RESUMEN
BACKGROUND: To analyze the clinicopathological profile of young patients (≤ 40 years) with oral SCC and correlate with a control group (≥ 50 years) by means of histopathological grading systems. MATERIAL AND METHODS: 14 young patients and 14 control patients were selected with similar clinical stage and tumor location. Demographic and clinical data were obtained from patient records and histological sections were evaluated according to four histopathological grading systems. Associations between categories of demographic and clinical data were performed through Chi-square test and Exact Fisher test. The survival analyzes were performed according to the Kaplan-Meier method. RESULTS: The comparison between groups showed a greater association of treatment modalities in younger patients (p=0.022), they had a higher incidence of local recurrence and regional metastasis (p=0.018) and lower disease-free survival in 5 years (p=0.069). There was no difference in 5-year overall survival among the studied groups. There was no difference in histological grading between studied groups according to the four used systems. CONCLUSIONS: This study showed that, despite tumors had similar histological grade and more therapeutic modalities were used in the young group, tumors in young patients had a higher incidence of recurrence/metastasis, showing tendency to a more aggressive behavior.
Asunto(s)
Carcinoma de Células Escamosas/patología , Neoplasias de la Boca/patología , Adulto , Femenino , Humanos , Masculino , Recurrencia Local de Neoplasia , Estadificación de Neoplasias , Pronóstico , Estudios RetrospectivosRESUMEN
OBJECTIVE: This study evaluated the association of four histopathological grading systems (WHO grading system, malignancy grading of the deep invasive margins (MG), histological risk (HR) model, and tumor budding and depth of invasion (BD) model) with clinicopathological parameters and outcome of 113 oral squamous cell carcinomas to identify their roles in prognosis. METHODS: Demographic and clinical features were obtained from patients' records. Sections from all paraffin-embedded blocks were evaluated according to the four grading systems. Demographic and clinical associations were analyzed using chi-square test, and correlations between the grading systems were established with the Spearman's rank correlation test. Survival curves were performed with Kaplan-Meier method, and multivariate analysis based on Cox proportional hazard model was calculated. RESULTS: Significant associations with survival were observed for WHO grading system and BD model in the univariate analysis, but only the BD model was significantly associated with disease outcome as an independent prognostic marker. Age, tumor size, and presence of regional metastasis were also independent markers of reduced survival. CONCLUSION: A significant association between the BD model and outcome of OSCC patients was observed, indicating this new histopathological grading system as a possible prognostic tool.
Asunto(s)
Carcinoma de Células Escamosas/patología , Neoplasias de la Boca/patología , Clasificación del Tumor/métodos , Adulto , Factores de Edad , Anciano , Anciano de 80 o más Años , Carcinoma de Células Escamosas/secundario , Femenino , Humanos , Masculino , Persona de Mediana Edad , Valor Predictivo de las Pruebas , Pronóstico , Tasa de Supervivencia , Carga TumoralAsunto(s)
Infecciones Oportunistas Relacionadas con el SIDA/complicaciones , Candida albicans/aislamiento & purificación , Candidiasis Bucal/complicaciones , Enfermedades Mandibulares/complicaciones , Osteomielitis/complicaciones , Infecciones Estreptocócicas/complicaciones , Streptococcus/aislamiento & purificación , Infecciones Oportunistas Relacionadas con el SIDA/microbiología , Adulto , Humanos , Masculino , Enfermedades Mandibulares/microbiología , Osteomielitis/microbiologíaRESUMEN
The aim of this work is to provide an inventory of the scientific corpus produced by the Spanish members of the Expedition to Peru and Chile (1777-1788). This material is divided into six large sections. The first section covers the different versions of the diary of the journey taken by the Expedition. The second section covers the drafts and workbooks used by the Expedition members for the writing of "Flora Peruviana et Chilensis," the manuscripts and published editions of this work, the materials used in the preparation of both the "Prodromus" and the "Systema Vegetabilium," the contributions of the assistants on the Expedition and some monographs of taxonomic interest. The third section is dedicated to quinological studies and other pharmacological works undertaken by Hipólito Ruiz López and José Pavón Jiménez. The fourth section includes the writings concerning Ruiz's dispute with Antonio José Cavanilles. The fifth section contains texts which set forth the botanical thought of the members of the Expedition. The sixth and final section includes the Expedition members' writings on various subjects, from anthropology and ethnography to others of a purely historical nature.