Resolution of Wing-Beating Tremor and Magnetic Resonance Imaging Lesions in Wilson's Disease Following Penicillamine.

Background: The wing-beating tremor, characteristic of Wilson's disease (WD), is a disabling symptom that can be resistant to anti-copper and anti-tremor medications. Phenomenology Shown: This video illustrates severe bilateral wing-beating tremor, moderate head and lower limb tremors, mild cervical dystonia, and subtle cerebellar ataxia, with nearly resolution after penicillamine treatment. Educational Value: This case highlights a typical aspect of WD, emphasizing the importance of early detection and treatment, and its correlation with MRI findings. Highlights: This case highlights the typical wing-beating tremor in Wilson's disease and its correlation with the involvement of the dentato-rubro-thalamic pathway. The early diagnosis and initiation of treatment with penicillamine resulted in an excellent clinical and radiological response.

Digital Planning for Immediate Implants in Anterior Esthetic Area: Immediate Result and Follow-Up after 3 Years of Clinical Outcome-Case Report.

In this case report, we demonstrate how the correct positioning of implants, associated with optimal gingival conditioning, and the correct choice of biomaterial can yield very predictable and fantastic aesthetic results. OBJECTIVE: We aimed to use dental implants to rehabilitate the area of elements #11 and #21 in a satisfactory surgical and prosthetic manner, using guided surgery, connective tissue, nano-biomaterials, and a porcelain prosthesis. CASE REPORT: A 32-year-old male patient presented with bone loss of elements #11 and #21, which was proven radiographically and clinically. Thus, oral rehabilitation with the use of dental implants was required. It was decided to proceed via digital planning with the DSD program (Digital smile design) and with the software Exoplan, (Smart Dent-Germany) whenever it was possible to plan immediate provisional and accurate dental implant positioning through reverse diagnostics (Software Exoplan, Smart Dent-German). The dental elements were extracted atraumatically; then, a guide was established, the implants were positioned, the prosthetic components were placed, the conjunctive tissue was removed from the palate and redirected to the vestibular wall of the implants, the nano-graft (Blue Bone®) was conditioned in the gaps between the vestibular wall and the implants, and, finally, the cemented provision was installed. RESULTS: After a 5-month accompaniment, an excellent remodeling of the tissues had been achieved by the implants; consequently, the final prosthetic stage could begin, which also achieved a remarkable aesthetic result. CONCLUSIONS: This report demonstrates that the correct planning of dental implants, which is associated with appropriate soft tissue and bone manipulation, allows for the achievement of admirable clinical results.

Ultrastructural and Physicochemical Characterization of a Non-Crosslinked Type 1 Bovine Derived Collagen Membrane.

In this work, in vitro testing was used to study the properties of non-crosslinked type 1 bovine derived collagen membranes used in bone regeneration surgery. Collagen membranes were prepared, their surface roughness was quantified by interferometry, their morphology was observed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM), their wettability was measured by the contact angle technique, their mechanical properties were investigated by tensile testing, their phase transformation temperatures were measured by Differential Scanning Calorimetry (DSC), and their biocompatibility was evaluated by immunological testing. The calorimetry tests showed that the membrane is formed only by type 1 collagen. The SEM observations showed that the morphology consists of layers of highly organized collagen fibers and patterns of striated fibrils typical of type 1 collagen. The small contact angle showed that the membrane is hydrophilic, with the possibility of rapid absorption of body fluids. The tensile tests showed that the membrane has enough elasticity, ductility, and mechanical strength for use in tissue regeneration. With the immunostaining technique, it was possible to confirm the membrane biocompatibility.

Histomorphometric Evaluation of Bone-Guided Regeneration in Maxillary Sinus Floor Augmentation Using Nano-Hydroxyapatite/Beta-Tricalcium Phosphate Composite Biomaterial: A Case Report.

BACKGROUND: The development of techniques in biomaterials design and production added to advanced surgical procedures which enabled better and more predictable clinical outcomes. Maxillary sinus floor augmentation (MSFA) is among the more studied bone-guided regeneration procedure in the literature. The MSFA could be considered the gold standard procedure for bone-guided regeneration as it provides suitable functional and aesthetic solutions to alveolar ridge atrophy due to tooth loss. PURPOSE: This study aimed to conduct a detailed histomorphometric evaluation of collagen production in SFAs bone-guided regeneration, using nano-hydroxyapatite/ß-tricalcium phosphate (nano-HA/ß-TCP) composite. PATIENTS AND METHODS: A 52-year-old female had the left upper second premolar condemned due to periodontal disease, then a tooth implant replacement was planned. Due to maxillary sinus pneumatization, the MSFA had to be done before implant placement. Nano-HA/ß-TCP composite (2g) was used in the MSFA procedure. After nine months of the healing process, during the Cone Morse implant installation process, bone samples were collected for histologic analysis (sirius red, hematoxylin/eosin, polarized microscopy). Six months after implant installation, a ceramic crown was installed according to the patient's request. RESULTS: Proper masticatory function and aesthetics were re-established. The histomorphometric evaluation indicated that nano-HA/ß-TCP composite did not show any area devoid of cellular activity in sirius red or hematoxylin/eosin staining and the percentage (%) of new bone collagen fibers was achieved using polarization technique evaluation. CONCLUSION: According to these results, nano-HA/ß-TCP composite presented clinical and histomorphometric properties suit to be used as bone-guided regeneration biomaterial in MSFA. Furthermore, nano-HA/ß-TCP composite provided a favorable nano-environment to bone cells, enhancing bone matrix production.

Myelopathy in sickle cell disease: a case-oriented review.

INTRODUCTION: Although neurological complications are well recognized in patients with sickle cell disease, myelopathy has been rarely described, with few reported cases of compressive and ischemic myelopathy. We present the first case report of longitudinally extensive myelitis (LETM) in SCD and review the differential diagnosis of myelopathy in these patients. CASE PRESENTATION: We report the case of a 29-year-old African-Brazilian man with SCD, who experienced a subacute flaccid paraparesis, with T2 sensory level and urinary retention. Cerebrospinal fluid analysis showed a lymphocytic pleocytosis and increased protein levels. MRI disclosed a longitudinally extensive spinal cord lesion, with a high T2/STIR signal extending from C2 to T12. We searched Medline/PubMed, Embase, Scopus, and Google Scholar databases for myelopathy in SCD patients. DISCUSSION: Spinal cord compression by vertebral fractures, extramedullary hematopoietic tissue, and Salmonella epidural abscess have been reported in SCD. We found only three case reports of spinal cord infarction, which is unexpectedly infrequent compared to the prevalence of cerebral infarction in SCD. We found only one case report of varicella-zoster myelitis and no previous report of LETM in SCD patients. Specific and time-sensitive causes of myelopathy should be considered in SCD patients. In addition to compression and ischemia, LETM is a possible mechanism of spinal cord involvement in SCD patients.

Repair of Critical Size Bone Defects Using Synthetic Hydroxyapatite or Xenograft with or without the Bone Marrow Mononuclear Fraction: A Histomorphometric and Immunohistochemical Study in Rat Calvaria.

Bone defects are a challenging clinical situation, and the development of hydroxyapatite-based biomaterials is a prolific research field that, in addition, can be joined by stem cells and growth factors in order to deal with the problem. This study compares the use of synthetic hydroxyapatite and xenograft, used pure or enriched with bone marrow mononuclear fraction for the regeneration of critical size bone defects in rat calvaria through histomorphometric (Masson's staining) and immunohistochemical (anti-VEGF, anti-osteopontin) analysis. Forty young adult male rats were divided into five groups (n = 8). Animals were submitted to critical size bone defects (Ø = 8 mm) in the temporoparietal region. In the control group, there was no biomaterial placement in the critical bone defects; in group 1, it was filled with synthetic hydroxyapatite; in group 2, it was filled with xenograft; in group 3, it was filled with synthetic hydroxyapatite, enriched with bone marrow mononuclear fraction (BMMF), and in group 4 it was filled with xenograft, enriched with BMMF. After eight weeks, all groups were euthanized, and histological section images were captured and analyzed. Data analysis showed that in groups 1, 2, 3 and 4 (received biomaterials and biomaterials plus BMMF), a significant enhancement in new bone matrix formation was observed in relation to the control group. However, BMMF-enriched groups did not differ from hydroxyapatite-based biomaterials-only groups. Therefore, in this experimental model, BMMF did not enhance hydroxyapatite-based biomaterials' potential to induce bone matrix and related mediators.

Performance of Nano-Hydroxyapatite/Beta-Tricalcium Phosphate and Xenogenic Hydroxyapatite on Bone Regeneration in Rat Calvarial Defects: Histomorphometric, Immunohistochemical and Ultrastructural Analysis.

BACKGROUND: Synthetic biomaterials have played an increasingly prominent role in the substitution of naturally derived biomaterials in current surgery practice. In vitro and in vivo characterization studies of new synthetic biomaterials are essential to analyze their physicochemical properties and the underlying mechanisms associated with the modulation of the inflammatory process and bone healing. PURPOSE: This study compares the in vivo tissue behavior of a synthetic biomaterial nano-hydroxyapatite/beta-tricalcium phosphate (nano-HA/ß-TCP mixture) and deproteinized bovine bone mineral (DBBM) in a rat calvarial defect model. The innovation of this work is in the comparative analysis of the effect of new synthetic and commercially xenogenic biomaterials on the inflammatory response, bone matrix gain, and stimulation of osteoclastogenesis and osteoblastogenesis. METHODS: Both biomaterials were inserted in rat defects. The animals were divided into three groups, in which calvarial defects were filled with xenogenic biomaterials (group 1) and synthetic biomaterials (group 2), or left unfilled (group 3, controls). Sixty days after calvarial bone defects filled with biomaterials, periodic acid Schiff (PAS) and Masson's trichrome staining, immunohistochemistry tumor necrosis factor-alpha (TNF-α), matrix metalloproteinase-9 (MMP-9), and electron microscopy analyses were conducted. RESULTS: Histomorphometric analysis revealed powerful effects such as a higher amount of proteinaceous matrix and higher levels of TNF-α and MMP-9 in bone defects treated with alloplastic nano-HA/ß-TCP mixture than xenogenicxenogic biomaterial, as well as collagen-proteinaceous material in association with hydroxyapatite crystalloids. CONCLUSION: These data indicate that the synthetic nano-HA/ß-TCP mixture enhanced bone formation/remodeling in rat calvarial bone defects. The nano-HA/ß-TCP did not present risks of cross-infection/disease transmission. The synthetic nano-hydroxyapatite/beta-tricalcium phosphate mixture presented adequate properties for guided bone regeneration and guided tissue regeneration for dental surgical procedures.

Cost analysis of hemophilia treatment in a Brazilian public blood center / Custo-análise do tratamento da hemofilia em um hemocentro público brasileiro

Abstract Background hemophilia is a rare coagulopathy, treated by replacing the missing blood clotting factor. Objective to assess the direct costs of hemophilia treatment from the perspective of the Unified Health System, highlighting the impact costs of new therapeutic modalities. Method partial economic assessment of the direct costs of hemophilia, in which were collected data from patient records from 2011 to 2015, at the Blood Center in the city of Juiz de Fora. Costs were assigned to consultations, exams, hospitalizations, and medications according to the price list of the National Health Surveillance Agency (in Portuguese ANVISA) and the Table of Procedures, and Medications. Results among 98 patients evaluated, 76 had hemophilia A, and 43.3% presented severe hemophilia. The number of consultations and the consumption of Clotting Factor Concentrates (CFCs) were higher in severe hemophilia. Hospitalizations were rare. Direct costs increased 286.8% from 2011 to 2015. The mean annual cost per patient was R$57,416.43, with no significant difference between hemophilia A and B. The expenditures for factor concentrates amounted to 99.46% of total costs. The actual impact cost was more than R$6,000,000.00. Conclusion the direct costs of hemophilia were high, mainly due to factor concentrates. There was an increase in costs with the incorporation of technologies, although there are some areas with potential inefficiencies.

Resumo Introdução hemofilia é uma coagulopatia rara, tratada com reposição do fator de coagulação deficiente. Objetivo avaliar custos diretos do tratamento da hemofilia pela perspectiva do Sistema Único de Saúde brasileiro, destacando o impacto nos custos das novas modalidades terapêuticas. Método análise econômica parcial dos custos diretos da hemofilia. Foram coletados dados de prontuários de pacientes do Hemocentro de Juiz de Fora de 2011-2015. Aos atendimentos, exames, hospitalizações e medicamentos, foram atribuídos custos conforme as Tabelas de Preços da Agência de Vigilância Sanitária e de Procedimentos e Medicamentos do SUS. Resultados entre 98 pacientes avaliados, 76 tinham hemofilia A e 43,3%, hemofilia grave. O número de consultas e o consumo de concentrados de fatores da coagulação foram mais altos na hemofilia grave. Hospitalizações foram raras. Os custos diretos aumentaram 286,8% entre 2011-2015. O custo anual médio por paciente foi R$57.416,43 sem diferença significativa entre hemofilia A e B. Os concentrados de fator corresponderam a 99,46% dos custos totais. O impacto nos custos foi de mais de R$6.000.000,00. Conclusão custos diretos da hemofilia são altos, principalmente devido aos concentrados de fator. O aumento nos custos com as novas tecnologias foi muito elevado embora ainda haja áreas com ineficiências no tratamento da hemofilia.

Histomorphometric, Immunohistochemical, Ultrastructural Characterization of a Nano-Hydroxyapatite/Beta-Tricalcium Phosphate Composite and a Bone Xenograft in Sub-Critical Size Bone Defect in Rat Calvaria.

Nowadays, we can observe a worldwide trend towards the development of synthetic biomaterials. Several studies have been conducted to better understand the cellular mechanisms involved in the processes of inflammation and bone healing related to living tissues. The aim of this study was to evaluate tissue behaviors of two different types of biomaterials: synthetic nano-hydroxyapatite/beta-tricalcium phosphate composite and bone xenograft in sub-critical bone defects in rat calvaria. Twenty-four rats underwent experimental surgery in which two 3 mm defects in each cavity were tested. Rats were divided into two groups: Group 1 used xenogen hydroxyapatite (Bio Oss™); Group 2 used synthetic nano-hydroxyapatite/beta-tricalcium phosphate (Blue Bone™). Sixty days after surgery, calvaria bone defects were filled with biomaterial, animals were euthanized, and tissues were stained with Masson's trichrome and periodic acid-Schiff (PAS) techniques, immune-labeled with anti-TNF-α and anti-MMP-9, and electron microscopy analyses were also performed. Histomorphometric analysis indicated a greater presence of protein matrix in Group 2, in addition to higher levels of TNF-α and MMP-9. Ultrastructural analysis showed that biomaterial fibroblasts were associated with the tissue regeneration stage. Paired statistical data indicated that Blue Bone™ can improve bone formation/remodeling when compared to biomaterials of xenogenous origin.

Nanosized hydroxyapatite and ß-tricalcium phosphate composite: Physico-chemical, cytotoxicity, morphological properties and in vivo trial.

The objective of this work was to characterize the properties of a synthetic biomaterial composite with nanoparticles size (Blue Bone). This biomaterial is a composite recommended for dental and orthopedic grafting surgery, for guided bone regeneration, including maxillary sinus lift, fresh alveolus filling, and treatment of furcation lesions. The nano biomaterials surface area is from 30% to 50% higher than those with micro dimensions. Another advantage is that the alloplastic biomaterial has homogeneous properties due to the complete manufacturing control. The analyzed biomaterial composite was characterized by XRD, cytochemistry, scanning electron microscopy, porosimetry and in vivo experiments (animals). The results showed that the analyzed biomaterial composite has 78.76% hydroxyapatite [Ca5(PO4)3(OH)] with monoclinic structure, 21.03% ß-tricalcium phosphate [ß -Ca3(PO4)2] with trigonal structure and 0.19% of CaO with cubic structure, nanoparticles with homogeneous shapes, and nanoporosity. The in vivo experiments showed that the composite has null cytotoxicity, and the site of insertion biomaterials has a high level of vascularization and bone formation. The conclusion is that the synthetic biomaterial with Blue Bone designation presents characteristics suitable for use in grafting surgery applications.

Perfil epidemiológico dos atendimentos em um serviço público de urgência oftalmológica / Epidemiological profile of visits in a public ophthalmic emergency service

Resumo Objetivo: Identificar os principais diagnósticos e características epidemiológicas dos pacientes atendidos em um serviço público de urgência oftalmológica. Métodos: Estudo transversal e retrospectivo, com análise de prontuários de 2834 pacientes atendimentos no período de julho a setembro de 2017, no serviço de Urgência Oftalmológica do Complexo Hospitalar Ouro Verde, Campinas, Brasil. As variáveis estudadas foram idade, gênero e diagnóstico. Resultados: Houve a prevalência do gênero masculino (52,6%) e da faixa etária de 30 a 59 anos (43,5%); 21,1% eram idosos. Os diagnósticos mais prevalentes foram conjuntivite infecciosa (23,9%), trauma ocular (15,7%) e doenças da superfície ocular (14,6%). Entre mulheres e crianças houve o predomínio de quadros infecciosos/inflamatórios; 83,6% dos traumas ocorreram em homens, sendo 62,2% devido a corpo estranho. Conclusão: Os diagnósticos mais prevalentes no serviço de urgência oftalmológica foram conjuntivite infecciosa e trauma ocular. Medidas de educação e prevenção são necessárias para reduzir morbidade e absenteísmo e evitar o uso inapropriado dos serviços especializados de emergência.

Abstract Objective: To identify the most frequent diagnosis and epidemiological characteristics of patients attended in a public ophthalmic emergency service. Methods: This is a retrospective and transverse study based on 2834 patients' chart attended from July to September 2017 at the Ouro Verde Hospital Complex, Campinas, Brazil. The following variables were investigated: age, gender, and diagnosis. Results: Most patients were male (52.6%) and aged between 30 to 59 years (43.5%); 21.1% were elderly. The most frequent diagnostics were conjunctivitis (23.9%), ocular trauma (15.7%), and ocular surface disorders (14.6%). Infectious/inflammatory conditions predominated among children and female; 83.6% of traumas occurred in man, and 62.2% were due to a foreign body. Conclusion: The most prevalent diagnoses in the ophthalmologic emergency department were infectious conjunctivitis and ocular trauma. Education and prevention measures are necessary to reduce morbidity and absenteeism and to avoid inappropriate use of specialized emergency services.

Mortalidade por doenças do aparelho circulatório e fatores associados: estudo ecológico em municípios de Minas Gerais / Mortality due to circulatory system diseases and associated factors: an ecological study in municipalities of Minas Gerais

Introdução: As doenças do aparelho circulatório (DAC) são responsáveis por 30% das mortes no Brasil, além de gerar incapacidades e altos custos. Apesar disso, pouco se sabe sobre a relação entre a mortalidade por DAC e as condições de vida e assistência à saúde nos municípios brasileiros, especialmente em contextos regionais. Objetivo: Investigar a associação de variáveis de saúde e sociodemográficas com a mortalidade por DAC, em Minas Gerais (MG). Método: Estudo ecológico, a partir de dados secundários, tendo como unidade de análise 418 municípios de MG. A variável dependente foi a taxa de mortalidade por DAC e as variáveis de desfecho foram 32 indicadores de serviços de saúde e 22 indicadores demográficos e socioeconômicos. Realizou-se a análise bivariada dos dados, através do coeficiente de correlação de Pearson, seguida da análise fatorial e, por fim, da regressão linear múltipla. Resultados: As DAC ocasionaram 30,9% da mortalidade total nos municípios analisados, observando-se associação positiva com número de consultórios de clínica básica, população urbana e internações por DAC no SUS; e negativa com valor médio por internação e despesa total com profissionais da saúde. Conclusão: Frente ao elevado número de municípios com pequena estrutura assistencial em MG, as ações de promoção à saúde e prevenção parecem ser as mais adequadas visando à redução das taxas de mortalidade por DAC. Também com este objetivo, os casos mais graves e as complicações devem ser manejados em centros de referência, contando com recursos materiais e profissionais adequados.

Introduction: Circulatory system diseases (CSD) are responsible for 30% of deaths in Brazil, as well as causing disabilities and high costs. Despite that, little is known about the relation between the mortality from CSD and the conditions of life and health care in Brazilian municipalities, especially in regional contexts. Objective: To investigate the association of health and sociodemographic variables with CSD mortality in Minas Gerais (MG). Methodology: Ecological study in which secondary data of 418 municipalities of MG were analyzed. The dependent variable was the mortality rate from CSD and the outcome variables consisted of 32 health services indicators and 22 demographic and socioeconomic indicators. A bivariate analysis of the data was performed by means of the Pearson's correlation coefficient, followed by factorial analysis, and finally, multiple linear regression. Results: CSD caused 30.9% of total mortality among the municipalities analyzed and were found to be positively associated with the number of general medicine clinics, urban population, and hospitalizations due to CSD. A negative association was observed with the average cost of hospitalizations and the total expenses with health professionals. Conclusion: In view of the high number of municipalities in MG having a scarce health care structure, actions aimed at promoting health and preventing disease appear to meet the most appropriate conditions for the reduction of CSD mortality rates. With this same purpose, the more severe cases and complications of CSD must be managed in reference centers, which dispose of adequate material and professional resources.

Survival Study of Triple-Negative and Non-Triple-Negative Breast Cancer in a Brazilian Cohort.

OBJECTIVE: To analyze the clinical, pathological, and sociodemographic aspects between triple-negative breast cancer (TNBC) and non-TNBC in a Brazilian cohort and identify potential prognostic factors. METHODS: This hospital-based retrospective cohort study included 447 women with breast cancer treated at referral centers in Southeastern Brazil. Overall and disease-free survival were compared; prognostic factors were evaluated. RESULTS: Triple-negative breast cancer corresponded to 19.5% of breast cancer diagnosis and was more prevalent among nonwhite and less educated women. The patients with TNBC tended to present with stage III cancer, high p53 expression, lymphocytic infiltration, and multifocality and treated with radical surgery and chemotherapy. The 5-year overall and disease-free survival were 62.1% and 57.5% for TNBC and 80.8% and 75.3% for non-TNBC, respectively (P < .001). The TNBC recurrence was associated with multicentricity, whereas lymph node involvement increased the risk of both recurrence and death. Non-TNBC worse clinical course was associated with nonwhite ethnicity, lower education level, lymph node involvement, and advanced stage. CONCLUSIONS: Triple-negative breast cancer exhibited a more aggressive behavior, earlier and more frequent recurrence, and worse survival compared with non-TNBC. While biological and social variables were associated with poorer prognosis in non-TNBC, only lymph node involvement and multicentricity were correlated with worse clinical outcomes in TNBC.

Awareness about falls and elderly people's exposure to household risk factors. / Percepção sobre queda e exposição de idosos a fatores de risco domiciliares.

OBJECTIVES: to describe the awareness about falls among elderly people living in their households in communities, to measure the other risks that they are exposed to in their homes and to evaluate the influence that knowledge on falling brings in the adoption of preventative measures. METHOD: The FRAQ-Brazil questionnaire was used on 473 elderly people as well as a questionnaire on elderly people being exposed to 20 household risk factors. Associations between the variables were analyzed using the chi-squared test with a confidence interval of 95%. RESULTS: The age range was between 60 and 95 years with the average being 70.6 years. The majority of those interviewed were female (58.4%) who were earning 2 minimum wages (46.3%). The average amount of correct answers given with the use of the FRAQ-Brazil questionnaire was 19.5 out of 32 points and the elderly participants were, on average, exposed to 7.8 household risk factors. 180 of them stated that they had already received information on falls. CONCLUSION: The majority of the elderly population displayed little knowledge on falls and were exposed to a variety of daily risk factors. Individuals who were more advanced in years and who had more knowledge on falls, were exposed to less household risk factors. This may well have been due to the adoption of preventative measures through changing domestic environment.

Does Knowing Someone with Breast Cancer Influence the Prevalence of Adherence to Breast and Cervical Cancer Screening?

OBJECTIVE: To evaluate the prevalence of adherence to screening methods for breast and cervical cancer in patients attended at a university hospital and to investigate whether knowing someone with breast cancer, moreover belonging to the patient's family, affects the adherence to the screening recommendations. METHODS: This was a cross-sectional and quantitative study. A structured interview was applied to a sample of 820 women, between 20 and 69 years old, who attended a university hospital in the city of Juiz de for a, MG, Brazil. For the analysis, the chi-square test was used to assess possible associations between the variables, and the significance level was set at p-value ≤ 0.05 for a confidence interval (CI) of 95%. RESULTS: More than 95.0% of the sample performed mammography and cervical cytology exam; 62.9% reported knowing someone who has or had breast cancer, and this group was more likely to perform breast self-examination (64.9%; odds ratio [OR] 1.5; 95% CI 1.12-2.00), clinical breast examination (91.5%; OR 2.11; 95% CI 1.37-3.36), breast ultrasound (32.9%; OR 1.81, 95% CI 1.30-2.51), and to have had an appointment with a breast specialist (28.5%; OR 1.98, 95% CI 1.38-2.82). Women with family history of breast cancer showed higher propensity to perform breast self-examination (71.0%; OR 1.53 95% CI 1.04-2.26). CONCLUSION: There was high adherence to the recommended screening practices; knowing someone with breast cancer might make women more sensitive to this issue as they were more likely to undergo methods which are not recommended for the screening of the general population, such as breast ultrasound and specialist consultation; family history is possibly an additional cause of concern.

OBJETIVOS: Avaliar a prevalência da adesão aos métodos de rastreamento dos cânceres de mama e de colo uterino em pacientes atendidas em um hospital universitário e investigar se conhecer alguém com câncer de mama e, o fato de este pertencer à família, modifica a adesão às recomendações de rastreamento. MéTODOS: Estudo transversal e quantitativo. Uma entrevista estruturada foi aplicada a uma amostra de 820 pacientes do sexo feminino, entre 20 e 69 anos, usuárias de um hospital universitário na cidade de Juiz de Fora, MG. Para a análise, o Teste Qui-quadrado foi usado para avaliar a possibilidade de associação entre as varáveis, e o valor de significância foi determinado em valor-p ≤ 0,05 para um intervalo de confiança (IC) de 95%. RESULTADOS: Mais de 95,0% da amostra realizava os exames de mamografia e colpocitologia; 62,9% relataram conhecer alguém que teve ou tem câncer de mama, sendo que este grupo realizou, com maior frequência, autoexame (64,9%; razão de prevalência [RP] 1,5; IC 95% 1,12­2,00), exame clínico (91,5%; RP 2,11; IC 95% 1,37­3,36) e ultrassonografia das mamas (32,9%; RP 1,81, IC 95% 1,30­2,51) e consulta ao mastologista (28,5%; RP 1,98, IC 95% 1,38­2,82). Mulheres com história familiar de câncer de mama realizaram com maior prevalência o autoexame das mamas (71,0%; RP 1,53 IC 95% 1,04­2,26). CONCLUSãO: A amostra apresentou elevada adesão aos métodos de rastreamento preconizados; conhecer alguém com câncer de mama pode tornar as mulheres mais sensíveis a essa questão, aumentando a realização de medidas não recomendadas para o rastreamento da população geral, como ultrassonografia das mamas e consulta com médico especialista; a história familiar possivelmente implica em um fator de preocupação adicional.

Does knowing someone with breast cancer influence the prevalence of adherence to breast and cervical cancer screening? / Conhecer alguém com câncer de mama influencia a prevalência da adesão ao rastreamento dos cânceres de mama e colo uterino?

Abstract Objective To evaluate the prevalence of adherence to screening methods for breast and cervical cancer in patients attended at a university hospital and to investigate whether knowing someone with breast cancer, moreover belonging to the patient's family, affects the adherence to the screening recommendations. Methods This was a cross-sectional and quantitative study. A structured interview was applied to a sample of 820 women, between 20 and 69 years old, who attended a university hospital in the city of Juiz de for a, MG, Brazil. For the analysis, the chi-square test was used to assess possible associations between the variables, and the significance level was set at p-value ≤ 0.05 for a confidence interval (CI) of 95%. Results More than 95.0% of the sample performed mammography and cervical cytology exam; 62.9% reported knowing someone who has or had breast cancer, and this group was more likely to perform breast self-examination (64.9%; odds ratio [OR] 1.5; 95% CI 1.12-2.00), clinical breast examination (91.5%; OR 2.11; 95% CI 1.37-3.36), breast ultrasound (32.9%; OR 1.81, 95% CI 1.30-2.51), and to have had an appointment with a breast specialist (28.5%; OR 1.98, 95% CI 1.38-2.82).Women with family history of breast cancer showed higher propensity to perform breast self-examination (71.0%; OR 1.53 95% CI 1.04-2.26). Conclusion There was high adherence to the recommended screening practices; knowing someone with breast cancer might make women more sensitive to this issue as they were more likely to undergo methods which are not recommended for the screening of the general population, such as breast ultrasound and specialist consultation; family history is possibly an additional cause of concern.

Resumo Objetivos Avaliar a prevalência da adesão aosmétodos de rastreamento dos cânceres de mama e de colo uterino em pacientes atendidas em um hospital universitário e investigar se conhecer alguém com câncer de mama e, o fato de este pertencer à família, modifica a adesão às recomendações de rastreamento. Métodos Estudo transversal e quantitativo. Uma entrevista estruturada foi aplicada a uma amostra de 820 pacientes do sexo feminino, entre 20 e 69 anos, usuárias de um hospital universitário na cidade de Juiz de Fora, MG. Para a análise, o Teste Quiquadrado foi usado para avaliar a possibilidade de associação entre as varáveis, e o valor de significância foi determinado em valor-p ≤ 0,05 para um intervalo de confiança (IC) de 95%. Resultados Mais de 95,0% da amostra realizava os exames de mamografia e colpocitologia; 62,9% relataram conhecer alguém que teve ou tem câncer de mama, sendo que este grupo realizou, com maior frequência, autoexame (64,9%; razão de prevalência [RP] 1,5; IC 95% 1,12-2,00), exame clínico (91,5%; RP 2,11; IC 95% 1,37- 3,36) e ultrassonografia das mamas (32,9%; RP 1,81, IC 95% 1,30-2,51) e consulta ao mastologista (28,5%; RP 1,98, IC 95% 1,38-2,82). Mulheres com história familiar de câncer de mama realizaramcommaior prevalência o autoexame das mamas (71,0%; RP 1,53 IC 95% 1,04-2,26). Conclusão A amostra apresentou elevada adesão aos métodos de rastreamento preconizados; conhecer alguém com câncer de mama pode tornar as mulheres mais sensíveis a essa questão, aumentando a realização de medidas não recomendadas para o rastreamento da população geral, como ultrassonografia das mamas e consulta com médico especialista; a história familiar possivelmente implica em um fator de preocupação adicional.

Percepção sobre queda e exposição de idosos a fatores de risco domiciliares / Awareness about falls and elderly people's exposure to household risk factors

Resumo O objetivo deste artigo é descrever a percepção sobre quedas dos idosos residentes na comunidade; mensurar a exposição desses indivíduos a fatores de risco domiciliares relacionados; e avaliar a influência do conhecimento sobre queda na adoção de medidas preventivas. O questionário FRAQ-Brasil foi aplicado a 473 idosos, juntamente com um questionário sobre exposição a 20 fatores de risco domiciliares. Associações entre as variáveis foram analisadas utilizando o teste qui-quadrado com intervalo de confiança de 95%. A idade variou de 60 a 95 anos, com média de 70,6 anos; os entrevistados foram principalmente do sexo feminino (58,4%), e renda de 2 salários mínimos (46,3%); a média de acertos no questionário FRAQ-Brasil foi de 19,5 em até 32 pontos e os idosos entrevistados estavam expostos, em média, a 7,8 fatores de risco domiciliares; 180 idosos disseram já terem recebido informações sobre queda. A maioria da população idosa apresenta pouco conhecimento sobre queda. Indivíduos com idade mais avançada e com maior conhecimento sobre queda estão expostos a menos fatores de risco domiciliares, possivelmente pela maior adoção de medidas preventivas através da modificação do ambiente doméstico.

Abstract Objectives: to describe the awareness about falls among elderly people living in their households in communities, to measure the other risks that they are exposed to in their homes and to evaluate the influence that knowledge on falling brings in the adoption of preventative measures. Method: The FRAQ-Brazil questionnaire was used on 473 elderly people as well as a questionnaire on elderly people being exposed to 20 household risk factors. Associations between the variables were analyzed using the chi-squared test with a confidence interval of 95%. Results: The age range was between 60 and 95 years with the average being 70.6 years. The majority of those interviewed were female (58.4%) who were earning 2 minimum wages (46.3%). The average amount of correct answers given with the use of the FRAQ-Brazil questionnaire was 19.5 out of 32 points and the elderly participants were, on average, exposed to 7.8 household risk factors. 180 of them stated that they had already received information on falls. Conclusion: The majority of the elderly population displayed little knowledge on falls and were exposed to a variety of daily risk factors. Individuals who were more advanced in years and who had more knowledge on falls, were exposed to less household risk factors. This may well have been due to the adoption of preventative measures through changing domestic environment.