5,6-Di-hydro-1,4-dithiine-2,3-di-carb-oxy-lic anhydride.

In the title com-pound (systematic name: 2,3-di-hydro-1,4-dithiino[2,3-c]furan-5,7-dione), C6H4O3S2, the observed geometry agrees well with those of its phthalamide, thieno and hy-droxy analogs, and with a calculated geometry obtained by density functional theory (DFT) calculations. Specific structural features are an S-C-C-S torsion angle of -70.39 (17)° and S-C bonds to sp 2-hybridized C atoms approximately 0.1 Šshorter than those to sp 3-hybridized C atoms. Unlike the extended structures of the analogs, there are no directed inter-molecular inter-actions and the head-to-tail rows of mol-ecules that are a prominent structural motif of the packing can be rationalized in terms of optimized dipole-dipole inter-actions.

Eye Movements Predict Large-Scale Voting Decisions.

More than 100 countries allow people to vote directly on policies in direct democracy elections (e.g., 2016 Brexit referendum). Politicians are often responsible for writing ballot language, and voters frequently encounter ballot measures that are difficult to understand. We examined whether eye movements from a small group of individuals can predict the consequences of ballot language on large-scale voting decisions. Across two preregistered studies (Study 1: N = 120 registered voters, Study 2: N = 120 registered voters), we monitored laboratory participants' eye movements as they read real ballot measures. We found that eye-movement responses associated with difficulties in language comprehension predicted aggregate voting decisions to abstain from voting and vote against ballot measures in U.S. elections (total number of votes cast = 137,661,232). Eye movements predicted voting decisions beyond what was accounted for by widely used measures of language difficulty. This finding demonstrates a new way of linking eye movements to out-of-sample aggregate-level behaviors.

Don't dumb it down: The effects of jargon in COVID-19 crisis communication.

Experts are typically advised to avoid jargon when communicating with the general public, but previous research has not established whether avoiding jargon is necessary in a crisis. Using the ongoing COVID-19 pandemic as a backdrop, this online survey experiment (N = 393) examined the effect of jargon use across three different topics that varied in situational urgency: COVID-19 (high urgency), flood risk (low urgency), and federal emergency policy (control). Results revealed that although the use of jargon led to more difficult processing and reduced persuasion for the two less-urgent topics (flood risk, emergency policy), there was no effect of jargon in the COVID-19 condition. Theoretically, these findings suggest that the motivation to process information is an important moderator for crisis communication in particular and science communication in general. Practically, these findings suggest that science communicators, during times of crisis, do not need to "dumb down" their language in the same way they should during non-crises.

Risk factors for malaria infection prevalence and household vector density between mass distribution campaigns of long-lasting insecticidal nets in North-western Tanzania.

BACKGROUND: Long-lasting insecticidal nets (LLINs) are the most widely deployed vector control intervention in sub-Saharan Africa to prevent malaria. Recent reports indicate selection of pyrethroid insecticide resistance is widespread in mosquito vectors. This paper explores risk factors associated with malaria infection prevalence and vector density between mass distribution campaigns, changes in net coverage, and loss of protection in an area of high pyrethroid resistance in Northwest Tanzania. METHODS: A cross sectional malaria survey of 3456 children was undertaken in 2014 in Muleba district, Kagera region west of Lake Victoria. Vector density was assessed using indoor light traps and outdoor tent traps. Anophelines were identified to species using PCR and tested for Plasmodium falciparum circumsporozoite protein. Logistic regression was used to identify household and environmental factors associated with malaria infection and regression binomial negative for vector density. RESULTS: LLIN use was 27.7%. Only 16.9% of households had sufficient nets to cover all sleeping places. Malaria infection was independently associated with access to LLINs (OR: 0.57; 95% CI 0.34-0.98). LLINs less than 2 years old were slightly more protective than older LLINs (53 vs 65% prevalence of infection); however, there was no evidence that LLINs in good condition (hole index < 65) were more protective than LLINs, which were more holed. Other risk factors for malaria infection were age, group, altitude and house construction quality. Independent risk factors for vector density were consistent with malaria outcomes and included altitude, wind, livestock, house quality, open eaves and LLIN usage. Indoor collections comprised 4.6% Anopheles funestus and 95.4% Anopheles gambiae of which 4.5% were Anopheles arabiensis and 93.5% were Anopheles gambiae sensu stricto. CONCLUSION: Three years after the mass distribution campaign and despite top-ups, LLIN usage had declined considerably. While children living in households with access to LLINs were at lower risk of malaria, infection prevalence remained high even among users of LLINs in good condition. While effort should be made to maintain high coverage between campaigns, distribution of standard pyrethroid-only LLINs appears insufficient to prevent malaria transmission in this area of intense pyrethroid resistance.

Jargon as a barrier to effective science communication: Evidence from metacognition.

In this experiment (N = 650), we examine the negative consequences of jargon on individuals' perceptions of emerging scientific technology and aim to explain these effects. We find that the presence of jargon impairs people's ability to process scientific information, and that this impairment leads to greater motivated resistance to persuasion, increased risk perceptions, and lower support for technology adoption. These findings suggest that the use of jargon undermines efforts to inform and persuade the public through the cognitive mechanism of metacognition.

The Equity Impact Vaccines May Have On Averting Deaths And Medical Impoverishment In Developing Countries.

With social policies increasingly directed toward enhancing equity through health programs, it is important that methods for estimating the health and economic benefits of these programs by subpopulation be developed, to assess both equity concerns and the programs' total impact. We estimated the differential health impact (measured as the number of deaths averted) and household economic impact (measured as the number of cases of medical impoverishment averted) of ten antigens and their corresponding vaccines across income quintiles for forty-one low- and middle-income countries. Our analysis indicated that benefits across these vaccines would accrue predominantly in the lowest income quintiles. Policy makers should be informed about the large health and economic distributional impact that vaccines could have, and they should view vaccination policies as potentially important channels for improving health equity. Our results provide insight into the distribution of vaccine-preventable diseases and the health benefits associated with their prevention.