1.
Eur J Pharmacol
; 568(1-3): 287-8, 2007 Jul 30.
Artículo
en Inglés
| MEDLINE
| ID: mdl-17521627
RESUMEN
Exposure of the anterior hepatic plexus to 2% perineurial capsaicin solution over three days caused transient insulin resistance confirmed by hyperinsulinaemic euglycaemic glucose clamping. Three additional perineurial capsaicin treatments divided by 3-month intervals yielded diabetes characterized by an increase in fasting blood glucose and glycated haemoglobin levels. Both insulin sensitivity and glycated haemoglobin level re-normalized over an additional 6-month period. We conclude that chronic partial hepatic sensory denervation produces diabetes in rabbits.