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1.
Clin Transl Oncol ; 23(8): 1577-1584, 2021 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-33495981

RESUMEN

OBJECTIVES: To report outcomes of stereotactic body radiotherapy (SBRT) in metastatic castration-resistant prostate cancer (mCRPC) patients with oligoprogression (≤ 5 metastases) during first-line treatment with androgen receptor-targeted therapy (ARTT). PATIENTS AND METHODS: Retrospective multi-institutional analysis of mCRPC patients treated with SBRT to oligoprogressive lesions during ARTT. End-points were time to next-line systemic treatment (NEST), radiological progression-free survival (r-PFS) and overall survival (OS). Toxicity was registered according to Common Terminology Criteria for Adverse Events (CTCAE) v4.0. Survival analysis was performed using the Kaplan-Meier method, univariate and multivariate analysis (MVA) were performed. RESULTS: Data from 34 patients were analyzed. Median NEST-free survival, r-PFS, and OS were 16.97, 13.47, and 38.3 months, respectively. At MVA, factors associated with worse NEST-free survival and r-PFS were polymetastatic burden at diagnosis of metastatic hormone-sensitive disease (hazard ratio [HR] 3.66, p = 0.009; HR 3.03, p = 0.034), PSA ≤ 7 ng/ml at mCRPC diagnosis (HR 0.23, p = 0.017; HR 0.19, p = 0.006) and PSADT ≤ 3 months at mCRPC diagnosis (HR 3.39, p = 0.026; HR 2.79, p = 0.037). Polymetastatic state at mHSPC diagnosis was associated with a decreased OS (HR 4.68, p = 0.029). No patient developed acute or late grade ≥ 2 toxicity. CONCLUSION: Our results suggest that SBRT in oligoprogressive mCPRC is safe, effective and seems to prolong the efficacy of the ongoing systemic treatment positively affecting disease progression. Prospective trials are needed.


Asunto(s)
Antagonistas de Receptores Androgénicos/uso terapéutico , Terapia Molecular Dirigida/métodos , Neoplasias de la Próstata Resistentes a la Castración/tratamiento farmacológico , Neoplasias de la Próstata Resistentes a la Castración/radioterapia , Radiocirugia/métodos , Anciano , Análisis de Varianza , Terapia Combinada/métodos , Progresión de la Enfermedad , Humanos , Estimación de Kaplan-Meier , Masculino , Persona de Mediana Edad , Supervivencia sin Progresión , Neoplasias de la Próstata Resistentes a la Castración/mortalidad , Neoplasias de la Próstata Resistentes a la Castración/patología , Dosificación Radioterapéutica , Estudios Retrospectivos , Resultado del Tratamiento
2.
Clin Transl Oncol ; 23(2): 364-371, 2021 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-32602076

RESUMEN

AIMS: 68Ga-Prostate-specific membrane antigen (PSMA) PET/CT is widely used in patients with biochemical recurrence (BCR) after radical prostatectomy. We collected data about patients staged with PSMA PET/CT after BCR (PSA < 1 ng/ml) in four different institutes. Impact of baseline features (Gleason score, risk classification, PSA at recurrence, PSA doubling time and time to recurrence) was explored to understand predictive factors of (PSMA) PET/CT positivity. Impact of restaging on following treatment approaches was reported. RESULTS: 92 patients were included. PSMA PET/CT detection rate was 56.5% and low-volume disease (≤ 3 non-visceral lesions) was detected in 52.2% of patients. After positive scan, 13.5% of patients still lies on observation, ADT alone was administered in 30.8% of cases, Stereotactic body RT (SBRT) alone was delivered to 44.2% of patients and 11.5% of patients underwent concomitant SBRT and ADT. Seven patients underwent conventional salvage prostate bed RT. Chi-squared test showed a higher rate of positive PSMA PET/CT for patients with Gleason score > 7 (p = 0.004) and TTR < 29.5 months (p = 0.003). CONCLUSIONS: PSMA PET/CT showed a high detection rate. This influenced clinical management in a significant percentage of patients, allowing treatment tailoring on the basis of imaging.


Asunto(s)
Isótopos de Galio , Radioisótopos de Galio , Recurrencia Local de Neoplasia/diagnóstico por imagen , Tomografía Computarizada por Tomografía de Emisión de Positrones , Neoplasias de la Próstata/diagnóstico por imagen , Radiofármacos , Anciano , Antagonistas de Andrógenos/uso terapéutico , Antígenos de Superficie , Glutamato Carboxipeptidasa II , Humanos , Masculino , Persona de Mediana Edad , Clasificación del Tumor , Recurrencia Local de Neoplasia/sangre , Recurrencia Local de Neoplasia/patología , Recurrencia Local de Neoplasia/terapia , Estadificación de Neoplasias/métodos , Antígeno Prostático Específico/sangre , Prostatectomía , Neoplasias de la Próstata/sangre , Neoplasias de la Próstata/patología , Neoplasias de la Próstata/terapia , Radiocirugia/estadística & datos numéricos , Radioterapia/estadística & datos numéricos , Radioterapia de Intensidad Modulada/estadística & datos numéricos , Estudios Retrospectivos , Terapia Recuperativa/métodos , Terapia Recuperativa/estadística & datos numéricos , Factores de Tiempo
3.
Clin Transl Oncol ; 21(11): 1532-1537, 2019 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-30868389

RESUMEN

INTRODUCTION: Salvage radiotherapy (SRT) after radical prostatectomy for prostate cancer (PCa) is recommended as soon as PSA rises above 0.20 ng/ml, but many patients (pts) still experience local macroscopic relapse. The aim of this multicentric retrospective analysis was to evaluate the role of SRT in pts with macroscopic relapse. MATERIALS AND METHODS: From 2001 to 2016, 105 consecutive pts with macroscopic PCa relapse underwent SRT ± androgen deprivation therapy (ADT). Mean age was 72 years. At time of relapse, 29 pts had a PSA value < 1.0 ng/mL, 50 from 1.1 to 5, and 25 pts > 5. Before SRT, 23 pts had undergone 18F-choline PET and 15 pts pelvic MRI. Ninety-four pts had prostatic bed relapse only, and four nodal involvement. Fifty-one pts were previously submitted to first-line ADT, while 6 pts received ≥ 2 lines. RESULTS: At a median follow-up of 52 months, 89 pts were alive, while 16 were dead. Total RT dose to macroscopic lesions was > 70 Gy in 58 pts, 66-70 Gy in 43, and < 66 Gy in 4 pts. In 72 pts, target volume encompassed only the prostatic bed with sequential boost to macroscopic site; 33 pts received prophylactic pelvic RT. Ten-year overall survival was 76.1%, while distant metastasis-free survival was 73.3%. No grade 4-5 toxicities were found. CONCLUSIONS: SRT ± ADT for macroscopic relapse showed a favorable oncological outcome supporting its important role in this scenario. Data from this series suggest that SRT may either postpone ADT or improve results over ADT alone in appropriately selected pts.


Asunto(s)
Recurrencia Local de Neoplasia/radioterapia , Neoplasias de la Próstata/radioterapia , Terapia Recuperativa/métodos , Anciano , Anciano de 80 o más Años , Antagonistas de Andrógenos/uso terapéutico , Terapia Combinada/métodos , Estudios de Seguimiento , Humanos , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Recurrencia Local de Neoplasia/sangre , Recurrencia Local de Neoplasia/tratamiento farmacológico , Recurrencia Local de Neoplasia/mortalidad , Tomografía de Emisión de Positrones , Antígeno Prostático Específico/sangre , Prostatectomía , Neoplasias de la Próstata/sangre , Neoplasias de la Próstata/mortalidad , Neoplasias de la Próstata/terapia , Dosificación Radioterapéutica , Estudios Retrospectivos , Análisis de Supervivencia
4.
J Forensic Odontostomatol ; 35(2): 55-65, 2017 Dec 01.
Artículo en Inglés | MEDLINE | ID: mdl-29384737

RESUMEN

BACKGROUND: Forensic Dentistry has an important role in the human identification cases and, among the analyses that can be performed, age estimation has an important value in establishing an anthropological profile. Modern technology invests for new mechanisms of age estimation: software apps, based on special algorithms, because there is not interference based on personal knowledge, cultural and personal experiences for facial recognition. MATERIALS AND METHODS: This research evaluated the use of two different apps: "How Old Do I Look? - Age Camera" and "How Old Am I? - Age Camera, Do You Look Like in Selfie Face Pic?", for age estimation analysis in a sample of 100 people (50 females and 50 males). Univariate and multivariate statistical methods were used to evaluate data. RESULTS: A great reliability was seen when used for the male volunteers. However, for females, no equivalence was found between the real age and the estimated age. CONCLUSION: These applications presented satisfactory results as an auxiliary method, in male images.


Asunto(s)
Cara/anatomía & histología , Aplicaciones Móviles , Envejecimiento de la Piel , Teléfono Inteligente , Femenino , Antropología Forense , Humanos , Masculino
5.
Eur J Med Chem ; 40(4): 329-38, 2005 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-15804532

RESUMEN

A set of 25 quinone compounds with anti-trypanocidal activity was studied by using the density functional theory (DFT) method in order to calculate atomic and molecular properties to be correlated with the biological activity. The chemometric methods principal component analysis (PCA), hierarchical cluster analysis (HCA), stepwise discriminant analysis (SDA), Kth nearest neighbor (KNN) and soft independent modeling of class analogy (SIMCA) were used to obtain possible relationships between the calculated descriptors and the biological activity studied and to predict the anti-trypanocidal activity of new quinone compounds from a prediction set. Four descriptors were responsible for the separation between the active and inactive compounds: T5 (torsion angle), QTS1 (sum of absolute values of the atomic charges), VOLS2 (volume of the substituent at region B) and HOMO-1 (energy of the molecular orbital below HOMO). These descriptors give information on the kind of interaction that occurs between the compounds and the biological receptor. The prediction study was done with a set of three new compounds by using the PCA, HCA, SDA, KNN and SIMCA methods and two of them were predicted as active against the Trypanosoma cruzi.


Asunto(s)
Quinonas/química , Quinonas/farmacología , Tripanocidas/química , Tripanocidas/farmacología , Animales , Análisis por Conglomerados , Estructura Molecular , Análisis de Componente Principal , Relación Estructura-Actividad , Trypanosoma/efectos de los fármacos , Trypanosoma/fisiología
6.
Funct Neurol ; 13(3): 257-61, 1998.
Artículo en Inglés | MEDLINE | ID: mdl-9800154

RESUMEN

Alzheimer's disease (AD) is a common and serious disease whose incidence increases with age affecting millions of people. While the aetiology of sporadic AD cases remains obscure, considerable progress has been made in the isolation and cloning of genes causing familial AD (FAD). The problem of gene identification and isolation has been solved for chromosome 14 through the study of large, homogeneous pedigrees, like FAD Calabrian kindreds, which, having been the subject of extensive genealogical study, have a well-known clinical and genetic identity. Several independent families (N, To, C, and FJ01) affected with early onset FAD were studied in Calabria (Southern Italy). A genealogical "blanket" method has allowed these families to merge into two larger kindreds. Identical phenotypes and neighbouring places of origin suggested a common founder. Even though genealogical reconstruction failed to identify the common ancestor, inspection of the haplotype data showed that a common extended haplotype was shared by these kindreds. AD3 gene has been isolated and cloned in BCE sequence. Met 146 Leu mutation in these kindreds is indeed identical by descent.


Asunto(s)
Enfermedad de Alzheimer/genética , Proteínas de la Membrana/genética , Mutación Missense/genética , Adulto , Enfermedad de Alzheimer/diagnóstico , Argentina , Teorema de Bayes , Cromosomas Humanos Par 14/genética , Femenino , Genealogía y Heráldica , Tamización de Portadores Genéticos , Ligamiento Genético , Genética Médica/métodos , Haplotipos , Humanos , Italia/etnología , Masculino , Persona de Mediana Edad , Linaje , Presenilina-1
7.
Int Arch Occup Environ Health ; 69(5): 354-60, 1997.
Artículo en Inglés | MEDLINE | ID: mdl-9192221

RESUMEN

Characteristics of shiftwork schedules can have distinct impacts on workers' sleep. This report presents comparisons of the effects of two different shiftwork schedules on duration and quality of the main sleep episodes in comparable worker populations at two different petrochemical plants. No significant differences were found for sleep duration in comparing the two plants. However, within each plant's shift cycles, morning and night shifts showed shorter sleep durations than all other workdays and days off. Quality of sleep was perceived as lowest for night shifts of both plant schedules, and of lesser quality for weekly than for fast-rotating shifts. These results support recommendations for reducing the number of consecutive nights of shiftwork. However, before recommending any optimal shift schedule, interactions of sleep duration and quality with shift schedules need much further evaluation.


Asunto(s)
Admisión y Programación de Personal , Sueño/fisiología , Lugar de Trabajo/organización & administración , Adolescente , Adulto , Análisis de Varianza , Industria Química , Estudios Transversales , Humanos , Masculino , Persona de Mediana Edad
8.
Ergonomics ; 36(1-3): 43-9, 1993.
Artículo en Inglés | MEDLINE | ID: mdl-8440229

RESUMEN

Cross-sectional studies of working and living conditions were conducted in two Brazilian petrochemical plants between 1988-1989. This paper presents analyses of reported activities undertaken during day- and shiftworkers' leisure time. One hundred and sixteen workers (67 continuous shiftworkers) daily logged standard protocols of all leisure activities, for three consecutive weeks. Workers logged 11,957 instances grouped in 27 different activities. The 14 most commonly mentioned leisure activities were analysed. Those most reported were meals with the family (breakfast, lunch, and dinner) and home TV viewing. Using chi 2 statistics, the results showed that the two factors studied--activities and work schedules (day and shift)--were not related. Analysing estimated coefficients of a second order log linear model, only a very few of the 14 activities most mentioned, did not differ in their frequencies between day and shiftworkers of the same plant. The same happened with the 12 activities most-mentioned of both plants: shiftworkers and dayworkers showed significant differences (p < 0.0001) on almost all frequencies of those activities mentioned. Hypotheses are made to explain some of the results. Home placement, and types of shiftwork schedules (weekly or swiftly rotating shifts) can be responsible for some of the activities performed during the workers' leisure time. Further investigation of those activities which are disturbed or cannot be performed due to work schedules is suggested.


Asunto(s)
Ritmo Circadiano , Actividades Recreativas , Trabajo , Adolescente , Adulto , Estudios Transversales , Femenino , Humanos , Masculino , Persona de Mediana Edad , Ajuste Social , Conducta Social , Tolerancia al Trabajo Programado
9.
Med Cutan Ibero Lat Am ; 17(6): 349-53, 1989.
Artículo en Español | MEDLINE | ID: mdl-2699631

RESUMEN

Itching is the dermatologic symptom more often found in patients with chronic renal failure. We have studied 80 patients with end-stage renal disease; itching was present in 56.3% of the cases. We didn't detected in this study any correlation between itching, long term hemodialysis, high calcium, phosphorus, alkaline phosphatase or phosphocalcic product levels. We have seen: 1. Those patients with itching were older than the rest. 2. Itching was important in those patients with residual diuresis less than 500 ml/day (p greater than 0.01). 3. Those men without itching had higher hematocrit levels (p greater than 0.01). 4. Histologic findings on optic and electronic microscopy were more frequent in patients who presented this symptom.


Asunto(s)
Fallo Renal Crónico/complicaciones , Prurito/etiología , Adolescente , Adulto , Anciano , Biopsia , Femenino , Humanos , Fallo Renal Crónico/patología , Fallo Renal Crónico/fisiopatología , Masculino , Persona de Mediana Edad , Prurito/patología , Prurito/fisiopatología
10.
Arch. argent. dermatol ; 33(5): 283-90, 1983.
Artículo en Español | LILACS | ID: lil-16584

RESUMEN

Se presentan tres casos de sindrome de Down. El primero, asociado a tetralogia de Fallot, se caracteriza por dedos en palillo de tambor, unas en vidrio de reloj y cianosis central, debido al cuadro cardiologico. Asociaba desde el punto de vista cutaneo una foliculitis inflamatoria aguda de miembros superiores e inferiores, que se traducia en papulas foliculares en distintos grados de evolucion. Se plantea el diagnostico diferencial con el cuadro denominado por Finn "una singular dermatosis del mogolico", y se hacen comentarios sobre la frecuenccia de alteraciones foliculares en el sindrome de Down. El segundo caso presentaba una dermatosis no referida en la literatura en relacion al mongolismo Se trataba de una erupcion liquenoide de cara y cuello, cuyas caracteristicas clinicas e histologicas permiten incluirla dentro de los cuadros liquenianos atipicos y que nosotros denominamos papulosis liquenoide. El tercer caso estaba asociado a alopecia areata


Asunto(s)
Preescolar , Niño , Humanos , Masculino , Femenino , Síndrome de Down , Manifestaciones Cutáneas
11.
Arch. argent. dermatol ; 33(5): 283-90, 1983.
Artículo en Español | BINACIS | ID: bin-34603

RESUMEN

Se presentan tres casos de sindrome de Down. El primero, asociado a tetralogia de Fallot, se caracteriza por dedos en palillo de tambor, unas en vidrio de reloj y cianosis central, debido al cuadro cardiologico. Asociaba desde el punto de vista cutaneo una foliculitis inflamatoria aguda de miembros superiores e inferiores, que se traducia en papulas foliculares en distintos grados de evolucion. Se plantea el diagnostico diferencial con el cuadro denominado por Finn "una singular dermatosis del mogolico", y se hacen comentarios sobre la frecuenccia de alteraciones foliculares en el sindrome de Down. El segundo caso presentaba una dermatosis no referida en la literatura en relacion al mongolismo Se trataba de una erupcion liquenoide de cara y cuello, cuyas caracteristicas clinicas e histologicas permiten incluirla dentro de los cuadros liquenianos atipicos y que nosotros denominamos papulosis liquenoide. El tercer caso estaba asociado a alopecia areata


Asunto(s)
Preescolar , Niño , Humanos , Masculino , Femenino , Manifestaciones Cutáneas , Síndrome de Down
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