[Clinical, biochemical and allergological indices characterizing occupational diseases of the bronchial and pulmonary system in employees at aluminium production].

There are many harmful factors that possess a damaging impact on the body of employees at aluminum production. It leads to the development of bronchial asthma (BA), chronic nonobstructive bronchitis (CNB) and chronic obstructive pulmonary disease (COPD). The pathogenesis of these disorders, as well as sensitizing effect offluorine in the aluminum production is not fully understood. The purpose of this work was to study the characteristics of laboratory indices in patients with occupational diseases of the respiratory system. In workers of aluminum production with the diagnosis of occupational diseases of respiratory system (15 patients with a diagnosis of asthma, 30 CNB cases, 20 COPD patients) we evaluated the content of total protein, total cholesterol, high density lipoprotein cholesterol (HDLC), total calcium, phosphorus, ceruloplasmin, hematological indices and performed emigration of leukocytes braking test (TTEEL). Clinical and biochemical profile ofpersons with occupational asthma was characterized by a low level of total calcium and ceruloplasmin, a high concentration of phosphorus in the blood serum and inhibition of leukocyte emigration in the test with sodium fluoride. For aluminum production CNB workers characteristic active proatherogenic process was pronounced by a decrease in the HDLC level and an increase in atherogenic index; higher hematocrit value and concentration of erythrocytes, and more than 50% of cases of sensitization to the presence of sodium fluoride. COPD cases had occupational lower average concentration of hemoglobin in the erythrocyte, total protein in serum, as well as polymorphic variant response to sodium fluoride in the form of a depression and activation of leucocytes emigration.

[Application of immuno-biochemical indices for the identification of the chronic pathology of the upper respiratory tract].

A comprehensive survey of organized children aged 14-17 years residing in the industrial centers with moderate and high levels of air pollution was performed. On the base of the examination of otorhinolaryngologist in the each of cities there was selected the group of schoolchildren with chronic pathology of the upper respiratory tract at the stage of remission. In these groups there was performed the assessment of the informativeness of immuno-biochemical indices for the identification of pathology caused by the impact of man-made factors. The most informative (relative content of autoantibodies to ß2-glycoprotein-1, the average individual immunoreactivity, erythrocyte sedimentation rate, level of α1-antitrypsin) were used in the mathematical model, on the based of which it was possible to calculate the diagnostic coefficient, allowing to identify in the groups observed by ourselves, chronic pathology of upper respiratory tract, formed under the influence of ambient air pollution. The above approach can be used in the formation groups for health promotion of children exposed to the negative impact.

[State of common responsiveness of teenagers living in regions with different levels of ambient air pollution].

The integral indices based on element ratio of hemogram as well as alpha-1 antitripsin, interleukins 2 and 10 contents in the adolescents living in industrial town with a high pollution level are represented in this paper. The increase in the processes of the nonspecific phagocytic protection and exertion of adaptive mechanisms has been revealed.

[Cholesterol exchange in children and adolescents in the industrial towns of eastern Siberia].

A prospective cohort study was conducted to examine lipid metabolic parameters in 5-14-year-old children. A directional trend was established in lipid parameters (a reduction in the level of total cholesterol and a change in its fractional composition: higher levels of high-density lipoprotein cholesterol with a parallel decrease in the concentration of low-density lipoprotein cholesterol), which is due to age-related features. There was a change in the spread of deviations in cholesterol exchange parameters from the standard values with age.

[Patterns of biochemical disorders under exposure to neurotoxic chemicals varying in nature].

The article covers results of examination of workers engaged into chemical production and contacting neurotoxic factors varying in nature. Findings are disorders of cholesterol metabolism in individuals engaged into vinylchloride and metallic mercury production, modified protein metabolism, activated lipid peroxidation and depressed antioxidant

[Biochemical criteria of occupationally related diseases formation in firemen].

Results of medical examination among working firemen and firemen with diagnosed occupational disease prove changes in protein and lipid metabolism. Decreased alpha-globulin fractions and increased beta-globulins could result from toxic chemical load and stress. Thus early changes in cholesterol metabolism without hepatic involvement are seen.

[Features of biochemical parameters in firemen].

The authors present results of examinations covering firemen with varying length of service and intensity of chemical load. Those results prove lower amount of alpha1-globulines and increased beta1-globulines content. Lipid metabolism disorders in idividuals with lower frequency of fires attended are caused by discrepancy between hormonal demands in stress expectation and actual utilization of energy substrates by various body tissues.