudinales , Análisis de Clases Latentes , EtanolRESUMEN
Scientists have, for some time, recognized that development unfolds in numerous settings, including families, schools, neighborhoods, and organized and unorganized activity settings. Since the turn of the 20th century, the body of mainstream neighborhood effects scholarship draws heavily from the early 20th century Chicago School of Sociology frameworks and have been situating development in neighborhood contexts and working to identify the structures and processes via which neighborhoods matter for a range of developmental outcomes, especially achievement, behavioral and emotional problems, and sexual activity. From this body of work, two new areas of developmental scholarship are emerging. Both areas are promising for advancing an understanding of child development in context. First, cultural-developmental neighborhood researchers are advancing neighborhood effects research that explicitly recognizes the ways that racial, ethnic, cultural, and immigrant social positions matter for neighborhood environments and for youths' developmental demands, affordances, experiences, and competencies. This body of work substantially expands the range of developmental outcomes examined in neighborhood effects scholarship to recognize normative physical, emotional, cognitive, behavioral, social, and cultural competencies that have largely been overlooked in neighborhood effects scholarship that espoused a more color-blind developmental approach. Second, activity space neighborhood researchers are recognizing that residential neighborhoods have important implications for broader activity spaces-or the set of locations and settings to which youth are regularly exposed, including, for example, schools, work, organized activities, and hang-outs. They are using newer technologies and geographic frameworks to assess exposure to residential neighborhood and extra-neighborhood environments. These perspectives recognize that time (i.e., from microtime to mesotime) and place are critically bound and that exposures can be operationalized at numerous levels of the ecological system (i.e., from microsystems to macrosystems). These frameworks address important limitations of prior development in context scholarship by addressing selection and exposure. Addressing selection involves recognizing that families have some degree of choice when selecting into settings and variables that predict families' choices (e.g., income) also predict development. Considering exposure involves recognizing that different participants or residents experience different amounts of shared and nonshared exposures, resulting in both under-and over-estimation of contextual effects. Activity space scholars incorporate exposure to the residential neighborhood environments, but also to other locations and settings to which youth are regularly exposed, like schools, after-school settings, work, and hang-outs. Unfortunately, the cultural-development and activity space streams, which have both emerged from early 20th century work on neighborhood effects on development, have been advancing largely independently. Thus, the overarching aim of this monograph is to integrate scholarship on residential neighborhoods, cultural development, and activity spaces to advance a framework that can support a better understanding of development in context for diverse groups. In Chapters I and II we present the historical context of the three streams of theoretical, conceptual, and methodological research. We also advance a comprehensive cultural-developmental activity space framework for studying development in context among children, youth, and families that are ethnically, racially, and culturally heterogeneous. This framework actively recognized diversity in ethnic, racial, immigrant, and socioeconomic social positions. In Chapters III-V we advance specific features of the framework, focusing on: (1) the different levels of nested and nonnested ecological systems that can be captured and operationalized with activity space methods, (2) the different dimensions of time and exposures or experiences that can be captured and operationalized by activity space methods, and (3) the importance of settings structures and social processes for identifying underlying mechanisms of contextual effects on development. Structures are setting features related to the composition and spatial arrangement of people and institutions (e.g., socioeconomic disadvantage, ethnic/racial compositions). Social processes represent the collective social dynamics that take place in settings, like social interactions, group activities, experiences with local institutions, mechanisms of social control, or shared beliefs. In Chapter VI, we highlight a range of methodological and empirical exemplars from the United States that are informed by our comprehensive cultural-developmental activity space framework. These exemplars feature both quantitative and qualitative methods, including method mixing. These exemplars feature both quantitative and qualitative methods, including method mixing. The exemplars also highlight the application of the framework across four different samples from populations that vary in terms of race, ethnicity, gender, age, socioeconomic status (SES), geographic region, and urbanicity. They capture activity space characteristics and features in a variety of ways, in addition to incorporating family shared and nonshared activity space exposures. Finally, in Chapter VII we summarize the contributions of the framework for advancing a more comprehensive science of development in context, one that better realizes major developmental theories emphasizing persons, processes, contexts, and time. Additionally, we offer a place-based, culturally informed developmental research agenda to meet the needs of an increasingly diverse population.
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Desarrollo Infantil , Etnicidad , Niño , Humanos , Adolescente , Estados Unidos , Proyectos de InvestigaciónRESUMEN
BACKGROUND: Telomere length (TL), a biomarker of cellular aging, is influenced by adverse life experiences. Although depression and anxiety are associated with shorter TL in adults, the relationship in younger ages has received little attention. We examined relationships between depression and anxiety diagnoses and symptomatology and TL in adolescence, an important developmental window for early intervention. Sex differences in relationships were also examined. METHODS: Wave 1 survey and TL data from the Adolescent Health and Development in Context study were analyzed (N = 995). Depression and anxiety diagnosis were parent-reported measures categorized as: current diagnosis, prior diagnosis, and never diagnosed (reference category). Depressive symptoms were measured via adolescent-report using nine items from the Center for Epidemiologic Studies-Depression scale, short form. Anxiety symptoms were measured via adolescent-report using eight items from the pediatric anxiety scale obtained from the Patient-Reported Outcomes Measurement Information System. Genomic DNA was isolated from 500 µL saliva via ethanol precipitation. Genomic DNA TL was assessed using monoplexed quantitative polymerase chain reactions. Relative T/S quantities were calculated in accordance with established procedures. Covariates included sociodemographic factors (sex, age, race/ethnicity, caregiver marital status and education level, and household income), pubertal development, and season of collection. Descriptive and multivariable linear regression analyses were conducted, including an examination of sex as a moderator in the relationships between depression, anxiety, and TL. RESULTS: In multivariable analysis, adolescents with a current depression diagnosis (b = -0.26, p < .05), but not a prior diagnosis (b =0.05, p > .05) had shorter TL than those who were never diagnosed; higher depressive symptom scores were associated with shorter TL (b = -0.12, p < .05). No significant associations were found between anxiety diagnosis and TL; however, higher anxiety symptom scores were associated with shorter TL (b = -0.14, p < .01). Sex did not significantly moderate any of the relationships between depression, anxiety and TL. CONCLUSIONS: Depression and anxiety were associated with shorter TL in this diverse community sample of adolescents and the findings highlight the potential for impaired mental health to contribute to cellular senescence as early as adolescence. Prospective research on the long-term effect of depression and anxiety occurring earlier in the life span on TL over time is needed, including examination of potential mechanisms that may accelerate or buffer the negative effects of impaired mental health on TL.
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Ansiedad , Depresión , Adulto , Humanos , Masculino , Adolescente , Femenino , Niño , Depresión/genética , Estudios Prospectivos , Ansiedad/genética , Senescencia Celular , Telómero , Acortamiento del TelómeroRESUMEN
The formative work of Jane Jacobs underscores the combination of "eyes on the street" and trust between residents in deterring crime. Nevertheless, little research has assessed the effects of residential street monitoring on crime due partly to a lack of data measuring this process. We argue that neighborhood-level rates of households with dogs captures part of the residential street monitoring process core to Jacobs' hypotheses and test whether this measure is inversely associated with property and violent crime rates. Data from a large-scale marketing survey of Columbus, OH, USA residents (2013; n = 43,078) are used to measure census block group-level (n = 595) rates of households with dogs. Data from the Adolescent Health and Development in Context study are used to measure neighborhood-level rates of trust. Consistent with Jacobs' hypotheses, results indicate that neighborhood concentration of households with dogs is inversely associated with robbery, homicide, and, to a less consistent degree, aggravated assault rates within neighborhoods high in trust. In contrast, results for property crime suggest that the inverse association of dog concentration is independent of levels of neighborhood trust. These associations are observed net of controls for neighborhood sociodemographic characteristics, temporally lagged crime, and spatial lags of trust and dog concentration. This study offers suggestive evidence of crime deterrent benefits of local street monitoring and dog presence and calls attention to the contribution of pets to other facets of neighborhood social organization.
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OBJECTIVE: Black-White disparities in physiological stress during adolescence are increasingly evident but remain incompletely understood. We examine the role of real-time perceptions of safety in the context of everyday routines to gain insight into the sources of observed adolescent racial differences in chronic stress as measured by hair cortisol concentration (HCC). METHOD: We combined social survey, ecological momentary assessment (EMA), and hair cortisol data on 690 Black and White youth ages 11-17 from wave 1 of the Adolescent Health and Development in Context (AHDC) study to investigate racial differences in physiological stress. Individual-level, reliability-adjusted measures of perceived unsafety outside the home were drawn from a week-long smartphone-based EMA and tested for association with hair cortisol concentration. RESULTS: We observed a statistically significant interaction (p < .05) between race and perceptions of unsafety. For Black youth, perceived unsafety was associated with higher HCC (p < .05). We observed no evidence of an association between perceptions of safety and expected HCC for White youth. For youth who perceive their out-of-home activity locations to be consistently safe, the racial difference in expected HCC was not statistically significant. At the high end of perceived unsafety, however, Black-White differences in HCC were pronounced (0.75 standard deviations at the 95th percentile on perceived unsafety; p < .001). DISCUSSION: These findings call attention to the role of everyday perceptions of safety across non-home routine activity contexts in explaining race differences in chronic stress as assessed by hair cortisol concentrations. Future research may benefit from data on in situ experiences to capture disparities in psychological and physiological stress.
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Población Negra , Cabello , Hidrocortisona , Seguridad , Estrés Psicológico , Adolescente , Humanos , Población Negra/psicología , Cabello/química , Hidrocortisona/análisis , Reproducibilidad de los Resultados , Estrés Psicológico/psicología , Niño , Blanco/psicologíaRESUMEN
Human mobility analysis plays a crucial role in urban analysis, city planning, epidemic modeling, and even understanding neighborhood effects on individuals' health. Often, these studies model human mobility in the form of co-location networks. We have recently seen the tremendous success of network representation learning models on several machine learning tasks on graphs. To the best of our knowledge, limited attention has been paid to identifying communities using network representation learning methods specifically for co-location networks. We attempt to address this problem and study user mobility behavior through the communities identified with latent node representations. Specifically, we select several diverse network representation learning models to identify communities from a real-world co-location network. We include both general-purpose representation models that make no assumptions on network modality as well as approaches designed specifically for human mobility analysis. We evaluate these different methods on data collected in the Adolescent Health and Development in Context (AHDC) study. Our experimental analysis reveals that a recently proposed method (LocationTrails) offers a competitive advantage over other methods with respect to its ability to represent and reflect community assignment that is consistent with extant findings regarding neighborhood racial and socio-economic differences in mobility patterns. We also compare the learned activity profiles of individuals by factoring in their residential neighborhoods. Our analysis reveals a significant contrast in the activity profiles of individuals residing in white-dominated vs. black-dominated neighborhoods and advantaged vs. disadvantaged neighborhoods in a major metropolitan city of United States. We provide a clear rationale for this contrastive pattern through insights from the sociological literature.
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Telomere length (TL) is proposed to play a mechanistic role in how the exposome affects health outcomes. Little is known about TL during adolescence, a developmental period during which precursors of adult-onset health problems often emerge. We examined health and demographic sources of variation in TL in 899 youth aged 11-17. Demographic and health information included age, sex, race, household income, caregiver age and marital status, youth tobacco exposure, body mass index, pubertal status, health problems, medication use, and season of data collection. Genomic DNA was extracted from saliva, and T/S ratios were computed following qPCR. Age, race, season of data collection, and household income were associated with the telomere to single copy (T/S) ratio. We found that T/S ratios were larger at younger ages, among Black youth, for saliva collected during autumn and winter, and among households with higher income. Analyses stratified by race revealed that the association between age and T/S ratio was present for Black youth, that season of collection was present across races, but that family demographic associations with T/S ratio varied by race. The results provide information for future telomere research and highlight adolescence as a potentially important developmental phase for racial disparities in telomere shortening and health.
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Acortamiento del Telómero , Telómero , Adulto , Adolescente , Humanos , Índice de Masa Corporal , ADN , DemografíaRESUMEN
In the United States, Black youth tend to grow up in remarkably less resourced neighborhoods than White youth. This study investigates whether and to what extent Black youth are moreover exposed to less resourced activity spaces beyond the home. We draw on GPS data from a large sample of urban youth in the Columbus, Ohio-based Adolescent Health and Development in Context study (2014-2016) to examine to what extent Black youth experience nontrivial, disproportionate levels of exposure to more disadvantaged and segregated contexts in their daily routines compared with similarly residentially situated White youth. Specifically, we estimate Black-White differences in nonhome exposure to concentrated disadvantage, racial segregation, collective efficacy, and violent crime. We find that Black youths' activity spaces have substantially higher rates of racial segregation and violent crime than those of White youth, and substantially lower levels of collective efficacy-even after accounting for a host of individual- and home neighborhood-level characteristics. We find more modest evidence of differences in exposure to socioeconomic disadvantage. These findings have important implications for neighborhood-centered interventions focused on youth well-being and the contextual effects and segregation literatures more generally.
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Segregación Social , Adolescente , Humanos , Grupos Raciales , Características de la Residencia , Factores Socioeconómicos , Estados Unidos , ViolenciaRESUMEN
Glycogen is the major glucose reserve in eukaryotes, and defects in glycogen metabolism and structure lead to disease. Glycogenesis involves interaction of glycogenin (GN) with glycogen synthase (GS), where GS is activated by glucose-6-phosphate (G6P) and inactivated by phosphorylation. We describe the 2.6 Å resolution cryo-EM structure of phosphorylated human GS revealing an autoinhibited GS tetramer flanked by two GN dimers. Phosphorylated N- and C-termini from two GS protomers converge near the G6P-binding pocket and buttress against GS regulatory helices. This keeps GS in an inactive conformation mediated by phospho-Ser641 interactions with a composite "arginine cradle". Structure-guided mutagenesis perturbing interactions with phosphorylated tails led to increased basal/unstimulated GS activity. We propose that multivalent phosphorylation supports GS autoinhibition through interactions from a dynamic "spike" region, allowing a tuneable rheostat for regulating GS activity. This work therefore provides insights into glycogen synthesis regulation and facilitates studies of glycogen-related diseases.
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Glucosiltransferasas , Glucógeno Sintasa , Glucosa-6-Fosfato/metabolismo , Glucosiltransferasas/genética , Glucosiltransferasas/metabolismo , Glucógeno/metabolismo , Glucógeno Sintasa/genética , Glucógeno Sintasa/metabolismo , Glicoproteínas/metabolismo , Humanos , Músculo Esquelético/metabolismo , FosforilaciónRESUMEN
Foundational urban social theories view heterogeneity of exposure to spatial and social contexts as essential aspects of the urban experience. In contrast, contemporary neighborhood research emphasizes the isolation of city dwellers - particularly residents of racially segregated neighborhoods. Using geospatial data on a sample of youth from the 2014-16 Columbus, OH-based Adolescent Health and Development in Context study, we explore the extent to which the neighborhood locations of everyday activities vary with respect to residential racial composition. In the context of segregated US metro areas, the geographic isolation approach expects home census tract racial composition to powerfully shape the racial composition of activity location neighborhoods. In this view, Black youth residing in high proportion Black neighborhoods are expected to spend the vast majority of their time exposed to similarly Black-concentrated neighborhoods. Consistent with an alternative compelled mobility approach, we find that Black youth residing in high proportion Black neighborhoods exhibit among the highest levels of heterogeneity in the racial composition of neighborhoods encountered. Moreover, Black youth residing in high proportion Black neighborhoods are expected to spend 39% of their non-home time (roughly 2.5 hours a day) in low proportion Black neighborhoods compared to 23% (1.5 hours) in high proportion Black neighborhoods. Exposures to low proportion Black neighborhoods among these youth are largely driven by organizationally-based resource seeking. These findings call into question the assumption that residence in Black segregated neighborhoods leads to homogeneously Black segregated neighborhood exposures and encourage theoretical development and data collection strategies that acknowledge the potential for significant heterogeneity in the everyday neighborhood experiences of urban youth.
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The inadequacies of residential census geography in capturing urban residents' routine exposures have motivated efforts to more directly measure residents' activity spaces. In turn, insights regarding urban activity patterns have been used to motivate alternative residential neighborhood measurement strategies incorporating dimensions of activity space in the form of egocentric neighborhoods-measurement approaches that place individuals at the center of their own residential neighborhood units. Unexamined, however, is the extent to which the boundaries of residents' own self-defined residential neighborhoods compare with census-based and egocentric neighborhood measurement approaches in aligning with residents' routine activity locations. We first assess this question, examining whether the boundaries of residents' self-defined residential neighborhoods are in closer proximity to the coordinates of a range of activity location types than are the boundaries of their census and egocentric residential neighborhood measurement approaches. We find little evidence that egocentric or, crucially, self-defined residential neighborhoods better align with activity locations, suggesting a division in residents' activity locations and conceptions of their residential neighborhoods. We then examine opposing hypotheses about how self-defined residential neighborhoods and census tracts compare in socioeconomic and racial composition. Overall, our findings suggest that residents bound less segregated neighborhoods than those produced by census geography, but self-defined residential neighborhoods still reflect a preference toward homophily when considering areas beyond the immediate environment of their residence. These findings underscore the significance of individuals' conceptions of residential neighborhoods to understanding and measuring urban social processes such as residential segregation and social disorganization.
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BACKGROUND: Exposure to racism and associated adversities, such as poverty, is hypothesized to contribute to racial inequities in health via stress and immune pathways. Furthermore, the effects of adversity may be more salient during sensitive developmental periods. Our study examined racial differences in stress and immune biomarkers during adolescence and the effects of exposure to economic adversity at distinct developmental time periods and cumulatively in accounting for potential racial differences. METHODS: Secondary analysis of the Adolescent Health and Development in Context study was conducted. Data were derived from self-administered surveys; interviews; smartphone-based, geographic-explicit ecological momentary assessment; stress biomarkers (evening salivary cortisol over six nights and hair cortisol); and immune biomarkers (salivary shedding of Epstein-Barr virus [EBV] DNA among EBV-positive adolescents). Current socioeconomic status measures included annual household income and caregiver education. Caregivers also reported experiences of bankruptcy, difficulty paying bills, receipt of food stamps/Supplemental Nutrition Assistance Program/electronic benefit transfer, and job loss when the child was of ages birth-5 years, 6-10 years, and 11 years or older. An affirmative response to any item was defined as exposure to economic adversity for that developmental time period (yes/no). A cumulative economic adversity measure was calculated as the sum of exposures across developmental periods (0 = never exposed to 3 = exposed across all time periods). Descriptive and multivariable regression analyses were conducted, accounting for covariates. RESULTS: Black/African American adolescents had higher salivary cortisol concentration, higher hair cortisol concentration, and an increased odd of salivary shedding of EBV DNA compared to White adolescents. Racial differences were not attenuated by the current socioeconomic status or economic adversity (developmental period or cumulatively). DISCUSSION: Our study provides evidence that stress and immune biomarkers differ by race as early as adolescence and may be one pathway through which racism and associated adversities contribute to racial health inequities. Further research on the contribution of multiple adversities beyond poverty to racial inequities in physiological stress and health is critical for informing effective prevention and intervention efforts.
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Biomarcadores/análisis , Clase Social , Adolescente , Negro o Afroamericano/etnología , Negro o Afroamericano/psicología , Negro o Afroamericano/estadística & datos numéricos , Niño , Femenino , Herpesvirus Humano 4/inmunología , Herpesvirus Humano 4/patogenicidad , Humanos , Hidrocortisona/análisis , Masculino , Ohio , Saliva/metabolismo , Población Urbana/estadística & datos numéricosRESUMEN
The ecdysone receptor (EcR) possesses the remarkable capacity to adapt structurally to different types of ligands. EcR binds ecdysteroids, including 20-hydroxyecdysone (20E), as well as nonsteroidal synthetic agonists such as insecticidal dibenzoylhydrazines (DBHs). Here, we report the crystal structures of the ligand-binding domains of Heliothis virescens EcR/USP bound to the DBH agonist BYI09181 and to the imidazole-type compound BYI08346. The region delineated by helices H7 and H10 opens up to tightly fit a phenyl ring of the ligands to an extent that depends on the bulkiness of ring substituent. In the structure of 20E-bound EcR, this part of the ligand-binding pocket (LBP) contains a channel filled by water molecules that form an intricate hydrogen bond network between 20E and LBP. The water channel present in the nuclear receptor bound to its natural hormone acts as a critical molecular adaptation spring used to accommodate synthetic agonists inside its binding cavity.
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BACKGROUND: Emerging evidence indicates that exposure to police-related deaths is associated with negative health and wellbeing outcomes among black people. Yet, no study to date has directly examined the biological consequences of exposure to police-related deaths for urban black youth. METHODS AND FINDINGS: We employ unique data from the 2014-16 Adolescent Health and Development in Context (AHDC) study - a representative sample of youth ages 11 to 17 residing in the Columbus, OH area. A subsample of participants contributed nightly saliva samples for cortisol for up to six days, providing an opportunity to link recent exposures to police-related deaths within the residential county to physiological stress outcomes during the study period (N = 585). We examine the effect of exposure to a recent police-related death in the same county on the physiological stress (nightly cortisol) levels of black youth. We find evidence of elevated average levels of nightly cortisol (by 46%) for black boys exposed to a police-related death of a black victim in the 30 days prior to the subject's cortisol collection. We find no evidence of police-related death effects on the physiological stress levels of black girls or white youth. CONCLUSIONS: These analyses indicate that police-related deaths influence the biological functioning of black boys, with potential negative consequences for health. We consider the implications of exposure to lethal police violence among black boys for understanding racial disparities in health more broadly.